Open Access

Urethral meatus stricture BOO stimulates bladder smooth muscle cell proliferation and pyroptosis via IL‑1β and the SGK1‑NFAT2 signaling pathway

  • Authors:
    • Wang Kai
    • Chen Lin
    • Yang Jin
    • He Ping‑Lin
    • Liu Xun
    • Amend Bastian
    • Stenzl Arnulf
    • Xing Sha‑Sha
    • Luo Xu
    • Cui Shu
  • View Affiliations

  • Published online on: April 24, 2020     https://doi.org/10.3892/mmr.2020.11092
  • Pages: 219-226
  • Copyright: © Kai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Bladder outlet obstruction (BOO), which is primarily caused by benign prostatic hyperplasia, is a common chronic disease. However, previous studies have most commonly investigated BOO using the acute obstruction model. In the present study, a chronic obstruction model was established to investigate the different pathological alterations in the bladder between acute and chronic obstruction. Compared with chronic obstruction, acute obstruction led to increased expression of proliferating cell nuclear antigen and interleukin‑1β, which are markers of proliferation and inflammation, respectively. Furthermore, increased fibrosis in the bladder at week 2 was observed. Low pressure promoted mice bladder smooth muscle cell (MBSMC) proliferation, and pressure overload inhibited cell proliferation and increased the proportion of dead MBSMCs. Further investigation using serum/glucocorticoid regulated kinase 1 (SGK1) small interfering RNAs indicated that low pressure may promote MBSMC proliferation by upregulating SGK1 and nuclear factor of activated T‑cell expression levels. Therefore, the present study suggested that acute obstruction led to faster decompensation of bladder function and chronic bladder obstruction displayed an enhanced ability to progress to BOO.
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July 2020
Volume 22 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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APA
Kai, W., Lin, C., Jin, Y., Ping‑Lin, H., Xun, L., Bastian, A. ... Shu, C. (2020). Urethral meatus stricture BOO stimulates bladder smooth muscle cell proliferation and pyroptosis via IL‑1β and the SGK1‑NFAT2 signaling pathway. Molecular Medicine Reports, 22, 219-226. https://doi.org/10.3892/mmr.2020.11092
MLA
Kai, W., Lin, C., Jin, Y., Ping‑Lin, H., Xun, L., Bastian, A., Arnulf, S., Sha‑Sha, X., Xu, L., Shu, C."Urethral meatus stricture BOO stimulates bladder smooth muscle cell proliferation and pyroptosis via IL‑1β and the SGK1‑NFAT2 signaling pathway". Molecular Medicine Reports 22.1 (2020): 219-226.
Chicago
Kai, W., Lin, C., Jin, Y., Ping‑Lin, H., Xun, L., Bastian, A., Arnulf, S., Sha‑Sha, X., Xu, L., Shu, C."Urethral meatus stricture BOO stimulates bladder smooth muscle cell proliferation and pyroptosis via IL‑1β and the SGK1‑NFAT2 signaling pathway". Molecular Medicine Reports 22, no. 1 (2020): 219-226. https://doi.org/10.3892/mmr.2020.11092