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Article Open Access

Downregulation of miR‑142‑5p inhibits human aortic smooth muscle cell proliferation and migration by targeting MKL2

  • Authors:
    • Wei Wu
    • Yuqiang Shang
    • Shiling Dai
    • Chunjun Yu
    • Jie Wang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiothoracic Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 277-285
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    Published online on: April 24, 2020
       https://doi.org/10.3892/mmr.2020.11093
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Abstract

The increased proliferation and migration of vascular smooth muscle cells (VSMCs) are critical in the progression of atherosclerosis (AS). Platelet‑derived growth factor type BB (PDGF‑BB) may induce VSMC proliferation and migration. miR‑142‑5p plays a critical role in various biological processes, including tumorigenesis, angiogenesis and inflammation. However, whether miR‑142‑5p is involved in regulating the pathological process of arteriosclerosis remains to be elucidated. Therefore, in this study, the role of miR‑142‑5p in PDGF‑BB‑induced human aortic smooth muscle cell (HSAMC) proliferation and migration was investigated. The results revealed that the expression level of miR‑142‑5p was enhanced in the serum of patients with AS, while that of its target gene, myocardin‑like protein 2 (MKL2) was decreased, compared with that in healthy volunteers. Moreover, there was a negative correlation between miR‑142‑5p and MKL2 expression in the serum of patients with AS. Furthermore, the downregulation of miR‑142‑5p inhibited PDGF‑BB‑induced HASMC proliferation and migration; however, the inhibition of HASMC proliferation and migration was reversed by co‑transfection with small interfering RNA (siRNA) against MKL2 (siRNA‑MKL2). In addition, transfection with miR‑142‑5p inhibitor significantly increased the expression levels of MKL2, and decreased those of matrix metalloproteinase (MMP)2 and 9, and these effects were reversed by transfection with siRNA‑MKL2. Finally, MKL2 was proven to be a target of miR‑142‑5p. On the whole, the findings of the present study demonstrate that the downregulation of miR‑142‑5p inhibits human aortic smooth muscle cell (HSAMC) proliferation and migration possibly by targeting MKL2. Hence, miR‑142‑5p may prove to be a novel therapeutic target in the treatment of AS.
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1 

Gan WQ, Man SF, Senthilselvan A and Sin DD: Association between chronic obstructive pulmonary disease and systemic inflammation: A systematic review and a meta-analysis. Thorax. 59:574–580. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Ross R and Agius L: The process of atherogenesis-cellular and molecular interaction: From experimental animal models to humans. Diabetologia. 35 (Suppl 2):S34–S40. 1992. View Article : Google Scholar : PubMed/NCBI

3 

Ross R: The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature. 362:801–809. 1993. View Article : Google Scholar : PubMed/NCBI

4 

Seely S: Atherosclerosis or hardening of the arteries? Int J Cardiol. 22:5–12. 1989. View Article : Google Scholar : PubMed/NCBI

5 

Owens GK: Regulation of differentiation of vascular smooth muscle cells. Physiol Rev. 75:487–517. 1995. View Article : Google Scholar : PubMed/NCBI

6 

Ross R: Atherosclerosis-an inflammatory disease. New Engl J Med. 340:115–126. 1996. View Article : Google Scholar

7 

Kawai-Kowase K and Owens GK: Multiple repressor pathways contribute to phenotypic switching of vascular smooth muscle cells. Am J Physiol Cell Physiol. 292:C59–C69. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Heldin CH and Westermark B: Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev. 79:1283–1316. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Ha JM, Yun SJ, Kim KW, Jin SY, Lee HS, Song SH, Shin HK and Bae SS: Platelet-derived growth factor regulates vascular smooth muscle phenotype via mammalian target of rapamycin complex 1. Biochem Biophys Res Commun. 464:57–62. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Shawky NM and Segar L: Sulforaphane inhibits platelet-derived growth factor-induced vascular smooth muscle cell proliferation by targeting Mtor/P70S6kinase signaling independent of Nrf2 activation. Pharmacol Res. 119:251–264. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Dzau VJ, Braun-Dullaeus RC and Sedding DG: Vascular proliferation and atherosclerosis: New perspectives and therapeutic strategies. Nat Med. 8:1249–1256. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Ding S, Huang H, Xu Y, Zhu H and Zhong C: miR-222 in cardiovascular diseases: Physiology and pathology. Biomed Res Int. 2017:49624262017. View Article : Google Scholar : PubMed/NCBI

15 

Gu H, Liu Z and Zhou L: Roles of miR-17-92 cluster cardiovascular development and common diseases. Biomed Res Int. 2017:91029092017. View Article : Google Scholar : PubMed/NCBI

16 

Seeger T and Boon RA: MicroRNAs in cardiovascular aging. J Physiol. 594:2085–2094. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Price NL, Rotllan N, Canfrán-Duque A, Zhang X, Pati P, Arias N, Moen J, Mayr M, Ford DA, Baldán Á, et al: Genetic dissection of the impact of miR-33a and miR-33b during the progression of atherosclerosis. Cell Rep. 21:1317–1330. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Ouimet M, Ediriweera H, Afonso MS, Ramkhelawon B, Singaravelu R, Liao X, Bandler RC, Rahman K, Fisher EA, Rayner KJ, et al: microRNA-33 regulates macrophage autophagy in atherosclerosis. Arterioscler Thromb Vasc Biol. 37:1058–1067. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Xu RJ, Bi CL, Song JT, Wang L, Ge C, Liu XX and Zhang M: Upregulation of miR-142-5p in atherosclerotic plagues and regulation of oxidized low-density lipoprotein-induced apoptosis in macrophages. Mol Med Rep. 11:3229–3234. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Kee HJ, Park S, Kwon JS, Choe N, Ahn Y, Kook H and Jeong MH: B cell translocation gene, a direct target of miR-142-5p, inhibits vascular smooth muscle cell proliferation by down-regulating cell cycle progression. FEBS Lett. 587:2385–2392. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Wang Y, Han Z, Fan Y, Zhang J, Chen K, Gao L, Zeng H, Cao J and Wang C: MicroRNA-9 inhibits NLRP3 inflammasome activation in human atherosclerosis inflammation cell models through the JAK2/STAT signaling pathway. Cell Physiol Biochem. 41:1555–1571. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Liang X, Xu Z, Yuan M, Zhang Y, Zhao B, Wang J, Zhang A and Li G: MicroRNA-16 suppresses the activation of inflammation microphages in atherosclerosis by targeting PDCD4. Int J Mol Med. 37:967–975. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Chen J, Cui L, Yuan J, Zhang Y and Sang H: Circular RNA WDR77 target FGF-2 to regulate vascular smooth muscle cells proliferation and migration by sponging miR-124. Biochem Biophys Res Commun. 494:126–132. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Xie B, Zhang C, Kang K and Jiang S: miR-559 inhibits vascular smooth muscle cells proliferation and migration by targeting TGFB2. PLoS One. 10:e01415122015. View Article : Google Scholar : PubMed/NCBI

26 

Bi R, Ding F, He Y, Jiang L, Jiang Z, Mei J and Liu H: miR-503 inhibits platelet-derived growth factor-induced human aortic vascular smooth muscle cell proliferation and migration through targeting the insulin receptor. Biomed Pharmacother. 84:1711–1716. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Sudo R, Sato F, Azechi T and Wachi H: miR-29-mediated elastin down-regulation contributes to inorganic phosphorus-induced osteoblastic differentiation in vascular smooth muscle cells. Genes Cells. 20:1077–1087. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Islam F, Gopalan V, Vider J, Lu CT and Lam AK: MiR-142-5p act as an oncogenenic microRNA in colorectal cancer: Clinicopathological and functional insights. Exp Mol Pathol. 104:98–107. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Wang Z, Liu Z, Fang X and Yang H: MiR-142-5p suppresses tumorigenesis by targeting PIK3CA in non-small cell lung cancer. Cell Physiol Biochem. 43:2505–2515. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Kwanhian W, Lenze D, Alles J, Motsch N, Barth S, Döll C, Imig J, Hummel M, Tinguely M, Trivedi P, et al: microRNA-142 is mutated in about 20% of diffuse large B-cell lymphoma. Cancer Med. 1:141–155. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Swärd K, Stenkula KG, Rippe C, Alajbegovic A, Gomez MF and Albinsson S: Emerging roles of the myocardin family of proteins in lipid and glucose metabolism. J Physiol. 594:4741–4752. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Hampl V, Martin C, Aigner A, Hoebel S, Singer S, Frank N, Sarikas A, Ebert O, Prywes R, Gudermann T and Muehlich S: Depletion of the transcriptional coactivators megakaryoblastic leukemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence. EMBO Mol Med. 5:1367–1387. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Pipes GC, Creemers EE and Olson EN: The myocardin family of transcriptional coactivators: Versatile regulators of cell growth, migration and myogenesis. Genes Dev. 20:1545–1556. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Smith MC, Hudson CA, Kimura TE, White SJ, Sala-Newby GB, Newby AC and Bond M: Divergent regulation of actin dynamics and megakaryoblastic leukemia-1 and −2 (Mkl1/2) by cAMP in endothelial and smooth muscle cells. Sci Rep. 7:36812017. View Article : Google Scholar : PubMed/NCBI

35 

Goikuria H, Freijo MDM, Vega Manrigue R, Sastre M, Elizagaray E, Lorenzo A, Vandenbroeck K and Alloza I: Characterization of carotid smooth muscle cells during phenotypic transition. Cells. 7:E232018. View Article : Google Scholar : PubMed/NCBI

36 

Seo KW, Lee SJ, Ye BH, Kim YW, Bae SS and Kim CD: Mechanical stretch enhances the expression and activity of osteopointin and MMP2 via the Akt1/AP-1 pathways in VSMC. J Mol Cell Cardiol. 85:13–24. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Volcik KA, Campbell S, Chambless LE, Coresh J, Folsom AR, Mosley TH, Ni HY, Wagenknecht LE, Wasserman BA and Boerwinkle E: MMP2 genetic variation is associated with measures of fibrous cap thickness: The atherosclerosis risk in communities carotid MRI study. Atherosclerosis. 210:188–193. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Kim J and Ko J: Human sLZIP promotes atherosclerosis via MMP-9 transcription and vascular smooth muscle cell migration. FASEB J. 28:5010–5021. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Eilenberg W, Stojkovic S, Kaider A, Kozakowski N, Domenig CM, Burghuber C, Nanobachvili J, Huber K, Klinger M, Neumayer C, et al: NGAL and MMP-9/NGAL as biomarkers of plaque vulnerability and targets of statins in patiensts with carotid atherosclerosis. Clin Chem Lab Med. 56:147–156. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Ma L and Zhang L, Wang B, Wei J, Liu J and Zhang L: Berberine inhibts Chlamydia pneumoniae infection-induced vascular smooth muscle cell migration through downregulating MMP3 and MMP9 via PI3K. Eur J Pharmacol. 755:102–109. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Gan J, Li P, Wang Z, Chen J, Liang X, Liu M, Xie W, Yin R and Huang F: Posuvastatin suppresses platelet-derived growth factor-BB-induced vascular smooth muscle cell proliferation and migration via the MAPK signaling pathway. Exp Ther Med. 6:899–903. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Byun HJ, Darvin P, Kang DY, Sp N, Joung YH, Park JH, Kim SJ and Yang YM: Silibinin downregulates MMP2 expression via Jak2/STAT3 pathway and inhibits the migration and invasive potential in MDA-MB-231 cells. Oncol Rep. 37:3270–3278. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Zhen Y, Liu J, Huang Y, Wang Y, Li W and Wu J: miR-133b inhibits cell growth, migration, and invasion by targeting MMP9 in non-small cell lung cancer. Oncol Rep. 25:1109–1116. 2017. View Article : Google Scholar

44 

Zhang C, Wang L, Chen J, Liang J, Xu Y, Li Z, Chen F and Du D: Knockdown of Diaph1 expression inhibits migration and decreases the expression of MMP2 and MMP9 in human glioma cells. Biomed Pharmacother. 96:596–602. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu W, Shang Y, Dai S, Yu C and Wang J: Downregulation of miR‑142‑5p inhibits human aortic smooth muscle cell proliferation and migration by targeting MKL2. Mol Med Rep 22: 277-285, 2020.
APA
Wu, W., Shang, Y., Dai, S., Yu, C., & Wang, J. (2020). Downregulation of miR‑142‑5p inhibits human aortic smooth muscle cell proliferation and migration by targeting MKL2. Molecular Medicine Reports, 22, 277-285. https://doi.org/10.3892/mmr.2020.11093
MLA
Wu, W., Shang, Y., Dai, S., Yu, C., Wang, J."Downregulation of miR‑142‑5p inhibits human aortic smooth muscle cell proliferation and migration by targeting MKL2". Molecular Medicine Reports 22.1 (2020): 277-285.
Chicago
Wu, W., Shang, Y., Dai, S., Yu, C., Wang, J."Downregulation of miR‑142‑5p inhibits human aortic smooth muscle cell proliferation and migration by targeting MKL2". Molecular Medicine Reports 22, no. 1 (2020): 277-285. https://doi.org/10.3892/mmr.2020.11093
Copy and paste a formatted citation
x
Spandidos Publications style
Wu W, Shang Y, Dai S, Yu C and Wang J: Downregulation of miR‑142‑5p inhibits human aortic smooth muscle cell proliferation and migration by targeting MKL2. Mol Med Rep 22: 277-285, 2020.
APA
Wu, W., Shang, Y., Dai, S., Yu, C., & Wang, J. (2020). Downregulation of miR‑142‑5p inhibits human aortic smooth muscle cell proliferation and migration by targeting MKL2. Molecular Medicine Reports, 22, 277-285. https://doi.org/10.3892/mmr.2020.11093
MLA
Wu, W., Shang, Y., Dai, S., Yu, C., Wang, J."Downregulation of miR‑142‑5p inhibits human aortic smooth muscle cell proliferation and migration by targeting MKL2". Molecular Medicine Reports 22.1 (2020): 277-285.
Chicago
Wu, W., Shang, Y., Dai, S., Yu, C., Wang, J."Downregulation of miR‑142‑5p inhibits human aortic smooth muscle cell proliferation and migration by targeting MKL2". Molecular Medicine Reports 22, no. 1 (2020): 277-285. https://doi.org/10.3892/mmr.2020.11093
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