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Age‑dependent alterations in the immunoreactivity of macrophage inflammatory protein‑3α and its receptor CCR6 in the gerbil hippocampus

  • Authors:
    • Ji Hyeon Ahn
    • Joon Ha Park
    • Tae‑Kyung Lee
    • Go Eun Yang
    • Myoung Cheol Shin
    • Jun Hwi Cho
    • Moo‑Ho Won
    • Choong‑Hyun Lee
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of Korea, Department of Anatomy, College of Korean Medicine, Dongguk University, Gyeongju, Gyeongsangbuk 38066, Republic of Korea, Department of Radiology, Kangwon National University Hospital, Chuncheon, Gangwon 24289, Republic of Korea, Department of Emergency Medicine and Institute of Medical Sciences, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24289, Republic of Korea, Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea, Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan, Chungcheongnam 31116, Republic of Korea
    Copyright: © Ahn et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1317-1324
    |
    Published online on: June 9, 2020
       https://doi.org/10.3892/mmr.2020.11216
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Abstract

Neuroinflammation is a primary characteristic of the aging brain. During normal aging, macrophage inflammatory protein‑3α (MIP‑3α) and its receptor C‑C chemokine receptor type 6 (CCR6) serve pivotal roles in the neuroinflammatory process in the brain. The aim of the present study was to investigate age‑dependent alterations in the immunoreactivity of MIP‑3α and CCR6 in the gerbil hippocampus at postnatal month (PM) 1, 6, 12 and 24 via immunohistochemistry. In the PM 1 group, both MIP‑3α and CCR6 immunoreactivity were observed primarily in the stratum pyramidale in the hippocampus proper and in the granule cell layer in the dentate gyrus. In the PM 6 and PM 12 groups, MIP‑3α in the stratum pyramidale and granule cell layer was decreased compared with the PM 1 group, and CCR6 immunoreactivity in both layers was faint. In the PM 24 group, MIP‑3α expression in the stratum pyramidale and granule cell layer was higher than that in the PM 1 group, and CCR6 immunoreactivity in both layers was increased compared with the PM 12 group; however, it was decreased compared with the PM 1 group. In conclusion, MIP‑3α and CCR6 immunoreactivity were altered in the hippocampus during normal aging. The results of the current study suggested that age‑dependent alterations of MIP‑3α and CCR6 may be associated with age‑related neuroinflammation in the hippocampus.
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Copy and paste a formatted citation
Spandidos Publications style
Ahn J, Park J, Lee TK, Yang G, Shin M, Cho J, Won MH and Lee CH: Age‑dependent alterations in the immunoreactivity of macrophage inflammatory protein‑3α and its receptor CCR6 in the gerbil hippocampus. Mol Med Rep 22: 1317-1324, 2020.
APA
Ahn, J., Park, J., Lee, T., Yang, G., Shin, M., Cho, J. ... Lee, C. (2020). Age‑dependent alterations in the immunoreactivity of macrophage inflammatory protein‑3α and its receptor CCR6 in the gerbil hippocampus. Molecular Medicine Reports, 22, 1317-1324. https://doi.org/10.3892/mmr.2020.11216
MLA
Ahn, J., Park, J., Lee, T., Yang, G., Shin, M., Cho, J., Won, M., Lee, C."Age‑dependent alterations in the immunoreactivity of macrophage inflammatory protein‑3α and its receptor CCR6 in the gerbil hippocampus". Molecular Medicine Reports 22.2 (2020): 1317-1324.
Chicago
Ahn, J., Park, J., Lee, T., Yang, G., Shin, M., Cho, J., Won, M., Lee, C."Age‑dependent alterations in the immunoreactivity of macrophage inflammatory protein‑3α and its receptor CCR6 in the gerbil hippocampus". Molecular Medicine Reports 22, no. 2 (2020): 1317-1324. https://doi.org/10.3892/mmr.2020.11216
Copy and paste a formatted citation
x
Spandidos Publications style
Ahn J, Park J, Lee TK, Yang G, Shin M, Cho J, Won MH and Lee CH: Age‑dependent alterations in the immunoreactivity of macrophage inflammatory protein‑3α and its receptor CCR6 in the gerbil hippocampus. Mol Med Rep 22: 1317-1324, 2020.
APA
Ahn, J., Park, J., Lee, T., Yang, G., Shin, M., Cho, J. ... Lee, C. (2020). Age‑dependent alterations in the immunoreactivity of macrophage inflammatory protein‑3α and its receptor CCR6 in the gerbil hippocampus. Molecular Medicine Reports, 22, 1317-1324. https://doi.org/10.3892/mmr.2020.11216
MLA
Ahn, J., Park, J., Lee, T., Yang, G., Shin, M., Cho, J., Won, M., Lee, C."Age‑dependent alterations in the immunoreactivity of macrophage inflammatory protein‑3α and its receptor CCR6 in the gerbil hippocampus". Molecular Medicine Reports 22.2 (2020): 1317-1324.
Chicago
Ahn, J., Park, J., Lee, T., Yang, G., Shin, M., Cho, J., Won, M., Lee, C."Age‑dependent alterations in the immunoreactivity of macrophage inflammatory protein‑3α and its receptor CCR6 in the gerbil hippocampus". Molecular Medicine Reports 22, no. 2 (2020): 1317-1324. https://doi.org/10.3892/mmr.2020.11216
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