Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September-2020 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2020 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Expression levels of the α7 nicotinic acetylcholine receptor in the brains of patients with Alzheimer's disease and their effect on synaptic proteins in SH-SY5Y cells

  • Authors:
    • Jia-Mou Ren
    • Shu-Li Zhang
    • Xiao-Ling Wang
    • Zhi-Zhong Guan
    • Xiao-Lan Qi
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education, Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China
    Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2063-2075
    |
    Published online on: June 18, 2020
       https://doi.org/10.3892/mmr.2020.11253
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Alzheimer's disease (AD) is a chronic neurodegenerative, and abnormal aggregation of the neurotoxic β amyloid (Aβ) peptide is an early event in AD. The present study aimed to determine the correlation between the nicotinic acetylcholine receptor α7 subunit (α7 nAChR) and Aβ in the brains of patients with AD, and to investigate whether the increased expression levels of the α7 nAChR could alter the neurotoxicity of Aβ. The expression levels of α7 nAChR and Aβ in the brains of patients with AD and healthy brains were analyzed using immunofluorescence. Moreover, SH‑SY5Y cells were used to stably overexpress or silence α7 nAChR expression levels, prior to the treatment with or without 1 µmol/l Aβ1‑42 oligomer (AβO). The mRNA and protein expression levels of α7 nAChR, synaptophysin (SYP), postsynaptic density of 95 kDa (PSD‑95) and synaptosomal‑associated protein of 25 kDa (SNAP‑25) were subsequently analyzed using reverse transcription‑quantitative PCR and western blotting. In addition, the concentration of acetylcholine (ACh) and the activity of acetylcholinesterase (AChE) were analyzed using spectrophotometry, while the cell apoptotic rate was determined using flow cytometry. The expression of Aβ in the brains of patients with AD was found to be significantly increased, whereas the expression of α7 nAChR was significantly decreased compared with the healthy control group. In vitro, the expression levels of α7 nAChR were significantly increased or decreased following the overexpression or silencing of the gene, respectively. Consistent with these observations, the mRNA and protein expression levels of SYP, PSD‑95 and SNAP‑25 were also significantly increased following the overexpression of α7 nAChR and decreased following the genetic silencing of the receptor. In untransfected or negative control cells, the expression levels of these factors and the apoptotic rate were significantly reduced following the exposure to AβO, which was found to be attenuated by α7 nAChR overexpression, but potentiated by α7 nAChR RNA silencing. However, no significant differences were observed in either the ACh concentration or AChE activity following transfection. Collectively, these findings suggested that α7 nAChR may protect the brains of patients with AD against Aβ, as α7 nAChR overexpression increased the expression levels of SYP, SNAP‑25 and PSD‑95, and attenuated the inhibitory effect of Aβ on the expression of these synaptic proteins and cell apoptosis. Overall, this indicated that α7 nAChR may serve an important neuroprotective role in AD.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Bloom GS: Amyloid-β and tau: The trigger and bullet in Alzheimer disease pathogenesis. JAMA Neurol. 71:505–508. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Amemori T, Jendelova P, Ruzicka J, Urdzikova LM and Sykova E: Alzheimer's disease: Mechanism and approach to cell therapy. Int J Mol Sci. 16:26417–26451. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Ferreira ST, Lourenco MV, Oliveira MM and De Felice FG: Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease. Front Cell Neurosci. 9:1912015. View Article : Google Scholar : PubMed/NCBI

4 

Viola KL and Klein WL: Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis. Acta Neuropathol. 129:183–206. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Lesné SE, Sherman MA, Grant M, Kuskowski M, Schneider JA, Bennett DA and Ashe KH: Brain amyloid-β oligomers in ageing and Alzheimer's disease. Brain. 136:1383–1398. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Magi S, Castaldo P, Macrì ML, Maiolino M, Matteucci A, Bastioli G, Gratteri S, Amoroso S and Lariccia V: Intracellular calcium dysregulation: Implications for Alzheimer's disease. BioMed Res Int. 2016:67013242016. View Article : Google Scholar : PubMed/NCBI

7 

Jagust W: Is amyloid-β harmful to the brain? Insights from human imaging studies. Brain. 139:23–30. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Overk CR and Masliah E: Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease. Biochem Pharmacol. 88:508–516. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Sheng M, Sabatini BL and Südhof TC: Synapses and Alzheimer's disease. Csh Perspect Biol. 4:doi.org/10.1101/cshperspect.a005777.

10 

Harrill JA, Chen H, Streifel KM, Yang D, Mundy WR and Lein PJ: Ontogeny of biochemical, morphological and functional parameters of synaptogenesis in primary cultures of rat hippocampal and cortical neurons. Mol Brain. 8:102015. View Article : Google Scholar : PubMed/NCBI

11 

García-Morales V, Montero F, González-Forero D, Rodríguez-Bey G, Gómez-Pérez L, Medialdea-Wandossell MJ, Domínguez-Vías G, García-Verdugo JM and Moreno-López B: Membrane-derived phospholipids control synaptic neurotransmission and plasticity. PLoS Biol. 13:e10021532015. View Article : Google Scholar : PubMed/NCBI

12 

Wang DB, Kinoshita Y, Kinoshita C, Uo T, Sopher BL, Cudaback E, Keene CD, Bilousova T, Gylys K, Case A, et al: Loss of endophilin-B1 exacerbates Alzheimer's disease pathology. Brain. 138:2005–2019. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Marcello E, Epis R, Saraceno C and Di Luca M: Synaptic dysfunction in Alzheimer's disease. Adv Exp Med Biol. 970:573–601. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Wang DB, Kinoshita Y, Kinoshita C, Uo T, Sopher BL, Cudaback E, Keene CD, Bilousova T, Gylys K, Case A, et al: Loss of endophilin-B1 exacerbates Alzheimer's disease pathology. Brain. 138:2005–2019. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Sivanesan S, Tan A and Rajadas J: Pathogenesis of Abeta oligomers in synaptic failure. Curr Alzheimer Res. 10:316–323. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Antonucci F, Corradini I, Fossati G, Tomasoni R, Menna E and Matteoli M: SNAP-25, a known presynaptic protein with emerging postsynaptic functions. Front Synaptic Neurosci. 8:72016. View Article : Google Scholar : PubMed/NCBI

17 

Wang J, Yuan J, Pang J, Ma J, Han B, Geng Y, Shen L, Wang H, Ma Q, Wang Y and Wang M: Effects of chronic stress on cognition in male SAMP8 mice. Cell Physiol Biochem. 39:1078–1086. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Xi YD, Zhang DD, Ding J, Yu HL, Yuan LH, Ma WW, Han J and Xiao R: Genistein inhibits Aβ25-35-induced synaptic toxicity and regulates CaMKII/CREB pathway in SH-SY5Y cells. Cell Mol Neurobiol. 36:1151–1159. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Ito S, Ménard M, Atkinson T, Brown L, Whitfield J and Chakravarthy B: Relative expression of the p75 neurotrophin receptor, tyrosine receptor kinase A, and insulin receptor in SH-SY5Y neuroblastoma cells and hippocampi from Alzheimer's disease patients. Neurochem Int. 101:22–29. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Gray NE, Zweig JA, Kawamoto C, Quinn JF and Copenhaver PF: STX, a novel membrane estrogen receptor ligand, protects against amyloid-β toxicity. J Alzheimers Dis. 51:391–403. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Ferreira-Vieira TH, Guimaraes IM, Silva FR and Ribeiro FM: Alzheimer's disease: Targeting the cholinergic system. Curr Neuropharmacol. 14:101–115. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Park D, Choi EK, Cho TH, Joo SS and Kim YB: Human neural stem cells encoding ChAT gene restore cognitive function via acetylcholine synthesis, Aβ elimination, and neuroregeneration in APPswe/PS1dE9 mice. Int J Mol Sci. 21:212020. View Article : Google Scholar

23 

Badin AS, Eraifej J and Greenfield S: High-resolution spatio-temporal bioactivity of a novel peptide revealed by optical imaging in rat orbitofrontal cortex in vitro: Possible implications for neurodegenerative diseases. Neuropharmacology. 73:10–18. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Galimberti D and Scarpini E: Old and new acetylcholinesterase inhibitors for Alzheimer's disease. Expert Opin Investig Drugs. 25:1181–1187. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Fukunaga K and Yabuki Y: SAK3-induced neuroprotection is mediated by nicotinic acetylcholine receptors. In: Nicotinic Acetylcholine Receptor Signaling in Neuroprotection. Akaike A, Shimohama S and Yoshimi Misu Y: Springer; Berlin: pp. 159–171. 2018, PubMed/NCBI

26 

Hernandez CM, Kayed R, Zheng H, Sweatt JD and Dineley KT: Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease. J Neurosci. 30:2442–2453. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Gil SM and Metherate R: Enhanced sensory-cognitive processing by activation of nicotinic acetylcholine receptors. Nicotine Tob Res. 21:377–382. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Gu Z and Yakel JL: Timing-dependent septal cholinergic induction of dynamic hippocampal synaptic plasticity. Neuron. 71:155–165. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Lozada AF, Wang X, Gounko NV, Massey KA, Duan J, Liu Z and Berg DK: Glutamatergic synapse formation is promoted by α7-containing nicotinic acetylcholine receptors. J Neurosci. 32:7651–7661. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Yue Y, Liu R, Cheng W, Hu Y, Li J, Pan X, Peng J and Zhang P: GTS-21 attenuates lipopolysaccharide-induced inflammatory cytokine production in vitro by modulating the Akt and NF-κB signaling pathway through the α7 nicotinic acetylcholine receptor. Int Immunopharmacol. 29:504–512. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Tyagi E, Agrawal R, Nath C and Shukla R: Inhibitory role of cholinergic system mediated via alpha7 nicotinic acetylcholine receptor in LPS-induced neuro-inflammation. Innate Immun. 16:3–13. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Liao Y, Qi XL, Cao Y, Yu WF, Ravid R, Winblad B, Pei JJ and Guan ZZ: Elevations in the levels of NF-κB and inflammatory chemotactic factors in the brains with Alzheimer's disease - One mechanism may involve α3 nicotinic acetylcholine receptor. Curr Alzheimer Res. 13:1290–1301. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Domínguez-Álvaro M, Montero-Crespo M, Blazquez-Llorca L, Insausti R, DeFelipe J and Alonso-Nanclares L: Three-dimensional analysis of synapses in the transentorhinal cortex of Alzheimer's disease patients. Acta Neuropathol Commun. 6:202018. View Article : Google Scholar : PubMed/NCBI

34 

Bauwens M, Mottaghy FM and Bucerius J: PET imaging of the human nicotinic cholinergic pathway in atherosclerosis. Curr Cardiol Rep. 17:672015. View Article : Google Scholar : PubMed/NCBI

35 

Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J, Delacourte A, Galasko D, Gauthier S, Jicha G, et al: Research criteria for the diagnosis of Alzheimer's disease: Revising the NINCDS-ADRDA criteria. Lancet Neurol. 6:734–746. 2007. View Article : Google Scholar : PubMed/NCBI

36 

McKhann G, Drachman D, Folstein M, Katzman R, Price D and Stadlan EM: Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology. 34:939–944. 1984. View Article : Google Scholar : PubMed/NCBI

37 

Reisberg B, Ferris SH, de Leon MJ and Crook T: The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry. 139:1136–1139. 1982. View Article : Google Scholar : PubMed/NCBI

38 

Wang XL, Deng YX, Gao YM, Dong YT, Wang F, Guan ZZ, Wei H and Qi XL: Activation of α7 nAChR by PNU-282987 improves synaptic and cognitive functions through restoring the expression of synaptic-associated proteins and the CaM-CaMKII-CREB signaling pathway. Aging (Albany NY). 12:543–570. 2020. View Article : Google Scholar : PubMed/NCBI

39 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

40 

Dunant Y and Gisiger V: Ultrafast and slow cholinergic transmission. Different involvement of acetylcholinesterase molecular forms. Molecules. 22:13002017. View Article : Google Scholar

41 

Dani JA and Bertrand D: Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system. Annu Rev Pharmacol Toxicol. 47:699–729. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Albiñana E, Luengo JG, Baraibar AM, Muñoz MD, Gandía L, Solís JM and Hernández-Guijo JM: Choline induces opposite changes in pyramidal neuron excitability and synaptic transmission through a nicotinic receptor-independent process in hippocampal slices. Pflugers Arch. 469:779–795. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Huang M, Felix AR, Kwon S, Lowe D, Wallace T, Santarelli L and Meltzer HY: The alpha-7 nicotinic receptor partial agonist/5-HT3 antagonist RG3487 enhances cortical and hippocampal dopamine and acetylcholine release. Psychopharmacology (Berl). 231:2199–2210. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Stoiljkovic M, Kelley C, Nagy D, Hurst R and Hajós M: Activation of α7 nicotinic acetylcholine receptors facilitates long-term potentiation at the hippocampal-prefrontal cortex synapses in vivo. Eur Neuropsychopharmacol. 26:2018–2023. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Lagostena L, Trocme-Thibierge C, Morain P and Cherubini E: The partial alpha7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus. Neuropharmacology. 54:676–685. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Inestrosa NC, Godoy JA, Vargas JY, Arrazola MS, Rios JA, Carvajal FJ, Serrano FG and Farias GG: Nicotine prevents synaptic impairment induced by amyloid-β oligomers through α7-nicotinic acetylcholine receptor activation. Neuromolecular Med. 15:549–569. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Counts SE, Nadeem M, Lad SP, Wuu J and Mufson EJ: Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment. J Neuropathol Exp Neurol. 65:592–601. 2006. View Article : Google Scholar : PubMed/NCBI

48 

Cao Y, Xiao Y, Ravid R and Guan ZZ: Changed clathrin regulatory proteins in the brains of Alzheimer's disease patients and animal models. J Alzheimers Dis. 22:329–342. 2010. View Article : Google Scholar : PubMed/NCBI

49 

Carvalho C, Santos MS, Oliveira CR and Moreira PI: Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers. Biochim Biophys Acta. 1852:1665–1675. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Ferreira ST and Klein WL: The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease. Neurobiol Learn Mem. 96:529–543. 2011. View Article : Google Scholar : PubMed/NCBI

51 

Tu S, Okamoto S, Lipton SA and Xu H: Oligomeric Aβ-induced synaptic dysfunction in Alzheimer's disease. Mol Neurodegener. 9:482014. View Article : Google Scholar : PubMed/NCBI

52 

Wang S, Yu L, Yang H, Li C, Hui Z, Xu Y and Zhu X: Oridonin attenuates synaptic loss and cognitive deficits in an Aβ1-42-induced mouse model of Alzheimer's disease. PLoS One. 11:e01513972016. View Article : Google Scholar : PubMed/NCBI

53 

Liu SJ, Yang C, Zhang Y, Su RY, Chen JL, Jiao MM, Chen HF, Zheng N, Luo S, Chen YB, et al: Neuroprotective effect of β-asarone against Alzheimer's disease: Regulation of synaptic plasticity by increased expression of SYP and GluR1. Drug Des Devel Ther. 10:1461–1469. 2016. View Article : Google Scholar : PubMed/NCBI

54 

Chauhan NB, Lichtor T and Siegel GJ: Aging potentiates Abeta-induced depletion of SNAP-25 in mouse hippocampus. Brain Res. 982:219–227. 2003. View Article : Google Scholar : PubMed/NCBI

55 

Qi XL, Nordberg A, Xiu J and Guan ZZ: The consequences of reducing expression of the alpha7 nicotinic receptor by RNA interference and of stimulating its activity with an alpha7 agonist in SH-SY5Y cells indicate that this receptor plays a neuroprotective role in connection with the pathogenesis of Alzheimer's disease. Neurochem Int. 51:377–383. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ren J, Zhang S, Wang X, Guan Z and Qi X: Expression levels of the α7 nicotinic acetylcholine receptor in the brains of patients with Alzheimer's disease and their effect on synaptic proteins in SH-SY5Y cells. Mol Med Rep 22: 2063-2075, 2020.
APA
Ren, J., Zhang, S., Wang, X., Guan, Z., & Qi, X. (2020). Expression levels of the α7 nicotinic acetylcholine receptor in the brains of patients with Alzheimer's disease and their effect on synaptic proteins in SH-SY5Y cells. Molecular Medicine Reports, 22, 2063-2075. https://doi.org/10.3892/mmr.2020.11253
MLA
Ren, J., Zhang, S., Wang, X., Guan, Z., Qi, X."Expression levels of the α7 nicotinic acetylcholine receptor in the brains of patients with Alzheimer's disease and their effect on synaptic proteins in SH-SY5Y cells". Molecular Medicine Reports 22.3 (2020): 2063-2075.
Chicago
Ren, J., Zhang, S., Wang, X., Guan, Z., Qi, X."Expression levels of the α7 nicotinic acetylcholine receptor in the brains of patients with Alzheimer's disease and their effect on synaptic proteins in SH-SY5Y cells". Molecular Medicine Reports 22, no. 3 (2020): 2063-2075. https://doi.org/10.3892/mmr.2020.11253
Copy and paste a formatted citation
x
Spandidos Publications style
Ren J, Zhang S, Wang X, Guan Z and Qi X: Expression levels of the α7 nicotinic acetylcholine receptor in the brains of patients with Alzheimer's disease and their effect on synaptic proteins in SH-SY5Y cells. Mol Med Rep 22: 2063-2075, 2020.
APA
Ren, J., Zhang, S., Wang, X., Guan, Z., & Qi, X. (2020). Expression levels of the α7 nicotinic acetylcholine receptor in the brains of patients with Alzheimer's disease and their effect on synaptic proteins in SH-SY5Y cells. Molecular Medicine Reports, 22, 2063-2075. https://doi.org/10.3892/mmr.2020.11253
MLA
Ren, J., Zhang, S., Wang, X., Guan, Z., Qi, X."Expression levels of the α7 nicotinic acetylcholine receptor in the brains of patients with Alzheimer's disease and their effect on synaptic proteins in SH-SY5Y cells". Molecular Medicine Reports 22.3 (2020): 2063-2075.
Chicago
Ren, J., Zhang, S., Wang, X., Guan, Z., Qi, X."Expression levels of the α7 nicotinic acetylcholine receptor in the brains of patients with Alzheimer's disease and their effect on synaptic proteins in SH-SY5Y cells". Molecular Medicine Reports 22, no. 3 (2020): 2063-2075. https://doi.org/10.3892/mmr.2020.11253
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team