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Article Open Access

Adipose‑derived mesenchymal stem cells ameliorate dibutyltin dichloride‑induced chronic pancreatitis by inhibiting the PI3K/AKT/mTOR signaling pathway

  • Authors:
    • Xiangxiang Xu
    • Huajun Yu
    • Linxiao Sun
    • Chenlei Zheng
    • Yunfeng Shan
    • Zhenxu Zhou
    • Cheng Wang
    • Bicheng Chen
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Key Laboratory of Diagnosis and Treatment of Severe Hepato‑Pancreatic Diseases of Zhejiang Province, Zhejiang Provincial Top Key Discipline in Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1833-1840
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    Published online on: February 21, 2020
       https://doi.org/10.3892/mmr.2020.10995
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Abstract

Adipose‑derived mesenchymal stem cells (ASCs) play a positive role in tissue injury repair and regeneration. The aim of this study was to determine whether ASCs could ameliorate chronic pancreatitis (CP) induced by the injection of dibutyltin dichloride (DBTC) and to elucidate its potential mechanisms. Furthermore, this study also explored whether there was a significant difference if the ASCs were injected via the inferior vena cava or the left gastric artery. CP was induced in rats by a single intravenous administration of DBTC, and the accumulation of collagen and apoptotic rates of pancreatic acinar cells were analyzed. According to the results, ASCs markedly reduced DBTC‑induced pancreatic damage and collagen deposition in the rat model of CP. Moreover, ASCs significantly decreased pancreatic cell apoptosis by regulating the expression levels of caspase‑3, BAX and Bcl‑2. These effects were observed regardless of whether the injection was in the inferior vena cava or the left gastric artery. It was also found that the expression levels of phosphorylated PI3K, AKT and mTOR in pancreatic tissues of the DBTC‑induced CP model group were significantly increased, while the expression levels of phosphorylated PI3K, AKT and mTOR in the two treatment groups were markedly decreased. ASCs noticeably suppressed the PI3K/AKT/mTOR pathway in the pancreatic tissue of DBTC‑induced CP. This study indicated that ASCs protect against pancreatic fibrosis by modulating the PI3K/AKT/mTOR pathway, and have the potential to be a new strategy for the treatment of CP in the future.
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1 

Yadav D, Timmons L, Benson JT, Dierkhising RA and Chari ST: Incidence, prevalence, and survival of chronic pancreatitis: A population-based study. Am J Gastroenterol. 106:2192–2199. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Lankisch PG: Natural course of chronic pancreatitis. Pancreatology. 1:3–14. 2001. View Article : Google Scholar : PubMed/NCBI

3 

DiMagno MJ and Dimagno EP: Chronic pancreatitis. Curr Opin Gastroenterol. 22:487–497. 2006.PubMed/NCBI

4 

Andrén-Sandberg A, Hoem D and Gislason H: Pain management in chronic pancreatitis. Eur J Gastroenterol Hepatol. 14:957–970. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Argo JL, Contreras JL, Wesley MM and Christein JD: Pancreatic resection with islet cell autotransplant for the treatment of severe chronic pancreatitis. Am Surg. 74:530–536. 2008.PubMed/NCBI

6 

Dixon J, DeLegge M, Morgan KA and Adams DB: Impact of total pancreatectomy with islet cell transplant on chronic pancreatitis management at a disease-based center. Am Surg. 74:735–738. 2008.PubMed/NCBI

7 

da Silva Meirelles L, Chagastelles PC and Nardi NB: Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci. 119:2204–2213. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S and Marshak DR: Multilineage potential of adult human mesenchymal stem cells. Science. 284:143–147. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M, et al: Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 418:41–49. 2002. View Article : Google Scholar : PubMed/NCBI

10 

D'Addio F, Valderrama Vasquez A, Ben Nasr M, Franek E, Zhu D, Li L, Ning G, Snarski E and Fiorina P: Autologous nonmyeloablative hematopoietic stem cell transplantation in new-onset type 1 diabetes: A multicenter analysis. Diabetes. 63:3041–3046. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Frumento D, Ben Nasr M, El Essawy B, D'Addio F, Zuccotti GV and Fiorina P: Immunotherapy for type 1 diabetes. J Endocrinol Invest. 40:803–814. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Krampera M, Glennie S, Dyson J, Scott D, Laylor R, Simpson E and Dazzi F: Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood. 101:3722–3729. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Corcione A, Benvenuto F, Ferretti E, Giunti D, Cappiello V, Cazzanti F, Risso M, Gualandi F, Mancardi GL, Pistoia V and Uccelli A: Human mesenchymal stem cells modulate B-cell functions. Blood. 107:367–372. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Sotiropoulou PA, Perez SA, Gritzapis AD, Baxevanis CN and Papamichail M: Interactions between human mesenchymal stem cells and natural killer cells. Stem Cells. 24:74–85. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Nauta AJ and Fibbe WE: Immunomodulatory properties of mesenchymal stromal cells. Blood. 110:3499–3506. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Jurgens WJ, Oedayrajsingh-Varma MJ, Helder MN, Zandiehdoulabi B, Schouten TE, Kuik DJ, Ritt MJ and van Milligen FJ: Effect of tissue-harvesting site on yield of stem cells derived from adipose tissue: Implications for cell-based therapies. Cell Tissue Res. 332:415–426. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Bura A, Planat-Benard V, Bourin P, Silvestre JS, Gross F, Grolleau JL, Saint-Lebese B, Peyrafitte JA, Fleury S, Gadelorge M, et al: Phase I trial: The use of autologous cultured adipose-derived stroma/stem cells to treat patients with non-revascularizable critical limb ischemia. Cytotherapy. 16:245–257. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Kim HW, Song WJ, Li Q, Han SM, Jeon KO, Park SC, Ryu MO, Chae HK, Kyeong K and Youn HY: Canine adipose tissue-derived mesenchymal stem cells ameliorate severe acute pancreatitis by regulating T cells in rats. J Vet Sci. 17:539–548. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Kang HM, Kim J, Park S, Kim J, Kim H, Kim KS, Lee EJ, Seo SI, Kang SG, Lee JE and Lim H: Insulin-secreting cells from human eyelid-derived stem cells alleviate type I diabetes in immunocompetent mice. Stem Cells. 27:1999–2008. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Bassi ÊJ, Moraes-Vieira PM, Moreira-Sá CS, Almeida DC, Vieira LM, Cunha CS, Hiyane MI, Basso AS, Pacheco-Silva A and Câmara NO: Immune regulatory properties of allogeneic adipose-derived mesenchymal stem cells in the treatment of experimental autoimmune diabetes. Diabetes. 61:2534–2545. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Lopez-Santalla M, Mancheño-Corvo P, Escolano A, Menta R, DelaRosa O, Abad JL, Büscher D, Redondo JM, Bueren JA, Dalemans W, et al: Biodistribution and efficacy of human adipose-derived mesenchymal stem cells following intranodal administration in experimental colitis. Front Immunol. 8:6382017. View Article : Google Scholar : PubMed/NCBI

22 

Dozois EJ, Lightner AL, Mathis KL, Chua HK, Kelley SR, Fletcher JG, Dietz AB, Friton JJ, Butler GW and Faubion WA: Early results of a phase I trial using an adipose-derived mesenchymal stem cell-coated fistula plug for the treatment of transsphincteric cryptoglandular fistulas. Dis Colon Rectum. 62:615–622. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Sanz-Baro R, García-Arranz M, Guadalajara H, de la Quintana P, Herreros MD and García-Olmo D: First-in-human case study: Pregnancy in women with crohn's perianal fistula treated with adipose-derived stem cells: A safety study. Stem Cells Transl Med. 4:598–602. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Álvaro-Gracia JM, Jover JA, García-Vicuña R, Carreño L, Alonso A, Marsal S, Blanco F, Martínez-Taboada VM, Taylor P, Martín-Martín C, et al: Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis (Cx611): Results of a multicentre, dose escalation, randomised, single-blind, placebo-controlled phase Ib/IIa clinical trial. Ann Rheum Dis. 76:196–202. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Pers YM, Rackwitz L, Ferreira R, Pullig O, Delfour C, Barry F, Sensebe L, Casteilla L, Fleury S, Bourin P, et al: Adipose mesenchymal stromal cell-based therapy for severe osteoarthritis of the knee: A phase I dose-escalation trial. Stem Cells Transl Med. 5:847–856. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Guillaume-Jugnot P, Daumas A, Magalon J, Jouve E, Nguyen PS, Truillet R, Mallet S, Casanova D, Giraudo L, Veran J, et al: Autologous adipose-derived stromal vascular fraction in patients with systemic sclerosis: 12-month follow-up. Rheumatology (Oxford). 55:301–306. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Díez-Tejedor E, Gutiérrez-Fernández M, Martínez-Sánchez P, Rodríguez-Frutos B, Ruiz-Ares G, Lara ML and Gimeno BF: Reparative therapy for acute ischemic stroke with allogeneic mesenchymal stem cells from adipose tissue: A safety assessment: A phase II randomized, double-blind, placebo-controlled, single-center, pilot clinical trial. J Stroke Cerebrovasc Dis. 23:2694–2700. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Ke L, Ni HB, Tong ZH, Li WQ, Li N and Li JS: Efficacy of continuous regional arterial infusion with low-molecular-weight heparin for severe acute pancreatitis in a porcine model. Shock. 41:443–448. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Sarles H: Etiopathogenesis and definition of chronic pancreatitis. Dig Dis Sci. 31 (9 Suppl):91S–107S. 1986. View Article : Google Scholar : PubMed/NCBI

30 

Witt H, Apte MV, Keim V and Wilson JS: Chronic pancreatitis: Challenges and advances in pathogenesis, genetics, diagnosis, and therapy. Gastroenterology. 132:1557–1573. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Friedman SL: Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver. Physiol Rev. 88:125–172. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Omary MB, Lugea A, Lowe AW and Pandol SJ: The pancreatic stellate cell: A star on the rise in pancreatic diseases. J Clin Invest. 117:50–59. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Xu M, Wang G, Zhou H, Cai J, Li P, Zhou M, Lu Y, Jiang X, Huang H, Zhang Y and Gong A: TGF-β1-miR-200a-PTEN induces epithelial-mesenchymal transition and fibrosis of pancreatic stellate cells. Mol Cell Biochem. 43:1161–1168. 2017.

34 

Yu FX, Su LF, Dai CL, Wang Y, Teng YY, Fu JH, Zhang QY and Tang YH: Inhibition of pancreatic stellate cell activity by adipose-derived stem cells. Hepatobiliary Pancreat Dis Int. 14:215–221. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Zhang SK, Tsui NC, Li DH, Yao GW and Wang YN: Expression of transforming growth factor beta1/Sma- and Mad-related proteins in rat with chronic pancreatitis induced by dibutyltin dichloride. Pancreas. 39:252–253. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Schwer CI, Mutschler M, Stoll P, Goebel U, Humar M, Hoetzel A and Schmidt R: Carbon monoxide releasing molecule-2 inhibits pancreatic stellate cell proliferation by activating p38 mitogen-activated protein kinase/heme oxygenase-1 signaling. Mol Pharmacol. 77:660–669. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Fortunato F, Berger I, Gross ML, Rieger P, Buechler MW and Werner J: Immune-compromised state in the rat pancreas after chronic alcohol exposure: The role of peroxisome proliferator-activated receptor gamma. J Pathol. 213:441–452. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Mayer J, Rau B, Gansauge F and Beger HG: Inflammatory mediators in human acute pancreatitis: Clinical and pathophysiological implications. Gut. 47:546–552. 2000. View Article : Google Scholar : PubMed/NCBI

39 

Xie MJ, Motoo Y, Su SB and Sawabu N: Expression of tumor necrosis factor-alpha, interleukin-6, and interferon-gamma in spontaneous chronic pancreatitis in the WBN/Kob rat. Pancreas. 22:400–408. 2001. View Article : Google Scholar : PubMed/NCBI

40 

Mews P, Phillips P, Fahmy R, Korsten M, Pirola R, Wilson J and Apte M: Pancreatic stellate cells respond to inflammatory cytokines: Potential role in chronic pancreatitis. Gut. 50:535–541. 2002. View Article : Google Scholar : PubMed/NCBI

41 

Poudel B, Ki HH, Lee YM and Kim DK: Collagen I-induced dendritic cells activation is regulated by TNF-αlpha production through down-regulation of IRF4. J Biosci. 40:71–78. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Li J and Yuan J: Caspases in apoptosis and beyond. Oncogene. 27:6194–6206. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Man SM and Kanneganti TD: Converging roles of caspases in inflammasome activation, cell death and innate immunity. Nat Rev Immunol. 16:7–21. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Mareninova OA, Sung KF, Hong P, Lugea A, Pandol SJ, Gukovsky I and Gukovskaya AS: Cell death in pancreatitis: Caspases protect from necrotizing pancreatitis. J Biol Chem. 281:3370–3381. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Pop C and Salvesen GS: Human caspases: Activation, specificity, and regulation. J Biol Chem. 284:21777–21781. 2009. View Article : Google Scholar : PubMed/NCBI

46 

Leist M and Jäättelä M: Four deaths and a funeral: From caspases to alternative mechanisms. Nat Rev Mol Cell Biol. 2:589–598. 2001. View Article : Google Scholar : PubMed/NCBI

47 

Shen J, Wan R, Hu G, Yang L, Xiong J, Wang F, Shen J, He S, Guo X, Ni J, et al: miR-15b and miR-16 induce the apoptosis of rat activated pancreatic stellate cells by targeting Bcl-2 in vitro. Pancreatology. 12:91–99. 2012. View Article : Google Scholar : PubMed/NCBI

48 

Sung KF, Odinokova IV, Mareninova OA, Rakonczay Z Jr, Hegyi P, Pandol SJ, Gukovsky I and Gukovskaya AS: Prosurvival Bcl-2 proteins stabilize pancreatic mitochondria and protect against necrosis in experimental pancreatitis. Exp Cell Res. 315:1975–1989. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Gomez G, Lee HM, He Q, Englander EW, Uchida T and Greeley GH Jr: Acute pancreatitis signals activation of apoptosis-associated and survival genes in mice. Exp Biol Med (Maywood). 226:692–700. 2001. View Article : Google Scholar : PubMed/NCBI

50 

Djukom C, Porro LJ, Mrazek A, Townsend CM Jr, Hellmich MR and Chao C: Dual inhibition of PI3K and mTOR signaling pathways decreases human pancreatic neuroendocrine tumor metastatic progression. Pancreas. 43:88–92. 2014. View Article : Google Scholar : PubMed/NCBI

51 

Briest F and Grabowski P: PI3K-AKT-mTOR-signaling and beyond: The complex network in gastroenteropancreatic neuroendocrine neoplasms. Theranostics. 4:336–365. 2014. View Article : Google Scholar : PubMed/NCBI

52 

François RA, Maeng K, Nawab A, Kaye FJ, Hochwald SN and Zajac-Kaye M: Targeting focal adhesion kinase and resistance to mTOR inhibition in pancreatic neuroendocrine tumors. J Natl Cancer Inst. 107(pii): djv1232015. View Article : Google Scholar : PubMed/NCBI

53 

Falletta S, Partelli S, Rubini C, Nann D, Doria A, Marinoni I, Polenta V, Di Pasquale C, Degli Uberti E, Perren A, et al: mTOR inhibitors response and mTOR pathway in pancreatic neuroendocrine tumors. Endocr Relat Cancer. 23:883–891. 2016. View Article : Google Scholar : PubMed/NCBI

54 

Vandamme T, Beyens M, de Beeck KO, Dogan F, van Koetsveld PM, Pauwels P, Mortier G, Vangestel C, de Herder W, Van Camp G, et al: Long-term acquired everolimus resistance in pancreatic neuroendocrine tumours can be overcome with novel PI3K-AKT-mTOR inhibitors. Br J Cancer. 114:650–658. 2016. View Article : Google Scholar : PubMed/NCBI

55 

Zitzmann K, De Toni EN, Brand S, Göke B, Meinecke J, Spöttl G, Meyer HH and Auernhammer CJ: The novel mTOR inhibitor RAD001 (everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells. Neuroendocrinology. 85:54–60. 2007. View Article : Google Scholar : PubMed/NCBI

56 

Adamo B, Deal AM, Burrows E, Geradts J, Hamilton E, Blackwell KL, Livasy C, Fritchie K, Prat A, Harrell JC, et al: Phosphatidylinositol 3-kinase pathway activation in breast cancer brain metastases. Breast Cancer Res. 13:R1252011. View Article : Google Scholar : PubMed/NCBI

57 

Johnson SM, Gulhati P, Rampy BA, Han Y, Rychahou PG, Doan HQ, Weiss HL and Evers BM: Novel expression patterns of PI3K/Akt/mTOR signaling pathway components in colorectal cancer. J Am Coll Surg. 210:767–778. 2010. View Article : Google Scholar : PubMed/NCBI

58 

LoRusso PM: Inhibition of the PI3K/AKT/mTOR pathway in solid tumors. J Clin Oncol. 34:3803–3815. 2016. View Article : Google Scholar : PubMed/NCBI

59 

Rodon J, Dienstmann R, Serra V and Tabernero J: Development of PI3K inhibitors: Lessons learned from early clinical trials. Nat Rev Clin Oncol. 10:143–153. 2013. View Article : Google Scholar : PubMed/NCBI

60 

Engelman JA: Targeting PI3K signalling in cancer: Opportunities, challenges and limitations. Nat Rev Cancer. 9:550–562. 2009. View Article : Google Scholar : PubMed/NCBI

61 

Cui LH, Li CX, Zhuo YZ, Yang L, Cui NQ and Zhang SK: Saikosaponin d ameliorates pancreatic fibrosis by inhibiting autophagy of pancreatic stellate cells via PI3K/Akt/mTOR pathway. Chem Biol Interact. 300:18–26. 2019. View Article : Google Scholar : PubMed/NCBI

62 

Hirota M, Shimosegawa T, Kitamura K, Takeda K, Takeyama Y, Mayumi T, Ito T, Takenaka M, Iwasaki E, Sawano H, et al: Continuous regional arterial infusion versus intravenous administration of the protease inhibitor nafamostat mesilate for predicted severe acute pancreatitis: A multicenter, randomized, open-label, phase 2 trial. J Gastroenterol. Nov 22–2019.(Epub ahead of print).

63 

Yong FJ, Mao XY, Deng LH, Zhang MM and Xia Q: Continuous regional arterial infusion for the treatment of severe acute pancreatitis: A meta-analysis. Hepatobiliary Pancreat Dis Int. 14:10–17. 2015. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Xu X, Yu H, Sun L, Zheng C, Shan Y, Zhou Z, Wang C and Chen B: Adipose‑derived mesenchymal stem cells ameliorate dibutyltin dichloride‑induced chronic pancreatitis by inhibiting the PI3K/AKT/mTOR signaling pathway. Mol Med Rep 21: 1833-1840, 2020.
APA
Xu, X., Yu, H., Sun, L., Zheng, C., Shan, Y., Zhou, Z. ... Chen, B. (2020). Adipose‑derived mesenchymal stem cells ameliorate dibutyltin dichloride‑induced chronic pancreatitis by inhibiting the PI3K/AKT/mTOR signaling pathway. Molecular Medicine Reports, 21, 1833-1840. https://doi.org/10.3892/mmr.2020.10995
MLA
Xu, X., Yu, H., Sun, L., Zheng, C., Shan, Y., Zhou, Z., Wang, C., Chen, B."Adipose‑derived mesenchymal stem cells ameliorate dibutyltin dichloride‑induced chronic pancreatitis by inhibiting the PI3K/AKT/mTOR signaling pathway". Molecular Medicine Reports 21.4 (2020): 1833-1840.
Chicago
Xu, X., Yu, H., Sun, L., Zheng, C., Shan, Y., Zhou, Z., Wang, C., Chen, B."Adipose‑derived mesenchymal stem cells ameliorate dibutyltin dichloride‑induced chronic pancreatitis by inhibiting the PI3K/AKT/mTOR signaling pathway". Molecular Medicine Reports 21, no. 4 (2020): 1833-1840. https://doi.org/10.3892/mmr.2020.10995
Copy and paste a formatted citation
x
Spandidos Publications style
Xu X, Yu H, Sun L, Zheng C, Shan Y, Zhou Z, Wang C and Chen B: Adipose‑derived mesenchymal stem cells ameliorate dibutyltin dichloride‑induced chronic pancreatitis by inhibiting the PI3K/AKT/mTOR signaling pathway. Mol Med Rep 21: 1833-1840, 2020.
APA
Xu, X., Yu, H., Sun, L., Zheng, C., Shan, Y., Zhou, Z. ... Chen, B. (2020). Adipose‑derived mesenchymal stem cells ameliorate dibutyltin dichloride‑induced chronic pancreatitis by inhibiting the PI3K/AKT/mTOR signaling pathway. Molecular Medicine Reports, 21, 1833-1840. https://doi.org/10.3892/mmr.2020.10995
MLA
Xu, X., Yu, H., Sun, L., Zheng, C., Shan, Y., Zhou, Z., Wang, C., Chen, B."Adipose‑derived mesenchymal stem cells ameliorate dibutyltin dichloride‑induced chronic pancreatitis by inhibiting the PI3K/AKT/mTOR signaling pathway". Molecular Medicine Reports 21.4 (2020): 1833-1840.
Chicago
Xu, X., Yu, H., Sun, L., Zheng, C., Shan, Y., Zhou, Z., Wang, C., Chen, B."Adipose‑derived mesenchymal stem cells ameliorate dibutyltin dichloride‑induced chronic pancreatitis by inhibiting the PI3K/AKT/mTOR signaling pathway". Molecular Medicine Reports 21, no. 4 (2020): 1833-1840. https://doi.org/10.3892/mmr.2020.10995
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