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Article Open Access

Expression profiling of circular RNAs and their potential role in early‑stage diabetic cardiomyopathy

  • Authors:
    • Shengzhong Dong
    • Chunyan Tu
    • Xing Ye
    • Liliang Li
    • Mingchang Zhang
    • Aimin Xue
    • Shangheng Chen
    • Ziqin Zhao
    • Bin Cong
    • Junyi Lin
    • Yiwen Shen
  • View Affiliations / Copyright

    Affiliations: Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, P.R. China, Department of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Shijiazhuang, Hebei 050017, P.R. China
    Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1958-1968
    |
    Published online on: June 17, 2020
       https://doi.org/10.3892/mmr.2020.11248
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Abstract

Diabetic cardiomyopathy (DCM) is a severe cardiovascular complication of diabetes mellitus (DM). Detecting DCM during the early stages of the disease remains a challenge, as the molecular mechanisms underlying early‑stage DCM are not clearly understood. Circular RNA (circRNA), a type of non‑coding RNA, has been confirmed to be associated with numerous diseases. However, it is still unclear how circRNAs are involved in early‑stage DCM. In the present study, heart tissues harvested from BKS‑db/db knock‑out mice were identified through high‑throughput RNA sequencing technology. A total of 58 significantly differentially expressed circRNAs were identified in the db/db sample. Among these, six upregulated circRNAs and seven downregulated circRNAs were detected by reverse transcription‑quantitative PCR and analyzed using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. Furthermore, based on the predicted binding site with microRNAs (miRNAs) involved in DCM, five circRNAs (mmu_circ_0000652, mmu_circ_0000547, mmu_circ_0001058, mmu_circ_0000680 and novel_circ_0004285) were shown to serve as competing endogenous (ce)RNAs. The corresponding miRNAs and mRNAs of the ceRNAs were also verified, and two promising circRNA‑miRNA‑mRNA regulatory networks were determined. Finally, internal ribosome entry site prediction combined with open reading frame prediction indicated that it was highly possible that mmu_circ_0001160 encoded a protein. In the present study, a comprehensive analysis of the circRNA expression profile during the early phase of DCM was performed, and two promising circRNA‑miRNA‑mRNA regulatory networks were identified. These results lay the foundation for unravelling the underlying pathogenesis of DCM, and highlight potential biomarkers and therapeutic targets for the treatment of DCM at an early stage.
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1 

Cho NH, Shaw JE, Karuranga S, Huang Y, da Rocha Fernandes JD, Ohlrogge AW and Malanda B: IDF diabetes atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 138:271–281. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Marwick TH, Ritchie R, Shaw JE and Kaye D: Implications of underlying mechanisms for the recognition and management of diabetic cardiomyopathy. J Am Coll Cardiol. 71:339–351. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Jia G, Hill MA and Sowers JR: Diabetic cardiomyopathy: An update of mechanisms contributing to this clinical entity. Circ Res. 122:624–638. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Murtaza G, Virk HUH, Khalid M, Lavie CJ, Ventura H, Mukherjee D, Ramu V, Bhogal S, Kumar G, Shanmugasundaram M and Paul TK: Diabetic cardiomyopathy-A comprehensive updated review. Prog Cardiovasc Dis. 62:315–326. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Lam CS: Diabetic cardiomyopathy: An expression of stage B heart failure with preserved ejection fraction. Diab Vasc Dis Res. 12:234–238. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Tadic M, Celic V, Cuspidi C, Ilic S, Pencic B, Radojkovic J, Ivanovic B, Stanisavljevic D, Kocabay G and Marjanovic T: Right heart mechanics in untreated normotensive patients with prediabetes and type 2 diabetes mellitus: A Two- and three-dimensional echocardiographic study. J Am Soc Echocardiog. 28:317–327. 2015. View Article : Google Scholar

7 

Shaver A, Nichols A, Thompson E, Mallick A, Payne K, Jones C, Manne ND, Sundaram S, Shapiro JI and Sodhi K: Role of serum biomarkers in early detection of diabetic cardiomyopathy in the west virginian population. Int J Med Sci. 13:161–168. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Li X, Yang L and Chen LL: The biogenesis, functions, and challenges of circular RNAs. Mol Cell. 71:428–442. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Zhang HD, Jiang LH, Sun DW, Hou JC and Ji ZL: CircRNA: A novel type of biomarker for cancer. Breast Cancer. 25:1–7. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Pamudurti NR, Bartok O, Jens M, Ashwal-Fluss R, Stottmeister C, Ruhe L, Hanan M, Wyler E, Perez-Hernandez D, Ramberger E, et al: Translation of CircRNAs. Mol Cell. 66:9–21.e7. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Meng S, Zhou H, Feng Z, Xu Z, Tang Y, Li P and Wu M: Functions and properties of a novel potential biomarker for cancer. Mol Cancer. 16:942017. View Article : Google Scholar : PubMed/NCBI

12 

Huang C and Shan G: What happens at or after transcription: Insights into circRNA biogenesis and function. Transcription. 6:61–64. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Zhao Z, Li X, Jian D, Hao P, Rao L and Li M: Hsa_circ_0054633 in peripheral blood can be used as a diagnostic biomarker of pre-diabetes and type 2 diabetes mellitus. Acta Diabetol. 54:237–245. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Fang Y, Wang X, Li W, Han J, Jin J, Su F, Zhang J, Huang W, Xiao F, Pan Q and Zou L: Screening of circular RNAs and validation of circANKRD36 associated with inflammation in patients with type 2 diabetes mellitus. Int J Mol Med. 42:1865–1874. 2018.PubMed/NCBI

15 

Karkalas J: An improved enzymic method for the determination of native and modified starch. J Sci Food Agr. 36:1019–1027. 1985. View Article : Google Scholar

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Mi H, Muruganujan A, Ebert D, Huang X and Thomas PD: PANTHER version 14: More genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools. Nucleic Acids Res. 47:D419–D426. 2019. View Article : Google Scholar : PubMed/NCBI

19 

The Gene Ontology Consortium, . The gene ontology resource: 20 years and still GOing strong. Nucleic Acids Res. 47:D330–D338. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Kanehisa M, Goto S, Sato Y, Kawashima M, Furumichi M and Tanabe M: Data, information, knowledge and principle: Back to metabolism in KEGG. Nucleic Acids Res 42 (Database Issue). D199–D205. 2014. View Article : Google Scholar

22 

Jellis CL, Sacre JW, Wright J, Jenkins C, Haluska B, Jeffriess L, Martin J and Marwick TH: Biomarker and imaging responses to spironolactone in subclinical diabetic cardiomyopathy. Eur Heart J Cardiovasc Imaging. 15:776–786. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Nunes S, Soares E, Fernandes J, Viana S, Carvalho E, Pereira FC and Reis F: Early cardiac changes in a rat model of prediabetes: Brain natriuretic peptide overexpression seems to be the best marker. Cardiovasc Diabetol. 12:442013. View Article : Google Scholar : PubMed/NCBI

24 

Cai J, Chen Z, Wang J, Wang J, Chen X, Liang L, Huang M, Zhang Z and Zuo X: circHECTD1 facilitates glutaminolysis to promote gastric cancer progression by targeting miR-1256 and activating β-catenin/c-Myc signaling. Cell Death Dis. 10:5762019. View Article : Google Scholar : PubMed/NCBI

25 

Kuwabara Y, Horie T, Baba O, Watanabe S, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Otsu K, et al: MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1/AMPK pathway. Circ Res. 116:279–288. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Li X, Du N, Zhang Q, Li J, Chen X, Liu X, Hu Y, Qin W, Shen N, Xu C, et al: MicroRNA-30d regulates cardiomyocyte pyroptosis by directly targeting foxo3a in diabetic cardiomyopathy. Cell Death Dis. 5:e14792014. View Article : Google Scholar : PubMed/NCBI

27 

Zhu H, Yang Y, Wang Y, Li J, Schiller PW and Peng T: MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1. Cardiovasc Res. 92:75–84. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Wang XH, Qian RZ, Zhang W, Chen SF, Jin HM and Hu RM: MicroRNA-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats. Clin Exp Pharmacol Physiol. 36:181–188. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Thum T, Gross C, Fiedler J, Fischer T, Kissler S, Bussen M, Galuppo P, Just S, Rottbauer W, Frantz S, et al: MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature. 456:980–984. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Liu J, Liu W, Lu Y, Tian H, Duan C, Lu L, Gao G, Wu X, Wang X and Yang H: Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models. Autophagy. 14:845–861. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Chai C, Song LJ, Han SY, Li XQ and Li M: MicroRNA-21 promotes glioma cell proliferation and inhibits senescence and apoptosis by targeting SPRY1 via the PTEN/PI3K/AKT signaling pathway. Cns Neurosci Ther. 24:369–380. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Liang WC, Wong CW, Liang PP, Shi M, Cao Y, Rao ST, Tsui SK, Waye MM, Zhang Q, Fu WM and Zhang JF: Translation of the circular RNA circβ-catenin promotes liver cancer cell growth through activation of the Wnt pathway. Genome Biol. 20:842019. View Article : Google Scholar : PubMed/NCBI

33 

Yang Y, Gao X, Zhang M, Yan S, Sun C, Xiao F, Huang N, Yang X, Zhao K, Zhou H, et al: Novel role of FBXW7 circular RNA in repressing glioma tumorigenesis. J Natl Cancer Inst. 110:304–315. 2018. View Article : Google Scholar

34 

Li LJ, Leng RX, Fan YG, Pan HF and Ye DQ: Translation of noncoding RNAs: Focus on lncRNAs, pri-miRNAs, and circRNAs. Exp Cell Res. 361:1–8. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Liu H, Liu Y, Bian Z, Zhang J, Zhang R, Chen X, Huang Y, Wang Y and Zhu J: Circular RNA YAP1 inhibits the proliferation and invasion of gastric cancer cells by regulating the miR-367-5p/p27Kip1 axis. Mol Cancer. 17:1512019. View Article : Google Scholar

36 

Altesha MA, Ni T, Khan A, Liu K and Zheng X: Circular RNA in cardiovascular disease. J Cell Physiol. 234:5588–5600. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Lin F, Zhao G, Chen Z, Wang X, Lv F, Zhang Y, Yang X, Liang W, Cai R, Li J, et al: circRNA-miRNA association for coronary heart disease. Mol Med Rep. 19:2527–2536. 2019.PubMed/NCBI

38 

Patop IL and Kadener S: circRNAs in cancer. Curr Opin Genet Dev. 48:121–127. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Fischer JW and Leung AK: CircRNAs: A regulator of cellular stress. Crit Rev Biochem Mol. 52:220–233. 2017. View Article : Google Scholar

40 

Yang F, Li A, Qin Y, Che H, Wang Y, Lv J, Li Y, Li H, Yue E, Ding X, et al: A novel circular RNA mediates pyroptosis of diabetic cardiomyopathy by functioning as a competing endogenous RNA. Mol Ther Nucleic Acids. 17:636–643. 2019. View Article : Google Scholar : PubMed/NCBI

41 

Liu C, Ge HM, Liu BH, Dong R, Shan K, Chen X, Yao MD, Li XM, Yao J, Zhou RM, et al: Targeting Pericyte-endothelial cell crosstalk by circular RNA-cPWWP2A inhibition aggravates diabetes-induced microvascular dysfunction. Proc Natl Acad Sci USA. 116:7455–7464. 2019. View Article : Google Scholar : PubMed/NCBI

42 

Wu H, Wu S, Zhu Y, Ye M, Shen J, Liu Y, Zhang Y and Bu S: Hsa_circRNA_0054633 is highly expressed in gestational diabetes mellitus and closely related to glycosylation index. Clin Epigenetics. 11:222019. View Article : Google Scholar : PubMed/NCBI

43 

Fuentes-Antrás J, Picatoste B, Ramírez E, Egido J, Tuñón J and Lorenzo Ó: Targeting metabolic disturbance in the diabetic heart. Cardiovasc Diabetol. 14:172015. View Article : Google Scholar : PubMed/NCBI

44 

Duncan JG: Mitochondrial dysfunction in diabetic cardiomyopathy. Biochim Biophys Acta. 1813:1351–1359. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Huang P, Qi B, Yao H, Zhang L, Li Y and Li Q: Circular RNA cSMARCA5 regulates the progression of cervical cancer by acting as a microRNA-432 sponge. Mol Med Rep. 21:1217–1223. 2020.PubMed/NCBI

46 

Salzman J: Circular RNA expression: Its potential regulation and function. Trends Genet. 32:309–316. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Han D, Li J, Wang H, Su X, Hou J, Gu Y, Qian C, Lin Y, Liu X, Huang M, et al: Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression. Hepatology. 66:1151–1164. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Zheng D, Ma J, Yu Y, Li M, Ni R, Wang G, Chen R, Li J, Fan GC, Lacefield JC and Peng T: Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice. Diabetologia. 58:1949–1958. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Gu J, Wang S, Guo H, Tan Y, Liang Y, Feng A, Liu Q, Damodaran C, Zhang Z, Keller BB, et al: Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis. Cell Death Dis. 9:822018. View Article : Google Scholar : PubMed/NCBI

50 

Tuncay E and Turan B: Intracellular Zn2+ increase in cardiomyocytes induces both electrical and mechanical dysfunction in heart via endogenous generation of reactive nitrogen species. Biol Trace Elem Res. 169:294–302. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Huang L, Yan M and Kirschke CP: Over-expression of ZnT7 increases insulin synthesis and secretion in pancreatic beta-cells by promoting insulin gene transcription. Exp Cell Res. 316:2630–2643. 2010. View Article : Google Scholar : PubMed/NCBI

52 

Tuncay E, Bitirim CV, Olgar Y, Durak A, Rutter GA and Turan B: Zn2+-transporters ZIP7 and ZnT7 play important role in progression of cardiac dysfunction via affecting Sarco(endo)plasmic reticulum-mitochondria coupling in hyperglycemic cardiomyocytes. Mitochondrion. 44:41–52. 2019. View Article : Google Scholar : PubMed/NCBI

53 

Jia G, Whaley-Connell A and Sowers JR: Diabetic cardiomyopathy: A hyperglycaemia- and insulin-resistance-induced heart disease. Diabetologia. 61:21–28. 2018. View Article : Google Scholar : PubMed/NCBI

54 

Lorenzo-Almoros A, Tunon J, Orejas M, Cortes M, Egido J and Lorenzo O: Diagnostic approaches for diabetic cardiomyopathy. Cardiovasc Diabetol. 16:282017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Dong S, Tu C, Ye X, Li L, Zhang M, Xue A, Chen S, Zhao Z, Cong B, Lin J, Lin J, et al: Expression profiling of circular RNAs and their potential role in early‑stage diabetic cardiomyopathy. Mol Med Rep 22: 1958-1968, 2020.
APA
Dong, S., Tu, C., Ye, X., Li, L., Zhang, M., Xue, A. ... Shen, Y. (2020). Expression profiling of circular RNAs and their potential role in early‑stage diabetic cardiomyopathy. Molecular Medicine Reports, 22, 1958-1968. https://doi.org/10.3892/mmr.2020.11248
MLA
Dong, S., Tu, C., Ye, X., Li, L., Zhang, M., Xue, A., Chen, S., Zhao, Z., Cong, B., Lin, J., Shen, Y."Expression profiling of circular RNAs and their potential role in early‑stage diabetic cardiomyopathy". Molecular Medicine Reports 22.3 (2020): 1958-1968.
Chicago
Dong, S., Tu, C., Ye, X., Li, L., Zhang, M., Xue, A., Chen, S., Zhao, Z., Cong, B., Lin, J., Shen, Y."Expression profiling of circular RNAs and their potential role in early‑stage diabetic cardiomyopathy". Molecular Medicine Reports 22, no. 3 (2020): 1958-1968. https://doi.org/10.3892/mmr.2020.11248
Copy and paste a formatted citation
x
Spandidos Publications style
Dong S, Tu C, Ye X, Li L, Zhang M, Xue A, Chen S, Zhao Z, Cong B, Lin J, Lin J, et al: Expression profiling of circular RNAs and their potential role in early‑stage diabetic cardiomyopathy. Mol Med Rep 22: 1958-1968, 2020.
APA
Dong, S., Tu, C., Ye, X., Li, L., Zhang, M., Xue, A. ... Shen, Y. (2020). Expression profiling of circular RNAs and their potential role in early‑stage diabetic cardiomyopathy. Molecular Medicine Reports, 22, 1958-1968. https://doi.org/10.3892/mmr.2020.11248
MLA
Dong, S., Tu, C., Ye, X., Li, L., Zhang, M., Xue, A., Chen, S., Zhao, Z., Cong, B., Lin, J., Shen, Y."Expression profiling of circular RNAs and their potential role in early‑stage diabetic cardiomyopathy". Molecular Medicine Reports 22.3 (2020): 1958-1968.
Chicago
Dong, S., Tu, C., Ye, X., Li, L., Zhang, M., Xue, A., Chen, S., Zhao, Z., Cong, B., Lin, J., Shen, Y."Expression profiling of circular RNAs and their potential role in early‑stage diabetic cardiomyopathy". Molecular Medicine Reports 22, no. 3 (2020): 1958-1968. https://doi.org/10.3892/mmr.2020.11248
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