Open Access

Genetic variations associated with pharmacoresistant epilepsy (Review)

  • Authors:
    • Noemí Cárdenas‑Rodríguez
    • Liliana Carmona‑Aparicio
    • Diana L. Pérez‑Lozano
    • Daniel Ortega‑Cuellar
    • Saúl Gómez‑Manzo
    • Iván Ignacio‑Mejía
  • View Affiliations

  • Published online on: February 24, 2020     https://doi.org/10.3892/mmr.2020.10999
  • Pages: 1685-1701
  • Copyright: © Cárdenas‑Rodríguez et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Epilepsy is a common, serious neurological disorder worldwide. Although this disease can be successfully treated in most cases, not all patients respond favorably to medical treatments, which can lead to pharmacoresistant epilepsy. Drug‑resistant epilepsy can be caused by a number of mechanisms that may involve environmental and genetic factors, as well as disease‑ and drug‑related factors. In recent years, numerous studies have demonstrated that genetic variation is involved in the drug resistance of epilepsy, especially genetic variations found in drug resistance‑related genes, including the voltage‑dependent sodium and potassium channels genes, and the metabolizer of endogenous and xenobiotic substances genes. The present review aimed to highlight the genetic variants that are involved in the regulation of drug resistance in epilepsy; a comprehensive understanding of the role of genetic variation in drug resistance will help us develop improved strategies to regulate drug resistance efficiently and determine the pathophysiological processes that underlie this common human neurological disease.
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April-2020
Volume 21 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Cárdenas‑Rodríguez N, Carmona‑Aparicio L, Pérez‑Lozano DL, Ortega‑Cuellar D, Gómez‑Manzo S and Ignacio‑Mejía I: Genetic variations associated with pharmacoresistant epilepsy (Review). Mol Med Rep 21: 1685-1701, 2020
APA
Cárdenas‑Rodríguez, N., Carmona‑Aparicio, L., Pérez‑Lozano, D.L., Ortega‑Cuellar, D., Gómez‑Manzo, S., & Ignacio‑Mejía, I. (2020). Genetic variations associated with pharmacoresistant epilepsy (Review). Molecular Medicine Reports, 21, 1685-1701. https://doi.org/10.3892/mmr.2020.10999
MLA
Cárdenas‑Rodríguez, N., Carmona‑Aparicio, L., Pérez‑Lozano, D. L., Ortega‑Cuellar, D., Gómez‑Manzo, S., Ignacio‑Mejía, I."Genetic variations associated with pharmacoresistant epilepsy (Review)". Molecular Medicine Reports 21.4 (2020): 1685-1701.
Chicago
Cárdenas‑Rodríguez, N., Carmona‑Aparicio, L., Pérez‑Lozano, D. L., Ortega‑Cuellar, D., Gómez‑Manzo, S., Ignacio‑Mejía, I."Genetic variations associated with pharmacoresistant epilepsy (Review)". Molecular Medicine Reports 21, no. 4 (2020): 1685-1701. https://doi.org/10.3892/mmr.2020.10999