Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September-2020 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2020 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Anti‑chondrocyte apoptosis effect of genistein in treating inflammation‑induced osteoarthritis

  • Authors:
    • Yang Zou
    • Qiming Liu
    • Piaoting Guo
    • Yang Huang
    • Zhengcong Ye
    • Jiong Hu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310005, P.R. China, Department of Orthopedics Surgery, Fuyang Orthopedics and Traumatology Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 311400, P.R. China, Department of General Medicine, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310005, P.R. China, Department of Orthopedics, Municipal Hospital Affiliated to Medical School of Taizhou University, Taizhou, Zhejiang 318000, P.R. China, Department of Orthopedics, Xiaoshan Traditional Chinese Medicine Hospital, Hangzhou, Zhejiang 311201, P.R. China
    Copyright: © Zou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2032-2042
    |
    Published online on: June 18, 2020
       https://doi.org/10.3892/mmr.2020.11254
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Osteoarthritis (OA) is a chronic disease that is mainly characterized by chondrocyte degeneration. Inflammatory mediators participate in the development of OA, leading to chondrocyte apoptosis and destruction of the cartilage. Genistein is the major active component of isoflavone, with a chemical composition and a biological effect that is similar to that of estrogens, which prevents the degradation of cartilage; however, its underlying mechanisms of action remain unknown. The aim of the present study was to investigate the anti‑apoptotic effects of genistein on chondrocytes for the treatment of inflammation‑induced OA. Interleukin (IL)‑1β was used to establish a chondrocyte OA model. After treatment with different concentrations of genistein, western blotting identified that expression levels of collagen II and aggrecan were increased in a concentration‑dependent manner, while caspase 3 expression gradually decreased after genistein application. Moreover, flow cytometry and ELISA results demonstrated that genistein could decrease chondrocyte apoptosis and reduce the levels of tumor necrosis factor (TNF)‑α in a dose‑dependent manner. Furthermore, the in vitro data were evaluated in an OA rat model. Genistein increased the collagen and acid glycosaminoglycan content, as well as decreased the levels of TNF‑α and IL‑1β. Genistein also promoted the expression levels of collagen II and aggrecan in the articular cartilage, and decreased the expression of caspase 3, thus alleviating cartilage degradation. In conclusion, the results indicated that genistein mediated inflammation and had an anti‑apoptotic role in treating OA. Therefore, genistein may serve as an alternative treatment for OA.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Guilak F, Nims RJ, Dicks A, Wu CL and Meulenbelt I: Osteoarthritis as a disease of the cartilage pericellular matrix. Matrix Biol 71–72. 40–50. 2018. View Article : Google Scholar

2 

Yang X, Guan Y, Tian S, Wang Y, Sun K and Chen Q: Mechanical and IL-1β responsive miR-365 contributes to osteoarthritis development by targeting histone deacetylase 4. Int J Mol Sci. 17:4362016. View Article : Google Scholar : PubMed/NCBI

3 

Whitworth DJ and Banks TA: Stem cell therapies for treating osteoarthritis: Prescient or premature? Vet J. 202:416–424. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Singer SP, Dammerer D, Krismer M and Liebensteiner MC: Maximum lifetime body mass index is the appropriate predictor of knee and hip osteoarthritis. Arch Orthop Trauma Surg. 138:99–103. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Baker M, Brook BS and Owen MR: Mathematical modelling of cytokines, MMPs and fibronectin fragments in osteoarthritic cartilage. J Math Biol. 75:985–1024. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Kaneva MK, Kerrigan MJ, Grieco P, Curley GP, Locke IC and Getting SJ: Chondroprotective and anti-inflammatory role of melanocortin peptides in TNF-α activated human C-20/A4 chondrocytes. Br J Pharmacol. 167:67–79. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Yao ZZ, Hu AX and Liu XS: DUSP19 regulates IL-1β-induced apoptosis and MMPs expression in rat chondrocytes through JAK2/STAT3 signaling pathway. Biomed Pharmacother. 96:1209–1215. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Johnson KA, Vemuri S, Alsahafi S, Castillo R and Cheriyath V: Glycone-rich Soy Isoflavone Extracts Promote Estrogen Receptor Positive Breast Cancer Cell Growth. Nutr Cancer. 68:622–633. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Liu FC, Wang CC, Lu JW, Lee CH, Chen SC, Ho YJ and Peng YJ: Chondroprotective effects of genistein against osteoarthritis induced joint inflammation. Nutrients. 11:E11802019. View Article : Google Scholar : PubMed/NCBI

10 

Oliviero F, Scanu A, Zamudio-Cuevas Y, Punzi L and Spinella P: Anti-inflammatory effects of polyphenols in arthritis. J Sci Food Agric. 98:1653–1659. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Pie JE, Park JH, Park YH, Ryu YM, Kim KN, Suh SW, Becker KG, Cho-Chung YS and Kim MK: Effect of genistein on the expression of bone metabolism genes in ovariectomized mice using a cDNA microarray. J Nutr Biochem. 17:157–164. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Wang Y, Wang H, Zhang W, Shao C, Xu P, Shi CH, Shi JG, Li YM, Fu Q, Xue W, et al: Genistein sensitizes bladder cancer cells to HCPT treatment in vitro and in vivo via ATM/NF-κB/IKK pathway-induced apoptosis. PLoS One. 8:e501752013. View Article : Google Scholar : PubMed/NCBI

13 

Ma CH, Zhang YX, Tang LH, Yang XJ, Cui WM, Han CC and Ji WY: MicroRNA-1469, a p53-responsive microRNA promotes Genistein induced apoptosis by targeting Mcl1 in human laryngeal cancer cells. Biomed Pharmacother. 106:665–671. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Du G, Song Y, Wei L, Li L, Wang X, Xu Q, Zhan H, Cao Y, Zheng Y and Ding D: Osthole inhibits proliferation and induces catabolism in rat chondrocytes and cartilage tissue. Cell Physiol Biochem. 36:2480–2493. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Newcomer CE: The evolution and adoption of standards used by AAALAC. J Am Assoc Lab Anim Sci. 51:293–297. 2012.PubMed/NCBI

16 

Couto M and Cates C: Laboratory Guidelines for Animal Care. Methods Mol Biol. 1920:407–430. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Zhou X, Zhang L, Guo X, Liu G, Wang G and Fu S: A macaca fascicularis knee osteoarthritis model developed by modified hulth combined with joint scratches. Med Sci Monit. 24:3393–3404. 2018. View Article : Google Scholar : PubMed/NCBI

18 

King TJ, Shandala T, Lee AM, Foster BK, Chen KM, Howe PR and Xian CJ: Potential effects of phytoestrogen genistein in modulating acute methotrexate chemotherapy-induced osteoclastogenesis and bone damage in rats. Int J Mol Sci. 16:18293–18311. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Wang W, Cui G, Jin B, Wang K, Chen X, Sun Y, Qin L and Bai W: Estradiol Valerate and Remifemin ameliorate ovariectomy-induced decrease in a serotonin dorsal raphe-preoptic hypothalamus pathway in rats. Ann Anat. 208:31–39. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Rejtarová O, Hejna P, Soukup T and Kuchar M: Age and sexually dimorphic changes in costal cartilages. A preliminary microscopic study. Forensic Sci Int. 193:72–78. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Li ZC, Han N, Li X, Li G, Liu YZ, Sun GX, Wang Y, Chen GT and Li GF: Decreased expression of microRNA-130a correlates with TNF-α in the development of osteoarthritis. Int J Clin Exp Pathol. 8:2555–2564. 2015.PubMed/NCBI

22 

Bergholt NL, Lysdahl H, Lind M and Foldager CB: A standardized method of applying toluidine blue metachromatic staining for assessment of chondrogenesis. Cartilage. 10:370–374. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Zhang W, Ouyang H, Dass CR and Xu J: Current research on pharmacologic and regenerative therapies for osteoarthritis. Bone Res. 4:150402016. View Article : Google Scholar : PubMed/NCBI

24 

Wang XX and Cai L: Expression level of proteoglycan, collagen and type II collagen in osteoarthritis rat model is promoted and degradation of cartilage is prevented by glucosamine methyl ester. Eur Rev Med Pharmacol Sci. 22:3609–3616. 2018.PubMed/NCBI

25 

Bishnoi M, Jain A, Hurkat P and Jain SK: Chondroitin sulphate: A focus on osteoarthritis. Glycoconj J. 33:693–705. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Barreto RB, Sadigursky D, de Rezende MU and Hernandez AJ: Effect of hyaluronic acid on chondrocyte apoptosis. Acta Ortop Bras. 23:90–93. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Mantovani V, Maccari F and Volpi N: Chondroitin sulfate and glucosamine as disease modifying anti- osteoarthritis drugs (DMOADs). Curr Med Chem. 23:1139–1151. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Bonnet CS, Williams AS, Gilbert SJ, Harvey AK, Evans BA and Mason DJ: AMPA/kainate glutamate receptors contribute to inflammation, degeneration and pain related behaviour in inflammatory stages of arthritis. Ann Rheum Dis. 74:242–251. 2015. View Article : Google Scholar : PubMed/NCBI

29 

de Boer TN, van Spil WE, Huisman AM, Polak AA, Bijlsma JW, Lafeber FP and Mastbergen SC: Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage. Osteoarthritis Cartilage. 20:846–853. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Kobayashi M, Squires GR, Mousa A, Tanzer M, Zukor DJ, Antoniou J, Feige U and Poole AR: Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage. Arthritis Rheum. 52:128–135. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Santiago B, Baleux F, Palao G, Gutiérrez-Cañas I, Ramírez JC, Arenzana-Seisdedos F and Pablos JL: CXCL12 is displayed by rheumatoid endothelial cells through its basic amino-terminal motif on heparan sulfate proteoglycans. Arthritis Res Ther. 8:R432006. View Article : Google Scholar : PubMed/NCBI

32 

Chiu YC, Yang RS, Hsieh KH, Fong YC, Way TD, Lee TS, Wu HC, Fu WM and Tang CH: Stromal cell-derived factor-1 induces matrix metalloprotease-13 expression in human chondrocytes. Mol Pharmacol. 72:695–703. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Dondelinger Y, Darding M, Bertrand MJ and Walczak H: Poly-ubiquitination in TNFR1-mediated necroptosis. Cell Mol Life Sci. 73:2165–2176. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Vitale DC, Piazza C, Melilli B, Drago F and Salomone S: Isoflavones: Estrogenic activity, biological effect and bioavailability. Eur J Drug Metab Pharmacokinet. 38:15–25. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Basu P and Maier C: Phytoestrogens and breast cancer: In vitro anticancer activities of isoflavones, lignans, coumestans, stilbenes and their analogs and derivatives. Biomed Pharmacother. 107:1648–1666. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Landete JM, Arqués J, Medina M, Gaya P, de Las Rivas B and Muñoz R: Bioactivation of Phytoestrogens: Intestinal Bacteria and Health. Crit Rev Food Sci Nutr. 56:1826–1843. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Nanashima N, Horie K and Maeda H: Phytoestrogenic activity of blackcurrant anthocyanins is partially mediated through estrogen receptor beta. Molecules. 23:E742017. View Article : Google Scholar : PubMed/NCBI

38 

Chinigarzadeh A, Karim K, Muniandy S and Salleh N: Isoflavone genistein inhibits estrogen-induced chloride and bicarbonate secretory mechanisms in the uterus in rats. J Biochem Mol Toxicol. 31:e218782017. View Article : Google Scholar

39 

Schwartz N, Verma A, Bivens CB, Schwartz Z and Boyan BD: Rapid steroid hormone actions via membrane receptors. Biochim Biophys Acta. 1863:2289–2298. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Parikka V, Lehenkari P, Sassi ML, Halleen J, Risteli J, Härkönen P and Väänänen HK: Estrogen reduces the depth of resorption pits by disturbing the organic bone matrix degradation activity of mature osteoclasts. Endocrinology. 142:5371–5378. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Wang ZL, Sun JY, Wang DN, Xie YH, Wang SW and Zhao WM: Pharmacological studies of the large-scaled purified genistein from Huaijiao (Sophora japonica-Leguminosae) on anti-osteoporosis. Phytomedicine. 13:718–723. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Ji G, Yang Q, Hao J, Guo L, Chen X, Hu J, Leng L and Jiang Z: Anti-inflammatory effect of genistein on non-alcoholic steatohepatitis rats induced by high fat diet and its potential mechanisms. Int Immunopharmacol. 11:762–768. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Honndorf VS, Wiehr S, Rolle AM, Schmitt J, Kreft L, Quintanilla-Martinez L, Kohlhofer U, Reischl G, Maurer A, Boldt K, et al: Preclinical evaluation of the anti-tumor effects of the natural isoflavone genistein in two xenograft mouse models monitored by [18F]FDG, [18F]FLT, and [64Cu]NODAGA-cetuximab small animal PET. Oncotarget. 7:28247–28261. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Xu K, Sha Y, Wang S, Chi Q, Liu Y, Wang C and Yang L: Effects of Bakuchiol on chondrocyte proliferation via the PI3K-Akt and ERK1/2 pathways mediated by the estrogen receptor for promotion of the regeneration of knee articular cartilage defects. Cell Prolif. 52:e126662019. View Article : Google Scholar : PubMed/NCBI

45 

Fytili P, Giannatou E, Papanikolaou V, Stripeli F, Karachalios T, Malizos K and Tsezou A: Association of repeat polymorphisms in the estrogen receptors alpha, beta, and androgen receptor genes with knee osteoarthritis. Clin Genet. 68:268–277. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Son YO and Chun JS: Estrogen-related receptor γ is a novel catabolic regulator of osteoarthritis pathogenesis. BMB Rep. 51:165–166. 2018. View Article : Google Scholar : PubMed/NCBI

47 

Tian L, Su Z, Ma X, Wang F and Guo Y: Inhibition of miR-203 ameliorates osteoarthritis cartilage degradation in the postmenopausal rat model: Involvement of Estrogen Receptor α. Hum Gene Ther Clin Dev. 30:160–168. 2019. View Article : Google Scholar : PubMed/NCBI

48 

Xu X, Li X, Liang Y, Ou Y, Huang J, Xiong J, Duan L and Wang D: Estrogen modulates cartilage and subchondral bone remodeling in an ovariectomized rat model of postmenopausal osteoarthritis. Med Sci Monit. 25:3146–3153. 2019. View Article : Google Scholar : PubMed/NCBI

49 

Liang Y, Duan L, Xiong J, Zhu W, Liu Q and Wang D, Liu W, Li Z and Wang D: E2 regulates MMP-13 via targeting miR-140 in IL-1β-induced extracellular matrix degradation in human chondrocytes. Arthritis Res Ther. 18:1052016. View Article : Google Scholar : PubMed/NCBI

50 

Wang Q, Yan XB, Sun QQ, Hu AM, Liu HL and Yin YW: Genetic polymorphism of the estrogen receptor alpha gene and susceptibility to osteoarthritis: Evidence based on 15,022 subjects. Curr Med Res Opin. 31:1047–1055. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zou Y, Liu Q, Guo P, Huang Y, Ye Z and Hu J: Anti‑chondrocyte apoptosis effect of genistein in treating inflammation‑induced osteoarthritis. Mol Med Rep 22: 2032-2042, 2020.
APA
Zou, Y., Liu, Q., Guo, P., Huang, Y., Ye, Z., & Hu, J. (2020). Anti‑chondrocyte apoptosis effect of genistein in treating inflammation‑induced osteoarthritis. Molecular Medicine Reports, 22, 2032-2042. https://doi.org/10.3892/mmr.2020.11254
MLA
Zou, Y., Liu, Q., Guo, P., Huang, Y., Ye, Z., Hu, J."Anti‑chondrocyte apoptosis effect of genistein in treating inflammation‑induced osteoarthritis". Molecular Medicine Reports 22.3 (2020): 2032-2042.
Chicago
Zou, Y., Liu, Q., Guo, P., Huang, Y., Ye, Z., Hu, J."Anti‑chondrocyte apoptosis effect of genistein in treating inflammation‑induced osteoarthritis". Molecular Medicine Reports 22, no. 3 (2020): 2032-2042. https://doi.org/10.3892/mmr.2020.11254
Copy and paste a formatted citation
x
Spandidos Publications style
Zou Y, Liu Q, Guo P, Huang Y, Ye Z and Hu J: Anti‑chondrocyte apoptosis effect of genistein in treating inflammation‑induced osteoarthritis. Mol Med Rep 22: 2032-2042, 2020.
APA
Zou, Y., Liu, Q., Guo, P., Huang, Y., Ye, Z., & Hu, J. (2020). Anti‑chondrocyte apoptosis effect of genistein in treating inflammation‑induced osteoarthritis. Molecular Medicine Reports, 22, 2032-2042. https://doi.org/10.3892/mmr.2020.11254
MLA
Zou, Y., Liu, Q., Guo, P., Huang, Y., Ye, Z., Hu, J."Anti‑chondrocyte apoptosis effect of genistein in treating inflammation‑induced osteoarthritis". Molecular Medicine Reports 22.3 (2020): 2032-2042.
Chicago
Zou, Y., Liu, Q., Guo, P., Huang, Y., Ye, Z., Hu, J."Anti‑chondrocyte apoptosis effect of genistein in treating inflammation‑induced osteoarthritis". Molecular Medicine Reports 22, no. 3 (2020): 2032-2042. https://doi.org/10.3892/mmr.2020.11254
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team