Open Access

Protective and inhibitory effects of acteoside from Abeliophyllum distichum Nakai against oxidative DNA damage

  • Authors:
    • Tae Won Jang
    • Ji Soo Choi
    • Jae Ho Park
  • View Affiliations

  • Published online on: June 18, 2020     https://doi.org/10.3892/mmr.2020.11258
  • Pages: 2076-2084
  • Copyright: © Jang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Abeliophyllum distichum Nakai is a Korean endemic plant of the Oleaceae family that contains acteoside, a glycosylated caffeic acid, with neuroprotective, anti‑inflammatory and antibacterial properties. Previous studies, involving Accelerated Chromatographic Isolation, a high‑performance liquid chromatography‑photodiode array detector and a liquid chromatograph‑mass selective detector, isolated and identified acteoside in A. distichum (AAD) and documented its antioxidant and anti‑inflammatory activities. The aim of the present study was to determine whether AAD could protect from DNA damage by reducing oxidative stress. AAD treatment protected plasmid DNA against damage to DNA double‑strands induced by reactive oxygen species (ROS) and decreased the levels of phosphorylated p53 and γ‑H2AX in ROS‑treated NIH 3T3 cells. These findings suggested that AAD could reduce ROS‑mediated cellular damage and may represent an effective, natural antioxidant with the ability to protect genetic material.

Related Articles

Journal Cover

September-2020
Volume 22 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Jang T, Choi J and Park J: Protective and inhibitory effects of acteoside from Abeliophyllum distichum Nakai against oxidative DNA damage. Mol Med Rep 22: 2076-2084, 2020
APA
Jang, T., Choi, J., & Park, J. (2020). Protective and inhibitory effects of acteoside from Abeliophyllum distichum Nakai against oxidative DNA damage. Molecular Medicine Reports, 22, 2076-2084. https://doi.org/10.3892/mmr.2020.11258
MLA
Jang, T., Choi, J., Park, J."Protective and inhibitory effects of acteoside from Abeliophyllum distichum Nakai against oxidative DNA damage". Molecular Medicine Reports 22.3 (2020): 2076-2084.
Chicago
Jang, T., Choi, J., Park, J."Protective and inhibitory effects of acteoside from Abeliophyllum distichum Nakai against oxidative DNA damage". Molecular Medicine Reports 22, no. 3 (2020): 2076-2084. https://doi.org/10.3892/mmr.2020.11258