Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
August-2020 Volume 22 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2020 Volume 22 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Key miRNAs associated with memory and learning disorder upon exposure to sevoflurane determined by RNA sequencing

  • Authors:
    • Huaqin Sun
    • Hongyi Hu
    • Xiaoping Xu
    • Tao Tao
    • Zhehao Liang
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China, Laboratory Animal Research Center/Institute of Comparative Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China, Department of Ultrasound, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1567-1575
    |
    Published online on: June 1, 2020
       https://doi.org/10.3892/mmr.2020.11199
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The study aimed to identify differentially expressed microRNAs (miRNAs/miRs) and explore the mechanisms governing impaired memory and learning ability in developing brains exposed to sevoflurane. A total of six 7‑day‑old male ICR mice were randomly assigned into the sevoflurane anesthesia group (treated with 2.4% sevoflurane) or control group (treated with normal saline solution at the same dose). After 14 days, the mice were subjected to a Morris water maze experiment. Then, the animals were sacrificed and hippocampus tissues were isolated. RNAs in hippocampus tissues were sequenced and the differential miRNA expression profiles were identified by a bioinformatics approach. The learning and memory function of mice were significantly affected by sevoflurane exposure. A total of 18 miRNAs were found to be significantly affected by sevoflurane administration. Their target genes clustered into different functional groups, such as ‘dephosphorylation’, ‘vesicle localization’ and the ‘Wnt signaling pathway’. miR‑101b‑3p was closely related with ‘chromatin binding’ and ‘protein serine/threonine kinase activity’. The most represented pathways for miRNAs included ‘neuroactive ligand‑receptor interaction’ (miR‑1187), ‘long‑term depression’ (miR‑425‑5p), ‘FoxO signaling pathway’ (miR‑425‑5p) and the ‘neurotrophin signaling pathway’ (miR‑467a‑3p). miR‑467a‑3p (degree=89), miR‑101b‑3p (degree=59), and miR‑1187 (degree=51) were the hub nodes in the miRNA regulatory network. The Wnt signaling pathway, miR‑467a‑3p, miR‑1187 and miR‑101b‑3p may be therapeutic targets for preventing cognitive impairments induced by sevoflurane.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Wang SQ, Fang F, Xue ZG, Cang J and Zhang XG: Neonatal sevoflurane anesthesia induces long-term memory impairment and decreases hippocampal PSD-95 expression without neuronal loss. Eur Rev Med Pharmacol Sci. 17:941–950. 2013.PubMed/NCBI

2 

Xiao H, Liu B, Chen Y and Zhang J: Learning, memory and synaptic plasticity in hippocampus in rats exposed to sevoflurane. Int J Dev Neurosci. 48:38–49. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Kamal A, Ramakers G, Gispen WH and Biessels GJ: Hyperinsulinemia in rats causes impairment of spatial memory and learning with defects in hippocampal synaptic plasticity by involvement of postsynaptic mechanisms. Exp Brain Res. 226:45–51. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Liu XS, Xue QS, Zeng QW, Li Q, Liu J, Feng XM and Yu BW: Sevoflurane impairs memory consolidation in rats, possibly through inhibiting phosphorylation of glycogen synthase kinase-3β in the hippocampus. Neurobiol Learn Mem. 94:461–467. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Liu X, Song X, Yuan T, He J, Wang X and Wang Q: Effects of calpain on sevoflurane-induced aged rats hippocampal neuronal apoptosis. Aging Clin Exp Res. 28:633–639. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Ge X, Zhang Y, Zuo Y, Israr M, Li B, Yu P, Gao G, Chang YZ and Shi Z: Transcriptomic analysis reveals the molecular mechanism of Alzheimer-related neuropathology induced by sevoflurane in mice. J Cell Biochem. 120:17555–17565. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Liu Y, Gao M, Ma L, Zhang L and Pan N: Sevoflurane alters the expression of receptors and enzymes involved in Aβ clearance in rats. Acta Anaesthesiol Scand. 57:903–910. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Li Y, Liu L, Tian Y and Zhang J: Rapamycin improves sevoflurane-induced cognitive dysfunction in aged rats by mediating autophagy through the TLR4/MyD88/NF-κB signaling pathway. Mol Med Rep. 20:3085–3094. 2019.PubMed/NCBI

9 

Xu B, Hsu PK, Karayiorgou M and Gogos JA: MicroRNA dysregulation in neuropsychiatric disorders and cognitive dysfunction. Neurobiol Dis. 46:291–301. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Maffioletti E, Tardito D, Gennarelli M and Bocchio-Chiavetto L: Micro spies from the brain to the periphery: New clues from studies on microRNAs in neuropsychiatric disorders. Front Cell Neurosci. 8:752014. View Article : Google Scholar : PubMed/NCBI

11 

Veltri A, Lang C and Lien WH: Concise review: Wnt Signaling pathways in skin development and epidermal stem cells. Stem Cells. 36:22–35. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Amjadi-Moheb F and Akhavan-Niaki H: Wnt signaling pathway in osteoporosis: Epigenetic regulation, interaction with other signaling pathways, and therapeutic promises. J Cell Physiol. 234:14641–14650. 2019. View Article : Google Scholar

13 

Clevers H and Nusse R: Wnt/β-catenin signaling and disease. Cell. 149:1192–1205. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Mahmood S, Bhatti A, Syed NA and John P: The microRNA regulatory network: A far-reaching approach to the regulate the Wnt signaling pathway in number of diseases. J Recept Signal Transduct Res. 36:310–318. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Shih J, May LD, Gonzalez HE, Lee EW, Alvi RS, Sall JW, Rau V, Bickler PE, Lalchandani GR, Yusupova M, et al: Delayed environmental enrichment reverses sevoflurane-induced memory impairment in rats. Anesthesiology. 116:586–602. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Ishikawa M, Tanaka S, Arai M, Genda Y and Sakamoto A: Differences in microRNA changes of healthy rat liver between sevoflurane and propofol anesthesia. Anesthesiology. 117:1245–1252. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Su D, Zhao Y, Wang B, Xu H, Li W, Chen J and Wang X: Isoflurane-induced spatial memory impairment in mice is prevented by the acetylcholinesterase inhibitor donepezil. PLoS One. 6:e276322011. View Article : Google Scholar : PubMed/NCBI

18 

Gautier L, Cope L, Bolstad BM and Irizarry RA: Affy-analysis of affymetrix GeneChip data at the probe level. Bioinformatics. 20:307–315. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Bolstad BM, Irizarry RA, Astrand M and Speed TP: A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics. 19:185–193. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U and Speed TP: Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 4:249–264. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Ritchie ME, Phipson B, Wu DI, Hu Y, Law CW, Shi W and Smyth GK: Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

22 

Yu J, Zhu M, Lv M, Wu X, Zhang X, Zhang Y, Li J and Zhang Q: Characterization of a five-microRNA signature as a prognostic biomarker for esophageal squamous cell carcinoma. Sci Rep. 9:198472019. View Article : Google Scholar : PubMed/NCBI

23 

Zhang S, Liu W, Liu X, Qi J and Deng C: Biomarkers identification for acute myocardial infarction detection via weighted gene co-expression network analysis. Medicine (Baltimore). 96:e83752017. View Article : Google Scholar : PubMed/NCBI

24 

Breuer K, Foroushani AK, Laird MR, Chen C, Sribnaia A, Lo R, Winsor GL, Hancock REW, Brinkman FSL and Lynn DJ: InnateDB: Systems biology of innate immunity and beyond-recent updates and continuing curation. Nucleic Acids Res. 41((Database issue)): D1228–D1233. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Dweep H and Gretz N: miRWalk2.0: A comprehensive atlas of microRNA-target interactions. Nat Methods. 12:697. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The gene ontology consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

27 

Kanehisa M and Goto S: KEGG: Kyoto encyclopaedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Yu G, Wang LG, Han Y and He QY: clusterProfiler: An R package for comparing biological themes among gene clusters. OMICS. 16:284–287. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Jaksik R, Polańska J, Herok R and Rzeszowska-Wolny J: Calculation of reliable transcript levels of annotated genes on the basis of multiple probe-sets in affymetrix microarrays. Acta Biochim Pol. 56:271–277. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Ye J, Zhang Z, Wang Y, Chen C, Xu X, Yu H and Peng M: Altered hippocampal microRNA expression profiles in neonatal rats caused by sevoflurane anesthesia: MicroRNA profiling and bioinformatics target analysis. Exp Ther Med. 12:1299–1310. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Kyritsis N, Kizil C, Zocher S, Kroehne V, Kaslin J, Freudenreich D, Iltzsche A and Brand M: Acute inflammation initiates the regenerative response in the adult zebrafish brain. Science. 338:1353–1356. 2012. View Article : Google Scholar : PubMed/NCBI

33 

MacDonald BT, Tamai K and He X: Wnt/β-catenin signaling: Components, mechanisms, and diseases. Dev Cell. 17:9–26. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Herman PE, Papatheodorou A, Bryant SA, Waterbury CKM, Herdy JR, Arcese AA, Buxbaum JD, Smith JJ, Morgan JR and Bloom O: Highly conserved molecular pathways, including Wnt signaling, promote functional recovery from spinal cord injury in lampreys. Sci Rep. 8:7422018. View Article : Google Scholar : PubMed/NCBI

35 

L'Episcopo F, Tirolo C, Caniglia S, Testa N, Morale MC, Serapide MF, Pluchino S and Marchetti B: Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in parkinson's disease. J Mol Cell Biol. 6:13–26. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Marzo A, Galli S, Lopes D, McLeod F, Podpolny M, Segovia-Roldan M, Ciani L, Purro S, Cacucci F, Gibb A and Salinas PC: Reversal of synapse degeneration by restoring Wnt signaling in the adult hippocampus. Curr Biol. 26:2551–2561. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Qiu CW, Liu ZY, Hou K, Liu SY, Hu YX, Zhang L, Zhang FL, Lv KY, Kang Q, Hu WX, et al: Wip1 knockout inhibits neurogenesis by affecting the Wnt/β-catenin signaling pathway in focal cerebral ischemia in mice. Exp Neurol. 309:44–53. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Vangipuram SD and Lyman WD: Ethanol affects differentiation-related pathways and suppresses Wnt signaling protein expression in human neural stem cells. Alcohol Clin Exp Res. 36:788–797. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Wang L, Zheng M, Wu S and Niu Z: MicroRNA-188-3p is involved in sevoflurane anesthesia-induced neuroapoptosis by targeting MDM2. Mol Med Rep. 17:4229–4236. 2018.PubMed/NCBI

40 

Zhang L, Xue Z, Yan J, Wang J, Liu Q and Jiang H: LncRNA Riken-201 and Riken-203 modulates neural development by regulating the Sox6 through sequestering miRNAs. Cell Prolif. 52:e125732019. View Article : Google Scholar : PubMed/NCBI

41 

De Filippis L, Zalfa C and Ferrari D: Neural stem cells and human induced pluripotent stem cells to model rare CNS diseases. CNS Neurol Disord Drug Targets. 16:915–926. 2017.PubMed/NCBI

42 

Sugaya K and Vaidya M: Stem cell therapies for neurodegenerative diseases. Adv Exp Med Biol. 1056:61–84. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Cui R, Ye S, Zhong J, Liu L, Li S, Lin X, Yuan L and Yi L: MicroRNA-494 inhibits apoptosis of murine vascular smooth muscle cells in vitro. Mol Med Rep. 19:4457–4467. 2019.PubMed/NCBI

44 

Chen XQ, Sawa M and Mobley WC: Dysregulation of neurotrophin signaling in the pathogenesis of alzheimer disease and of alzheimer disease in down syndrome. Free Radic Biol Med. 114:52–61. 2018. View Article : Google Scholar : PubMed/NCBI

45 

John AA, Prakash R, Kureel J and Singh D: Identification of novel microRNA inhibiting actin cytoskeletal rearrangement thereby suppressing osteoblast differentiation. J Mol Med (Berl). 96:427–444. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Takeuchi M, Oda S, Tsuneyama K and Yokoi T: Comprehensive analysis of serum microRNAs in hepatic sinusoidal obstruction syndrome (SOS) in rats: Implication as early phase biomarkers for SOS. Arch Toxicol. 92:2947–2962. 2018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sun H, Hu H, Xu X, Tao T and Liang Z: Key miRNAs associated with memory and learning disorder upon exposure to sevoflurane determined by RNA sequencing. Mol Med Rep 22: 1567-1575, 2020.
APA
Sun, H., Hu, H., Xu, X., Tao, T., & Liang, Z. (2020). Key miRNAs associated with memory and learning disorder upon exposure to sevoflurane determined by RNA sequencing. Molecular Medicine Reports, 22, 1567-1575. https://doi.org/10.3892/mmr.2020.11199
MLA
Sun, H., Hu, H., Xu, X., Tao, T., Liang, Z."Key miRNAs associated with memory and learning disorder upon exposure to sevoflurane determined by RNA sequencing". Molecular Medicine Reports 22.2 (2020): 1567-1575.
Chicago
Sun, H., Hu, H., Xu, X., Tao, T., Liang, Z."Key miRNAs associated with memory and learning disorder upon exposure to sevoflurane determined by RNA sequencing". Molecular Medicine Reports 22, no. 2 (2020): 1567-1575. https://doi.org/10.3892/mmr.2020.11199
Copy and paste a formatted citation
x
Spandidos Publications style
Sun H, Hu H, Xu X, Tao T and Liang Z: Key miRNAs associated with memory and learning disorder upon exposure to sevoflurane determined by RNA sequencing. Mol Med Rep 22: 1567-1575, 2020.
APA
Sun, H., Hu, H., Xu, X., Tao, T., & Liang, Z. (2020). Key miRNAs associated with memory and learning disorder upon exposure to sevoflurane determined by RNA sequencing. Molecular Medicine Reports, 22, 1567-1575. https://doi.org/10.3892/mmr.2020.11199
MLA
Sun, H., Hu, H., Xu, X., Tao, T., Liang, Z."Key miRNAs associated with memory and learning disorder upon exposure to sevoflurane determined by RNA sequencing". Molecular Medicine Reports 22.2 (2020): 1567-1575.
Chicago
Sun, H., Hu, H., Xu, X., Tao, T., Liang, Z."Key miRNAs associated with memory and learning disorder upon exposure to sevoflurane determined by RNA sequencing". Molecular Medicine Reports 22, no. 2 (2020): 1567-1575. https://doi.org/10.3892/mmr.2020.11199
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team