Open Access

Advances of the experimental models of idiopathic membranous nephropathy (Review)

  • Authors:
    • Han Xue Jiang
    • Zhendong Feng
    • Ze Bing Zhu
    • Chen Hui Xia
    • Wenting Zhang
    • Jing Guo
    • Bao‑Li Liu
    • Yaoxian Wang
    • Yu Ning Liu
    • Wei Jing Liu
  • View Affiliations

  • Published online on: March 9, 2020     https://doi.org/10.3892/mmr.2020.11014
  • Pages: 1993-2005
  • Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Idiopathic membranous nephropathy (IMN) is one of the main types of chronic kidney disease in adults and one of the most common causes of end‑stage renal disease. In recent years, the morbidity of IMN among primary glomerular diseases has markedly increased, while the pathogenesis of the disease remains unclear. To address this, a number of experimental models, including Heymann nephritis, anti‑thrombospondin type‑1 domain‑containing 7A antibody‑induced IMN, cationic bovine serum albumin, anti‑human podocyte antibodies and zymosan‑activated serum‑induced C5b‑9, have been established. This review comprehensively summarized the available animal and cell models for IMN. The limitations and advantages of the current models were discussed and two improved models were introduced to facilitate the selection of an appropriate model for further studies on IMN.

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May 2020
Volume 21 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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APA
Jiang, H.X., Feng, Z., Zhu, Z.B., Xia, C.H., Zhang, W., Guo, J. ... Liu, W.J. (2020). Advances of the experimental models of idiopathic membranous nephropathy (Review). Molecular Medicine Reports, 21, 1993-2005. https://doi.org/10.3892/mmr.2020.11014
MLA
Jiang, H. X., Feng, Z., Zhu, Z. B., Xia, C. H., Zhang, W., Guo, J., Liu, B., Wang, Y., Liu, Y. N., Liu, W. J."Advances of the experimental models of idiopathic membranous nephropathy (Review)". Molecular Medicine Reports 21.5 (2020): 1993-2005.
Chicago
Jiang, H. X., Feng, Z., Zhu, Z. B., Xia, C. H., Zhang, W., Guo, J., Liu, B., Wang, Y., Liu, Y. N., Liu, W. J."Advances of the experimental models of idiopathic membranous nephropathy (Review)". Molecular Medicine Reports 21, no. 5 (2020): 1993-2005. https://doi.org/10.3892/mmr.2020.11014