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Article

miR‑192‑5p upregulation mediates the suppression of curcumin in human NSCLC cell proliferation, migration and invasion by targeting c‑Myc and inactivating the Wnt/β‑catenin signaling pathway

  • Authors:
    • Yancheng Pan
    • Ying Sun
    • Ziqi Liu
    • Chao Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, The Tengzhou Central People's Hospital, Tengzhou, Shandong 277500, P.R. China, Department of Pharmacy, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong 264000, P.R. China
  • Pages: 1594-1604
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    Published online on: June 4, 2020
       https://doi.org/10.3892/mmr.2020.11213
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Abstract

Curcumin is a naturally active phenolic compound extracted from the rhizome of the plant Curcuma longa, which has been demonstrated to serve as an anticancer drug in different types of cancer, including non‑small‑cell lung cancer (NSCLC). Accumulating evidence has suggested that curcumin may exert epigenetic regulatory effects on microRNAs (miRs). Therefore, the present study aimed to investigate the role of miR‑192‑5p, and the effects of curcumin, in NSCLC, alongside the underlying mechanisms. Human NSCLC cells, A427 and A549, were treated with curcumin, and the expression levels of miR‑192‑5p and c‑Myc were detected using reverse transcription‑quantitative PCR and western blotting. Cellular proliferation was analyzed using Cell Counting Kit‑8 assays and cell viability was determined using a MTT assay. Additionally, the migratory and invasive abilities of cells were analyzed using Transwell and Matrigel assays, respectively. The binding sites between miR‑192‑5p and c‑Myc were predicted using TargetScanHuman software, and confirmed using a dual‑luciferase reporter assay and RNA immunoprecipitation. Finally, the Wnt pathway regulator, β‑catenin, and cyclin D1 expression levels were determined using western blotting. Curcumin treatment inhibited NSCLC cell proliferation, migration, invasion and viability in a dose‑dependent manner, in addition to promoting a dose‑dependent increase in the expression levels of miR‑192‑5p and a reduction in c‑Myc expression levels. Notably, the genetic knockdown of miR‑192‑5p blocked the inhibitory effects of curcumin on NSCLC progression and instead promoted NSCLC progression, which was observed to be partially reversed by c‑Myc silencing; thus, c‑Myc was suggested to be a direct target gene of miR‑192‑5p as demonstrated by the TargetScanHuman database, dual‑lucierase and RIP assay results. In addition, the curcumin‑induced decreased expression levels of β‑catenin, cyclin D1 and c‑Myc were rescued following the genetic knockdown of miR‑192‑5p. In conclusion, these findings suggested that the upregulation of miR‑192‑5p may underlie the inhibitory effects of curcumin on NSCLC cells through targeting c‑Myc and inactivating the Wnt/β‑catenin signaling pathway.
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View References

1 

Gerber DE, Laccetti AL, Xuan L, Halm EA and Pruitt SL: Impact of prior cancer on eligibility for lung cancer clinical trials. J Natl Cancer Inst. 106(pii): dju3022014.PubMed/NCBI

2 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Lochowski M, Lochowska B, Rebowski M, Brzezinski D, Cieslik-Wolski B and Kozak J: Five-year survival analysis and prognostic factors in patients operated on for non-small cell lung cancer with N2 disease. J Thorac Dis. 10:3180–3186. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Stinchcombe TE and Socinski MA: Current treatments for advanced stage non-small cell lung cancer. Proc Am Thorac Soc. 6:233–241. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Correction, . New perspectives of curcumin in cancer prevention. Cancer Prev Res (Phila). 10:3712017. View Article : Google Scholar : PubMed/NCBI

6 

Ibrahim S, Tagami T, Kishi T and Ozeki T: Curcumin marinosomes as promising nano-drug delivery system for lung cancer. Int J Pharm. 540:40–49. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Maran A, Yaszemski MJ, Kohut A and Voronov A: Curcumin and osteosarcoma: Can invertible polymeric micelles help? Materials (Basel). 9(pii): E5202016. View Article : Google Scholar : PubMed/NCBI

8 

Khan MA, Akhtar N, Sharma V and Pathak K: Product development studies on sonocrystallized curcumin for the treatment of gastric cancer. Pharmaceutics. 7:43–63. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Ye MX, Li Y, Yin H and Zhang J: Curcumin: Updated molecular mechanisms and intervention targets in human lung cancer. Int J Mol Sci. 13:3959–3978. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Du X, Zhang J, Wang J, Lin X and Ding F: Role of miRNA in lung cancer-potential biomarkers and therapies. Curr Pharm Des. 23:5997–6010. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Lelli D, Pedone C, Majeed M and Sahebkar A: Curcumin and lung cancer: The role of microRNAs. Curr Pharm Des. 23:3440–3444. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Simental-Mendia LE and Sahebkar A: Modulation of microRNAs by curcumin in pancreatic cancer. Clin Nutr. 35:15852016. View Article : Google Scholar : PubMed/NCBI

13 

Ye M and Zhang J and Zhang J, Miao Q, Yao L and Zhang J: Curcumin promotes apoptosis by activating the p53-miR-192-5p/215-XIAP pathway in non-small cell lung cancer. Cancer Lett. 357:196–205. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Jin H, Qiao F, Wang Y, Xu Y and Shang Y: Curcumin inhibits cell proliferation and induces apoptosis of human non-small cell lung cancer cells through the upregulation of miR-192-5p and suppression of PI3K/Akt signaling pathway. Oncol Rep. 34:2782–2789. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Lu Y, Wei C and Xi Z: Curcumin suppresses proliferation and invasion in non-small cell lung cancer by modulation of MTA1-mediated Wnt/β-catenin pathway. In Vitro Cell Dev Biol Anim. 50:840–850. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Zhu JY, Yang X, Chen Y, Jiang Y, Wang SJ, Li Y, Wang XQ, Meng Y, Zhu MM, Ma X, et al: Curcumin suppresses lung cancer stem cells via inhibiting wnt/β-catenin and sonic hedgehog pathways. Phytother Res. 31:680–688. 2017. View Article : Google Scholar : PubMed/NCBI

17 

He M, Li Y, Zhang L, Li L, Shen Y, Lin L, Zheng W, Chen L, Bian X, Ng HK and Tang L: Curcumin suppresses cell proliferation through inhibition of the Wnt/β-catenin signaling pathway in medulloblastoma. Oncol Rep. 32:173–180. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Dou H, Shen R, Tao J, Huang L, Shi H, Chen H, Wang Y and Wang T: Curcumin suppresses the colon cancer proliferation by inhibiting wnt/β-catenin pathways via miR-130a. Front Pharmacol. 8:8772017. View Article : Google Scholar : PubMed/NCBI

19 

Wang JY, Wang X, Wang XJ, Zheng BZ, Wang Y, Wang X and Liang B: Curcumin inhibits the growth via Wnt/β-catenin pathway in non-small-cell lung cancer cells. Eur Rev Med Pharmacol Sci. 22:7492–7499. 2018.PubMed/NCBI

20 

Xu JH, Yang HP, Zhou XD, Wang HJ, Gong L and Tang CL: Role of Wnt inhibitory factor-1 in inhibition of bisdemethoxycurcumin mediated epithelial-to-mesenchymal transition in highly metastatic lung cancer 95D cells. Chin Med J (Engl). 128:1376–1383. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Zhang X, Peng Y, Huang Y, Yang M, Yan R, Zhao Y, Cheng Y, Liu X, Deng S, Feng X, et al: SMG-1 inhibition by miR-192/-215 causes epithelial-mesenchymal transition in gastric carcinogenesis via activation of Wnt signaling. Cancer Med. 7:146–156. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Chen J, Chen Z, Huang J, Chen F, Ye W, Ding G and Wang X: Bioinformatics identification of dysregulated microRNAs in triple negative breast cancer based on microRNA expression profiling. Oncol Lett. 15:3017–3023. 2018.PubMed/NCBI

23 

Zhang H, Zhang C, Feng R, Zhang H, Gao M and Ye L: Investigating the microRNA-mRNA regulatory network in acute myeloid leukemia. Oncol Lett. 14:3981–3988. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Zhang T, Chen Y, Ge Y, Hu Y, Li M and Jin Y: Inhalation treatment of primary lung cancer using liposomal curcumin dry powder inhalers. Acta Pharm Sin B. 8:440–448. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Kang HW, Crawford M, Fabbri M, Nuovo G, Garofalo M, Nana-Sinkam SP and Friedman A: A mathematical model for microRNA in lung cancer. PLoS One. 8:e536632013. View Article : Google Scholar : PubMed/NCBI

27 

Cui J, Mo J, Luo M, Yu Q, Zhou S, Li T, Zhang Y and Luo W: C-Myc-activated long non-coding RNA H19 downregulates miR-107 and promotes cell cycle progression of non-small cell lung cancer. Int J Clin Exp Pathol. 8:12400–12409. 2015.PubMed/NCBI

28 

Chen Z, Zeng H, Guo Y, Liu P, Pan H, Deng A and Hu J: MiRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-Myc. J Exp Clin Cancer Res. 29:1512010. View Article : Google Scholar : PubMed/NCBI

29 

Park W, Amin AR, Chen ZG and Shin DM: New perspectives of curcumin in cancer prevention. Cancer Prev Res (Phila). 6:387–400. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Gupta SC, Patchva S and Aggarwal BB: Therapeutic roles of curcumin: Lessons learned from clinical trials. AAPS J. 15:195–218. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Reuter S, Eifes S, Dicato M, Aggarwal BB and Diederich M: Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells. Biochem Pharmacol. 76:1340–1351. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Datta R, Halder SK and Zhang B: Role of TGF-β signaling in curcumin-mediated inhibition of tumorigenicity of human lung cancer cells. J Cancer Res Clin Oncol. 139:563–572. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Yang CL, Liu YY, Ma YG, Xue YX, Liu DG, Ren Y, Liu XB, Li Y and Li Z: Curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signalling pathway. PLoS One. 7:e379602012. View Article : Google Scholar : PubMed/NCBI

34 

Zhang J, Zhang T, Ti X, Shi J, Wu C, Ren X and Yin H: Curcumin promotes apoptosis in A549/DDP multidrug-resistant human lung adenocarcinoma cells through an miRNA signaling pathway. Biochem Biophys Res Commun. 399:1–6. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Zhang J, Du Y, Wu C, Ren X, Ti X, Shi J, Zhao F and Yin H: Curcumin promotes apoptosis in human lung adenocarcinoma cells through miR-186* signaling pathway. Oncol Rep. 24:1217–1223. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Zhan JW, Jiao DM, Wang Y, Song J, Wu JH, Wu LJ, Chen QY and Ma SL: Integrated microRNA and gene expression profiling reveals the crucial miRNAs in curcumin anti-lung cancer cell invasion. Thorac Cancer. 8:461–470. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Jiao DM, Yan L, Wang LS, Hu HZ, Tang XL, Chen J, Wang J, Li Y and Chen QY: Exploration of inhibitory mechanisms of curcumin in lung cancer metastasis using a miRNA-transcription factor-target gene network. PLoS One. 12:e01724702017. View Article : Google Scholar : PubMed/NCBI

38 

Lu Y, Wang J, Liu L, Yu L, Zhao N, Zhou X and Lu X: Curcumin increases the sensitivity of Paclitaxel-resistant NSCLC cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction. Tumour Biol. 39:10104283176983532017. View Article : Google Scholar : PubMed/NCBI

39 

Suresh R, Ali S, Ahmad A, Philip PA and Sarkar FH: The role of cancer stem cells in recurrent and drug-resistant lung cancer. Adv Exp Med Biol. 890:57–74. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Zhang W, Bai W and Zhang W: MiR-21 suppresses the anticancer activities of curcumin by targeting PTEN gene in human non-small cell lung cancer A549 cells. Clin Transl Oncol. 16:708–713. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Chen S, Gu T, Lu Z, Qiu L, Xiao G, Zhu X, Li F, Yu H, Li G and Liu H: Roles of MYC-targeting long non-coding RNA MINCR in cell cycle regulation and apoptosis in non-small cell lung Cancer. Respir Res. 20:2022019. View Article : Google Scholar : PubMed/NCBI

42 

Wang J, Jia Y, Zhao S, Zhang X, Wang X, Han X, Wang Y, Ma M, Shi J and Liu L: BIN1 reverses PD-L1-mediated immune escape by inactivating the c-MYC and EGFR/MAPK signaling pathways in non-small cell lung cancer. Oncogene. 36:6235–6243. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Chou YT, Lin HH, Lien YC, Wang YH, Hong CF, Kao YR, Lin SC, Chang YC, Lin SY, Chen SJ, et al: EGFR promotes lung tumorigenesis by activating miR-7 through a Ras/ERK/Myc pathway that targets the Ets2 transcriptional repressor ERF. Cancer Res. 70:8822–8831. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Miao LJ, Huang SF, Sun ZT, Gao ZY, Zhang RX, Liu Y and Wang J: MiR-449c targets c-Myc and inhibits NSCLC cell progression. FEBS Lett. 587:1359–1365. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Wang Y, Cong W, Wu G, Ju X, Li Z, Duan X, Wang X and Gao H: MiR-376a suppresses the proliferation and invasion of non-small-cell lung cancer by targeting c-Myc. Cell Biol Int. 42:25–33. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Krishnamurthy N and Kurzrock R: Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors. Cancer Treat Rev. 62:50–60. 2018. View Article : Google Scholar : PubMed/NCBI

47 

Stewart DJ: Wnt signaling pathway in non-small cell lung cancer. J Natl Cancer Inst. 106:djt3562014. View Article : Google Scholar : PubMed/NCBI

48 

Shang S, Hua F and Hu ZW: The regulation of β-catenin activity and function in cancer: Therapeutic opportunities. Oncotarget. 8:33972–33989. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Park M, Kim M, Hwang D, Park M, Kim WK, Kim SK, Shin J, Park ES, Kang CM, Paik YK and Kim H: Characterization of gene expression and activated signaling pathways in solid-pseudopapillary neoplasm of pancreas. Mod Pathol. 27:580–593. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Kang DW, Lee SW, Hwang WC, Lee BH, Choi YS, Suh YA, Choi KY and Min DS: Phospholipase D1 Acts through Akt/TopBP1 and RB1 to regulate the E2F1-dependent apoptotic program in cancer cells. Cancer Res. 77:142–152. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Pan Y, Sun Y, Liu Z and Zhang C: miR‑192‑5p upregulation mediates the suppression of curcumin in human NSCLC cell proliferation, migration and invasion by targeting c‑Myc and inactivating the Wnt/β‑catenin signaling pathway. Mol Med Rep 22: 1594-1604, 2020.
APA
Pan, Y., Sun, Y., Liu, Z., & Zhang, C. (2020). miR‑192‑5p upregulation mediates the suppression of curcumin in human NSCLC cell proliferation, migration and invasion by targeting c‑Myc and inactivating the Wnt/β‑catenin signaling pathway. Molecular Medicine Reports, 22, 1594-1604. https://doi.org/10.3892/mmr.2020.11213
MLA
Pan, Y., Sun, Y., Liu, Z., Zhang, C."miR‑192‑5p upregulation mediates the suppression of curcumin in human NSCLC cell proliferation, migration and invasion by targeting c‑Myc and inactivating the Wnt/β‑catenin signaling pathway". Molecular Medicine Reports 22.2 (2020): 1594-1604.
Chicago
Pan, Y., Sun, Y., Liu, Z., Zhang, C."miR‑192‑5p upregulation mediates the suppression of curcumin in human NSCLC cell proliferation, migration and invasion by targeting c‑Myc and inactivating the Wnt/β‑catenin signaling pathway". Molecular Medicine Reports 22, no. 2 (2020): 1594-1604. https://doi.org/10.3892/mmr.2020.11213
Copy and paste a formatted citation
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Spandidos Publications style
Pan Y, Sun Y, Liu Z and Zhang C: miR‑192‑5p upregulation mediates the suppression of curcumin in human NSCLC cell proliferation, migration and invasion by targeting c‑Myc and inactivating the Wnt/β‑catenin signaling pathway. Mol Med Rep 22: 1594-1604, 2020.
APA
Pan, Y., Sun, Y., Liu, Z., & Zhang, C. (2020). miR‑192‑5p upregulation mediates the suppression of curcumin in human NSCLC cell proliferation, migration and invasion by targeting c‑Myc and inactivating the Wnt/β‑catenin signaling pathway. Molecular Medicine Reports, 22, 1594-1604. https://doi.org/10.3892/mmr.2020.11213
MLA
Pan, Y., Sun, Y., Liu, Z., Zhang, C."miR‑192‑5p upregulation mediates the suppression of curcumin in human NSCLC cell proliferation, migration and invasion by targeting c‑Myc and inactivating the Wnt/β‑catenin signaling pathway". Molecular Medicine Reports 22.2 (2020): 1594-1604.
Chicago
Pan, Y., Sun, Y., Liu, Z., Zhang, C."miR‑192‑5p upregulation mediates the suppression of curcumin in human NSCLC cell proliferation, migration and invasion by targeting c‑Myc and inactivating the Wnt/β‑catenin signaling pathway". Molecular Medicine Reports 22, no. 2 (2020): 1594-1604. https://doi.org/10.3892/mmr.2020.11213
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