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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
September-2020 Volume 22 Issue 3

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Telomerase and telomeres in aging theory and chronographic aging theory (Review)

Mayya P. Razgonova, Alexander M. Zakharenko, Kirill S. Golokhvast, Maria Thanasoula, Evangelia Sarandi, Konstantinos Nikolouzakis, Persefoni Fragkiadaki, Dimitris Tsoukalas, Demetrios A. Spandidos, Aristidis Tsatsakis
Pages: 1679-1694
Published online on: 25 June 2020

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Review

A potential role for astaxanthin in the treatment of bone diseases (Review)

Maria Teresa Valenti, Massimiliano Perduca, Maria Grazia Romanelli, Monica Mottes, Luca Dalle Carbonare
Pages: 1695-1701
Published online on: 26 June 2020

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Article Open Access

Expression of Notch family is altered in non‑alcoholic fatty liver disease

Wen‑Jin Ding, Wei‑Jie Wu, Yuan‑Wen Chen, Han‑Bei Chen, Jian‑Gao Fan, Liang Qiao
Pages: 1702-1708
Published online on: 17 June 2020

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Article Open Access

Genome‑wide analysis of DNA methylation and gene expression changes in an ovalbumin‑induced asthma mouse model

Joong‑Sun Kim, In‑Sik Shin, Na‑Rae Shin, Jae‑Yong Nam, Chul Kim
Pages: 1709-1716
Published online on: 17 June 2020

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Article Open Access

miR‑27a‑3p negatively regulates osteogenic differentiation of MC3T3‑E1 preosteoblasts by targeting osterix

Yuexin Xu, Dong Li, Zhu Zhu, Lingyun Li, Yucui Jin, Changyan Ma, Wei Zhang
Pages: 1717-1726
Published online on: 17 June 2020

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Article Open Access

Effects of GPR81 silencing combined with cisplatin stimulation on biological function in hypopharyngeal squamous cell carcinoma

Qiaojing Jia, Ou Xu, Jianxing Wang, Jinhui Dong, Xiumin Ren, Xiaofang Jia, Chunguang Shan
Pages: 1727-1736
Published online on: 18 June 2020

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Article Open Access

Mmu_circ_003795 regulates osteoblast differentiation and mineralization in MC3T3‑E1 and MDPC23 by targeting COL15A1

Jingwen Wu, Wen Ren, Zhichao Zheng, Zhu Huang, Tingting Liang, Fuyao Li, Zhan Shi, Qianzhou Jiang, Xuechao Yang, Lvhua Guo
Pages: 1737-1746
Published online on: 22 June 2020

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Article Open Access

Liriopesides B from Liriope spicata var. prolifera inhibits metastasis and induces apoptosis in A2780 human ovarian cancer cells

Haizhong Yu, Haiyan Wang, Youping Yin, Zhongkang Wang
Pages: 1747-1758
Published online on: 18 June 2020

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Article Open Access

Exogenous hydrogen sulfide reduces atrial remodeling and atrial fibrillation induced by diabetes mellitus via activation of the PI3K/Akt/eNOS pathway

Xiaofei Xue, Xinyu Ling, Wang Xi, Pei Wang, Jianjun Sun, Qian Yang, Jian Xiao
Pages: 1759-1766
Published online on: 30 June 2020

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Article Open Access

Silencing of BRF2 inhibits the growth and metastasis of lung cancer cells

Yuan Bian, Qiu Li, Qiaolian Li, Ruigen Pan
Pages: 1767-1774
Published online on: 26 June 2020

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Article Open Access

Risk gene identification and support vector machine learning to construct an early diagnosis model of myocardial infarction

Hong‑Zhi Fang, Dan‑Li Hu, Qin Li, Su Tu
Pages: 1775-1782
Published online on: 17 June 2020

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Article Open Access

Calcium inhibitor inhibits high glucose‑induced hypertrophy of H9C2 cells

Xiaohong Xu, Luoyang Ruan, Xiaohua Tian, Fengjuan Pan, Cailan Yang, Guosheng Liu
Pages: 1783-1792
Published online on: 26 June 2020

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Article Open Access

Toosendanin induces apoptosis of MKN‑45 human gastric cancer cells partly through miR‑23a‑3p‑mediated downregulation of BCL2

Shuli Shao, Shanshan Li, Chang Liu, Weiwei Zhang, Zhenzhu Zhang, Shaowei Zhu, Yunjianan Feng, Yang Pan
Pages: 1793-1802
Published online on: 22 June 2020

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Article Open Access

MicroRNA‑375 prevents TGF‑β‑dependent transdifferentiation of lung fibroblasts via the MAP2K6/P38 pathway

Xinghua Zhang, Qian Chen, Hengya Song, Wanli Jiang, Songping Xie, Jie Huang, Ganjun Kang
Pages: 1803-1810
Published online on: 22 June 2020

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Article Open Access

Long non‑coding RNA HOTAIR promotes burn wound healing by regulating epidermal stem cells

Yan Shi, Ronghua Yang, Longxiang Tu, Dewu Liu
Pages: 1811-1820
Published online on: 23 June 2020

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Article Open Access

Effects of the NF‑κB/p53 signaling pathway on intervertebral disc nucleus pulposus degeneration

Litao Zhang, Xiujuan Li, Xue Kong, Hua Jin, Yaoqi Han, Yuanzhong Xie
Pages: 1821-1830
Published online on: 30 June 2020

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Article Open Access

Peroxiredoxin I deficiency increases pancreatic β‑cell apoptosis after streptozotocin stimulation via the AKT/GSK3β signaling pathway

Mei‑Hua Jin, Gui‑Nan Shen, Ying‑Hua Jin, Hu‑Nan Sun, Xing Zhen, Yong‑Qing Zhang, Dong‑Seok Lee, Yu‑Dong Cui, Li‑Yun Yu, Ji‑Su Kim, Taeho Kwon, Ying‑Hao Han
Pages: 1831-1838
Published online on: 26 June 2020

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Article Open Access

Tanshinone IIA promotes cardiac differentiation and improves cell motility by modulating the Wnt/β‑catenin signaling pathway

Kun Li, Xiuyan Wang, Chenxing Fan, Chunxia Wu, Shizheng Li, Hua Liu
Pages: 1839-1846
Published online on: 24 June 2020

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Article Open Access

Role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice

Guoqing Chen, Ying Lin, Lu Chen, Fa Zeng, Li Zhang, Yan Huang, Pingping Huang, Lingling Liao, Yuanlan Yu
Pages: 1847-1858
Published online on: 23 June 2020

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Article Open Access

Age‑related changes in mineralocorticoid receptors in rat hearts

Danli Hu, Ruolan Dong, Yanjun Zhang, Yan Yang, Zhihui Chen, Ying Tang, Menglu Fu, Xizhen Xu, Ling Tu
Pages: 1859-1867
Published online on: 19 June 2020

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Article Open Access

Identification of potential markers for type 2 diabetes mellitus via bioinformatics analysis

Yana Lu, Yihang Li, Guang Li, Haitao Lu
Pages: 1868-1882
Published online on: 26 June 2020

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Article Open Access

miR‑802 inhibits the epithelial‑mesenchymal transition, migration and invasion of cervical cancer by regulating BTF3

Xiuhui Wu, Leng Liu, Hongxia Zhang
Pages: 1883-1891
Published online on: 23 June 2020

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Article Open Access

Aggravated intestinal ischemia‑reperfusion injury is associated with activated mitochondrial autophagy in a mouse model of diabetes

Zi Zeng, Hui‑Min Liu, Yun‑Yan Zhang, Rong Chen, Tao Sun, Wei Li, Qian Sun, Zhong‑Yuan Xia, Qing‑Tao Meng
Pages: 1892-1900
Published online on: 24 June 2020

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Article Open Access

2‑Hydroxypropyl‑β‑cyclodextrin blocks autophagy flux and triggers caspase‑8‑mediated apoptotic cascades in HepG2 cells

Haidong Sun, Huajie Zong, Gang Wu
Pages: 1901-1909
Published online on: 26 June 2020

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Article Open Access

Human apolipoprotein L1 interferes with mitochondrial function in Saccharomyces cerevisiae

Mounia Chidiac, Jalil Daher, Mélanie Boeckstaens, Philippe Poelvoorde, Bassam Badran, Anna Maria Marini, Roy Khalaf, Luc Vanhamme
Pages: 1910-1920
Published online on: 24 June 2020

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Article Open Access

Downregulation of microRNA‑29c reduces pain after child delivery by activating the oxytocin‑GABA pathway

Caijuan Li, Xian Wang, Guangfen Zhang, Yao Zhang, Fan Xia, Shiqin Xu, Xiaofeng Shen
Pages: 1921-1931
Published online on: 26 June 2020

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Article Open Access

Circulating extracellular vesicles from patients with breast cancer enhance migration and invasion via a Src‑dependent pathway in MDA‑MB‑231 breast cancer cells

Javier Ramírez‑Ricardo, Elizabeth Leal‑Orta, Elia Martínez‑Baeza, Carlos Ortiz‑Mendoza, Fernando Breton‑Mora, Analy Herrera‑Torres, Irma Elizalde‑Acosta, Pedro Cortes‑Reynosa, Rocio Thompson‑Bonilla, Eduardo Perez Salazar
Pages: 1932-1948
Published online on: 18 June 2020

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Article Open Access

Wild‑type IDH1 affects cell migration by modulating the PI3K/AKT/mTOR pathway in primary glioblastoma cells

Xiaopeng Shen, Shen Wu, Jingyi Zhang, Meng Li, Feng Xu, Ao Wang, Yang Lei, Guoping Zhu
Pages: 1949-1957
Published online on: 18 June 2020

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Article Open Access

Expression profiling of circular RNAs and their potential role in early‑stage diabetic cardiomyopathy

Shengzhong Dong, Chunyan Tu, Xing Ye, Liliang Li, Mingchang Zhang, Aimin Xue, Shangheng Chen, Ziqin Zhao, Bin Cong, Junyi Lin, Yiwen Shen
Pages: 1958-1968
Published online on: 17 June 2020

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Article Open Access

Butorphanol protects PC12 cells against OGD/R-induced inflammation and apoptosis

Zijing Yang, Li Wang, Yingjun Hu, Feixiang Wang
Pages: 1969-1975
Published online on: 30 June 2020

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Article Open Access

oxLDL promotes podocyte migration by regulating CXCL16, ADAM10 and ACTN4

Yuan Chen, Zhiyi Wang, Qian Li, Lichun Yu, Yanji Zhu, Jing Wang, Shuzhen Sun
Pages: 1976-1984
Published online on: 30 June 2020

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Article Open Access

Anti‑inflammatory activity of 3,5,6,7,3',4'‑hexamethoxyflavone via repression of the NF‑κB and MAPK signaling pathways in LPS‑stimulated RAW264.7 cells

Eun Suk Son, Jeong‑Woong Park, Se‑Hee Kim, Hye Ran Park, Woorijarang Han, O Chul Kwon, Jae Young Nam, Sung Hwan Jeong, Chang Soo Lee
Pages: 1985-1993
Published online on: 18 June 2020

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Article Open Access

Scorpion primer PCR analysis for genotyping of allele variants of thiopurine s‑methyltransferase*3

Pu Yao, Xue‑Mei Qu, Sai Ren, Xiao‑Dong Ren, Ning Su, Na Zhao, Liu Wang, Lin Cheng, Bang‑Bi Weng, Feng‑Jun Sun, Qing Huang
Pages: 1994-2002
Published online on: 26 June 2020

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Article Open Access

Appropriate timing for hypothermic machine perfusion to preserve livers donated after circulatory death

Xiaoyan Hu, Wei Wang, Cheng Zeng, Weiyang He, Zibiao Zhong, Zhongzhong Liu, Yanfeng Wang, Qifa Ye
Pages: 2003-2011
Published online on: 18 June 2020

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Article Open Access

Antibodies specific to ferritin light chain polypeptide are frequently detected in patients with immune‑related pancytopenia

Shanfeng Hao, Yang Zhang, Luogang Hua, Ning Xie, Na Xiao, Huaquan Wang, Rong Fu, Zonghong Shao
Pages: 2012-2020
Published online on: 26 June 2020

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Article Open Access

Activation of calcium‑sensing receptor‑mediated autophagy in high glucose‑induced cardiac fibrosis in vitro

Hui Yuan, Jiyu Xu, Yanfei Zhu, Li Li, Qi Wang, Yaquan Yu, Bin Zhou, Yi Liu, Xiaoyi Xu, Zhilong Wang
Pages: 2021-2031
Published online on: 26 June 2020

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Article Open Access

Anti‑chondrocyte apoptosis effect of genistein in treating inflammation‑induced osteoarthritis

Yang Zou, Qiming Liu, Piaoting Guo, Yang Huang, Zhengcong Ye, Jiong Hu
Pages: 2032-2042
Published online on: 18 June 2020

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Article Open Access

Stress response in periodontal ligament stem cells may contribute to bisphosphonate‑associated osteonecrosis of the jaw: A gene expression array analysis

Yueqi Shi, Mengyu Li, Yejia Yu, Yuqiong Zhou, Wenjie Zhang, Hongfei Hua, Shaoyi Wang
Pages: 2043-2051
Published online on: 26 June 2020

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Article Open Access

Statin rosuvastatin inhibits apoptosis of human coronary artery endothelial cells through upregulation of the JAK2/STAT3 signaling pathway

Kuijing Wang, Bo Li, Yuanyuan Xie, Nan Xia, Minghui Li, Guang Gao
Pages: 2052-2062
Published online on: 23 June 2020

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Article Open Access

Expression levels of the α7 nicotinic acetylcholine receptor in the brains of patients with Alzheimer's disease and their effect on synaptic proteins in SH-SY5Y cells

Jia-Mou Ren, Shu-Li Zhang, Xiao-Ling Wang, Zhi-Zhong Guan, Xiao-Lan Qi
Pages: 2063-2075
Published online on: 18 June 2020

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Article Open Access

Protective and inhibitory effects of acteoside from Abeliophyllum distichum Nakai against oxidative DNA damage

Tae Won Jang, Ji Soo Choi, Jae Ho Park
Pages: 2076-2084
Published online on: 18 June 2020

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Article

miR‑142‑5p inhibits pancreatic cancer cell migration and invasion by targeting PIK3CA

Jing Zhu, Leilei Zhou, Bin Wei, Zhaoye Qian, Jiru Wang, Hongxia Hui, Yuan Sun
Pages: 2085-2092
Published online on: 18 June 2020

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Article

A twin‑pair analysis indicates congenital scoliosis is associated with allele‑specific methylation in the SVIL gene

Zhifa Zhang, Yongjun Chen, Yuezhou Wu, Yongyu Hao, Xuelin Zhao, Xiangyu Wang, Yan Wang, Yanhai Xi, Xuesong Zhang
Pages: 2093-2100
Published online on: 24 June 2020

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Article

Aquaporin‑4 deletion ameliorates enterovirus 71 infection in mice

Lei Zhu, Xiuwei Hao, Xiaole Wu, Boxiang Qi, Ting Yue, Haijun Wang
Pages: 2101-2106
Published online on: 23 June 2020

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Article

Vitamin D protects against necrotising enterocolitis in newborn mice by activating the ERK signalling pathway

Chunmei Lyu, Suhua Jiang, Muxian Kong, Xiaoqian Chen, Li Zhang
Pages: 2107-2114
Published online on: 26 June 2020

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Article

A critical role for miR‑135a‑5p‑mediated regulation of SLC24A2 in neuropathic pain

Xiao‑Gang Zhou, Hui He, Pei‑Ji Wang
Pages: 2115-2122
Published online on: 22 June 2020

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Article

Downregulation of miR‑486‑5p alleviates LPS‑induced inflammatory injury, oxidative stress and apoptosis in Chondrogenic cell ATDC5 by targeting NRF1

Qing Chang, Mingliang Ji, Chao Li, Rui Geng
Pages: 2123-2131
Published online on: 30 June 2020

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Article

Effectiveness of Bailing capsules in the treatment of lupus nephritis: A meta‑analysis

Yue Li, Tianhua Xu, Xiaobo Qiu, Binyao Tian, Chao Bi, Li Yao
Pages: 2132-2140
Published online on: 30 June 2020

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Correction Open Access

[Corrigendum] Pro‑neurogenic effects of andrographolide on RSC96 Schwann cells in vitro

Fuben Xu, Huayu Wu, Kun Zhang, Peizhen Lv, Li Zheng, Jinmin Zhao
Pages: 2141-2141
Published online on: 26 June 2020

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Review Open Access

Cellular senescence: A pathogenic mechanism of pelvic organ prolapse (Review)

Liwei Huang, Zhiwei Zhao, Jirui Wen, Wang Ling, Yali Miao, Jiang Wu
Pages: 2155-2162
Published online on: 13 July 2020

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Review Open Access

Significance of taurine transporter (TauT) in homeostasis and its layers of regulation (Review)

Stella Baliou, Anthony M. Kyriakopoulos, Maria Goulielmaki, Michalis I. Panayiotidis, Demetrios A. Spandidos, Vassilios Zoumpourlis
Pages: 2163-2173
Published online on: 09 July 2020

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Article Open Access

Trimetazidine improves hepatic lipogenesis and steatosis in non‑alcoholic fatty liver disease via AMPK‑ChREBP pathway

Ying Zhang, Can Li, Xiuqi Li, Cheng Wu, Haiyan Zhou, Shuang Lu, Xingde Liu
Pages: 2174-2182
Published online on: 08 July 2020

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Article Open Access

Sphingosine kinase 1 contributes to doxorubicin resistance and glycolysis in osteosarcoma

Xiaojun Ren, Chunhong Su
Pages: 2183-2190
Published online on: 03 July 2020

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Article Open Access

Levistilide A reverses rat hepatic fibrosis by suppressing angiotensin II‑induced hepatic stellate cells activation

Shu Li, Wei Zhao, Zhimin Zhao, Binbin Cheng, Shuang Li, Chenghai Liu
Pages: 2191-2198
Published online on: 10 July 2020

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Article Open Access

Downregulation of miR‑193a‑3p via targeting cyclin D1 in thyroid cancer

Xiao‑Jiao Li, Rong Wen, Dong‑Yue Wen, Peng Lin, Deng‑Hua Pan, Li‑Jie Zhang, Yu He, Lin Shi, Yong‑Ying Qin, Yun‑Hui Lai, Jing‑Ni Lai, Jun‑Lin Yang, Qin‑Qiao Lai, Jun Wang, Jun Ma, Hong Yang, Yu‑Yan Pang
Pages: 2199-2218
Published online on: 08 July 2020

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Article Open Access

Suppression of sirtuin 1 alleviates airway inflammation through mTOR‑mediated autophagy

Yuanyuan Wu, Wei Li, Yifan Hu, Yun Liu, Xiuzhen Sun
Pages: 2219-2226
Published online on: 13 July 2020

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Article Open Access

lncRNA‑MM2P downregulates the production of pro‑inflammatory cytokines in acute gouty arthritis

Xifeng Zhang, Ying Zou, Jiangxia Zheng, Senguo Ji, Xiuzhen Wen, Feng Ye, Ju Liu, Xueyong Li, Jin Lei, Mingliang Qiu
Pages: 2227-2234
Published online on: 09 July 2020

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Article Open Access

Combined administration of SHP2 inhibitor SHP099 and the α7nAChR agonist PNU282987 protect mice against DSS‑induced colitis

Junhua Xiao, Gufang Zhang, Sujun Gao, Jiaqing Shen, Huang Feng, Zhilong He, Chunfang Xu
Pages: 2235-2244
Published online on: 10 July 2020

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Article Open Access

CLEC4M overexpression inhibits progression and is associated with a favorable prognosis in hepatocellular carcinoma

Qianle Yu, Kai Gao
Pages: 2245-2252
Published online on: 13 July 2020

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Article Open Access

Role of ROCK/NF‑κB/AQP8 signaling in ethanol‑induced intestinal epithelial barrier dysfunction

Hang Zhao, Xiaonan Sun, Jing Tong
Pages: 2253-2262
Published online on: 09 July 2020

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Article Open Access

Shikonin inhibits CEBPD downregulation in IL‑17‑treated HaCaT cells and in an imiquimod‑induced psoriasis model

Xiao‑Ou Lan, He‑Xiao Wang, Rui‑Qun Qi, Yuan‑Yuan Xu, Ya‑Jie  Yu, Yang Yang, Hao Guo, Xing‑Hua Gao, Long Geng
Pages: 2263-2272
Published online on: 09 July 2020

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Article Open Access

DUSP6 protects murine podocytes from high glucose‑induced inflammation and apoptosis

Liqiang Chen, Yaokun Wang, Haiyan Luan, Guangyu Ma, Huiming Zhang, Guang Chen
Pages: 2273-2282
Published online on: 09 July 2020

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Detection and analysis of angiogenesis pathway‑associated lncRNA expression profiles in human skin fibroblasts under high‑glucose conditions

Longxiang Tu, Qin Huang, Yanghong Hu, Dewu Liu
Pages: 2283-2290
Published online on: 10 July 2020

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Altered spontaneous brain activity patterns in diabetic patients with vitreous hemorrhage using amplitude of low‑frequency fluctuation: A resting‑state fMRI study

Wen‑Qing Shi, Li‑Ying Tang, Qi Lin, Biao Li, Nan Jiang, Pei‑Wen Zhu, Qing Yuan, Lei Ye, Yi Shao
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Published online on: 03 July 2020

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Downregulation of lncRNA ZFAS1 protects H9c2 cardiomyocytes from ischemia/reperfusion‑induced apoptosis via the miR‑590‑3p/NF‑κB signaling pathway

Peng Huang, Dongbai Yang, Lianzhi Yu, Yu Shi
Pages: 2300-2306
Published online on: 13 July 2020

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MicroRNA‑199a‑5p suppresses cell proliferation, migration and invasion by targeting ITGA3 in colorectal cancer

Lijun Tian, Mingtong Chen, Qiang He, Qiuliang Yan, Chunbao Zhai
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Published online on: 10 July 2020

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Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration

Xiuying Wang, Yuanyuan Lin, Yi Zheng
Pages: 2318-2328
Published online on: 10 July 2020

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Proteomic analysis of differentially expressed proteins in the serum of patients with acute renal allograft rejection using iTRAQ labelling technology

Yue Zhang, Minglin Ou, Hua Lin, Liusheng Lai, Huaizhou Chen, Jiejing Chen, Weiguo Sui, Wen Xue, Ruohan Zhang, Qing Gan, Donge Tang, Xuyong Sun, Jianhui Dong, Qiang Yan, Yong Dai
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Published online on: 06 July 2020

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Yes‑associated protein protects and rescues SH‑SY5Y cells from ketamine‑induced apoptosis

Yanni Chen, Zeyong Yang, Luyao Wei, Jie Wang, Wenting Xuan, Yiqiao Wang, Jun Li, Zunji Ke, Yuanhai Li
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Published online on: 10 July 2020

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Upregulated microRNA‑330‑3p promotes calcification in the bicuspid aortic valve via targeting CREBBP

Rui Zheng, Hao Liu, Jiaxi Gu, Buqing Ni, Haoliang Sun, Yaojun Guo, Chen Su, Keshuai He, Junjie Du, Yongfeng Shao
Pages: 2351-2363
Published online on: 06 July 2020

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Asiaticoside produces an antidepressant‑like effect in a chronic unpredictable mild stress model of depression in mice, involving reversion of inflammation and the PKA/pCREB/BDNF signaling pathway

Luoqing Wang, Ting Guo, Yuanfang Guo, Yujie Xu
Pages: 2364-2372
Published online on: 06 July 2020

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Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy

Zhongzhong Liu, Shaojun Ye, Xiang Zhong, Wei Wang, Chin‑Hui Lai, Wang Yang, Pengpeng Yue, Jun Luo, Xiaoying Huang, Zibiao Zhong, Yan Xiong, Xiaoli Fan, Ling Li, Yanfeng Wang, Qifa Ye
Pages: 2373-2385
Published online on: 08 July 2020

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Punicalagin inhibited proliferation, invasion and angiogenesis of osteosarcoma through suppression of NF‑κB signaling

Tao Huang, Xin Zhang, Haipeng Wang
Pages: 2386-2394
Published online on: 06 July 2020

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Overexpressed p32 localized in the endoplasmic reticulum and mitochondria negatively regulates calcium‑dependent endothelial nitric oxide synthase activit

Kwanhoon Choi, Bon‑Hyeock Koo, Byeong Jun Yoon, Minkyo Jung, Hye Young Yun, Byung Hwa Jeon, Moo‑Ho Won, Young‑Myeong Kim, Ji Young Mun, Hyun Kyo Lim, Sungwoo Ryoo
Pages: 2395-2403
Published online on: 06 July 2020

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MicroRNA-1 promotes cartilage matrix synthesis and regulates chondrocyte differentiation via post-transcriptional suppression of Ihh expression

Taoyu Chen, Xianda Che, Pengfei Han, Jiangong Lu, Chunfang Wang, Bin Liang, Ziqi Hou, Xiaochun Wei, Lei Wei, Pengcui Li
Pages: 2404-2414
Published online on: 03 July 2020

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Low expression of miR‑532‑3p contributes to cerebral ischemia/reperfusion oxidative stress injury by directly targeting NOX2

Li Mao, Mei‑Ling Zuo, Ai‑Ping Wang, Ying Tian, Li‑Chen Dong, Tao‑Ming  Li, Da‑Bin Kuang, Gui‑Lin Song, Zhong‑Bao Yang
Pages: 2415-2423
Published online on: 10 July 2020

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Protective effects of catalpol on mitochondria of hepatocytes in cholestatic liver injury

Xingjuan Gao, Jiaju Xu, Hongbo Liu
Pages: 2424-2432
Published online on: 13 July 2020

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Protective effect of bromfenac sodium on femtosecond laser‑assisted cataract surgery via modulating cyclooxygenase‑2 expression

Lu Lu, Jiangyue Zhao, Jing Wang, Yu Qin, Jingsong Zhang
Pages: 2433-2441
Published online on: 08 July 2020

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Dexmedetomidine alleviates LPS‑induced acute lung injury via regulation of the p38/HO‑1 pathway

Yingying Sun, Yin Xia, Xinghui Liu, Junxia Liu, Weitian He, Hongwu Ye, Xianren Yuan
Pages: 2442-2450
Published online on: 10 July 2020

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Article

ACY‑1215, a HDAC6 inhibitor, decreases the dexamethasone‑induced suppression of osteogenesis in MC3T3‑E1 cells

Na Wang, Hua Wang, Jianming Chen, Fubin Wang, Shuaiyi Wang, Qiang Zhou, Jichong Ying, Shanzhao Huang, Pu Wang, Fangfang Yuan
Pages: 2451-2459
Published online on: 09 July 2020

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Long non‑coding RNA growth arrest‑specific 5 (GAS5) acts as a tumor suppressor by promoting autophagy in breast cancer

Guangping Li, Lin Qian, Xiaoqin Tang, Yuan Chen, Ziyi Zhao, Cuiwei Zhang
Pages: 2460-2468
Published online on: 10 July 2020

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Whole‑exome sequencing identifies a novel mutation of SLC20A2 (c.C1849T) as a possible cause of hereditary multiple exostoses in a Chinese family

Yiqiang Li, Xuemei Lin, Mingwei Zhu, Jingchun Li, Zhe Yuan, Hongwen Xu
Pages: 2469-2477
Published online on: 06 July 2020

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Biological effect of ribosomal protein L32 on human breast cancer cell behavior

Lu Xu, Lintao Wang, Chaojun Jiang, Qiannan Zhu, Rui Chen, Jue Wang, Shui Wang
Pages: 2478-2486
Published online on: 06 July 2020

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Differentially expressed lncRNAs, miRNAs and mRNAs with associated ceRNA networks in a mouse model of myocardial ischemia/reperfusion injury

Rui Zhang, Jiali Wang, Baoshan Liu, Wenjun Wang, Xinhui Fan, Boyuan Zheng, Qiuhuan Yuan, Mengyang Xue, Feng Xu, Ping Guo, Yuguo Chen
Pages: 2487-2495
Published online on: 06 July 2020

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Effects of Egr1 on pancreatic acinar intracellular trypsinogen activation and the associated ceRNA network

Bo Gao, Xueming Zhang, Dongbo Xue, Weihui Zhang
Pages: 2496-2506
Published online on: 09 July 2020

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Dexmedetomidine alleviates blunt chest trauma and hemorrhagic shock‑resuscitation‑induced acute lung injury through inhibiting the NLRP3 inflammasome

Tingqian Ming, Min Yuan, Qian Kong, Qin Huang, Zhongyuan Xia, Xiaojing Wu
Pages: 2507-2515
Published online on: 10 July 2020

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Identification of a novel homozygous variant in the CNGA1 gene in a Chinese family with autosomal recessive retinitis pigmentosa

Le Wang, Tongdan Zou, Yongqiong Lin, Ling Li, Peng Zhang, Bo Gong, Jilong Hao, Houbin Zhang
Pages: 2516-2520
Published online on: 10 July 2020

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Influence of reaming intramedullary nailing on MSC population after surgical treatment of patients with long bone fracture

Ioannis Sperelakis, Eliza Tsitoura, Chara Koutoulaki, Semeli Mastrodimou, Theodoros H. Tosounidis, Demetrios A. Spandidos, Katerina M. Antoniou, George Kontakis
Pages: 2521-2527
Published online on: 09 July 2020

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Weighted gene co‑expression network analysis identifies key genes from extracellular vesicles as potential prognostic biomarkers for congenital pulmonary stenosis

Zirui Huang, Xiaohong Li, Min Qiu, Jing Chen, Miao Tian, Fengzhen Han, Yanqiu Ou, Xiaoqing Liu, Chengbin Zhou, Haiyun Yuan, Jian Zhuang, Jimei Chen
Pages: 2528-2536
Published online on: 10 July 2020

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MicroRNA‑204‑5p inhibits the osteogenic differentiation of ankylosing spondylitis fibroblasts by regulating the Notch2 signaling pathway

Jianjun Zhao, Yanyan Zhang, Bo Liu
Pages: 2537-2544
Published online on: 06 July 2020

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Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis

Ruli Li, Jianbo Xiao, Sufan Tang, Xinjing Lin, Honglin Xu, Bin Han, Ming Yang, Fu Liu
Pages: 2545-2550
Published online on: 10 July 2020

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Puerarin restores the autophagic flux to alleviate cadmium‑induced endoplasmic reticulum stress in NRK‑52E cells

Gang Liu, Kanglei Zhang, Wenxuan Dong, Yun Tan, Mengfei Long, Hui Zou, Zongping Liu
Pages: 2551-2563
Published online on: 06 July 2020

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Montelukast improves bronchopulmonary dysplasia by inhibiting epithelial‑mesenchymal transition via inactivating the TGF‑β1/Smads signaling pathway

Xin Chen, Wansheng Peng, Rui Zhou, Zhen Zhang, Jiali Xu
Pages: 2564-2572
Published online on: 06 July 2020

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Inhibition of sphingosine kinase 2 attenuates hypertrophic scar formation via upregulation of Smad7 in human hypertrophic scar fibroblasts

Jian Zeng, Bin Jiang, Xia Xiao, Rou Zhang
Pages: 2573-2582
Published online on: 09 July 2020

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Clinical characteristics of 2019 novel coronavirus pneumonia in Zhejiang province, China

Ling Chen, Qiuhong Jin, Ying Zhou, Jiao Yang, Zhehua  Wang, Ke Ge, Jiangle Yang, Hong Wang
Pages: 2583-2587
Published online on: 10 July 2020

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March-2026 Volume 33 Issue 3

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article

CTRP4 ameliorates dexamethasone‑induced insulin resistance through the IRS‑1/PI3K/AKT pathway in 3T3‑L1 adipocytes

Maireyanmu Rouzi, Xi Sun, Luguang Sheng, Bilin Xu, Tao Lei, Jun Lu, Jie Gao
Article Number: 101
Published online on: 27 January 2026

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PTUPB, a soluble epoxide hydrolase/cyclooxygenase‑2 dual inhibitor, reduces endothelial‑to‑mesenchymal transition and improves doxorubicin‑induced vascular and cardiac toxicity

Hevna Dhulkifle, Lubna Therachiyil, Maram H. Hasan, Shahd M. Younis, Nizar A. Al‑Shar'i, Huseyin C. Yalcin, Zaid H. Maayah
Article Number: 100
Published online on: 27 January 2026

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[Retracted] miR‑367 enhances the proliferation and invasion of cutaneous malignant melanoma by regulating phosphatase and tensin homolog expression

Jianwen Long, Jing Luo, Xuwen Yin
Article Number: 99
Published online on: 26 January 2026

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Advances in the mechanisms of the NLRP3 inflammasome in sepsis‑induced cardiomyopathy and targeted therapeutic studies 
(Review)

Yifei Chen, Zhaohui Zhang, Gaosheng Zhou
Article Number: 98
Published online on: 22 January 2026

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HMGN2 induces pyroptosis in tumour cells by modulating the STT3B/PD‑L1/caspase‑1/GSDMD axis

Wenwen Han, Hongli Chen, Bomiao Cui, Jiao Chen, Ping Zhang, Yun Feng
Article Number: 97
Published online on: 22 January 2026

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Naringin ameliorates intestinal injury in ulcerative colitis model mice by modulating the JAK2/STAT3 signaling pathway

Miaomiao Wu, Yating An, Yongmin Li, Wei He, Ying Wang, Yaqi Wang, Caixia Wu
Article Number: 96
Published online on: 22 January 2026

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PDX1 in human cancers: Molecular mechanisms, dual roles and clinical implications (Review)

Chen Zhou, Yifei Wang, Jie Zhao, Yantao Yang, Yuhang Yuan, Xiaochen Hou, Yu Tang, Lianhua Ye
Article Number: 95
Published online on: 22 January 2026

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[Retracted] Autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL‑induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species

Uddin Md Nazim, Honghua Yin, Sang-Youel Park
Article Number: 94
Published online on: 19 January 2026

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Converting ‘cold’ to ‘hot’ hepatocellular carcinoma for improved immunotherapy (Review)

Ching-Hua Hsieh, Pei-Chin Chuang
Article Number: 93
Published online on: 15 January 2026

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Pathological mechanism of ferroptosis in a rat model of α‑naphthyl isothiocyanate‑induced chronic cholestasis

Zhen Guo, Jiaxuan Wang, Yiwen Wang, Xinzhu Liu, Yubing Xia, Ping Liu, Li Qi, Jia Liu, Xiaoning Wang
Article Number: 92
Published online on: 14 January 2026

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[Corrigendum] Role of hypoxia‑inducible factor‑1α and CD146 in epidermal growth factor receptor‑mediated angiogenesis in salivary gland adenoid cystic carcinom

Wei-Ming Wang, Zhi-Li Zhao, Wen-Feng Zhang, Yi-Fang Zhao, Lu Zhang, Zhi-Jun Sun
Article Number: 91
Published online on: 13 January 2026

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Klebsiella pneumoniae and pyogenic liver abscess: Emerging clinical threats, virulence mechanisms and therapeutic strategies (Review)

Gulam Mustafa Hasan, Taj Mohammad, Sobia Zaidi, Anas Shamsi, Sukhwinder Singh Sohal, Md. Imtaiyaz Hassan
Article Number: 90
Published online on: 13 January 2026

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Collagen III regulates the termination of liver regeneration by suppressing hepatocyte proliferation and promoting functional recovery

Haiyang Peng, Zhiyong Chen, Qiwei Zhang, Yuezhou Zhang, Peng Yang, Jianping Gong, Andong Zhao
Article Number: 89
Published online on: 13 January 2026

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Application of extracellular vesicles in the diagnosis and treatment of chronic obstructive pulmonary disease (Review)

Yixin Zhang, Tong Ren, Jianbo Xue, Yan Yu, Xianqiang Zhou, Xiaoyi Hu, Wenyi Yu, Zhancheng Gao, Cuiling Feng
Article Number: 88
Published online on: 13 January 2026

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Cigarette smoke combined with Klebsiella pneumoniae induce damage to the air‑blood barrier in chronic obstructive pulmonary disease rats via the MAPK/NF‑κB/IκBα pathway

Yange Tian, Kexin Xu, Ruilong Lu, Kangchen Li, Xuejie Shao, Yixi Liao, Yakun Zhao, Zhiguang Qiu, Haoran Dong, Xuefang Liu
Article Number: 87
Published online on: 12 January 2026

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[Retracted] 8‑bromo‑7‑methoxychrysin induces apoptosis by regulating Akt/FOXO3a pathway in cisplatin‑sensitive and resistant ovarian cancer cells

Qing Ding, Yi Chen, Qing Zhang, Yanling Guo, Zhi Huang, Liqing Dai, Sudan Cao
Article Number: 86
Published online on: 12 January 2026

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Anxiety‑induced overactive bladder: The role of oxidative stress and NF‑κB signaling pathway with Hsp90 as a potential biomarker

Zhipeng Zhou, Lina Xu, Han Wu, Huaishan Hong
Article Number: 85
Published online on: 12 January 2026

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Echinacoside alleviates asthenozoospermia by upregulating Sox5‑mediated transcriptional activation of the CatSper gene

Zi-Run Jin, Yong-Wei Huo, Bo-Heng Liu, Hong Tian, Shuo Yuan, Yue Tian, Ke Xi, Jie Cai, Hui Jiang, Yong Jiang, Guo-Gang Xing
Article Number: 84
Published online on: 12 January 2026

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Artemisiae Scopariae Herba (Yinchen) suppresses ferroptosis in mice with osteoporosis via the Nrf2/Slc7a11/Gpx4 pathway

Pei Li, Xinyu Wan, Wenjie Li, Ding Cheng, Ying Yang, Yuhan Wang, Ruyuan Zhu, Yanjing Chen, Haixia Liu, Zhiguo Zhang
Article Number: 83
Published online on: 12 January 2026

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Prolyl hydroxylase domain proteins: Localization, regulation, function and their role in erythropoiesis (Review)

Yan Hou, Zhao-Hua Zhang, Wen-Qian Li, Guo-Xiong Han, Kuo Shen, You-Bang Xie
Article Number: 82
Published online on: 12 January 2026

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Therapeutic potential of saponins for allergic rhinitis: Molecular mechanisms and clinical perspectives (Review)

Bing-Yu Liang, Zi-Yue Fu, Fen-Fen Li, Ping-Ting Zhou, Zi-Hui Xie, Ke Han, Yan-Xun Han, Shan-Wen Chen, Yi Zhao, Hai-Feng Pan, Ye-Hai Liu, Yu-Chen Liu
Article Number: 81
Published online on: 07 January 2026

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Interleukin‑6 and ischemic stroke: From mechanisms to clinical prospects (Review)

Xinyue Wang, Xiaohang Zhang, Jianing Lin, Ping Lin
Article Number: 80
Published online on: 05 January 2026

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Preliminary exploration of the putative function of SF3A2 in clear cell renal cell carcinoma

Ru Chen, Jie Xu
Article Number: 79
Published online on: 05 January 2026

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Retraction Open Access

[Retracted] TIPE‑2 suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3‑kinase/AKT signaling pathway

Lin Wang, Chen Chen, Shuzhi Feng, Jianli Tian
Article Number: 78
Published online on: 05 January 2026

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Journal Cover
April-2026 Volume 33 Issue 4

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Circular RNAs in intervertebral disc degeneration: Current insights into mechanisms and therapeutic potentials (Review)

Luyan Wang, Ke Yang, Houjun Zhu, Dachuan Wang, Feng Wang, Xianfa Du
Article Number: 111
Published online on: 05 February 2026

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T‑cadherin and its impact on human diseases (Review)

Yan Song, Xinyi Wang, Yunfei Bian
Article Number: 110
Published online on: 05 February 2026

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CD20 monoclonal antibody‑rituximab for the treatment of diffuse alveolar hemorrhage in children (Review)

Xiaobo Zhang, Xiao Wu, Yan Li, Guangmin Nong
Article Number: 109
Published online on: 05 February 2026

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N6‑methyladenosine reader insulin‑like growth factor 2 mRNA‑binding protein 2 promotes abnormal proliferation of colonic epithelial cells in type 2 diabetes mellitus by regulating midkine

Jieyao Li, Qingsheng Xie, Jihao Xu
Article Number: 108
Published online on: 04 February 2026

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[Expression of Concern] Curcumin suppresses breast tumor angiogenesis by abrogating osteopontin‑induced VEGF expression

Goutam Chakraborty, Shalini Jain, Smita Kale, Remya Raja, Santosh Kumar, Rosalin Mishra, Gopal C. Kundu
Article Number: 107
Published online on: 04 February 2026

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Research status and molecular mechanisms of disulfidptosis in cardiovascular diseases (Review)

Xiao Jin, Zelin Cheng, Xinyue Ding, Zongjun Liu
Article Number: 106
Published online on: 03 February 2026

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Role and mechanism of tetrahedral DNA nanostructures in the repair of urethral injury in rats

Caifen Guo, Jian Li
Article Number: 105
Published online on: 02 February 2026

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[Retracted] MicroRNA‑4500 suppresses tumor progression in non‑small cell lung cancer by regulating STAT3

Zhi-Ying Li, Zi-Zhou Zhang, Hui Bi, Qiu-Di Zhang, Su-Juan Zhang, Lin Zhou, Xiao-Qin Zhu, Jun Zhou
Article Number: 104
Published online on: 02 February 2026

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Integrative bioinformatics and experimental analysis reveals FRA1 as a key mediator of tubulointerstitial inflammation in lupus nephritis

Wenpeng Ni, Jialin He, Zhouyu Zeng, Jialong Ke, Runpei Lin, Jianming Peng, Kunyi Deng, Lijuan Wen, Yanhui Chen, Chilun Zhang, Yanfen Li, Guanghong Gu
Article Number: 103
Published online on: 28 January 2026

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[Corrigendum] Resveratrol improves neurological outcome and neuroinflammation following spinal cord injury through enhancing autophagy involving the AMPK/mTOR pathway

Hong-Yu Meng, De-Cheng Shao, Han Li, Xiao-Dan Huang, Guang Yang, Bing Xu, Hai-Yun Niu
Article Number: 102
Published online on: 28 January 2026

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