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Comprehensive analysis of the differential expression profile of microRNAs in rats with spinal cord injury treated by electroacupuncture

  • Authors:
    • Zhidong Zhou
    • Hejian Li
    • Hongchun Li
    • Jing Zhang
    • Kaiwen Fu
    • Cao Cao
    • Fumou Deng
    • Jun Luo
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330000, P.R. China, Department of Rehabilitation Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330000, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 751-762
    |
    Published online on: May 20, 2020
       https://doi.org/10.3892/mmr.2020.11161
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Abstract

Abnormal microRNA (miRNA) expression has been implicated in spinal cord injury (SCI), but the underlying mechanisms are poorly understood. To observe the effect of electroacupuncture (EA) on miRNA expression profiles in SCI rats and investigate the potential mechanisms involved in this process, Sprague‑Dawley rats were divided into sham, SCI and SCI+EA groups (n=6 each). Basso, Beattie and Bresnahan (BBB) scoring and hematoxylin‑eosin staining of cortical tissues were used to evaluate spinal cord recovery with EA treatment 21 days post‑surgery across the three groups. To investigate miRNA expression profiles, 6 Sprague‑Dawley rats were randomly divided into SCI and SCI+EA groups (n=3 in each group) and examined using next‑generation sequencing. Integrated miRNA‑mRNA‑pathway network analysis was performed to elucidate the interaction network of the candidate miRNAs, their target genes and the involved pathways. Behavioral scores suggested that hindlimb motor functions improved with EA treatments. Apoptotic indices were lower in the SCI+EA group compared with the SCI group. It was also observed that 168 miRNAs were differentially expressed between the SCI and SCI+EA groups, with 29 upregulated and 139 downregulated miRNAs in the SCI+EA group. Changes in miRNA expression are involved in SCI physiopathology, including inflammation and apoptosis. Reverse transcription‑quantitative PCR measurement of the five candidate miRNAs, namely rno‑miR‑219a‑5p, rno‑miR‑486, rno‑miR‑136‑5p, rno‑miR‑128‑3p, and rno‑miR‑7b, was consistent with RNA sequencing data. Integrated miRNA‑mRNA‑pathway analysis suggested that the MAPK, Wnt and NF‑κB signaling pathways were involved in EA‑mediated recovery from SCI. The present study evaluated the miRNA expression profiles involved in EA‑treated SCI rats and demonstrated the potential mechanism and functional role of miRNAs in SCI in rats.
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View References

1 

McDonald JW and Sadowsky C: Spinal-cord injury. Lancet. 359:417–425. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Sharif-Alhoseini M and Rahimi-Movaghar V: Animal models in traumatic spinal cord injury. Top Paraplegia. 2014.

3 

Gao L, Sun Y, Li J, Bai F and Li P: Effects of electroacupuncture in different time on variations of fractional anisotropy mean value of diffusion tensor tractogra-phy in spinal cord injured rats. Chin J Rehabil Theory Prac. 20:728–733. 2014.

4 

Majdan M, Plancikova D, Nemcovska E, Krajcovicova L, Brazinova A and Rusnak M: Mortality due to traumatic spinal cord injuries in Europe: A cross-sectional and pooled analysis of population-wide data from 22 countries. Scand J Trauma Resusc Emerg Med. 25:642017. View Article : Google Scholar : PubMed/NCBI

5 

Blight AR, Leroy EC Jr and Heyes MP: Quinolinic acid accumulation in injured spinal cord: Time course, distribution, and species differences between rat and guinea pig. J Neurotrauma. 14:89–98. 1997. View Article : Google Scholar : PubMed/NCBI

6 

Hall ED and Springer JE: Neuroprotection and acute spinal cord injury: A reappraisal. NeuroRx. 1:80–100. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Tator CH: Update on the pathophysiology and pathology of acute spinal cord injury. Brain Pathol. 5:407–413. 1995. View Article : Google Scholar : PubMed/NCBI

8 

Dong J, Lu M, He X, Xu J, Qin J, Cheng Z, Liang B, Wang D and Li H: Identifying the role of microRNAs in spinal cord injury. Neurol Sci. 35:1663–1671. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Ning B, Gao L, Liu RH, Liu Y, Zhang NS and Chen ZY: MicroRNAs in spinal cord injury: Potential roles and therapeutic implications. Int J Biol Sci. 10:997–1006. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Li J, Li L and Shen Y: Protective role of microRNA-219-5p inhibitor against spinal cord injury via liver receptor homolog-1/Wnt/β-catenin signaling pathway regulation. Exp Ther Med. 15:3563–3569. 2018.PubMed/NCBI

11 

Bhalala OG, Srikanth M and Kessler JA: The emerging roles of microRNAs in CNS injuries. Nat Rev Neurol. 9:328–339. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Zheng Q, Zhang D, Yang YU, Cui X, Sun J, Liang C, Qin H, Yang X, Liu S and Yan Q: MicroRNA-200c impairs uterine receptivity formation by targeting FUT4 and 1,3-fucosylation. Cell Death Differ. 24:2161–2172. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Zeng Y, Liu JX, Yan ZP, Yao XH and Liu XH: Potential microRNA biomarkers for acute ischemic stroke. Int J Mol Med. 36:1639–1647. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Hinkel R, Penzkofer D, Zühlke S, Fischer A, Husada W, Xu QF, Baloch E, Van RE, Zeiher AM, Kupatt C and Dimmeler S: Inhibition of microRNA-92a protects against ischemia/reperfusion injury in a large-animal model. Circulation. 128:1066–1075. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Beermann J, Piccoli MT, Viereck J and Thum T: Non-coding RNAs in development and disease: Background, mechanisms, and therapeutic approaches. Physiol Rev. 96:1297–1325. 2016. View Article : Google Scholar : PubMed/NCBI

16 

van Rooij E, Sutherland LB, Liu N, Williams AH, McAnally J, Gerard RD, Richardson JA and Olson EN: A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci USA. 103:18255–18260. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ and Srivastava D: Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell. 129:303–317. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Bala S, Marcos M and Szabo G: Emerging role of microRNAsin liver diseases. World J Gastroenterol. 15:5633–5640. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Krutzfeldt J, Rajewsky N, Braich R, Rajeev KG, Tuschl T, Manoharan M and Stoffel M: Silencing of microRNAs in vivo with ‘antagomirs’. Nature. 438:685–689. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Jackson AL, Burchard J, Leake D, Reynolds A, Schelter J, Guo J, Johnson JM, Lim L, Karpilow J, Nichols K, et al: Position-specific chemical modification of siRNAs reduces ‘off-target’ transcript silencing. RNA. 12:1197–1205. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Rao P, Benito E and Fischer A: MicroRNAs as biomarkers for CNS disease. Front Mol Neurosci. 6:392013. View Article : Google Scholar : PubMed/NCBI

22 

Wang W, Kwon EJ and Tsai LH: MicroRNAs in learning, memory, and neurological diseases. Learn Mem. 19:359–368. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Zhang T, Ni SF, Luo Z, Lang Y, Hu J and Lu H: The protective effect of microRNA-21 in neurons after spinal cord injury. Spinal Cord. 57:141–149. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Gao L, Dai C, Feng Z, Zhang L and Zhang Z: MiR-137 inhibited inflammatory response and apoptosis after spinal cord injury via targeting of MK2. J Cell Biochem. 119:3280–3292. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Bao N, Fang B, Lv H, Jiang Y, Chen F, Wang Z and Ma H: Upregulation of miR-199a-5p protects spinal cord against ischemia/reperfusion-induced injury via downregulation of ECE1 in rat. Cell Mol Neurobiol. 38:1293–1303. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Obermair FJ, Schröter A and Thallmair M: Endogenous neural progenitor cells as therapeutic target after spinal cord injury. Physiology (Bethesda). 23:296–304. 2008.PubMed/NCBI

27 

Yan Q, Ruan JW, Ding Y, Li WJ, Li Y and Zeng YS: Electro-acupuncture promotes differentiation of mesenchymal stem cells, regeneration of nerve fibers and partial functional recovery after spinal cord injury. Exp Toxicol Pathol. 63:151–156. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Jiang SH, Tu WZ, Zou EM, Hu J, Wang S, Li JR, Wang WS, He R, Cheng RD and Liao WJ: Neuroprotective effects of different modalities of acupuncture on traumatic spinal cord injury in rats. Evid Based Complement Alternat Med. 2014:4315802014. View Article : Google Scholar : PubMed/NCBI

29 

Park JH, Han JB, Kim SK, Park JH, Go DH, Sun B and Min BI: Spinal GABA receptors mediate the suppressive effect of electroacupuncture on cold allodynia in rats. Brain Res. 1322:24–29. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Aloe L and Manni L: Low-frequency electro-acupuncture reduces the nociceptive response and the pain mediator enhancement induced by nerve growth factor. Neurosci Lett. 449:173–177. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Park JH, Kim SK, Kim HN, Sun B, Koo S, Choi SM, Bae H and Min BI: Spinal cholinergic mechanism of the relieving effects of electroacupuncture on cold and warm allodynia in a rat model of neuropathic pain. J Physiol Sci. 59:291–298. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Min YJ, Cheng LH and Gao J: Comparative observations on three-unblocking acupuncture for the treatment of spinal cord injury in convalescent patients with paraplegia. Shanghai Zhenjiu Zazhi. 32:1010–1013. 2013.

33 

Huang C, Wang Y, Han JS and Wan Y: Characteristics of electroacupuncture-induced analgesia in mice: Variation with strain, frequency, intensity and opioid involvement. Brain Res. 945:20–25. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Lao L, Zhang RX, Zhang G, Wang X, Berman BM and Ren K: A para-metric study of electroacupuncture on persistent hyperalgesia and Fos protein expression in rats. Brain Res. 1020:18–29. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Lin JG, Lo MW, Wen YR, Hsieh CL, Tsai SK and Sun WZ: The effect of high and low frequency electroacupuncture in pain after lower abdominal surgery. Pain. 99:509–514. 2002. View Article : Google Scholar : PubMed/NCBI

36 

Zhang JF, Li SS and Wu YC: Recovery of spinal cord injury following electroacupuncture in rats through enhancement of Wnt/β-catenin signaling. Mol Med Rep. 16:2185–2190. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Filipp ME, Travis BJ, Henry SS, Idzikowski EC, Magnuson SA, Loh MY, Hellenbrand DJ and Hanna AS: Differences in neuroplasticity after spinal cord injury in varying animal models and humans. Neural Regen Res. 14:7–19. 2019. View Article : Google Scholar : PubMed/NCBI

38 

Basso DM, Beattie MS and Bresnahan JC: A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma. 12:1–21. 1995. View Article : Google Scholar : PubMed/NCBI

39 

Ramayo-Caldas Y, Mach N, Esteve-Codina A, Corominas J, Castelló A, Ballester M, Estellé J, Ibáñez-Escriche N, Fernández AI, Pérez-Enciso M and Folch JM: Liver transcriptome profile in pigs with extreme phenotypes of intramuscular fatty acid composition. BMC Genomics. 13:5472012. View Article : Google Scholar : PubMed/NCBI

40 

Wright GW and Simon RM: A random variance model for detection of differential gene expression in small microarray experiments. Bioinformatics. 19:2448–2455. 2003. View Article : Google Scholar : PubMed/NCBI

41 

Turner DA: Miranda: A non-strict functional language with polymorphic types. Proc of a conference on functional programming languages and computer architecture. 1–16. 1985. View Article : Google Scholar

42 

Krüger J and Rehmsmeier M: RNAhybrid: MicroRNA target prediction easy, fast and flexible. Nucleic Acids Res. 34((Web Server issue)): W451–W454. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

44 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

45 

Deng G, Gao Y, Cen Z, He J, Cao B, Zeng G and Zong S: miR-136-5p regulates the inflammatory response by targeting the IKKβ/NF-κB/A20 pathway after spinal cord injury. Cell Physiol Biochem. 50:512–524. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Knierim E, Hirata H, Wolf NI, Morales-Gonzalez S, Schottmann G, Tanaka Y, Rudnik-Schöneborn S, Orgeur M, Zerres K, Vogt S, et al: Mutations in subunits of the activating signal cointegrator 1 complex are associated with prenatal spinal muscular atrophy and congenital bone fractures. Am J Human Genet. 98:473–489. 2016. View Article : Google Scholar

47 

Matsuda M, Kanno H, Sugaya T, Yamaya S, Yahata K, Handa K, Shindo T, Shimokawa H, Ozawa H and Itoi E: Low-energy extracorporeal shock wave therapy promotes BDNF expression and improves functional recovery after spinal cord injury in rats. Exp Neurol. 328:1132512020. View Article : Google Scholar : PubMed/NCBI

48 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

49 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

50 

Saugstad JA: MicroRNAs as effectors of brain function with roles in ischemia and injury, neuroprotection, and neurodegeneration. J Cereb Blood Flow Metab. 30:1564–1576. 2010. View Article : Google Scholar : PubMed/NCBI

51 

Yip PK, Bowes AL, Hall JCE, Burguillos MA, Ip THR, Baskerville T, Liu ZH, Mohamed MAEK, Getachew F, Lindsay AD, et al: Docosahexaenoic acid reduces microglia phagocytic activity via miR-124 and induces neuroprotection in rodent models of spinal cord contusion injury. Human Mol Genet. 28:2427–2448. 2019. View Article : Google Scholar

52 

Yan L, Shi E, Jiang X, Shi J, Gao S and Liu H: Inhibition of microRNA-204 conducts neuroprotection against spinal cord ischemia. Ann Thorac Surg. 107:76–83. 2019. View Article : Google Scholar : PubMed/NCBI

53 

Min YJ, Ding LLQ, Cheng LH, Xiao WP, He XW, Zhang H, Min ZY and Pei J: Effect of electroacupuncture on the mRNA and protein expression of Rho-A and Rho-associated kinase II in spinal cord injury rats. Neural Regen Res. 12:110–116. 2017.

54 

Yunta M, Nieto-Díaz M, Esteban FJ, Caballero-López M, Navarro-Ruíz R, Reigada D, Pita-Thomas DW, del Águila A, Muñoz-Galdeano T and Maza RM: MicroRNA dysregulation in the spinal cord following traumatic injury. PLoS One. 7:e345342012. View Article : Google Scholar : PubMed/NCBI

55 

Strickland ER, Hook MA, Balaraman S, Huie JR, Grau JW and Miranda RC: MicroRNA dysregulation following spinal cord contusion: Implications for neural plasticity and repair. Neuroscience. 186:146–160. 2011. View Article : Google Scholar : PubMed/NCBI

56 

Xing SM, Wang J, He X, Lai J, Shen L, Chen D, Fu K and Tan J: Identification of disease-related miRNAs based on co-expression network in spinal cord injury. Int Neurosci. 125:270–276. 2015. View Article : Google Scholar

57 

Wei H, Wang C, Zhang C, Li P, Wang F and Zhang Z: Comparative profiling of microRNA expression between neural stem cells and motor neurons in embryonic spinal cord in rat. Int J Dev Neurosci. 28:545–551. 2010. View Article : Google Scholar : PubMed/NCBI

58 

Izumi B, Nakasa T, Tanaka N, Nakanishi K, Kamei N, Yamamoto R, Nakamae T, Ohta R, Fujioka Y, Yamasaki K and Ochi M: MicroRNA-223 expression in neutrophils in the early phase of secondary damage after spinal cord injury. Neurosci Lett. 492:114–118. 2011. View Article : Google Scholar : PubMed/NCBI

59 

He J, Zhao J, Peng X, Shi X, Zong S and Zeng G: molecular mechanism of MiR-136-5p targeting NF-κB/A20 in the IL-17-mediated inflammatory response after spinal cord injury. Cell Physiol Biochem. 44:1224–1241. 2017. View Article : Google Scholar : PubMed/NCBI

60 

Zhang Z, Wan F, Zhuang Q, Zhang Y and Xu Z: Suppression of miR-127 protects PC-12 cells from LPS-induced inflammatory injury by downregulation of PDCD4. Biomed Pharmacother. 96:1154–1162. 2017. View Article : Google Scholar : PubMed/NCBI

61 

Ahn KS, Sethi G and Aggarwal BB: Nuclear factor-kappa B: From clone to clinic. Curr Mol Med. 7:619–637. 2007. View Article : Google Scholar : PubMed/NCBI

62 

Wang C, Wang Q, Lou Y, Xu J, Feng Z, Chen Y, Tang Q, Zheng G, Zhang Z, Wu Y, et al: Salidroside attenuates neuroinflammation and improves functional recovery after spinal cord injury through microglia polarization regulation. J Cell Mol Med. 22:1148–1166. 2018.PubMed/NCBI

63 

Zhang Y, Liu Z, Zhang W, Wu Q, Zhang Y, Liu Y, Guan Y and Chen X: Melatonin improves functional recovery in female rats after acute spinal cord injury by modulating polarization of spinal microglial/macrophages. J Neurosci Res. 97:733–743. 2019. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Zhou Z, Li H, Li H, Zhang J, Fu K, Cao C, Deng F and Luo J: Comprehensive analysis of the differential expression profile of microRNAs in rats with spinal cord injury treated by electroacupuncture. Mol Med Rep 22: 751-762, 2020.
APA
Zhou, Z., Li, H., Li, H., Zhang, J., Fu, K., Cao, C. ... Luo, J. (2020). Comprehensive analysis of the differential expression profile of microRNAs in rats with spinal cord injury treated by electroacupuncture. Molecular Medicine Reports, 22, 751-762. https://doi.org/10.3892/mmr.2020.11161
MLA
Zhou, Z., Li, H., Li, H., Zhang, J., Fu, K., Cao, C., Deng, F., Luo, J."Comprehensive analysis of the differential expression profile of microRNAs in rats with spinal cord injury treated by electroacupuncture". Molecular Medicine Reports 22.2 (2020): 751-762.
Chicago
Zhou, Z., Li, H., Li, H., Zhang, J., Fu, K., Cao, C., Deng, F., Luo, J."Comprehensive analysis of the differential expression profile of microRNAs in rats with spinal cord injury treated by electroacupuncture". Molecular Medicine Reports 22, no. 2 (2020): 751-762. https://doi.org/10.3892/mmr.2020.11161
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Spandidos Publications style
Zhou Z, Li H, Li H, Zhang J, Fu K, Cao C, Deng F and Luo J: Comprehensive analysis of the differential expression profile of microRNAs in rats with spinal cord injury treated by electroacupuncture. Mol Med Rep 22: 751-762, 2020.
APA
Zhou, Z., Li, H., Li, H., Zhang, J., Fu, K., Cao, C. ... Luo, J. (2020). Comprehensive analysis of the differential expression profile of microRNAs in rats with spinal cord injury treated by electroacupuncture. Molecular Medicine Reports, 22, 751-762. https://doi.org/10.3892/mmr.2020.11161
MLA
Zhou, Z., Li, H., Li, H., Zhang, J., Fu, K., Cao, C., Deng, F., Luo, J."Comprehensive analysis of the differential expression profile of microRNAs in rats with spinal cord injury treated by electroacupuncture". Molecular Medicine Reports 22.2 (2020): 751-762.
Chicago
Zhou, Z., Li, H., Li, H., Zhang, J., Fu, K., Cao, C., Deng, F., Luo, J."Comprehensive analysis of the differential expression profile of microRNAs in rats with spinal cord injury treated by electroacupuncture". Molecular Medicine Reports 22, no. 2 (2020): 751-762. https://doi.org/10.3892/mmr.2020.11161
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