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Advances of the experimental models of idiopathic membranous nephropathy (Review)

  • Authors:
    • Han Xue Jiang
    • Zhendong Feng
    • Ze Bing Zhu
    • Chen Hui Xia
    • Wenting Zhang
    • Jing Guo
    • Bao‑Li Liu
    • Yaoxian Wang
    • Yu Ning Liu
    • Wei Jing Liu
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Chinese Internal Medicine of The Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, P.R. China, Beijing Chinese Medicine Hospital Pinggu Hospital, Beijing 101200, P.R. China, Department of Nephrology, Beijing Traditional Chinese Medicine Hospital, Capital Medical University, Beijing 100010, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1993-2005
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    Published online on: March 9, 2020
       https://doi.org/10.3892/mmr.2020.11014
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Abstract

Idiopathic membranous nephropathy (IMN) is one of the main types of chronic kidney disease in adults and one of the most common causes of end‑stage renal disease. In recent years, the morbidity of IMN among primary glomerular diseases has markedly increased, while the pathogenesis of the disease remains unclear. To address this, a number of experimental models, including Heymann nephritis, anti‑thrombospondin type‑1 domain‑containing 7A antibody‑induced IMN, cationic bovine serum albumin, anti‑human podocyte antibodies and zymosan‑activated serum‑induced C5b‑9, have been established. This review comprehensively summarized the available animal and cell models for IMN. The limitations and advantages of the current models were discussed and two improved models were introduced to facilitate the selection of an appropriate model for further studies on IMN.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang HX, Feng Z, Zhu ZB, Xia CH, Zhang W, Guo J, Liu BL, Wang Y, Liu YN, Liu WJ, Liu WJ, et al: Advances of the experimental models of idiopathic membranous nephropathy (Review). Mol Med Rep 21: 1993-2005, 2020.
APA
Jiang, H.X., Feng, Z., Zhu, Z.B., Xia, C.H., Zhang, W., Guo, J. ... Liu, W.J. (2020). Advances of the experimental models of idiopathic membranous nephropathy (Review). Molecular Medicine Reports, 21, 1993-2005. https://doi.org/10.3892/mmr.2020.11014
MLA
Jiang, H. X., Feng, Z., Zhu, Z. B., Xia, C. H., Zhang, W., Guo, J., Liu, B., Wang, Y., Liu, Y. N., Liu, W. J."Advances of the experimental models of idiopathic membranous nephropathy (Review)". Molecular Medicine Reports 21.5 (2020): 1993-2005.
Chicago
Jiang, H. X., Feng, Z., Zhu, Z. B., Xia, C. H., Zhang, W., Guo, J., Liu, B., Wang, Y., Liu, Y. N., Liu, W. J."Advances of the experimental models of idiopathic membranous nephropathy (Review)". Molecular Medicine Reports 21, no. 5 (2020): 1993-2005. https://doi.org/10.3892/mmr.2020.11014
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang HX, Feng Z, Zhu ZB, Xia CH, Zhang W, Guo J, Liu BL, Wang Y, Liu YN, Liu WJ, Liu WJ, et al: Advances of the experimental models of idiopathic membranous nephropathy (Review). Mol Med Rep 21: 1993-2005, 2020.
APA
Jiang, H.X., Feng, Z., Zhu, Z.B., Xia, C.H., Zhang, W., Guo, J. ... Liu, W.J. (2020). Advances of the experimental models of idiopathic membranous nephropathy (Review). Molecular Medicine Reports, 21, 1993-2005. https://doi.org/10.3892/mmr.2020.11014
MLA
Jiang, H. X., Feng, Z., Zhu, Z. B., Xia, C. H., Zhang, W., Guo, J., Liu, B., Wang, Y., Liu, Y. N., Liu, W. J."Advances of the experimental models of idiopathic membranous nephropathy (Review)". Molecular Medicine Reports 21.5 (2020): 1993-2005.
Chicago
Jiang, H. X., Feng, Z., Zhu, Z. B., Xia, C. H., Zhang, W., Guo, J., Liu, B., Wang, Y., Liu, Y. N., Liu, W. J."Advances of the experimental models of idiopathic membranous nephropathy (Review)". Molecular Medicine Reports 21, no. 5 (2020): 1993-2005. https://doi.org/10.3892/mmr.2020.11014
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