Open Access

Role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice

  • Authors:
    • Guoqing Chen
    • Ying Lin
    • Lu Chen
    • Fa Zeng
    • Li Zhang
    • Yan Huang
    • Pingping Huang
    • Lingling Liao
    • Yuanlan Yu
  • View Affiliations

  • Published online on: June 23, 2020     https://doi.org/10.3892/mmr.2020.11269
  • Pages: 1847-1858
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Preeclampsia (PE) is a complication during pregnancy that is diagnosed by a new onset of hypertension and proteinuria. Although the pathogenesis of PE is not fully understood, a growing body of evidence indicates that oxidative stress and mitochondrial dysfunction might contribute to the progression of PE. Therefore, the aim of the present study was to determine the role of mitophagy in mitochondrial dysfunction and oxidative stress in PE, and to evaluate the role of DNA damage‑regulated autophagy modulator 1 (DRAM1) in the development of PE. First, a mouse model of PE induced by hypoxia‑inducible factor 1α was established, and high levels of oxidative stress, apoptosis and mitochondrial dysfunction were found in the placentas of PE mice. Additionally, the placentas of PE mice exhibited decreased mitophagy and significantly decreased DRAM1 expression. To further explore the role of DRAM1 in mitophagy, DRAM1 was overexpressed in the placental tissues of PE mice, and this overexpression effectively improved the symptoms of PE mice and significantly reduced blood lipid and urine protein levels. DRAM1 overexpression also improved mitochondrial function and reduced oxidative stress in the placentas of PE mice. In addition, the overexpression of DRAM1 improved mitochondrial fusion and fission, and enhanced mitophagy. Altogether, these results indicated a key role for DRAM1 in mitophagy that contributed to the regulation of PE. To the best of the authors' knowledge, the present study provided the first evidence of a role for DRAM1 in PE, and offered novel insight into the pathophysiological mechanisms of PE.
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September-2020
Volume 22 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Chen G, Lin Y, Chen L, Zeng F, Zhang L, Huang Y, Huang P, Liao L and Yu Y: Role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice. Mol Med Rep 22: 1847-1858, 2020
APA
Chen, G., Lin, Y., Chen, L., Zeng, F., Zhang, L., Huang, Y. ... Yu, Y. (2020). Role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice. Molecular Medicine Reports, 22, 1847-1858. https://doi.org/10.3892/mmr.2020.11269
MLA
Chen, G., Lin, Y., Chen, L., Zeng, F., Zhang, L., Huang, Y., Huang, P., Liao, L., Yu, Y."Role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice". Molecular Medicine Reports 22.3 (2020): 1847-1858.
Chicago
Chen, G., Lin, Y., Chen, L., Zeng, F., Zhang, L., Huang, Y., Huang, P., Liao, L., Yu, Y."Role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice". Molecular Medicine Reports 22, no. 3 (2020): 1847-1858. https://doi.org/10.3892/mmr.2020.11269