Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
July-2020 Volume 22 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2020 Volume 22 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

IgE and IgG4 responses to shrimp allergen tropomyosin and its epitopes in patients from coastal areas of northern China

  • Authors:
    • Junpu Li
    • Zhiwei Li
    • Deyu Kong
    • Shaoshen Li
    • Yang Yu
    • Huiqiang Li
  • View Affiliations / Copyright

    Affiliations: The Clinical Laboratory of Tianjin Chest Hospital, Tianjin 300222, P.R. China, Department of Clinical Laboratory, School of Medical Laboratory, Tianjin Medical University, Tianjin 300203, P.R. China, Department of Laboratory Medicine, Tianjin Port Hospital, Tianjin 300456, P.R. China, Department of Laboratory Medicine, Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 371-379
    |
    Published online on: April 21, 2020
       https://doi.org/10.3892/mmr.2020.11084
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Sensitization to allergens and their peptides varies among patients due to geographical or ethnic differences. The present study aimed to investigate immunoglobulin (Ig)E and IgG4 responses to tropomyosin and its peptides in shrimp allergic patients from northern China. A total of 92 subjects were studied, including 35 shrimp allergic patients, 29 patients with house dust mite (HDM) and/or cockroach allergic patients and 28 healthy volunteers. Serum IgE and IgG4 antibodies to recombinant shrimp tropomyosin (rPen a 1) and its peptides were measured by means of a light‑initiated chemiluminescent assay. A total of 9 major sequential epitopes of Pen a 1 reported in the literature were synthesized. Of 35 shrimp allergic patients, 25 (71.4%) had positive Pen 1‑specific IgE (sIgE) antibodies and 22 (62.9%) contained measurable rPen a 1‑specific IgG4 (sIgG4) antibodies. A strong IgG4 response accompanied the presence of IgE to Pen a 1. None of the patients with HDM and/or cockroach allergy demonstrated IgE reactivity to rPen a 1. The reaction frequency of IgE binding epitope was 20‑48%, while that of IgG4 binding epitope was 63.6‑90.9%. The IgE and IgG4 recognition patterns of the tropomyosin peptides demonstrated high interpatient heterogeneity. Diversity of IgE binding epitopes was positively correlated with Pen a 1 sIgE levels. In the study population, tropomyosin was a major allergen recognized by the majority of shrimp allergic patients, which is consistent with previous reports. However, none of the 9 epitopes are major (reaction frequency >50%) IgE‑binding regions, indicating the epitopes profile may be different in other regions.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Pedrosa M, Boyano-Martinez T, Garcia-Ara C and Quirce S: Shellfish allergy: A comprehensive review. Clin Rev Allergy Immunol. 49:203–216. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Khora SS: Seafood-associated shellfish allergy: A comprehensive review. Immunol Invest. 45:504–530. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Ruethers T, Taki AC, Johnston EB, Nugraha R, Le TTK, Kalic T, McLean TR, Kamath SD and Lopata AL: Seafood allergy: A comprehensive review of fish and shellfish allergens. Mol Immunol. 100:28–57. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Naqpal S, Rajappa L, Metcalfe DD and Rao PV: Isolation and characterization of heat-stable allergens from shrimp (Penaeus indicus). J Allergy Clin Immunol. 83:26–36. 1989. View Article : Google Scholar : PubMed/NCBI

5 

Daul C, Slattery M, Reese G and Lehrer SB: Identification of the major brown shrimp (Penaeus aztecus) allergen as the muscle protein tropomyosin. Int Arch Allergy Immunol. 105:49–55. 1994. View Article : Google Scholar : PubMed/NCBI

6 

Reese G, Schicktanz S, Lauer I, Randow S, Lüttkopf D, Vogel L, Lehrer SB and Vieths S: Structural, immunological and functional properties of natural recombinant Pen a 1, the major allergen of Brown Shrimp, Penaeus aztecus. Clin Exp Allergy. 36:517–524. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Albrecht M, Alessandri S, Conti A, Reuter A, Lauer I, Vieths S and Reese G: High level expression, purification and physico- and immunochemical characterisation of recombinant Pen a 1: A major allergen of shrimp. Mol Nutr Food Res. 52 (Suppl 2):S186–S195. 2008.PubMed/NCBI

8 

Faber MA, Pascal M, El Kharbouchi O, Sabato V, Hagendorens MM, Decuyper II, Bridts CH and Ebo DG: Shellfish allergens: Tropomyosin and beyond. Allergy. 72:842–848. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Leung PS, Chow WK, Duffey S, Kwan HS, Gershwin ME and Chu KH: IgE reactivity against a cross-reactive allergen in crustacea and mollusca: Evidence for tropomyosin as the common allergen. J Allergy Clin Immunol. 98:954–961. 1996. View Article : Google Scholar : PubMed/NCBI

10 

Ayuso R, Reese G, Leong-Kee S, Plante M and Lehrer SB: Molecular basis of arthropod cross-reactivity: IgE-binding cross-reactive epitopes of shrimp, house dust mite and cockroach tropomyosins. Int Arch Allergy Immunol. 129:38–48. 2002. View Article : Google Scholar : PubMed/NCBI

11 

DeWitt AM, Mattsson L, Lauer I, Reese G and Lidholm J: Recombinant tropomyosin from Penaeus aztecus (rPen a 1) for measurement of specific immunoglobulin E antibodies relevant in food allergy to crustaceans and other invertebrates. Mol Nutr Food Res. 48:370–379. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Yang AC, Arruda LK, Santos AB, Barbosa MC, Chapman MD, Galvão CE, Kalil J and Morato-Castro FF: Measurement of IgE antibodies to shrimp tropomyosin is superior to skin prick testing with commercial extract and measurement of IgE to shrimp for predicting clinically relevant allergic reactions after shrimp ingestion. J Allergy Clin Immunol. 125:872–878. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Gámez C, Sánchez-García S, Ibáñez MD, López R, Aguado E, López E, Sastre B, Sastre J and del Pozo V: Tropomyosin IgE-positive results are a good predictor of shrimp allergy. Allergy. 66:1375–1383. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Matricardi PM, Dramburg S, Potapova E, Skevaki C and Renz H: Molecular diagnosis for allergen immunotherapy. J Allergy Clin Immunol. 143:831–843. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Matsuo H, Yokooji T and Taogoshi T: Common food allergens and their IgE-binding epitopes. Allergol Int. 64:332–343. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Wai CY, Leung NY, Ho MH, Gershwin LJ, Shu SA, Leung PS and Chu KH: Immunization with Hypoallergens of shrimp allergen tropomyosin inhibits shrimp tropomyosin specific IgE reactivity. PLoS One. 9:e1116492014. View Article : Google Scholar : PubMed/NCBI

17 

Asero R, Mistrello G, Amato S, Ariano R, Colombo G, Conte ME, Crivellaro M, De Carli M, Della Torre F, Emiliani F, et al: Shrimp allergy in Italian adults: A multicenter study showing a high prevalence of sensitivity to novel high molecular weight allergens. Int Arch Allergy Immunol. 157:3–10. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Roberts G, Ollert M, Aalberse R, Austin M, Custovic A, DunnGalvin A, Eigenmann PA, Fassio F, Grattan C, Hellings P, et al: A new framework for the interpretation of IgE sensitization tests. Allergy. 71:1540–1551. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Siroux V, Lupinek C, Resch Y, Curin M, Just J, Keil T, Kiss R, Lødrup Carlsen K, Melén E, Nadif R, et al: Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure: The EGEA study. J Allergy Clin Immunol. 139:643–654.e6. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Hansen KS, Ballmer-Weber BK, Sastre J, Lidholm J, Andersson K, Oberhofer H, Lluch-Bernal M, Ostling J, Mattsson L, Schocker F, et al: Component-resolved in vitro diagnosis of hazelnut allergy in Europe. J Allergy Clin Immunol. 123:1134–1141.e1-e3. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Ayuso R, Lehrer S and Reese G: Identification of continuous, allergenic regions of the major shrimp allergen Pen a 1 (tropomyosin). Int Arch Allergy Immunol. 127:27–37. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Reese G, Ayuso R, Carle T and Lehrer SB: IgE binding epitopes of shrimp tropomyosin, the major allergen Pen a 1. Int Arch Allergy Immunol. 118:300–301. 1999. View Article : Google Scholar : PubMed/NCBI

23 

Mine Y and Wei Zhang J: Identification and fine mapping of IgG and IgE epitopes in ovomucoid. Biochem Biophys Res Commun. 292:1070–1074. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Jarvinen KM, Beyer K, Vila L, Bardina L, Mishoe M and Sampson HA: Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy. Allergy. 62:758–765. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Martinez-Botas J, Cerecedo I, Zamora J, Vlaicu C, Dieguez MC, Gómez-Coronado D, de Dios V, Terrados S and de la Hoz B: Mapping of the IgE and IgG4 sequential epitopes of ovomucoid with a peptide microarray immunoassay. Int Arch Allergy Immunol. 161:11–20. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Cerecedo I, Zamora J, Shreffler WG, Lin J, Bardina L, Dieguez MC, Wang J, Muriel A, de la Hoz B and Sampson HA: Mapping of the IgE and IgG4 sequential epitopes of milk allergens with a peptide microarray-based immunoassay. J Allergy Clin Immunol. 122:589–594. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Steckelbroeck S, Ballmer-Weber BK and Vieths S: Potential, pitfalls, and prospects of food allergy diagnostics with recombinant allergens or synthetic sequential epitopes. J Allergy Clin Immunol. 121:1323–1330. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Suarez-Farinas M, Suprun M, Chang HL, Gimenez G, Grishina G, Getts R, Nadeau K, Wood RA and Sampson HA: Predicting development of sustained unresponsiveness to milk oral immunotherapy using epitope-specific antibody binding profiles. J Allergy Clin Immunol. 143:1038–1046. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Jenmalm MC and Bjorksten B: Development of immunoglobulin G subclass antibodies to ovalbumin, birch and cat during the first eight years of life in atopic and non-atopic children. Pediatr Allergy Immunol. 10:112–121. 1999. View Article : Google Scholar : PubMed/NCBI

30 

Yang Z, Zhao J, Wei N, Feng M, Xian M, Shi X, Zheng Z, Su Q, Wong GWK and Li J: Cockroach is a major cross-reactive allergen source in shrimp-sensitized rural children in southern China. Allergy. 73:585–592. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Beyer K, Bindslev-Jensen C, Cardona V, Dubois A, duToit G, Eigenmann P, et al: EAACI food allergy and anaphylaxis guidelines: Diagnosis and management of food allergy. Allergy. 69:1008–1025. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, Hofmaier S, Aalberse RC, Agache I, Asero R, Ballmer-Weber B, et al: EAACI molecular allergology user's guide. Pediatr Allergy Immunol. 27 (Suppl 23):S1–S250. 2016. View Article : Google Scholar

33 

Dodig S and Cepelak I: The potential of component-resolved diagnosis in laboratory diagnostics of allergy. Biochem Med (Zagreb). 28:0205012018. View Article : Google Scholar : PubMed/NCBI

34 

Bian Y, Liu C, She T, Wang M, Yan J, Wei D and Li H: Development of a light-initiated chemiluminescent assay for the quantitation of sIgE against egg white allergens based on component-resolved diagnosis. Anal Bioanal Chem. 410:1501–1510. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Li J, Li S, Huang L, Cui Y, She T, Bian Y and Li H: A light-initiated chemiluminescent assay for rapid quantitation of allergen-specific IgG4 in clinical samples. Clin Chim Acta. 489:83–88. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Ullman E, Kirakossian H, Switchenko AC, Ishkanian J, Ericson M, Wartchow CA, Pirio M, Pease J, Irvin BR, Singh S, et al: Luminescent oxygen channeling assay (LOCI): Sensitive, broadly applicable homogeneous immunoassay method. Clin Chem. 42:1518–1526. 1996. View Article : Google Scholar : PubMed/NCBI

37 

Ullman E, Kirakossian H, Singh S, Wu ZP, Irvin BR, Pease JS, Switchenko AC, Irvine JD, Dafforn A, Skold CN, et al: Luminescent oxygen channeling immunoassay: Measurement of particle binding kinetics by chemiluminescence. Proc Natl Acad Sci USA. 91:5426–5430. 1994. View Article : Google Scholar : PubMed/NCBI

38 

Sverremark-Ekstrom E, Hultgren EH, Borres MP and Nilsson C: Peanut sensitization during the first 5 yr of life is associated with elevated levels of peanut-specific IgG. Pediatr Allergy Immunol. 23:224–229. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Huang X, Tsilochristou O, Perna S, Hofmaier S, Cappella A, Bauer CP, Hoffman U, Forster J, Zepp F, Schuster A, et al: Evolution of the IgE and IgG repertoire to a comprehensive array of allergen molecules in the first decade of life. Allergy. 73:421–430. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Hofmaier S, Comberiati P and Matricardi PM: Immunoglobulin G in IgE-mediated allergy and allergen-specific immunotherapy. Eur Ann Allergy Clin Immunol. 46:6–11. 2014.PubMed/NCBI

41 

Akdis M and Akdis CA: Mechanisms of allergen-specific immunotherapy: Multiple suppressor factors at work in immune tolerance to allergens. J Allergy Clin Immunol. 133:621–631. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Stapel SO, Asero R, Ballmer-Weber BK, Knol EF, Strobel S, Vieths S and Kleine-Tebbe J; EAACI Task Force, : Testing for IgG4 against foods is not recommended as a diagnostic tool: EAACI Task Force Report. Allergy. 63:793–796. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Caubet JC, Lin J, Ahrens B, Gimenez G, Bardina L, Niggemann B, Sampson HA and Beyer K: Natural tolerance development in cow's milk allergic children: IgE and IgG4 epitope binding. Allergy. 72:1677–1685. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Farioli L, Losappio LM, Giuffrida MG, Pravettoni V, Micarelli G, Nichelatti M, Scibilia J, Mirone C, Cavallarin L, Lamberti C, et al: Mite-induced asthma and IgE levels to shrimp, mite, tropomyosin, arginine kinase, and Der p 10 Are the most relevant risk factors for challenge-proven shrimp allergy. Int Arch Allergy Immunol. 174:133–143. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Varshney S, Goldblum RM, Kearney C, Watanabe M and Midoro-Horiuti T: Major mountain cedar allergen, Jun a 1, contains conformational as well as linear IgE epitopes. Mol Immunol. 44:2781–2785. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Lombardero M, Heymann PW, Platts-Mills TA, Fox JW and Chapman MD: Conformational stability of B cell epitopes on group I and group II Dermatophagoides spp. allergens. Effect of thermal and chemical denaturation on the binding of murine IgG and human IgE antibodies. J Immunol. 144:1353–1360. 1990.PubMed/NCBI

47 

Hu H, Luo W, Wu Z, Cai C, Huang H and Sun B: A pilot study on the allergen-specific IgE to molecular components on polysensitized mite allergic asthmatic patients in Guangzhou, China. Mol Immunol. 105:38–45. 2018. View Article : Google Scholar : PubMed/NCBI

48 

Pascal M, Grishina G, Yang AC, Sánchez-García S, Lin J, Towle D, Ibañez MD, Sastre J, Sampson HA and Ayuso R: Molecular diagnosis of shrimp allergy: Efficiency of several allergens to predict clinical reactivity. J Allergy Clin Immunol Pract. 3:521–529. e10. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Koplin JJ, Perrett KP and Sampson HA: Diagnosing peanut allergy with fewer oral food challenges. J Allergy Clin Immunol Pract. 7:375–380. 2018. View Article : Google Scholar : PubMed/NCBI

50 

Aalberse RC: Shrimp Serology: We need tests with more and less cross-reactivity. J Allergy Clin Immunol Pract. 3:530–531. 2015. View Article : Google Scholar : PubMed/NCBI

51 

King N, Helm R, Stanley JS, Vieths S, Lüttkopf D, Hatahet L, Sampson H, Pons L, Burks W and Bannon GA: Allergenic characteristics of a modified peanut allergen. Mol Nutr Food Res. 49:963–971. 2005. View Article : Google Scholar : PubMed/NCBI

52 

Beyer K, Jarvinen KM, Bardina L, Mishoe M, Turjanmaa K, Niggemann B, Ahlstedt S, Venemalm L and Sampson HA: IgE-binding peptides coupled to a commercial matrix as a diagnostic instrument for persistent cow's milk allergy. J Allergy Clin Immunol. 116:704–705. 2005. View Article : Google Scholar : PubMed/NCBI

53 

Shreffler WG, Beyer K, Chu TH, Burks AW and Sampson HA: Microarray immunoassay: Association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes. J Allergy Clin Immunol. 113:776–782. 2004. View Article : Google Scholar : PubMed/NCBI

54 

Lin J and Sampson HA: The role of immunoglobulin E-binding epitopes in the characterization of food allergy. Curr Opin Allergy Clin Immunol. 9:357–363. 2009. View Article : Google Scholar : PubMed/NCBI

55 

Matsuo H, Kohno K, Niihara H and Morita E: Specific IgE determination to epitope peptides of omega-5 gliadin and high molecular weight glutenin subunit is a useful tool for diagnosis of wheat-dependent exercise-induced anaphylaxis. J Immunol. 175:8116–8122. 2005. View Article : Google Scholar : PubMed/NCBI

56 

Lin J, Bruni FM, Fu Z, Maloney J, Bardina L, Boner AL, Gimenez G and Sampson HA: A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay. J Allergy Clin Immunol. 129:1321–1328 e5. 2012. View Article : Google Scholar : PubMed/NCBI

57 

Wang J, Lin J, Bardina L, Goldis M, Nowak-Wegrzyn A, Shreffler WG and Sampson HA: Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy. J Allergy Clin Immunol. 125:695–702, 702. e1-702.6. 2010. View Article : Google Scholar : PubMed/NCBI

58 

Vickery BP, Lin J, Kulis M, Fu Z, Steele PH, Jones SM, Scurlock AM, Gimenez G, Bardina L, Sampson HA and Burks AW: Peanut oral immunotherapy modifies IgE and IgG4 responses to major peanut allergens. J Allergy Clin Immunol. 131:128–134 e1-3. 2013. View Article : Google Scholar : PubMed/NCBI

59 

Sicherer SH and Sampson HA: Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. J Allergy Clin Immunol. 141:41–58. 2018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li J, Li Z, Kong D, Li S, Yu Y and Li H: IgE and IgG4 responses to shrimp allergen tropomyosin and its epitopes in patients from coastal areas of northern China. Mol Med Rep 22: 371-379, 2020.
APA
Li, J., Li, Z., Kong, D., Li, S., Yu, Y., & Li, H. (2020). IgE and IgG4 responses to shrimp allergen tropomyosin and its epitopes in patients from coastal areas of northern China. Molecular Medicine Reports, 22, 371-379. https://doi.org/10.3892/mmr.2020.11084
MLA
Li, J., Li, Z., Kong, D., Li, S., Yu, Y., Li, H."IgE and IgG4 responses to shrimp allergen tropomyosin and its epitopes in patients from coastal areas of northern China". Molecular Medicine Reports 22.1 (2020): 371-379.
Chicago
Li, J., Li, Z., Kong, D., Li, S., Yu, Y., Li, H."IgE and IgG4 responses to shrimp allergen tropomyosin and its epitopes in patients from coastal areas of northern China". Molecular Medicine Reports 22, no. 1 (2020): 371-379. https://doi.org/10.3892/mmr.2020.11084
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Li Z, Kong D, Li S, Yu Y and Li H: IgE and IgG4 responses to shrimp allergen tropomyosin and its epitopes in patients from coastal areas of northern China. Mol Med Rep 22: 371-379, 2020.
APA
Li, J., Li, Z., Kong, D., Li, S., Yu, Y., & Li, H. (2020). IgE and IgG4 responses to shrimp allergen tropomyosin and its epitopes in patients from coastal areas of northern China. Molecular Medicine Reports, 22, 371-379. https://doi.org/10.3892/mmr.2020.11084
MLA
Li, J., Li, Z., Kong, D., Li, S., Yu, Y., Li, H."IgE and IgG4 responses to shrimp allergen tropomyosin and its epitopes in patients from coastal areas of northern China". Molecular Medicine Reports 22.1 (2020): 371-379.
Chicago
Li, J., Li, Z., Kong, D., Li, S., Yu, Y., Li, H."IgE and IgG4 responses to shrimp allergen tropomyosin and its epitopes in patients from coastal areas of northern China". Molecular Medicine Reports 22, no. 1 (2020): 371-379. https://doi.org/10.3892/mmr.2020.11084
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team