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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
September-2020 Volume 22 Issue 3

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Telomerase and telomeres in aging theory and chronographic aging theory (Review)

Mayya P. Razgonova, Alexander M. Zakharenko, Kirill S. Golokhvast, Maria Thanasoula, Evangelia Sarandi, Konstantinos Nikolouzakis, Persefoni Fragkiadaki, Dimitris Tsoukalas, Demetrios A. Spandidos, Aristidis Tsatsakis
Pages: 1679-1694
Published online on: 25 June 2020

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Review

A potential role for astaxanthin in the treatment of bone diseases (Review)

Maria Teresa Valenti, Massimiliano Perduca, Maria Grazia Romanelli, Monica Mottes, Luca Dalle Carbonare
Pages: 1695-1701
Published online on: 26 June 2020

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Article Open Access

Expression of Notch family is altered in non‑alcoholic fatty liver disease

Wen‑Jin Ding, Wei‑Jie Wu, Yuan‑Wen Chen, Han‑Bei Chen, Jian‑Gao Fan, Liang Qiao
Pages: 1702-1708
Published online on: 17 June 2020

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Article Open Access

Genome‑wide analysis of DNA methylation and gene expression changes in an ovalbumin‑induced asthma mouse model

Joong‑Sun Kim, In‑Sik Shin, Na‑Rae Shin, Jae‑Yong Nam, Chul Kim
Pages: 1709-1716
Published online on: 17 June 2020

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Article Open Access

miR‑27a‑3p negatively regulates osteogenic differentiation of MC3T3‑E1 preosteoblasts by targeting osterix

Yuexin Xu, Dong Li, Zhu Zhu, Lingyun Li, Yucui Jin, Changyan Ma, Wei Zhang
Pages: 1717-1726
Published online on: 17 June 2020

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Article Open Access

Effects of GPR81 silencing combined with cisplatin stimulation on biological function in hypopharyngeal squamous cell carcinoma

Qiaojing Jia, Ou Xu, Jianxing Wang, Jinhui Dong, Xiumin Ren, Xiaofang Jia, Chunguang Shan
Pages: 1727-1736
Published online on: 18 June 2020

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Article Open Access

Mmu_circ_003795 regulates osteoblast differentiation and mineralization in MC3T3‑E1 and MDPC23 by targeting COL15A1

Jingwen Wu, Wen Ren, Zhichao Zheng, Zhu Huang, Tingting Liang, Fuyao Li, Zhan Shi, Qianzhou Jiang, Xuechao Yang, Lvhua Guo
Pages: 1737-1746
Published online on: 22 June 2020

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Article Open Access

Liriopesides B from Liriope spicata var. prolifera inhibits metastasis and induces apoptosis in A2780 human ovarian cancer cells

Haizhong Yu, Haiyan Wang, Youping Yin, Zhongkang Wang
Pages: 1747-1758
Published online on: 18 June 2020

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Article Open Access

Exogenous hydrogen sulfide reduces atrial remodeling and atrial fibrillation induced by diabetes mellitus via activation of the PI3K/Akt/eNOS pathway

Xiaofei Xue, Xinyu Ling, Wang Xi, Pei Wang, Jianjun Sun, Qian Yang, Jian Xiao
Pages: 1759-1766
Published online on: 30 June 2020

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Article Open Access

Silencing of BRF2 inhibits the growth and metastasis of lung cancer cells

Yuan Bian, Qiu Li, Qiaolian Li, Ruigen Pan
Pages: 1767-1774
Published online on: 26 June 2020

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Article Open Access

Risk gene identification and support vector machine learning to construct an early diagnosis model of myocardial infarction

Hong‑Zhi Fang, Dan‑Li Hu, Qin Li, Su Tu
Pages: 1775-1782
Published online on: 17 June 2020

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Article Open Access

Calcium inhibitor inhibits high glucose‑induced hypertrophy of H9C2 cells

Xiaohong Xu, Luoyang Ruan, Xiaohua Tian, Fengjuan Pan, Cailan Yang, Guosheng Liu
Pages: 1783-1792
Published online on: 26 June 2020

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Article Open Access

Toosendanin induces apoptosis of MKN‑45 human gastric cancer cells partly through miR‑23a‑3p‑mediated downregulation of BCL2

Shuli Shao, Shanshan Li, Chang Liu, Weiwei Zhang, Zhenzhu Zhang, Shaowei Zhu, Yunjianan Feng, Yang Pan
Pages: 1793-1802
Published online on: 22 June 2020

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Article Open Access

MicroRNA‑375 prevents TGF‑β‑dependent transdifferentiation of lung fibroblasts via the MAP2K6/P38 pathway

Xinghua Zhang, Qian Chen, Hengya Song, Wanli Jiang, Songping Xie, Jie Huang, Ganjun Kang
Pages: 1803-1810
Published online on: 22 June 2020

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Article Open Access

Long non‑coding RNA HOTAIR promotes burn wound healing by regulating epidermal stem cells

Yan Shi, Ronghua Yang, Longxiang Tu, Dewu Liu
Pages: 1811-1820
Published online on: 23 June 2020

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Article Open Access

Effects of the NF‑κB/p53 signaling pathway on intervertebral disc nucleus pulposus degeneration

Litao Zhang, Xiujuan Li, Xue Kong, Hua Jin, Yaoqi Han, Yuanzhong Xie
Pages: 1821-1830
Published online on: 30 June 2020

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Article Open Access

Peroxiredoxin I deficiency increases pancreatic β‑cell apoptosis after streptozotocin stimulation via the AKT/GSK3β signaling pathway

Mei‑Hua Jin, Gui‑Nan Shen, Ying‑Hua Jin, Hu‑Nan Sun, Xing Zhen, Yong‑Qing Zhang, Dong‑Seok Lee, Yu‑Dong Cui, Li‑Yun Yu, Ji‑Su Kim, Taeho Kwon, Ying‑Hao Han
Pages: 1831-1838
Published online on: 26 June 2020

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Article Open Access

Tanshinone IIA promotes cardiac differentiation and improves cell motility by modulating the Wnt/β‑catenin signaling pathway

Kun Li, Xiuyan Wang, Chenxing Fan, Chunxia Wu, Shizheng Li, Hua Liu
Pages: 1839-1846
Published online on: 24 June 2020

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Article Open Access

Role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice

Guoqing Chen, Ying Lin, Lu Chen, Fa Zeng, Li Zhang, Yan Huang, Pingping Huang, Lingling Liao, Yuanlan Yu
Pages: 1847-1858
Published online on: 23 June 2020

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Article Open Access

Age‑related changes in mineralocorticoid receptors in rat hearts

Danli Hu, Ruolan Dong, Yanjun Zhang, Yan Yang, Zhihui Chen, Ying Tang, Menglu Fu, Xizhen Xu, Ling Tu
Pages: 1859-1867
Published online on: 19 June 2020

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Article Open Access

Identification of potential markers for type 2 diabetes mellitus via bioinformatics analysis

Yana Lu, Yihang Li, Guang Li, Haitao Lu
Pages: 1868-1882
Published online on: 26 June 2020

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Article Open Access

miR‑802 inhibits the epithelial‑mesenchymal transition, migration and invasion of cervical cancer by regulating BTF3

Xiuhui Wu, Leng Liu, Hongxia Zhang
Pages: 1883-1891
Published online on: 23 June 2020

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Article Open Access

Aggravated intestinal ischemia‑reperfusion injury is associated with activated mitochondrial autophagy in a mouse model of diabetes

Zi Zeng, Hui‑Min Liu, Yun‑Yan Zhang, Rong Chen, Tao Sun, Wei Li, Qian Sun, Zhong‑Yuan Xia, Qing‑Tao Meng
Pages: 1892-1900
Published online on: 24 June 2020

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Article Open Access

2‑Hydroxypropyl‑β‑cyclodextrin blocks autophagy flux and triggers caspase‑8‑mediated apoptotic cascades in HepG2 cells

Haidong Sun, Huajie Zong, Gang Wu
Pages: 1901-1909
Published online on: 26 June 2020

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Article Open Access

Human apolipoprotein L1 interferes with mitochondrial function in Saccharomyces cerevisiae

Mounia Chidiac, Jalil Daher, Mélanie Boeckstaens, Philippe Poelvoorde, Bassam Badran, Anna Maria Marini, Roy Khalaf, Luc Vanhamme
Pages: 1910-1920
Published online on: 24 June 2020

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Article Open Access

Downregulation of microRNA‑29c reduces pain after child delivery by activating the oxytocin‑GABA pathway

Caijuan Li, Xian Wang, Guangfen Zhang, Yao Zhang, Fan Xia, Shiqin Xu, Xiaofeng Shen
Pages: 1921-1931
Published online on: 26 June 2020

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Article Open Access

Circulating extracellular vesicles from patients with breast cancer enhance migration and invasion via a Src‑dependent pathway in MDA‑MB‑231 breast cancer cells

Javier Ramírez‑Ricardo, Elizabeth Leal‑Orta, Elia Martínez‑Baeza, Carlos Ortiz‑Mendoza, Fernando Breton‑Mora, Analy Herrera‑Torres, Irma Elizalde‑Acosta, Pedro Cortes‑Reynosa, Rocio Thompson‑Bonilla, Eduardo Perez Salazar
Pages: 1932-1948
Published online on: 18 June 2020

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Article Open Access

Wild‑type IDH1 affects cell migration by modulating the PI3K/AKT/mTOR pathway in primary glioblastoma cells

Xiaopeng Shen, Shen Wu, Jingyi Zhang, Meng Li, Feng Xu, Ao Wang, Yang Lei, Guoping Zhu
Pages: 1949-1957
Published online on: 18 June 2020

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Article Open Access

Expression profiling of circular RNAs and their potential role in early‑stage diabetic cardiomyopathy

Shengzhong Dong, Chunyan Tu, Xing Ye, Liliang Li, Mingchang Zhang, Aimin Xue, Shangheng Chen, Ziqin Zhao, Bin Cong, Junyi Lin, Yiwen Shen
Pages: 1958-1968
Published online on: 17 June 2020

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Article Open Access

Butorphanol protects PC12 cells against OGD/R-induced inflammation and apoptosis

Zijing Yang, Li Wang, Yingjun Hu, Feixiang Wang
Pages: 1969-1975
Published online on: 30 June 2020

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Article Open Access

oxLDL promotes podocyte migration by regulating CXCL16, ADAM10 and ACTN4

Yuan Chen, Zhiyi Wang, Qian Li, Lichun Yu, Yanji Zhu, Jing Wang, Shuzhen Sun
Pages: 1976-1984
Published online on: 30 June 2020

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Article Open Access

Anti‑inflammatory activity of 3,5,6,7,3',4'‑hexamethoxyflavone via repression of the NF‑κB and MAPK signaling pathways in LPS‑stimulated RAW264.7 cells

Eun Suk Son, Jeong‑Woong Park, Se‑Hee Kim, Hye Ran Park, Woorijarang Han, O Chul Kwon, Jae Young Nam, Sung Hwan Jeong, Chang Soo Lee
Pages: 1985-1993
Published online on: 18 June 2020

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Article Open Access

Scorpion primer PCR analysis for genotyping of allele variants of thiopurine s‑methyltransferase*3

Pu Yao, Xue‑Mei Qu, Sai Ren, Xiao‑Dong Ren, Ning Su, Na Zhao, Liu Wang, Lin Cheng, Bang‑Bi Weng, Feng‑Jun Sun, Qing Huang
Pages: 1994-2002
Published online on: 26 June 2020

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Article Open Access

Appropriate timing for hypothermic machine perfusion to preserve livers donated after circulatory death

Xiaoyan Hu, Wei Wang, Cheng Zeng, Weiyang He, Zibiao Zhong, Zhongzhong Liu, Yanfeng Wang, Qifa Ye
Pages: 2003-2011
Published online on: 18 June 2020

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Article Open Access

Antibodies specific to ferritin light chain polypeptide are frequently detected in patients with immune‑related pancytopenia

Shanfeng Hao, Yang Zhang, Luogang Hua, Ning Xie, Na Xiao, Huaquan Wang, Rong Fu, Zonghong Shao
Pages: 2012-2020
Published online on: 26 June 2020

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Article Open Access

Activation of calcium‑sensing receptor‑mediated autophagy in high glucose‑induced cardiac fibrosis in vitro

Hui Yuan, Jiyu Xu, Yanfei Zhu, Li Li, Qi Wang, Yaquan Yu, Bin Zhou, Yi Liu, Xiaoyi Xu, Zhilong Wang
Pages: 2021-2031
Published online on: 26 June 2020

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Article Open Access

Anti‑chondrocyte apoptosis effect of genistein in treating inflammation‑induced osteoarthritis

Yang Zou, Qiming Liu, Piaoting Guo, Yang Huang, Zhengcong Ye, Jiong Hu
Pages: 2032-2042
Published online on: 18 June 2020

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Article Open Access

Stress response in periodontal ligament stem cells may contribute to bisphosphonate‑associated osteonecrosis of the jaw: A gene expression array analysis

Yueqi Shi, Mengyu Li, Yejia Yu, Yuqiong Zhou, Wenjie Zhang, Hongfei Hua, Shaoyi Wang
Pages: 2043-2051
Published online on: 26 June 2020

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Article Open Access

Statin rosuvastatin inhibits apoptosis of human coronary artery endothelial cells through upregulation of the JAK2/STAT3 signaling pathway

Kuijing Wang, Bo Li, Yuanyuan Xie, Nan Xia, Minghui Li, Guang Gao
Pages: 2052-2062
Published online on: 23 June 2020

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Article Open Access

Expression levels of the α7 nicotinic acetylcholine receptor in the brains of patients with Alzheimer's disease and their effect on synaptic proteins in SH-SY5Y cells

Jia-Mou Ren, Shu-Li Zhang, Xiao-Ling Wang, Zhi-Zhong Guan, Xiao-Lan Qi
Pages: 2063-2075
Published online on: 18 June 2020

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Article Open Access

Protective and inhibitory effects of acteoside from Abeliophyllum distichum Nakai against oxidative DNA damage

Tae Won Jang, Ji Soo Choi, Jae Ho Park
Pages: 2076-2084
Published online on: 18 June 2020

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Article

miR‑142‑5p inhibits pancreatic cancer cell migration and invasion by targeting PIK3CA

Jing Zhu, Leilei Zhou, Bin Wei, Zhaoye Qian, Jiru Wang, Hongxia Hui, Yuan Sun
Pages: 2085-2092
Published online on: 18 June 2020

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Article

A twin‑pair analysis indicates congenital scoliosis is associated with allele‑specific methylation in the SVIL gene

Zhifa Zhang, Yongjun Chen, Yuezhou Wu, Yongyu Hao, Xuelin Zhao, Xiangyu Wang, Yan Wang, Yanhai Xi, Xuesong Zhang
Pages: 2093-2100
Published online on: 24 June 2020

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Article

Aquaporin‑4 deletion ameliorates enterovirus 71 infection in mice

Lei Zhu, Xiuwei Hao, Xiaole Wu, Boxiang Qi, Ting Yue, Haijun Wang
Pages: 2101-2106
Published online on: 23 June 2020

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Article

Vitamin D protects against necrotising enterocolitis in newborn mice by activating the ERK signalling pathway

Chunmei Lyu, Suhua Jiang, Muxian Kong, Xiaoqian Chen, Li Zhang
Pages: 2107-2114
Published online on: 26 June 2020

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Article

A critical role for miR‑135a‑5p‑mediated regulation of SLC24A2 in neuropathic pain

Xiao‑Gang Zhou, Hui He, Pei‑Ji Wang
Pages: 2115-2122
Published online on: 22 June 2020

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Article

Downregulation of miR‑486‑5p alleviates LPS‑induced inflammatory injury, oxidative stress and apoptosis in Chondrogenic cell ATDC5 by targeting NRF1

Qing Chang, Mingliang Ji, Chao Li, Rui Geng
Pages: 2123-2131
Published online on: 30 June 2020

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Article

Effectiveness of Bailing capsules in the treatment of lupus nephritis: A meta‑analysis

Yue Li, Tianhua Xu, Xiaobo Qiu, Binyao Tian, Chao Bi, Li Yao
Pages: 2132-2140
Published online on: 30 June 2020

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Correction Open Access

[Corrigendum] Pro‑neurogenic effects of andrographolide on RSC96 Schwann cells in vitro

Fuben Xu, Huayu Wu, Kun Zhang, Peizhen Lv, Li Zheng, Jinmin Zhao
Pages: 2141-2141
Published online on: 26 June 2020

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Review Open Access

Cellular senescence: A pathogenic mechanism of pelvic organ prolapse (Review)

Liwei Huang, Zhiwei Zhao, Jirui Wen, Wang Ling, Yali Miao, Jiang Wu
Pages: 2155-2162
Published online on: 13 July 2020

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Review Open Access

Significance of taurine transporter (TauT) in homeostasis and its layers of regulation (Review)

Stella Baliou, Anthony M. Kyriakopoulos, Maria Goulielmaki, Michalis I. Panayiotidis, Demetrios A. Spandidos, Vassilios Zoumpourlis
Pages: 2163-2173
Published online on: 09 July 2020

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Article Open Access

Trimetazidine improves hepatic lipogenesis and steatosis in non‑alcoholic fatty liver disease via AMPK‑ChREBP pathway

Ying Zhang, Can Li, Xiuqi Li, Cheng Wu, Haiyan Zhou, Shuang Lu, Xingde Liu
Pages: 2174-2182
Published online on: 08 July 2020

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Article Open Access

Sphingosine kinase 1 contributes to doxorubicin resistance and glycolysis in osteosarcoma

Xiaojun Ren, Chunhong Su
Pages: 2183-2190
Published online on: 03 July 2020

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Article Open Access

Levistilide A reverses rat hepatic fibrosis by suppressing angiotensin II‑induced hepatic stellate cells activation

Shu Li, Wei Zhao, Zhimin Zhao, Binbin Cheng, Shuang Li, Chenghai Liu
Pages: 2191-2198
Published online on: 10 July 2020

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Article Open Access

Downregulation of miR‑193a‑3p via targeting cyclin D1 in thyroid cancer

Xiao‑Jiao Li, Rong Wen, Dong‑Yue Wen, Peng Lin, Deng‑Hua Pan, Li‑Jie Zhang, Yu He, Lin Shi, Yong‑Ying Qin, Yun‑Hui Lai, Jing‑Ni Lai, Jun‑Lin Yang, Qin‑Qiao Lai, Jun Wang, Jun Ma, Hong Yang, Yu‑Yan Pang
Pages: 2199-2218
Published online on: 08 July 2020

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Article Open Access

Suppression of sirtuin 1 alleviates airway inflammation through mTOR‑mediated autophagy

Yuanyuan Wu, Wei Li, Yifan Hu, Yun Liu, Xiuzhen Sun
Pages: 2219-2226
Published online on: 13 July 2020

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Article Open Access

lncRNA‑MM2P downregulates the production of pro‑inflammatory cytokines in acute gouty arthritis

Xifeng Zhang, Ying Zou, Jiangxia Zheng, Senguo Ji, Xiuzhen Wen, Feng Ye, Ju Liu, Xueyong Li, Jin Lei, Mingliang Qiu
Pages: 2227-2234
Published online on: 09 July 2020

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Article Open Access

Combined administration of SHP2 inhibitor SHP099 and the α7nAChR agonist PNU282987 protect mice against DSS‑induced colitis

Junhua Xiao, Gufang Zhang, Sujun Gao, Jiaqing Shen, Huang Feng, Zhilong He, Chunfang Xu
Pages: 2235-2244
Published online on: 10 July 2020

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Article Open Access

CLEC4M overexpression inhibits progression and is associated with a favorable prognosis in hepatocellular carcinoma Corrigendum in /10.3892/mmr.2026.14003

Qianle Yu, Kai Gao
Pages: 2245-2252
Published online on: 13 July 2020

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Article Open Access

Role of ROCK/NF‑κB/AQP8 signaling in ethanol‑induced intestinal epithelial barrier dysfunction

Hang Zhao, Xiaonan Sun, Jing Tong
Pages: 2253-2262
Published online on: 09 July 2020

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Article Open Access

Shikonin inhibits CEBPD downregulation in IL‑17‑treated HaCaT cells and in an imiquimod‑induced psoriasis model

Xiao‑Ou Lan, He‑Xiao Wang, Rui‑Qun Qi, Yuan‑Yuan Xu, Ya‑Jie  Yu, Yang Yang, Hao Guo, Xing‑Hua Gao, Long Geng
Pages: 2263-2272
Published online on: 09 July 2020

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DUSP6 protects murine podocytes from high glucose‑induced inflammation and apoptosis

Liqiang Chen, Yaokun Wang, Haiyan Luan, Guangyu Ma, Huiming Zhang, Guang Chen
Pages: 2273-2282
Published online on: 09 July 2020

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Detection and analysis of angiogenesis pathway‑associated lncRNA expression profiles in human skin fibroblasts under high‑glucose conditions

Longxiang Tu, Qin Huang, Yanghong Hu, Dewu Liu
Pages: 2283-2290
Published online on: 10 July 2020

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Altered spontaneous brain activity patterns in diabetic patients with vitreous hemorrhage using amplitude of low‑frequency fluctuation: A resting‑state fMRI study

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Downregulation of lncRNA ZFAS1 protects H9c2 cardiomyocytes from ischemia/reperfusion‑induced apoptosis via the miR‑590‑3p/NF‑κB signaling pathway

Peng Huang, Dongbai Yang, Lianzhi Yu, Yu Shi
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MicroRNA‑199a‑5p suppresses cell proliferation, migration and invasion by targeting ITGA3 in colorectal cancer

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Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration

Xiuying Wang, Yuanyuan Lin, Yi Zheng
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Proteomic analysis of differentially expressed proteins in the serum of patients with acute renal allograft rejection using iTRAQ labelling technology

Yue Zhang, Minglin Ou, Hua Lin, Liusheng Lai, Huaizhou Chen, Jiejing Chen, Weiguo Sui, Wen Xue, Ruohan Zhang, Qing Gan, Donge Tang, Xuyong Sun, Jianhui Dong, Qiang Yan, Yong Dai
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Yes‑associated protein protects and rescues SH‑SY5Y cells from ketamine‑induced apoptosis

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Upregulated microRNA‑330‑3p promotes calcification in the bicuspid aortic valve via targeting CREBBP

Rui Zheng, Hao Liu, Jiaxi Gu, Buqing Ni, Haoliang Sun, Yaojun Guo, Chen Su, Keshuai He, Junjie Du, Yongfeng Shao
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Asiaticoside produces an antidepressant‑like effect in a chronic unpredictable mild stress model of depression in mice, involving reversion of inflammation and the PKA/pCREB/BDNF signaling pathway

Luoqing Wang, Ting Guo, Yuanfang Guo, Yujie Xu
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Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy

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Punicalagin inhibited proliferation, invasion and angiogenesis of osteosarcoma through suppression of NF‑κB signaling

Tao Huang, Xin Zhang, Haipeng Wang
Pages: 2386-2394
Published online on: 06 July 2020

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Overexpressed p32 localized in the endoplasmic reticulum and mitochondria negatively regulates calcium‑dependent endothelial nitric oxide synthase activit

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MicroRNA-1 promotes cartilage matrix synthesis and regulates chondrocyte differentiation via post-transcriptional suppression of Ihh expression Corrigendum in /10.3892/mmr.2026.13911

Taoyu Chen, Xianda Che, Pengfei Han, Jiangong Lu, Chunfang Wang, Bin Liang, Ziqi Hou, Xiaochun Wei, Lei Wei, Pengcui Li
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Published online on: 03 July 2020

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Low expression of miR‑532‑3p contributes to cerebral ischemia/reperfusion oxidative stress injury by directly targeting NOX2

Li Mao, Mei‑Ling Zuo, Ai‑Ping Wang, Ying Tian, Li‑Chen Dong, Tao‑Ming  Li, Da‑Bin Kuang, Gui‑Lin Song, Zhong‑Bao Yang
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Protective effects of catalpol on mitochondria of hepatocytes in cholestatic liver injury

Xingjuan Gao, Jiaju Xu, Hongbo Liu
Pages: 2424-2432
Published online on: 13 July 2020

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Protective effect of bromfenac sodium on femtosecond laser‑assisted cataract surgery via modulating cyclooxygenase‑2 expression

Lu Lu, Jiangyue Zhao, Jing Wang, Yu Qin, Jingsong Zhang
Pages: 2433-2441
Published online on: 08 July 2020

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Dexmedetomidine alleviates LPS‑induced acute lung injury via regulation of the p38/HO‑1 pathway

Yingying Sun, Yin Xia, Xinghui Liu, Junxia Liu, Weitian He, Hongwu Ye, Xianren Yuan
Pages: 2442-2450
Published online on: 10 July 2020

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Article

ACY‑1215, a HDAC6 inhibitor, decreases the dexamethasone‑induced suppression of osteogenesis in MC3T3‑E1 cells

Na Wang, Hua Wang, Jianming Chen, Fubin Wang, Shuaiyi Wang, Qiang Zhou, Jichong Ying, Shanzhao Huang, Pu Wang, Fangfang Yuan
Pages: 2451-2459
Published online on: 09 July 2020

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Long non‑coding RNA growth arrest‑specific 5 (GAS5) acts as a tumor suppressor by promoting autophagy in breast cancer

Guangping Li, Lin Qian, Xiaoqin Tang, Yuan Chen, Ziyi Zhao, Cuiwei Zhang
Pages: 2460-2468
Published online on: 10 July 2020

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Whole‑exome sequencing identifies a novel mutation of SLC20A2 (c.C1849T) as a possible cause of hereditary multiple exostoses in a Chinese family

Yiqiang Li, Xuemei Lin, Mingwei Zhu, Jingchun Li, Zhe Yuan, Hongwen Xu
Pages: 2469-2477
Published online on: 06 July 2020

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Biological effect of ribosomal protein L32 on human breast cancer cell behavior

Lu Xu, Lintao Wang, Chaojun Jiang, Qiannan Zhu, Rui Chen, Jue Wang, Shui Wang
Pages: 2478-2486
Published online on: 06 July 2020

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Differentially expressed lncRNAs, miRNAs and mRNAs with associated ceRNA networks in a mouse model of myocardial ischemia/reperfusion injury

Rui Zhang, Jiali Wang, Baoshan Liu, Wenjun Wang, Xinhui Fan, Boyuan Zheng, Qiuhuan Yuan, Mengyang Xue, Feng Xu, Ping Guo, Yuguo Chen
Pages: 2487-2495
Published online on: 06 July 2020

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Effects of Egr1 on pancreatic acinar intracellular trypsinogen activation and the associated ceRNA network

Bo Gao, Xueming Zhang, Dongbo Xue, Weihui Zhang
Pages: 2496-2506
Published online on: 09 July 2020

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Dexmedetomidine alleviates blunt chest trauma and hemorrhagic shock‑resuscitation‑induced acute lung injury through inhibiting the NLRP3 inflammasome

Tingqian Ming, Min Yuan, Qian Kong, Qin Huang, Zhongyuan Xia, Xiaojing Wu
Pages: 2507-2515
Published online on: 10 July 2020

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Identification of a novel homozygous variant in the CNGA1 gene in a Chinese family with autosomal recessive retinitis pigmentosa

Le Wang, Tongdan Zou, Yongqiong Lin, Ling Li, Peng Zhang, Bo Gong, Jilong Hao, Houbin Zhang
Pages: 2516-2520
Published online on: 10 July 2020

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Influence of reaming intramedullary nailing on MSC population after surgical treatment of patients with long bone fracture

Ioannis Sperelakis, Eliza Tsitoura, Chara Koutoulaki, Semeli Mastrodimou, Theodoros H. Tosounidis, Demetrios A. Spandidos, Katerina M. Antoniou, George Kontakis
Pages: 2521-2527
Published online on: 09 July 2020

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Weighted gene co‑expression network analysis identifies key genes from extracellular vesicles as potential prognostic biomarkers for congenital pulmonary stenosis

Zirui Huang, Xiaohong Li, Min Qiu, Jing Chen, Miao Tian, Fengzhen Han, Yanqiu Ou, Xiaoqing Liu, Chengbin Zhou, Haiyun Yuan, Jian Zhuang, Jimei Chen
Pages: 2528-2536
Published online on: 10 July 2020

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MicroRNA‑204‑5p inhibits the osteogenic differentiation of ankylosing spondylitis fibroblasts by regulating the Notch2 signaling pathway

Jianjun Zhao, Yanyan Zhang, Bo Liu
Pages: 2537-2544
Published online on: 06 July 2020

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Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis

Ruli Li, Jianbo Xiao, Sufan Tang, Xinjing Lin, Honglin Xu, Bin Han, Ming Yang, Fu Liu
Pages: 2545-2550
Published online on: 10 July 2020

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Puerarin restores the autophagic flux to alleviate cadmium‑induced endoplasmic reticulum stress in NRK‑52E cells

Gang Liu, Kanglei Zhang, Wenxuan Dong, Yun Tan, Mengfei Long, Hui Zou, Zongping Liu
Pages: 2551-2563
Published online on: 06 July 2020

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Montelukast improves bronchopulmonary dysplasia by inhibiting epithelial‑mesenchymal transition via inactivating the TGF‑β1/Smads signaling pathway

Xin Chen, Wansheng Peng, Rui Zhou, Zhen Zhang, Jiali Xu
Pages: 2564-2572
Published online on: 06 July 2020

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Inhibition of sphingosine kinase 2 attenuates hypertrophic scar formation via upregulation of Smad7 in human hypertrophic scar fibroblasts

Jian Zeng, Bin Jiang, Xia Xiao, Rou Zhang
Pages: 2573-2582
Published online on: 09 July 2020

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Clinical characteristics of 2019 novel coronavirus pneumonia in Zhejiang province, China

Ling Chen, Qiuhong Jin, Ying Zhou, Jiao Yang, Zhehua  Wang, Ke Ge, Jiangle Yang, Hong Wang
Pages: 2583-2587
Published online on: 10 July 2020

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November-2026 Volume 34 Issue 5

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CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Research on the role and mechanism of SLC7A5 in idiopathic pulmonary fibrosis

Menghan Wang, Yao Yu, Zhaoyu Liu, Dandan Xu, Yupeng Li, Xing Zou, Ning Shan, Xining Liu, Ce Shi, Hong Chen
Article Number: 323
Published online on: 01 October 2026

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Electroencephalography research in neuropathic pain (Review)

Lanling Zhou, Nianshun Liao, Hongmei Wang, Jiaxi Zhao, Haijun Jiang, Shihua Dang, Sixun Yu, Haifeng Shu, Xin Chen
Article Number: 322
Published online on: 25 September 2026

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BMAL1 in cardiovascular diseases: Molecular mechanisms, circadian regulation and translational perspectives (Review)

Yu Liang, Tingjin Chen, Xuemei Wen, Dan Liu, Zhongjian Zhang, Weiqing Li, Hengdi Zhang
Article Number: 321
Published online on: 24 September 2026

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Progress on quinoline‑based antitumour agents: Mechanistic insights and optimization strategies (Review)

Yuwen Zeng, Yutong Yan, Shiye Wu, Wanshan Wu, Ke Chen, Youyi Lai, Qing Ye, Nan Zhang, Yuanyuan Zhou
Article Number: 320
Published online on: 23 September 2026

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Lactylation in gastric cancer: From mechanisms to clinical applications (Review)

Yuliang Fang, Peng Chen, Yuhong Gao, Yanpiao Li, Xue Li
Article Number: 319
Published online on: 23 September 2026

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Sleep deprivation exacerbates lens‑induced myopia in association with ERK/NF‑κB pathway activation

Xueli Yang, Zhou Zhang, Chengbai Zhu, Jianbo Li, Wenting Gong, Ruirui Yang, Lipeng Guan
Article Number: 318
Published online on: 22 September 2026

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Advances in biomarkers of benzene exposure and toxicity: From mechanistic insights to occupational health applications (Review)

Yuanshe Huang, Zhenjun Xi, Jingxin Mao, Xiaobing Li
Article Number: 317
Published online on: 21 September 2026

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[Retracted] CALB1 enhances the interaction between p53 and MDM2, and inhibits the senescence of ovarian cancer cells

Long-Qiao Cao, Ya-Nan Wang, Ming Liang, Mei-Zhou Pan
Article Number: 316
Published online on: 21 September 2026

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Artemisinin and its derivatives for metabolic syndrome: From multi‑target mechanisms to translational opportunities (Review)

Shuo Cao, Mo Yang, Siyu Qu, Jinsong Wu, Jiaheng Li, Ying Zhao
Article Number: 315
Published online on: 17 September 2026

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Demethylase FTO attenuates atherosclerotic plaque via upregulating ABCA1 and ABCG1 expression by targeting ATG5

Fengxia Guo, Mei He, Yaonan Li, Kangning Zhu, Bing Hu
Article Number: 314
Published online on: 16 September 2026

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[Corrigendum] Bcl11b regulates enamel matrix protein expression and dental epithelial cell differentiation during rat tooth development

Ziyue Li, Guoqing Chen, Yaling Yang, Weihua Guo, Weidong Tian
Article Number: 313
Published online on: 16 September 2026

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Integrin αVβ3 as a context‑dependent regulator of bone homeostasis: Insights into osteoporosis pathogenesis and therapeutic targeting (Review)

Changshun Chen, Xingxi Hu, Sixing Wei, Yongcheng Deng, Qinggang Zhao, Ge Chen, Zhong Cheng, Jianhua Ji, Jinyi Gu
Article Number: 312
Published online on: 15 September 2026

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Therapeutic effects of exosome‑based hyperin delivery in a cyclophosphamide‑induced mouse model of diminished ovarian reserve

Yi Ying, Yue Wu, Ji Zhou, Yaming Wang, Hongtao Yin, Gang Lu, Ruolang Pan, Liangzhong Lv
Article Number: 311
Published online on: 15 September 2026

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Arginine metabolism, polyamine homeostasis and ferroptosis in cancer: Molecular links and therapeutic opportunities (Review)

Xin Dong, Yongkun Hou, Jingjing Shao, Haixia Zhu, Jibin Liu
Article Number: 310
Published online on: 15 September 2026

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Mitochondria‑associated endoplasmic reticulum membranes in degenerative musculoskeletal disorders: Mechanistic evidence and therapeutic perspectives (Review)

Shilong Meng, Xinlei Fu, Yawei Xu, Zhiliang Peng, Xu Zhang, Yanguang Cao, Binbin Tang, Xiaolin Shi, Kang Liu
Article Number: 309
Published online on: 15 September 2026

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High‑fat diet exacerbates hepatic and adipose insulin signaling impairment and ovarian lesions in a rat model of letrozole‑induced polycystic ovary syndrome

Sunju So, Sujin Kwon, La Yoon Choi, Dae Yong Kim, Mi Hye Kim
Article Number: 308
Published online on: 15 September 2026

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[Retracted] RNAi‑mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non‑small lung cancer in vitro and in vivo

Liang Chang, Fangchao Gong, Youbin Cui
Article Number: 307
Published online on: 14 September 2026

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A four‑gene signature identifies TKI‑induced persister cells and uncovers a ZLN005‑induced pyroptotic vulnerability via the GSDME pathway in EGFR‑mutant lung cancer

Wenwen Chang, Jiaxin Yuan, Huilin Zhang, Ying Yu, Yan Ma, Mingyue Li, Wenjing Li, Hongxia Yan, Chongran Sun, Peng Zhang, Yang Tian, Feng Guo, Pan Li, Yang Sun
Article Number: 306
Published online on: 11 September 2026

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Research advances in the microbiota‑gut‑brain axis and Parkinson's disease (Review)

Yangping Meng, Qian Liu, Hao Zou, Xingyu Zhu, Xinxin Mi, Sitong Li, Yutian Xia, Yucheng Ma, Qianyu Yang, Jiaxin Peng, Junrui Li, Xingliang Liu, Junli Chen
Article Number: 305
Published online on: 10 September 2026

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Ameliorative effects of Paulownia tomentosa flower absolute on atopic dermatitis‑related responses in mast cells and keratinocytes and its chemical composition

Da Yeon Yoo, Kyung Jong Won, Do Yoon Kim, Yoon Yi Kim, Ji Hye Bae, Ji Seong Yun, Hwan Myung Lee
Article Number: 304
Published online on: 10 September 2026

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[Retracted] PYGB siRNA inhibits the cell proliferation of human osteosarcoma cell lines

Shuwei Zhang, Yichi Zhou, Yuanyu Zha, Yang Yang, Linlong Wang, Jingfeng Li, Wei Jin
Article Number: 303
Published online on: 10 September 2026

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KIF4A drives esophageal squamous cell carcinoma via Wnt/β‑catenin signaling and predicts poor prognosis

Jialong Chen, Tong Wang, Da Wang, Weiguo Liu, Chunlai Liu, Yang Yang, Xiangfu Sun, Lei Zhou
Article Number: 302
Published online on: 08 September 2026

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Research progress of aptamers in the diagnosis and treatment of colorectal cancer (Review)

Yiwen Li, Penghui Yan, Ji Zhang, Binghui Wu, Min Li, Baoliang Bao
Article Number: 301
Published online on: 08 September 2026

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Role of the circadian rhythm in squamous cell carcinoma: From molecular mechanism to therapy (Review)

Mary-Lyn Eichhorn, Anna M. Dmitrieva, Lydia Meder
Article Number: 300
Published online on: 08 September 2026

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Expression of Concern Open Access

[Expression of Concern] Ganoderma lucidum polysaccharide inhibits prostate cancer cell migration via the protein arginine methyltransferase 6 signaling pathway

Xiaohui Zhao, Dayu Zhou, Yunen Liu, Chun Li, Xiaoguang Zhao, Ying Li, Wei Li
Article Number: 299
Published online on: 07 September 2026

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Multi‑omics approaches to decipher the molecular mechanisms of exercise‑mediated bone protection: From mechanistic insights to personalized exercise prescription (Review)

Bin Tian, Xuesong Chen, Xin Kang
Article Number: 298
Published online on: 03 September 2026

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Retraction Open Access

[Retracted] MicroRNA‑27a promotes tumorigenesis via targeting AKT in triple negative breast cancer

Jing Wu, Zhihui Sun, Huijie Sun, Yanhua Li
Article Number: 297
Published online on: 03 September 2026

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December-2026 Volume 34 Issue 6

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Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Glycyrrhizic acid attenuates corneal inflammation and pathological angiogenesis through FAK/PI3K/AKT signaling

Jinjin Yu, Huiheng Qu, Yinming Fang, Weicheng Xu, Nannan Ding, Jie Ji, Nan Wang, Wei Shi
Article Number: 335
Published online on: 15 October 2026

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Erbin deficiency exacerbates sepsis‑induced liver injury through mitochondrial ROS/NLRP3‑mediated inflammatory responses

Jing Zuo, Xing Wang, Guoqing Jing, Xiaojing Wu, Xuemin Song
Article Number: 334
Published online on: 15 October 2026

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Gut microbiota in patients receiving dialysis: Mechanisms, complications and the road to personalized microbiome‑based care (Review)

Chenxia Jin, Yanping Wang
Article Number: 333
Published online on: 15 October 2026

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Epigallocatechin gallate and thermal cycling‑stimulation synergistically promote apoptosis in A549 cells via endoplasmic reticulum stress‑induced calcium ion dysregulation and oxidative stress

Fang-Tzu Hsu, Hsu-Hsiang Liu, Yi Kung, Chieh-Jou Lin, Chih-Yu Chao
Article Number: 332
Published online on: 15 October 2026

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Piezo1 knockdown alleviates high‑altitude cerebral edema by improving brain microvascular endothelial cell tight junctions via blocking the calcium influx‑mediated Calpain‑1 activity

Taijian Cao, Zhicheng Xiang, Yangyang Zhao, Drolma Gomchok, Haifeng Ma, Shiwang Li, Dahai Cao, Chunqing Yang, Qiang Zhang
Article Number: 331
Published online on: 13 October 2026

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Navigating the landscape of targeted therapies for renal cell carcinoma in the era of precision medicine (Review)

Hongguo Cui, Jingheng Song, Peisen Yang, Zhengchao Zhang, Yuanyuan Liu, Gang Zhang, Aimin Tian, Jizhong Che, Yangyang Liu, Hui Sun, Yankai Xu
Article Number: 330
Published online on: 13 October 2026

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ΔNp63α‑mediated regulation of tumor‑associated genes and pathways in hepatocellular carcinoma progression

Xiaowen Lin, Anghui Peng, Min Zhang, Xinyang Yu
Article Number: 329
Published online on: 13 October 2026

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 Leptin promotes obesity‑related osteoarthritis progression via CD44/JAK2/STAT3 axis‑mediated chondrocyte apoptosis

Hao Qiu, Chao Zeng, Cheng Chen, Xin Zhou, Yongjun Zhu, Zhongliang Deng
Article Number: 328
Published online on: 09 October 2026

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Mechanical‑immune feedback regulation in distraction osteogenesis: From mechanotransduction to immune microenvironment remodeling (Review)

Xian Wang, Yuetong Wang, Shixi He, Cheng Ma, Zhengzhong He, Xuanping Huang
Article Number: 327
Published online on: 08 October 2026

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Research progress in synergistic multimechanism of nanomaterial-mediated neuroinflammatory therapy (Review)

Heng Wang, Pei Yang, Wantao Liu
Article Number: 326
Published online on: 07 October 2026

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Retraction Open Access

[Retracted] (‑)‑Epicatechin protects against myocardial ischemia‑induced cardiac injury via activation of the PTEN/PI3K/AKT pathway

Jia-Wen Li, Xiao-Yun Wang, Xin Zhang, Lei Gao, Li-Feng Wang, Xin-Hua Yin
Article Number: 325
Published online on: 05 October 2026

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Lactylation and exercise: A molecular link to disease alleviation (Review)

Jian Wang, Lei Wu
Article Number: 324
Published online on: 02 October 2026

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