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Article Open Access

Transcriptomic changes involved in the dedifferentiation of myofibroblasts derived from the lung of a patient with idiopathic pulmonary fibrosis

  • Authors:
    • Kenichi Suzuki
    • Jun‑Dal Kim
    • Keita Ugai
    • Shuichi Matsuda
    • Hideki  Mikami
    • Kento  Yoshioka
    • Jun Ikari
    • Masahiko Hatano
    • Akiyoshi  Fukamizu
    • Koichiro Tatsumi
    • Yoshitoshi Kasuya
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Science, Graduate School of Medicine, Chiba University, Chuo‑ku, Chiba 260‑8670, Japan, Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Ibaraki 305‑8577, Japan, Department of Respirology, Graduate School of Medicine, Chiba University, Chuo‑ku, Chiba 260‑8670, Japan
    Copyright: © Suzuki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1518-1526
    |
    Published online on: June 10, 2020
       https://doi.org/10.3892/mmr.2020.11218
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Abstract

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease of unknown etiology. Under pathological conditions in lungs with IPF, myofibroblasts serve a key role in fibrogenesis via the accumulation of an excessive amount of extracellular matrix. To develop effective therapeutic interventions against IPF, studies have recently focused on how to dedifferentiate established myofibroblasts. The present study revealed that JQ1, an inhibitor of bromodomain and extra‑terminal proteins, markedly suppressed the expression levels of α‑smooth muscle actin and ED‑A‑fibronectin in myofibroblasts prepared from the lung of a patient with end‑stage IPF. Furthermore, these findings were supported by transcriptome analysis using RNA sequencing, in which differentially expressed genes (DEGs) downregulated by JQ1 treatment were significantly enriched in the fibrosis‑related signaling pathway. On the other hand, the upregulated DEGs in response to JQ1 treatment were significantly enriched in glutathione metabolism, which may affect the cell status of fibroblast/myofibroblast. To the best of our knowledge, this was the first study to comprehensively analyze transcriptome profiles associated with dedifferentiation of IPF myofibroblasts.
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1 

Wynn TA and Ramalingam TR: Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med. 18:1028–1040. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Lederer DJ and Martinez FJ: Idiopathic Pulmonary Fibrosis. N Engl J Med. 378:1811–1823. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Kendall RT and Feghali-Bostwick CA: Fibroblasts in fibrosis: Novel roles and mediators. Front Pharmacol. 5:1232014. View Article : Google Scholar : PubMed/NCBI

4 

King TE Jr, Schwarz MI, Brown K, Tooze JA, Colby TV, Waldron JA Jr, Flint A, Thurlbeck W and Cherniack RM: Idiopathic pulmonary fibrosis: relationship between histopathologic features and mortality. Am J Respir Crit Care Med. 164:1025–1032. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Tang X, Peng R, Phillips JE, Deguzman J, Ren Y, Apparsundaram S, Luo Q, Bauer CM, Fuentes ME, DeMartino JA, et al: Assessment of Brd4 inhibition in idiopathic pulmonary fibrosis lung fibroblasts and in vivo models of lung fibrosis. Am J Pathol. 183:470–479. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Wang J, Zhou F, Li Z, Mei H, Wang Y, Ma H, Shi L, Huang A, Zhang T, Lin Z, et al: Pharmacological targeting of BET proteins attenuates radiation-induced lung fibrosis. Sci Rep. 8:9982018. View Article : Google Scholar : PubMed/NCBI

7 

Yamazaki R, Kasuya Y, Fujita T, Umezawa H, Yanagihara M, Nakamura H, Yoshino I, Tatsumi K and Murayama T: Antifibrotic effects of cyclosporine A on TGF-beta1-treated lung fibroblasts and lungs from bleomycin-treated mice: role of hypoxia-inducible factor-1alpha. FASEB J. 31:3359–3371. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCq method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Ohkuro M, Kim JD, Kuboi Y, Hayashi Y, Mizukami H, Kobayashi-Kuramochi H, Muramoto K, Shirato M, Michikawa-Tanaka F, Moriya J, et al: Calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease. Nat Commun. 9:19822018. View Article : Google Scholar : PubMed/NCBI

10 

Chen J, Bardes EE, Aronow BJ and Jegga AG: ToppGene Suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Res. 37:W305–W311. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, et al: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 102:15545–15550. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Serini G, Bochaton-Piallat ML, Ropraz P, Geinoz A, Borsi L, Zardi L and Gabbiani G: The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1. J Cell Biol. 142:873–881. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Sandbo N and Dulin N: Actin cytoskeleton in myofibroblast differentiation: ultrastructure defining form and driving function. Transl Res. 158:181–196. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Hunninghake GW: Antioxidant therapy for idiopathic pulmonary fibrosis. N Engl J Med. 353:2285–2287. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Raghu G, Noth I and Martinez F: N-acetylcysteine for idiopathic pulmonary fibrosis: the door is still open. Lancet Respir Med. 5:e1–e2. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Pierce EM, Carpenter K, Jakubzick C, Kunkel SL, Flaherty KR, Martinez FJ and Hogaboam CM: Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice. Am J Pathol. 170:1152–1164. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Yang X, Chen B, Liu T and Chen X: Reversal of myofibroblast differentiation: a review. Eur J Pharmacol. 734:83–90. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Sieber P, Schäfer A, Lieberherr R, Le Goff F, Stritt M, Welford WD, Gatfield J, Peter O, Nayler O and Lüthi U: Novel high-throughput myofibroblast assays identify agonists with therapeutic potential in pulmonary fibrosis that act via EP2 and EP4 receptors. PLoS One. 13:e02078722018. View Article : Google Scholar : PubMed/NCBI

19 

Garrison G, Huang SK, Okunishi K, Scott JP, Kumar Penke LR, Scruggs AM and Peters-Golden M: Reversal of myofibroblast differentiation by prostaglandin E(2). Am J Respir Cell Mol Biol. 48:550–558. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Huang SK, Fisher AS, Scruggs AM, White ES, Hogaboam CM, Richardson BC and Peters-Golden M: Hypermethylation of PTGER2 confers prostaglandin E2 resistance in fibrotic fibroblasts from humans and mice. Am J Pathol. 177:2245–2255. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Anathy V, Roberson EC, Guala AS, Godburn KE, Budd RC and Janssen-Heininger YM: Redox-based regulation of apoptosis: S-glutathionylation as a regulatory mechanism to control cell death. Antioxid Redox Signal. 16:496–505. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Ono A, Utsugi M, Masubuchi K, Ishizuka T, Kawata T, Shimizu Y, Hisada T, Hamuro J, Mori M and Dobashi K: Glutathione redox regulates TGF-beta-induced fibrogenic effects through Smad3 activation. FEBS Lett. 583:357–362. 2009. View Article : Google Scholar : PubMed/NCBI

23 

McMillan DH, van der Velden JL, Lahue KG, Qian X, Schneider RW, Iberg MS, Nolin JD, Abdalla S, Casey DT, Tew KD, et al: Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π. JCI Insight. 1:e857172016. View Article : Google Scholar

24 

Wynes MW, Edelman BL, Kostyk AG, Edwards MG, Coldren C, Groshong SD, Cosgrove GP, Redente EF, Bamberg A, Brown KK, et al: Increased cell surface Fas expression is necessary and sufficient to sensitize lung fibroblasts to Fas ligation-induced apoptosis: implications for fibroblast accumulation in idiopathic pulmonary fibrosis. J Immunol. 187:527–537. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Gong Y, Wang N, Liu N and Dong H: Lipid peroxidation and GPX4 inhibition are common causes for myofibroblast differentiation and ferroptosis. DNA Cell Biol. 38:725–733. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Stratton MS, Haldar SM and McKinsey TA: BRD4 inhibition for the treatment of pathological organ fibrosis. F1000Res. 6:10152017. View Article : Google Scholar

27 

Sanders YY, Ambalavanan N, Halloran B, Zhang X, Liu H, Crossman DK, Bray M, Zhang K, Thannickal VJ and Hagood JS: Altered DNA methylation profile in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 186:525–535. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Davies ER, Haitchi HM, Thatcher TH, Sime PJ, Kottmann RM, Ganesan A, Packham G, O'Reilly KM and Davies DE: Spiruchostatin A inhibits proliferation and differentiation of fibroblasts from patients with pulmonary fibrosis. Am J Respir Cell Mol Biol. 46:687–694. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Tzouvelekis A and Kaminski N: Epigenetics in idiopathic pulmonary fibrosis. Biochem Cell Biol. 93:159–170. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Mullenbrock S, Liu F, Szak S, Hronowski X, Gao B, Juhasz P, Sun C, Liu M, McLaughlin H, Xiao Q, et al: Systems analysis of transcriptomic and proteomic profiles identifies novel regulation of fibrotic programs by miRNAs in pulmonary fibrosis fibroblasts. Genes (Basel). 9:E5882018. View Article : Google Scholar : PubMed/NCBI

31 

Dakhlallah D, Batte K, Wang Y, Cantemir-Stone CZ, Yan P, Nuovo G, Mikhail A, Hitchcock CL, Wright VP, Nana-Sinkam SP, et al: Epigenetic regulation of miR-17-92 contributes to the pathogenesis of pulmonary fibrosis. Am J Respir Crit Care Med. 187:397–405. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Lyu X, Fang W, Cai L, Zheng H, Ye Y, Zhang L, Li J, Peng H, Cho WC, Wang E, et al: TGFβR2 is a major target of miR-93 in nasopharyngeal carcinoma aggressiveness. Mol Cancer. 13:512014. View Article : Google Scholar : PubMed/NCBI

33 

Oak SR, Murray L, Herath A, Sleeman M, Anderson I, Joshi AD, Coelho AL, Flaherty KR, Toews GB, Knight D, et al: A micro RNA processing defect in rapidly progressing idiopathic pulmonary fibrosis. PLoS One. 6:e212532011. View Article : Google Scholar : PubMed/NCBI

34 

Liu G, Friggeri A, Yang Y, Milosevic J, Ding Q, Thannickal VJ, Kaminski N and Abraham E: miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med. 207:1589–1597. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Christmann RB, Wooten A, Sampaio-Barros P, Borges CL, Carvalho CR, Kairalla RA, Feghali-Bostwick C, Ziemek J, Mei Y, Goummih S, et al: miR-155 in the progression of lung fibrosis in systemic sclerosis. Arthritis Res Ther. 18:1552016. View Article : Google Scholar : PubMed/NCBI

36 

Fu LL, Tian M, Li X, Li JJ, Huang J, Ouyang L, Zhang Y and Liu B: Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery. Oncotarget. 6:5501–5516. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Suzuki K, Kim JD, Ugai K, Matsuda S, Mikami H, Yoshioka K, Ikari J, Hatano M, Fukamizu A, Tatsumi K, Tatsumi K, et al: Transcriptomic changes involved in the dedifferentiation of myofibroblasts derived from the lung of a patient with idiopathic pulmonary fibrosis . Mol Med Rep 22: 1518-1526, 2020.
APA
Suzuki, K., Kim, J., Ugai, K., Matsuda, S., Mikami, H., Yoshioka, K. ... Kasuya, Y. (2020). Transcriptomic changes involved in the dedifferentiation of myofibroblasts derived from the lung of a patient with idiopathic pulmonary fibrosis . Molecular Medicine Reports, 22, 1518-1526. https://doi.org/10.3892/mmr.2020.11218
MLA
Suzuki, K., Kim, J., Ugai, K., Matsuda, S., Mikami, H., Yoshioka, K., Ikari, J., Hatano, M., Fukamizu, A., Tatsumi, K., Kasuya, Y."Transcriptomic changes involved in the dedifferentiation of myofibroblasts derived from the lung of a patient with idiopathic pulmonary fibrosis ". Molecular Medicine Reports 22.2 (2020): 1518-1526.
Chicago
Suzuki, K., Kim, J., Ugai, K., Matsuda, S., Mikami, H., Yoshioka, K., Ikari, J., Hatano, M., Fukamizu, A., Tatsumi, K., Kasuya, Y."Transcriptomic changes involved in the dedifferentiation of myofibroblasts derived from the lung of a patient with idiopathic pulmonary fibrosis ". Molecular Medicine Reports 22, no. 2 (2020): 1518-1526. https://doi.org/10.3892/mmr.2020.11218
Copy and paste a formatted citation
x
Spandidos Publications style
Suzuki K, Kim JD, Ugai K, Matsuda S, Mikami H, Yoshioka K, Ikari J, Hatano M, Fukamizu A, Tatsumi K, Tatsumi K, et al: Transcriptomic changes involved in the dedifferentiation of myofibroblasts derived from the lung of a patient with idiopathic pulmonary fibrosis . Mol Med Rep 22: 1518-1526, 2020.
APA
Suzuki, K., Kim, J., Ugai, K., Matsuda, S., Mikami, H., Yoshioka, K. ... Kasuya, Y. (2020). Transcriptomic changes involved in the dedifferentiation of myofibroblasts derived from the lung of a patient with idiopathic pulmonary fibrosis . Molecular Medicine Reports, 22, 1518-1526. https://doi.org/10.3892/mmr.2020.11218
MLA
Suzuki, K., Kim, J., Ugai, K., Matsuda, S., Mikami, H., Yoshioka, K., Ikari, J., Hatano, M., Fukamizu, A., Tatsumi, K., Kasuya, Y."Transcriptomic changes involved in the dedifferentiation of myofibroblasts derived from the lung of a patient with idiopathic pulmonary fibrosis ". Molecular Medicine Reports 22.2 (2020): 1518-1526.
Chicago
Suzuki, K., Kim, J., Ugai, K., Matsuda, S., Mikami, H., Yoshioka, K., Ikari, J., Hatano, M., Fukamizu, A., Tatsumi, K., Kasuya, Y."Transcriptomic changes involved in the dedifferentiation of myofibroblasts derived from the lung of a patient with idiopathic pulmonary fibrosis ". Molecular Medicine Reports 22, no. 2 (2020): 1518-1526. https://doi.org/10.3892/mmr.2020.11218
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