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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July-2020 Volume 22 Issue 1

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Obesity ‑ a risk factor for increased COVID‑19 prevalence, severity and lethality (Review)

Demetrios Petrakis, Denisa Margină, Konstantinos Tsarouhas, Fotios Tekos, Miriana Stan, Dragana Nikitovic, Demetrios Kouretas, Demetrios A. Spandidos, Aristidis Tsatsakis
Pages: 9-19
Published online on: 05 May 2020

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Review Open Access

COVID‑19 in Northern Italy: An integrative overview of factors possibly influencing the sharp increase of the outbreak (Review)

Marina Goumenou, Dimosthenis Sarigiannis, Aristidis Tsatsakis, Ourania Anesti, Anca Oana Docea, Dimitrios Petrakis, Dimitris Tsoukalas, Ronald Kostoff, Valeri Rakitskii, Demetrios A. Spandidos, Michael Aschner, Daniela Calina
Pages: 20-32
Published online on: 16 April 2020

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Article Open Access

Effect of VX‑765 on the transcriptome profile of mice spinal cords with acute injury

Jing Chen, Yu‑Qing Chen, Sai‑Nan Wang, Fei‑Xiang Duan, Yu‑Jiao Shi, Shu‑Qin Ding, Jian‑Guo Hu, He‑Zuo Lü
Pages: 33-42
Published online on: 05 May 2020

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Article Open Access

Dehydrocorydaline inhibits the tumorigenesis of breast cancer MDA‑MB‑231 cells

Ying Huang, Hui Huang, Shiying Wang, Feixiang Chen, Gang Zheng
Pages: 43-50
Published online on: 05 May 2020

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Article Open Access

MicroRNA‑19b inhibitors can attenuate the STAT3 signaling pathway in NPC C666‑1 cells

Li‑Hui Bian, Jing‑Ling Duan, Chen Zhou, Guo‑Wen Shen, Xiao‑Yu Wang, Yang Yang, Xiao‑Ling Zhang, Sheng‑Jun Xiao
Pages: 51-56
Published online on: 04 May 2020

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Article Open Access

High expression of CDCA7 predicts tumor progression and poor prognosis in human colorectal cancer

Siman Li, Jiean Huang, Mengbin Qin, Jinxiu Zhang, Cun Liao
Pages: 57-66
Published online on: 22 April 2020

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Article Open Access

miR‑133b affects cell proliferation, invasion and chemosensitivity in renal cell carcinoma by inhibiting the ERK signaling pathway

Yuan Xu, Yuan Ma, Xiao‑Ling Liu, Sheng‑Li Gao
Pages: 67-76
Published online on: 05 May 2020

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Article Open Access

Low penetrance of hearing loss in two Chinese families carrying the mitochondrial tRNASer(UCN) mutations

Wei Peng, Yi Zhong, Xueyan Zhao, Jie Yuan
Pages: 77-86
Published online on: 30 April 2020

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Article

Expression profile of circular RNAs in the peripheral blood of neonates with hypoxic‑ischemic encephalopathy

Xiaohua Dong, Sisi Zhuang, Yun Huang, Xiaojing Yang, Yanrong Fu, Lingling Yu, Yingmin Zhao
Pages: 87-96
Published online on: 23 April 2020

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Article Open Access

7ND protein exerts inhibitory effects on both osteoclast differentiation in vitro and lipopolysaccharide‑induced bone erosion in vivo

Weilin Long, Jingjing Quan, Yiwen Liu, Jing Li, Qimei Gong, Hongwei Jiang
Pages: 97-104
Published online on: 05 May 2020

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Article Open Access

Comprehensive analysis of long non‑coding RNA using an associated competitive endogenous RNA network in Wilms tumor

Zhichao Wang, Huiyan Cheng, Lingli Qi, Dayun Sui
Pages: 105-116
Published online on: 05 May 2020

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Article Open Access

Role of the microRNA‑214/Bax axis in the progression of acute liver failure

Shaohong Wu, Xiaoping Huang, Wei Sun, Li Chen, Yan Huang, Yan Wang, Erping Luo, Ailan Qin, Weifeng Zhao, Jianhe Gan
Pages: 117-126
Published online on: 05 May 2020

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Article Open Access

High glucose contributes to the polarization of peritoneal macrophages to the M2 phenotype in vivo and in vitro

Jieshan Lin, Qingyu Kong, Wenke Hao, Wenxue Hu
Pages: 127-134
Published online on: 05 May 2020

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Article Open Access

miR‑10a‑5p inhibits osteogenic differentiation of bone marrow‑derived mesenchymal stem cells

Yingjie Zhang, Lishu Zhou, Zhaoqiang Zhang, Fei Ren, Liangjiao Chen, Zedong Lan
Pages: 135-144
Published online on: 04 May 2020

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Article Open Access

Nicotinamide mononucleotide attenuates glucocorticoid‑induced osteogenic inhibition by regulating the SIRT1/PGC‑1α signaling pathway

Rui‑Xiong Huang, Jun Tao
Pages: 145-154
Published online on: 04 May 2020

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Article Open Access

p53/PGC‑1α‑mediated mitochondrial dysfunction promotes PC3 prostate cancer cell apoptosis

Jiuling Li, Yany Li, Lanlan Chen, Bingbing Yu, Yanan Xue, Rui Guo, Jing Su, Yanan Liu, Liankun Sun
Pages: 155-164
Published online on: 05 May 2020

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Article Open Access

MicroRNA‑125a‑mediated regulation of the mevalonate signaling pathway contributes to high glucose‑induced proliferation and migration of vascular smooth muscle cells

Dan Ye, Guo‑Hua Lou, Ai‑Chun Li, Feng‑Qin Dong, Guo‑Ping Chen, Wei‑Wei Xu, Yan‑Ning Liu, Shen‑Jiang Hu
Pages: 165-174
Published online on: 16 April 2020

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Article Open Access

Dexmedetomidine alleviated sepsis‑induced myocardial ferroptosis and septic heart injury

Chunyan Wang, Wenlin Yuan, Anmin Hu, Juan Lin, Zhengyuan Xia, Catherine F. Yang, Yalan Li, Zhongjun Zhang
Pages: 175-184
Published online on: 04 May 2020

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Article

Association between aberrant dynein cytoplasmic 1 light intermediate chain 1 expression levels, mucins and chemosensitivity in colorectal cancer

Chun‑Chao Chang, Kuo‑Ching Chao, Chi‑Jung Huang, Chih‑Sheng Hung, Yen‑Chieh Wang
Pages: 185-192
Published online on: 22 April 2020

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Article Open Access

Identification of novel USH2A mutations in patients with autosomal recessive retinitis pigmentosa via targeted next‑generation sequencing

Xiong Zhu, Xiao Li, Wanli Tian, Yeming Yang, Kuanxiang Sun, Shuzhen Li, Xianjun Zhu
Pages: 193-200
Published online on: 22 April 2020

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Article Open Access

PNU282987 inhibits amyloid‑β aggregation by upregulating astrocytic endogenous αB‑crystallin and HSP‑70 via regulation of the α7AChR, PI3K/Akt/HSF‑1 signaling axis

Zhenkui Ren, Zhihui Dong, Peng Xie, Ju Lv, Yumei Hu, Zhizhong Guan, Chunlin Zhang, Wenfeng Yu
Pages: 201-208
Published online on: 05 May 2020

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Article Open Access

Ischemic postconditioning attenuates the inflammatory response in ischemia/reperfusion myocardium by upregulating miR‑499 and inhibiting TLR2 activation

Xin‑Yue Zhang, Zheng Huang, Qing‑Jie Li, Guo‑Qiang Zhong, Jian‑Jun Meng, Dong‑Xiao Wang, Rong‑Hui Tu
Pages: 209-218
Published online on: 30 April 2020

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Article Open Access

Urethral meatus stricture BOO stimulates bladder smooth muscle cell proliferation and pyroptosis via IL‑1β and the SGK1‑NFAT2 signaling pathway

Wang Kai, Chen Lin, Yang Jin, He Ping‑Lin, Liu Xun, Amend Bastian, Stenzl Arnulf, Xing Sha‑Sha, Luo Xu, Cui Shu
Pages: 219-226
Published online on: 24 April 2020

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Article Open Access

Elevated plasma levels of exosomal BACE1‑AS combined with the volume and thickness of the right entorhinal cortex may serve as a biomarker for the detection of Alzheimer's disease

Dewei Wang, Ping Wang, Xianli Bian, Shunliang Xu, Qingbo Zhou, Yuan Zhang, Mao Ding, Min Han, Ling Huang, Jianzhong Bi, Yuxiu Jia, Zhaohong Xie
Pages: 227-238
Published online on: 05 May 2020

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Article Open Access

Petatewalide B alleviates oxygen‑glucose deprivation/reoxygenation‑induced neuronal injury via activation of the AMPK/Nrf2 signaling pathway

Sun Young Park, Min Hyun Cho, Mei Li, Ke Li, Geuntae Park, Young‑Whan Choi
Pages: 239-246
Published online on: 16 April 2020

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Article Open Access

Ginsenoside Rb1 reduces H2O2‑induced HUVEC dysfunction by stimulating the sirtuin‑1/AMP‑activated protein kinase pathway

Zhenda Zheng, Min Wang, Cailian Cheng, Dinghui Liu, Lin Wu, Jieming Zhu, Xiaoxian Qian
Pages: 247-256
Published online on: 28 April 2020

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Article Open Access

Excessive production of mitochondrion‑derived reactive oxygen species induced by titanium ions leads to autophagic cell death of osteoblasts via the SIRT3/SOD2 pathway

Siqian Wang, Jingyuan Yang, Tingting Lin, Shengbing Huang, Jianfeng Ma, Xin Xu
Pages: 257-264
Published online on: 24 April 2020

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Article Open Access

Hypoxia/reoxygenation activates the JNK pathway and accelerates synovial senescence

Yubiao Zhang, Siqi Zhou, Weisong Cai, Guangtao Han, Jianping Li, Mao Chen, Haohuan Li
Pages: 265-276
Published online on: 30 April 2020

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Article Open Access

Downregulation of miR‑142‑5p inhibits human aortic smooth muscle cell proliferation and migration by targeting MKL2

Wei Wu, Yuqiang Shang, Shiling Dai, Chunjun Yu, Jie Wang
Pages: 277-285
Published online on: 24 April 2020

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Article Open Access

Identification, characterization and microRNA expression profiling of side population cells in human oral squamous cell carcinoma Tca8113 cell lines

Wei Luo, Rong‑Sen Liu, Ling‑Ling E, Yang Bai, Xiang‑Pan Kong, Hua‑Wei Liu, Hao Wu, Hong‑Chen Liu
Pages: 286-296
Published online on: 16 April 2020

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Article Open Access

Mutation spectrum analysis of 29 causative genes in 43 Chinese patients with congenital hypothyroidism

Huijuan Wang, Xiaohong Kong, Yanrui Pei, Xuemei Cui, Yijie Zhu, Zixuan He, Yanxia Wang, Lirong Zhang, Lixia Zhuo, Chao Chen, Xiaoli Yan
Pages: 297-309
Published online on: 16 April 2020

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Article Open Access

Ginkgolide B inhibits hydrogen peroxide‑induced apoptosis and attenuates cytotoxicity via activating the PI3K/Akt/mTOR signaling pathway in H9c2 cells

Jin Liu, Peng Wu, Zhihui Xu, Jun Zhang, Jiabao Liu, Zhijian Yang
Pages: 310-316
Published online on: 30 April 2020

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Article Open Access

Phosphorylated GSK‑3β protects stress‑induced apoptosis of myoblasts via the PI3K/Akt signaling pathway

Meixi Liu, Xia Huang, Yihong Tian, Xiao Yan, Fang Wang, Junbo Chen, Qi Zhang, Qiang Zhang, Xiao Yuan
Pages: 317-327
Published online on: 30 April 2020

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Article Open Access

MicroRNA‑138‑5p regulates the development of spinal cord injury by targeting SIRT1

Jinchuan Chen, Rujie Qin
Pages: 328-336
Published online on: 16 April 2020

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Article Open Access

Combination of HSP90 and autophagy inhibitors promotes hepatocellular carcinoma apoptosis following incomplete thermal ablation

Fen Chen, Haiyang Xie, Haiwei Bao, Laurencia Violetta, Shusen Zheng
Pages: 337-343
Published online on: 21 April 2020

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Article Open Access

Protective effect of CTRP6 on cerebral ischemia/reperfusion injury by attenuating inflammation, oxidative stress and apoptosis in PC12 cells

Ying Li, Jie Sun, Lei Gu, Xufang Gao
Pages: 344-352
Published online on: 04 May 2020

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Article Open Access

Ginsenoside metabolite 20(S)‑protopanaxadiol promotes neural stem cell transition from a state of proliferation to differentiation by inducing autophagy and cell cycle arrest

Shali Chen, Ji He, Xiyuan Qin, Tiao Luo, Aparna Pandey, Jijia Li, Suyou Liu, Junli Luo, Qi Wang, Zhiyong Luo
Pages: 353-361
Published online on: 21 April 2020

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Article Open Access

Immunotherapy of Bacillus Calmette‑Guérin by targeting macrophages against bladder cancer in a NOD/scid IL2Rg‑/‑ mouse model

Qing‑Long Tan, Chang‑Yuan Zhou, Lin Cheng, Min Luo, Chun‑Ping Liu, Wen‑Xing Xu, Xian Zhang, Xing Zeng
Pages: 362-370
Published online on: 22 April 2020

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Article Open Access

IgE and IgG4 responses to shrimp allergen tropomyosin and its epitopes in patients from coastal areas of northern China

Junpu Li, Zhiwei Li, Deyu Kong, Shaoshen Li, Yang Yu, Huiqiang Li
Pages: 371-379
Published online on: 21 April 2020

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Article Open Access

HBV DNA integrates into upregulated ZBTB20 in patients with hepatocellular carcinoma

Zebao He, Jiansheng Zhu, Jinggang Mo, Haihong Zhao, Qiuyue Chen
Pages: 380-386
Published online on: 16 April 2020

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Article Open Access

The sympathetic transmitter norepinephrine inhibits VSMC proliferation induced by TGFβ by suppressing the expression of the TGFβ receptor ALK5 in aorta remodeling

Zhipeng Hu, Bowen Li, Zhiwei Wang, Xiaoping Hu, Min Zhang, Ruoshi Chen, Qi Wu, Fangyuan Jia
Pages: 387-397
Published online on: 22 April 2020

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Article Open Access

Mammalian STE20‑like kinase 1 regulates pancreatic cancer cell survival and migration through Mfn2‑mediated mitophagy Retraction in /10.3892/mmr.2024.13294

Yongli Hu, Bing Wang, Lie Wang, Zhenran Wang, Zhiyuan Jian, Lin Deng
Pages: 398-404
Published online on: 28 April 2020

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Article Open Access

Comprehensive analysis of aberrantly expressed long non‑coding RNAs, microRNAs, and mRNAs associated with the competitive endogenous RNA network in cervical cancer

Peng Chen, Weiyuan Zhang, Yu Chen, Xiaoli Zheng, Dong Yang
Pages: 405-415
Published online on: 05 May 2020

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Article Open Access

BPA disrupts 17‑estradiol‑mediated hepatic protection against ischemia/reperfusion injury in rat liver by upregulating the Ang II/AT1R signaling pathway

Yili Zhang, Yu Shi, Zeyu Li, Liankang Sun, Mei Zhang, Liang Yu, Shengli Wu
Pages: 416-422
Published online on: 16 April 2020

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Article Open Access

Integrated analysis of a lncRNA‑mRNA network reveals a potential mechanism underlying necrotizing enterocolitis

Wenjuan Chen, Xiangyun Yan, Tian Tian, Ru Yan, Xingyun Wang, Zhangbin Yu, Yingzheng Li, Le Zhang, Shuping Han
Pages: 423-435
Published online on: 21 April 2020

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Article Open Access

Vitamin C decreases VEGF expression levels via hypoxia‑inducible factor‑1α dependent and independent pathways in lens epithelial cells

Lin Zhao, Jianming Wang, Yi Zhang, Lijun Wang, Miao Yu, Feng Wang
Pages: 436-444
Published online on: 30 April 2020

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Article Open Access

Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons

Man Yang, Naqi Lian, Yang Yu, Yaoqi Wang, Keliang Xie, Yonghao Yu
Pages: 445-453
Published online on: 05 May 2020

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Article Open Access

Upregulation of microRNA‑1 inhibits proliferation and metastasis of breast cancer

Jing Peng, Chenwei Yuan, Ziping Wu, Yan Wang, Wenjin Yin, Yanping Lin, Liheng Zhou, Jinsong Lu
Pages: 454-464
Published online on: 04 May 2020

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Article Open Access

WAVE3 upregulation in esophageal squamous cell carcinoma and its effect on the migration of human esophageal cancer cell lines in vitro

Xuebing Li, Jie Geng, Zhenzhen Ren, Chao Xiong, Yuqing Li, Hongchun Liu
Pages: 465-473
Published online on: 05 May 2020

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Article Open Access

MicroRNA‑21 serves an important role during PAOO‑facilitated orthodontic tooth movement

Yuanyuan Zhang, Yulou Tian, Xiaofeng Yang, Zhenjin Zhao, Cuijuan Feng, Yang Zhang
Pages: 474-482
Published online on: 04 May 2020

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Article Open Access

MicroRNA‑93 promotes angiogenesis and attenuates remodeling via inactivation of the Hippo/Yap pathway by targeting Lats2 after myocardial infarctionω

Chengjie Ma, Peipei Peng, Yan Zhou, Tianya Liu, Lijuan Wang, Chen Lu
Pages: 483-493
Published online on: 21 April 2020

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Article Open Access

Identification of key miRNAs and genes for mouse retinal development using a linear model

Yishen Wang, Xiao Wang, Yukang Jiang, Ruyuan Liu, Di Cao, Jianying Pan, Yan Luo
Pages: 494-506
Published online on: 21 April 2020

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Article Open Access

Heptapeptide HP3 acts as a potent inhibitor of experimental imiquimod‑induced murine psoriasis and impedes the trans‑endothelial migration of mononuclear cells

Ernesto A. Vázquez‑Sánchez, José S. Mendoza‑Figueroa, Guadalupe Gutiérrez‑Gonzalez, Luis A. Zapi‑Colín, Azael Torales‑Cardeña, Paola E. Briseño‑Lugo, Iván  Díaz‑Toalá, Juan C. Cancino‑Diaz, Sonia M. Pérez‑Tapia, Mario   E. Cancino‑Diaz, Fernando Gómez‑Chávez, Sandra Rodríguez‑Martínez
Pages: 507-515
Published online on: 05 May 2020

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Article Open Access

A novel heterozygous mutation in the HMBS gene in a patient with acute intermittent porphyria and posterior reversible encephalopathy syndrome

Yang Yang, Xiyun Chen, Huijuan Wu, Hua Peng, Wenjing Sun, Bin He, Zhengang Yuan
Pages: 516-524
Published online on: 04 May 2020

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Article Open Access

3‑N‑Butyphthalide improves learning and memory in rats with vascular cognitive impairment by activating the SIRT1/BDNF pathway

Ayong Tian, Wan Li, Qing Zai, Hui Li, Rong‑Wei Zhang
Pages: 525-533
Published online on: 04 May 2020

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Article Open Access

Tim‑3 regulates the ability of macrophages to counter lipopolysaccharide‑induced pulmonary epithelial barrier dysfunction via the PI3K/Akt pathway in epithelial cells

Yuntao Zhang, Wang Zhang
Pages: 534-542
Published online on: 04 May 2020

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Article

miR‑96 exerts an oncogenic role in the progression of cervical cancer by targeting CAV‑1

Yong Chen, Changqing Liu, Bingfan Xie, Shangqiu Chen, Yuan Zhuang, Shaoxia Zhang
Pages: 543-550
Published online on: 30 April 2020

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Article

A HGF‑derived peptide suppresses EMT in human lens epithelial cells via the TGF‑β/Smad and Akt/mTOR signaling pathways

Xiaobo Huang, Yulan Wang, Pei Zhang, Haidong Zou
Pages: 551-558
Published online on: 28 April 2020

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Article

Hypoxia‑inducible factor‑1α regulates Lipin1 differently in pre‑adipocytes and mature adipocytes

Yoshitaka Kihira, Yoshino Fujimura, Shuhei Tomita, Toshiaki Tamaki, Eiji Sato
Pages: 559-565
Published online on: 16 April 2020

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Article

Juglone potentiates BRAF inhibitor‑induced apoptosis in melanoma through reactive oxygen species and the p38‑p53 pathway

Zheng Li, Xiao Liu, Ming Li, Jingxiu Chai, Shan He, Jinfeng Wu, Jinhua Xu
Pages: 566-574
Published online on: 28 April 2020

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Effect of SIRT1 activators and inhibitors on CD44+/CD133+‑enriched non‑small cell lung cancer cells

Zuhal Eroglu, Ceren Erdem, Gulperi Oktem, Vildan Bozok Cetintas, Zekeriya Duzgun
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Published online on: 04 May 2020

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Anti‑inflammatory effects of the NF‑κB inhibitor dehydroxymethylepoxyquinomicin on ARPE‑19 cells

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Pages: 582-590
Published online on: 04 May 2020

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January-2026 Volume 33 Issue 1

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CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

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SCImago Journal Rank (SJR): 0.841

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Ziqiao Liu, Hanshen Zhou, Junxiao Shen, Yiming Qi, Xuke Gong, Cheng Zhang
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Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
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Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
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Chih-Hsuan Hsia, Chun-Ming Yang, Chao-Chien Chang, Ting-Lin Yen, Arief Gunawan Darmanto, Chi-Chang Huang, Joen-Rong Sheu
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Weiwei Wang, Gangwei Cheng, Qi Zhou, Sheng Wang, Linyi Zhang
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Published online on: 21 November 2025

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Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut‑joint axis’ (Review)

Wenjie Hu, Rui Li, Zhongming Zhang
Article Number: 46
Published online on: 20 November 2025

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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

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Article Number: 45
Published online on: 20 November 2025

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

Banghao Sun, Zhenyu Zhao, Qingyu Meng, Luya Pu, Xingyu Jiang, Shuai Li, Fadi Cao, Fan Li
Article Number: 44
Published online on: 20 November 2025

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
Published online on: 18 November 2025

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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
Published online on: 12 November 2025

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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
Published online on: 12 November 2025

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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
Published online on: 12 November 2025

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 33 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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