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Article Open Access

HER4 promotes the progression of colorectal cancer by promoting epithelial‑mesenchymal transition

  • Authors:
    • Xiaojing Jia
    • Huien Wang
    • Zhongxin Li
    • Jing Yan
    • Yan Guo
    • Wujie Zhao
    • Lixia Gao
    • Bin Wang
    • Yitao Jia
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China, Department of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China, Second Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Fifth Department of Oncology, The First Hospital of Shijiazhuang, Shijiazhuang, Hebei 050011, P.R. China
    Copyright: © Jia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1779-1788
    |
    Published online on: February 4, 2020
       https://doi.org/10.3892/mmr.2020.10974
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Abstract

Colorectal cancer (CRC) remains one of the most common cancer types worldwide. A few previous studies have examined whether HER4 may promote the progression of CRC. The present study examined the associations among the expression levels of members of the HER family, and investigated the potential mechanism underlying the function of HER4 in CRC cells. Immunohistochemistry analysis was conducted to detect the expression levels of HER family members in patients with CRC. HER4 expression was knocked down using short hairpin RNA in HCT116 cells, and confirmed by quantitative PCR and western blotting. The proliferation and adhesion of CRC cells were analyzed by CCK‑8 assays and adhesive assays, respectively. Flow cytometry was used to measure cell apoptosis. Western blotting and immunofluorescence staining in CRC cells were performed to identify proteins related to epithelial‑mesenchymal transition. The proportion of patients with CRC presenting positive expression of the HER family members epidermal growth factor receptor (EGFR), HER2, HER3 and HER4 were 72.1, 45.2, 43.8 and 34.2%, respectively. No relationship was found between HER4 and EGFR, HER2 or HER3 expression. Higher expression of HER4 was positively associated with lymph node metastasis (P=0.039). In the present study, HER4 expression was found to be associated with an unfavorable clinical outcome in patients with CRC (Plogrank=0.020). Cell proliferation was inhibited, and apoptosis was increased following HER4 knockdown. Furthermore, HER4 knockdown increased the expression of E‑cadherin and decreased the expressions of N‑cadherin and vimentin (P<0.05). HER4 expression was found to be unrelated to other HER family members. In the present study, positive expression of HER4 promoted the progression of CRC through epithelial‑mesenchymal transition.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Sung JJ, Lau JY, Goh KL and Leung WK; Asia Pacific Working Group on Colorectal Cancer, : Increasing incidence of colorectal cancer in Asia: Implications for screening. Lancet Oncol. 6:871–876. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Dawson H and Lugli A: Molecular and pathogenetic aspects of tumor budding in colorectal cancer. Front Med (Lausanne). 2:112015.PubMed/NCBI

4 

Roskoski R: The ErbB/HER family of protein-tyrosine kinases and cancer. Pharmacol Res. 79:34–74. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Rego RL, Foster NR, Smyrk TC, Le M, O'Connell MJ, Sargent DJ, Windschitl H and Sinicrope FA: Prognostic effect of activated EGFR expression in human colon carcinomas: Comparison with EGFR status. Br J Cancer. 102:165–172. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Kapitanović S, Radosević S, Kapitanović M, Andelinović S, Ferencić Z, Tavassoli M, Primorać D, Sonicki Z, Spaventi S, Pavelic K and Spaventi R: The expression of p185(HER-2/neu) correlates with the stage of disease and survival in colorectal cancer. Gastroenterology. 112:1103–1113. 1997. View Article : Google Scholar : PubMed/NCBI

7 

Mitsui K, Yonezawa M, Tatsuguchi A, Shinji S, Gudis K, Tanaka S, Fujimori S and Sakamoto C: Localization of phosphorylated ErbB1-4 and heregulin in colorectal cancer. BMC Cancer. 14:8632014. View Article : Google Scholar : PubMed/NCBI

8 

Machleidt A, Buchholz S, Diermeier-Daucher S, Zeman F, Ortmann O and Brockhoff G: The prognostic value of Her4 receptor isoform expression in triple-negative and Her2 positive breast cancer patients. BMC Cancer. 13:4372013. View Article : Google Scholar : PubMed/NCBI

9 

Göthlin EA, Tina E, Wegman P, Stål O, Fransén K, Fornander T and Wingren S: HER4 tumor expression in breast cancer patients randomized to treatment with or without tamoxifen. Int J Oncol. 47:1311–1120. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Nielsen TO, Poulsen SS, Journe F, Ghanem G and Sorensen BS: HER4 and its cytoplasmic isoforms are associated with progression-free survival of malignant melanoma. Melanoma Res. 24:88–91. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Wang H, Sun W, Sun M, Fu Z, Zhou C, Wang C, Zuo D, Zhou Z, Wang G, Zhang T, et al: HER4 promotes cell survival and chemoresistance in osteosarcoma via interaction with NDRG1. Biochim Biophys Acta Mol Basis Dis. 1864:1839–1849. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Guo Y, Duan Z, Jia Y, Ren C, Lv J, Guo P, Zhao W, Wang B, Zhang S, Li Y and Li Z: HER4 isoform CYT2 and its ligand NRG1III are expressed at high levels in human colorectal cancer. Oncol Lett. 15:6629–6635. 2018.PubMed/NCBI

13 

Thiery JP and Sleeman JP: Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol. 7:131–142. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Savagner P, Boyer B, Valles AM, Jouanneau J and Thiery JP: Modulations of the epithelial phenotype during embryogenesis and cancer progression. Cancer Treat Res. 71:229–249. 1994. View Article : Google Scholar : PubMed/NCBI

15 

Tam WL and Weinberg RA: The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat Med. 19:1438–1449. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Vu T and Datta PK: Regulation of EMT in colorectal cancer: A culprit in metastasis. Cancers (Basel). 9(pii): E1712017. View Article : Google Scholar : PubMed/NCBI

17 

Jacobs TW, Gown AM, Yaziji H, Barnes MJ and Schnitt SJ: Specificity of HercepTest in determining HER-2/neu status of breast cancers using the United States Food and Drug Administration-approved scoring system. J Clin Oncol. 17:1983–1987. 1999. View Article : Google Scholar : PubMed/NCBI

18 

Williams CS, Bernard JK, Demory Beckler M, Almohazey D, Washington MK, Smith JJ and Frey MR: ERBB4 is over-expressed in human colon cancer and enhances cellular transformation. Carcinogenesis. 36:710–718. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Huang KK, Ramnarayanan K, Zhu F, Srivastava S, Xu C, Tan ALK, Lee M, Tay S, Das K, Xing M, et al: Genomic and epigenomic profiling of high-risk intestinal metaplasia reveals molecular determinants of progression to gastric cancer. Cancer Cell. 33:137–150.e5. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Tiwari A, Mukherjee B, Hassan MK, Pattanaik N, Jaiswal AM and Dixit M: Reduced FRG1 expression promotes prostate cancer progression and affects prostate cancer cell migration and invasion. BMC Cancer. 19:3462019. View Article : Google Scholar : PubMed/NCBI

21 

Ljuslinder I, Malmer B, Isaksson-Mettävainio M, Oberg A, Henriksson R, Stenling R and Palmqvist R: ErbB 1–4 expression alterations in primary colorectal cancers and their corresponding metastases. Anticancer Res. 29:1489–1494. 2009.PubMed/NCBI

22 

Baiocchi G, Lopes A, Coudry RA, Rossi BM, Soares FA, Aguiar S, Guimarães GC, Ferreira FO and Nakagawa WT: ErbB family immunohistochemical expression in colorectal cancer patients with higher risk of recurrence after radical surgery. Int J Colorectal Dis. 24:1059–1068. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Kountourakis P, Pavlakis K, Psyrri A, Rontogianni D, Xiros N, Patsouris E, Pectasides D and Economopoulos T: Prognostic significance of HER3 and HER4 protein expression in colorectal adenocarcinomas. BMC Cancer. 6:462006. View Article : Google Scholar : PubMed/NCBI

24 

Huang F, Shi Q, Li Y, Xu L, Xu C, Chen F, Wang H, Liao H, Chang Z, Liu F, et al: HER2/EGFR-AKT signaling switches TGF-β from inhibiting cell proliferation to promoting cell migration in breast cancer. Cancer Res. 78:6073–6085. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Siddiqa A, Long LM, Li L, Marciniak RA and Kazhdan I: Expression of HER-2 in MCF-7 breast cancer cells modulates anti-apoptotic proteins Survivin and Bcl-2 via the extracellular signal-related kinase (ERK) and phosphoinositide-3 kinase (PI3K) signalling pathways. BMC Cancer. 8:1292008. View Article : Google Scholar : PubMed/NCBI

26 

Béguelin W, Díaz Flaqué MC, Proietti CJ, Cayrol F, Rivas MA, Tkach M, Rosemblit C, Tocci JM, Charreau EH, Schillaci R and Elizalde PV: Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3. Mol Cell Biol. 30:5456–5472. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Lo HW: Targeting Ras-RAF-ERK and its interactive pathways as a novel therapy for malignant gliomas. Curr Cancer Drug Targets. 10:840–848. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Lee JC, Wang ST, Chow NH and Yang HB: Investigation of the prognostic value of coexpressed erbB family members for the survival of colorectal cancer patients after curative surgery. Eur J Cancer. 38:1065–1071. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Donoghue JF, Kerr LT, Alexander NW, Greenall SA, Longano AB, Gottardo NG, Wang R, Tabar V, Adams TE, Mischel PS and Johns TG: Activation of ERBB4 in glioblastoma can contribute to increased tumorigenicity and influence therapeutic response. Cancers (Basel). 10(pii): E2432018. View Article : Google Scholar : PubMed/NCBI

30 

Shi J, Li F, Yao X, Mou T, Xu Z, Han Z, Chen S, Li W, Yu J, Qi X, et al: The HER4-YAP1 axis promotes trastuzumab resistance in HER2-positive gastric cancer by inducing epithelial and mesenchymal transition. Oncogene. 37:3022–3038. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Wang W, Zhao HF, Yao TF and Gong H: Advanced development of ErbB family-targeted therapies in osteosarcoma treatment. Invest New Drugs. 37:175–183. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Yun S, Kwak Y, Nam SK, Seo AN, Oh HK, Kim DW, Kang SB and Lee HS: Ligand-independent epidermal growth factor receptor overexpression correlates with poor prognosis in colorectal cancer. Cancer Res Treat. 50:1351–1361. 2018. View Article : Google Scholar : PubMed/NCBI

33 

De Craene B and Berx G: Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer. 13:97–110. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Sulaiman A, Li L and Wang L: E-cadherin adhesion-mediated Wnt activation for mesoderm specification in human embryonic stem cells needs a soft mattress. Stem Cell Investig. 3:772016. View Article : Google Scholar : PubMed/NCBI

35 

Song G, Zhang H, Chen C, Gong L, Chen B, Zhao S, Shi J, Xu J and Ye Z: MiR-551b regulates epithelial-mesenchymal transition and metastasis of gastric cancer by inhibiting ERBB4 expression. Oncotarget. 8:45725–45735. 2017.PubMed/NCBI

36 

Chen T, Zhou L, Li H, Tian Y, Li J, Dong L, Zhao Y and Wei D: Fatty acid synthase affects expression of ErbB receptors in epithelial to mesenchymal transition of breast cancer cells and invasive ductal carcinoma. Oncol Lett. 14:5934–5946. 2017.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jia X, Wang H, Li Z, Yan J, Guo Y, Zhao W, Gao L, Wang B and Jia Y: HER4 promotes the progression of colorectal cancer by promoting epithelial‑mesenchymal transition. Mol Med Rep 21: 1779-1788, 2020.
APA
Jia, X., Wang, H., Li, Z., Yan, J., Guo, Y., Zhao, W. ... Jia, Y. (2020). HER4 promotes the progression of colorectal cancer by promoting epithelial‑mesenchymal transition. Molecular Medicine Reports, 21, 1779-1788. https://doi.org/10.3892/mmr.2020.10974
MLA
Jia, X., Wang, H., Li, Z., Yan, J., Guo, Y., Zhao, W., Gao, L., Wang, B., Jia, Y."HER4 promotes the progression of colorectal cancer by promoting epithelial‑mesenchymal transition". Molecular Medicine Reports 21.4 (2020): 1779-1788.
Chicago
Jia, X., Wang, H., Li, Z., Yan, J., Guo, Y., Zhao, W., Gao, L., Wang, B., Jia, Y."HER4 promotes the progression of colorectal cancer by promoting epithelial‑mesenchymal transition". Molecular Medicine Reports 21, no. 4 (2020): 1779-1788. https://doi.org/10.3892/mmr.2020.10974
Copy and paste a formatted citation
x
Spandidos Publications style
Jia X, Wang H, Li Z, Yan J, Guo Y, Zhao W, Gao L, Wang B and Jia Y: HER4 promotes the progression of colorectal cancer by promoting epithelial‑mesenchymal transition. Mol Med Rep 21: 1779-1788, 2020.
APA
Jia, X., Wang, H., Li, Z., Yan, J., Guo, Y., Zhao, W. ... Jia, Y. (2020). HER4 promotes the progression of colorectal cancer by promoting epithelial‑mesenchymal transition. Molecular Medicine Reports, 21, 1779-1788. https://doi.org/10.3892/mmr.2020.10974
MLA
Jia, X., Wang, H., Li, Z., Yan, J., Guo, Y., Zhao, W., Gao, L., Wang, B., Jia, Y."HER4 promotes the progression of colorectal cancer by promoting epithelial‑mesenchymal transition". Molecular Medicine Reports 21.4 (2020): 1779-1788.
Chicago
Jia, X., Wang, H., Li, Z., Yan, J., Guo, Y., Zhao, W., Gao, L., Wang, B., Jia, Y."HER4 promotes the progression of colorectal cancer by promoting epithelial‑mesenchymal transition". Molecular Medicine Reports 21, no. 4 (2020): 1779-1788. https://doi.org/10.3892/mmr.2020.10974
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