Open Access

Neuroprotective effect of tormentic acid against memory impairment and neuro‑inflammation in an Alzheimer's disease mouse model

  • Authors:
    • Weigang Cui
    • Chunli Sun
    • Yuqi Ma
    • Songtao Wang
    • Xianwei Wang
    • Yinghua Zhang
  • View Affiliations

  • Published online on: May 18, 2020     https://doi.org/10.3892/mmr.2020.11154
  • Pages: 739-750
  • Copyright: © Cui et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cognitive impairment and neuro‑inflammatory responses are the distinctive characteristics of Alzheimer's disease (AD). Tormentic acid (TA) is one of the major active components of Potentilla chinensis and has been demonstrated to have anti‑inflammatory properties. However, the potential effects of TA on neuro‑inflammatory responses and memory impairment in AD remain unknown. The present study investigated the therapeutic effect of TA on neuro‑inflammation, as well as learning and memory impairment in AD mice. In addition, the effects of TA treatment were also examined in a co‑culture system of microglia and primary neurons. Intraperitoneal administration of TA attenuated memory deficits in amyloid β precursor protein/presenilin 1 transgenic mice, with a marked decrease in amyloid plaque deposition. TA also reduced microglial activation and decreased the secretion of pro‑inflammatory factors in AD mice. Furthermore, pre‑treatment with TA suppressed the production of pro‑inflammatory markers, as well as the nuclear translocation of nuclear factor‑κB (NF‑κB) p65 induced by Aβ exposure in BV2 cells. TA also reduced inhibited neurotoxicity and improved neuron survival in a neuron‑microglia co‑culture system. Taken together, these findings suggested that TA could attenuate neuro‑inflammation and memory impairment, which may be closely associated with regulation of the NF‑κB pathway.

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August-2020
Volume 22 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos
Cui W, Sun C, Ma Y, Wang S, Wang X and Zhang Y: Neuroprotective effect of tormentic acid against memory impairment and neuro‑inflammation in an Alzheimer's disease mouse model. Mol Med Rep 22: 739-750, 2020
APA
Cui, W., Sun, C., Ma, Y., Wang, S., Wang, X., & Zhang, Y. (2020). Neuroprotective effect of tormentic acid against memory impairment and neuro‑inflammation in an Alzheimer's disease mouse model. Molecular Medicine Reports, 22, 739-750. https://doi.org/10.3892/mmr.2020.11154
MLA
Cui, W., Sun, C., Ma, Y., Wang, S., Wang, X., Zhang, Y."Neuroprotective effect of tormentic acid against memory impairment and neuro‑inflammation in an Alzheimer's disease mouse model". Molecular Medicine Reports 22.2 (2020): 739-750.
Chicago
Cui, W., Sun, C., Ma, Y., Wang, S., Wang, X., Zhang, Y."Neuroprotective effect of tormentic acid against memory impairment and neuro‑inflammation in an Alzheimer's disease mouse model". Molecular Medicine Reports 22, no. 2 (2020): 739-750. https://doi.org/10.3892/mmr.2020.11154