|
1
|
Hosogai N, Fukuhara A, Oshima K, Miyata Y,
Tanaka S, Segawa K, Furukawa S, Tochino Y, Komuro R, Matsuda M, et
al: Adipose tissue hypoxia in obesity and its impact on
adipocytokine dysregulation. Diabetes. 56:901–911. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Rausch ME, Weisberg S, Vardhana P and
Tortoriello DV: Obesity in C57BL/6J mice is characterized by
adipose tissue hypoxia and cytotoxic T-cell infiltration. Int J
Obes. 32:451–463. 2008. View Article : Google Scholar
|
|
3
|
Wang B, Wood IS and Trayhurn P:
Dysregulation of the expression and secretion of
inflammation-related adipokines by hypoxia in human adipocytes.
Pflugers Arch. 455:479–492. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Ye J, Gao Z, Yin J and He Q: Hypoxia is a
potential risk factor for chronic inflammation and adiponectin
reduction in adipose tissue of ob/ob and dietary obese mice. Am J
Physiol Endocrinol Metab. 293:E1118–E1128. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Halberg N, Khan T, Trujillo ME,
Wernstedt-Asterholm I, Attie AD, Sherwani S, Wang ZV,
Landskroner-Eiger S, Dineen S, Magalang UJ, et al: HIF 1 alpha
induces fibrosis and insulin resistance in white adipose tissue.
Mol Cell Biol. 29:4467–4483. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Semenza GL: Targeting HIF-1 for cancer
therapy. Nat Rev Cancer. 3:721–732. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Brahimi-Horn MC and Pouysségur J: HIF at a
glance. J Cell Sci. 122:1055–1057. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Huang LE, Arany Z, Livingston DM and Bunn
HF: Activation of hypoxia-inducible transcription factor depends
primarily upon redox-sensitive stabilization of its alpha subunit.
J Biol Chem. 271:32253–32259. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Ivan M, Kondo K, Yang H, Kim W, Valiando
J, Ohh M, Salic A, Asara JM, Lane WS and Kaelin WG Jr: HIFalpha
targeted for VHL-mediated destruction by proline hydroxylation:
Implications for O2 sensing. Science. 292:464–468. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Kihira Y, Miyake M, Hirata M, Hoshina Y,
Kato K, Shirakawa H, Sakaue H, Yamano N, Izawa-Ishizawa Y, Ishizawa
K, et al: Deletion of hypoxia-inducible factor-1α in adipocytes
enhances glucagon-like peptide-1 secretion and reduces adipose
tissue inflammation. PLoS One. 9:e938562014. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Jiang C, Kim JH, Li F, Qu A, Gavrilova O,
Shah YM and Gonzalez FJ: Hypoxia-inducible factor 1α regulates a
SOCS3-STAT3-adiponectin signal transduction pathway in adipocytes.
J Biol Chem. 288:3844–3857. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Jiang C, Qu A, Matsubara T, Chanturiya T,
Jou W, Gavrilova O, Shah YM and Gonzalez FJ: Disruption of
hypoxia-inducible factor 1 in adipocytes improves insulin
sensitivity and decreases adiposity in high-fat diet-fed mice.
Diabetes. 60:2484–2495. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Reue K and Dwyer JR: Lipin proteins and
metabolic homeostasis. J Lipid Res. 50 (Suppl):S109–S114. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Phan J and Reue K: Lipin, a lipodystrophy
and obesity gene. Cell Metab. 1:73–83. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Langner CA, Birkenmeier EH, Ben-Zeev O,
Schotz MC, Sweet HO, Davisson MT and Gordon JI: The fatty liver
dystrophy (fld) mutation. A new mutant mouse with a developmental
abnormality in triglyceride metabolism and associated
tissue-specific defects in lipoprotein lipase and hepatic lipase
activities. J Biol Chem. 264:7994–8003. 1989.PubMed/NCBI
|
|
16
|
Finck BN, Gropler MC, Chen Z, Leone TC,
Croce MA, Harris TE, Lawrence JC Jr and Kelly DP: Lipin 1 is an
inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory
pathway. Cell Metab. 4:199–210. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Phan J, Péterfy M and Reue K: Lipin
expression preceding peroxisome proliferator-activated
receptor-gamma is critical for adipogenesis in vivo and in vitro. J
Biol Chem. 279:29558–29564. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Péterfy M, Phan J, Xu P and Reue K:
Lipodystrophy in the fld mouse results from mutation of a new gene
encoding a nuclear protein, lipin. Nat Genet. 27:121–124. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Koh YK, Lee MY, Kim JW, Kim M, Moon JS,
Lee YJ, Ahn YH and Kim KS: Lipin1 is a key factor for the
maturation and maintenance of adipocytes in the regulatory network
with CCAAT/enhancer-binding protein alpha and peroxisome
proliferator-activated receptor gamma 2. J Biol Chem.
283:34896–34906. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Mylonis I, Sembongi H, Befani C, Liakos P,
Siniossoglou S and Simos G: Hypoxia causes triglyceride
accumulation by HIF-1-mediated stimulation of lipin 1 expression. J
Cell Sci. 125:3485–3493. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Tomita S, Ueno M, Sakamoto M, Kitahama Y,
Ueki M, Maekawa N, Sakamoto H, Gassmann M, Kageyama R, Ueda N, et
al: Defective brain development in mice lacking the Hif-1alpha gene
in neural cells. Mol Cell Biol. 23:6739–6749. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Arai T, Tanaka M and Goda N:
HIF-1-dependent lipin1 induction prevents excessive lipid
accumulation in choline-deficient diet-induced fatty liver. Sci
Rep. 8:142302018. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Kourti M, Ikonomou G, Giakoumakis NN,
Rapsomaniki MA, Landegren U, Siniossoglou S, Lygerou Z, Simos G and
Mylonis I: CK1δ restrains lipin-1 induction, lipid droplet
formation and cell proliferation under hypoxia by reducing
HIF-1α/ARNT complex formation. Cell Signal. 27:1129–1140. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Imagawa M, Tsuchiya T and Nishihara T:
Identification of inducible genes at the early stage of adipocyte
differentiation of 3T3-L1 cells. Biochem Biophys Res Commun.
254:299–305. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Lin Q, Lee YJ and Yun Z: Differentiation
arrest by hypoxia. J Biol Chem. 281:30678–30683. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Yun Z, Maecker HL, Johnson RS and Giaccia
AJ: Inhibition of PPAR gamma 2 gene expression by the
HIF-1-regulated gene DEC1/Stra13: A mechanism for regulation of
adipogenesis by hypoxia. Dev Cell. 2:331–341. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Zhou S, Lechpammer S, Greenberger JS and
Glowacki J: Hypoxia inhibition of adipocytogenesis in human bone
marrow stromal cells requires transforming growth factor-beta/Smad3
signaling. J Biol Chem. 280:22688–22696. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Ouchi N and Walsh K: Adiponectin as an
anti-inflammatory factor. Clin Chim Acta. 380:24–30. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Yamauchi T, Kamon J, Waki H, Terauchi Y,
Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N,
et al: The fat-derived hormone adiponectin reverses insulin
resistance associated with both lipoatrophy and obesity. Nat Med.
7:941–946. 2001. View
Article : Google Scholar : PubMed/NCBI
|
|
30
|
Fruebis J, Tsao TS, Javorschi S,
Ebbets-Reed D, Erickson MR, Yen FT, Bihain BE and Lodish HF:
Proteolytic cleavage product of 30-kDa adipocyte complement-related
protein increases fatty acid oxidation in muscle and causes weight
loss in mice. Proc Natl Acad Sci USA. 98:2005–2010. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Berg AH, Combs TP, Du X, Brownlee M and
Scherer PE: The adipocyte-secreted protein Acrp30 enhances hepatic
insulin action. Nat Med. 7:947–953. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Kern PA, Di Gregorio GB, Lu T, Rassouli N
and Ranganathan G: Adiponectin expression from human adipose
tissue: Relation to obesity, insulin resistance, and tumor necrosis
factor-α expression. Diabetes. 52:1779–1785. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Michailidou Z, Morton NM, Moreno Navarrete
JM, West CC, Stewart KJ, Fernández-Real JM, Schofield CJ, Seckl JR
and Ratcliffe PJ: Adipocyte pseudohypoxia suppresses lipolysis and
facilitates benign adipose tissue expansion. Diabetes. 64:733–745.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Wang F, Zhang G, Xing T, Lu Z, Li J, Peng
C, Liu G and Wang N: Renalase contributes to the renal protection
of delayed ischaemic preconditioning via the regulation of
hypoxia-inducible factor-1α. J Cell Mol Med. 19:1400–1409. 2015.
View Article : Google Scholar : PubMed/NCBI
|
