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Stress response in periodontal ligament stem cells may contribute to bisphosphonate‑associated osteonecrosis of the jaw: A gene expression array analysis

  • Authors:
    • Yueqi Shi
    • Mengyu Li
    • Yejia Yu
    • Yuqiong Zhou
    • Wenjie Zhang
    • Hongfei Hua
    • Shaoyi Wang
  • View Affiliations / Copyright

    Affiliations: Department of Oral Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology; National Clinical Research Center of Stomatology, Shanghai 200011, P.R. China
    Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2043-2051
    |
    Published online on: June 26, 2020
       https://doi.org/10.3892/mmr.2020.11276
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Abstract

Gene expression alterations in periodontal ligament stem cells (PDLSCs) during bisphosphonate (BP) usage and the transcriptomic mechanism underlying BP‑related osteonecrosis of the jaw have not been fully elucidated. In the present study, human PDLSCs were isolated from adults with no history of periodontal disease, and subsequently incubated and treated with zoledronate on days 3 and 5. Subsequently, PDLSCs from all timepoints were screened using an Affymetrix Gene Expression Array. Limma differential expression analysis was performed on a normalized gene expression matrix, followed by cluster analysis, pathway and network analyses. Overall, 906 genes (352 upregulated and 554 downregulated) exhibited differential expression levels between days 0 and 5, and these were termed slow‑response genes. These slow‑response genes were enriched in cellular stress response signaling pathways (upregulated genes), as well as proliferation‑ and ossification‑associated signaling pathways (downregulated genes). Furthermore, 168 (day 3 vs. 0) and 105 (day 5 vs. 3) genes were differentially expressed between adjacent timepoints. These genes were also enriched in stress response‑ and proliferation‑associated signaling pathways, but not in ossification‑associated signaling pathways. Poly(ADP‑ribose) polymerase 1 (PARP1) and CYLD lysine 63 deubiquitinase (CYLD) had the most protein‑protein interaction partners among the slow‑response genes and were connected with both stress‑ (e.g. caspase‑1) and ossification‑associated genes [e.g. secreted phosphoprotein 1 and collagen type I α1 chain (COL1A1)]. BP treatment induced stress response‑like transcriptional alterations in PDLSCs, followed by inhibition of proliferation and ossification. These alterations may contribute to the onset of jaw osteonecrosis. PARP1 and CYLD may be two key genes involved in this pathological procedure.
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View References

1 

Woo SB, Hellstein JW and Kalmar JR: Systematic review: Bisphosphonates and osteonecrosis of the jaws. Ann Intern Med. 144:7532006. View Article : Google Scholar : PubMed/NCBI

2 

Holen I and Coleman RE: Bisphosphonates as treatment of bone metastases. Curr Pharm Des. 16:1262–1271. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Lo JC, O'Ryan FS, Gordon NP, Yang J, Hui RL, Martin D, Hutchinson M, Lathon PV, Sanchez G, Silver P, et al: Prevalence of osteonecrosis of the jaw in patients with oral bisphosphonate exposure. J Oral Maxillofac Surg. 68:243–253. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Elsayed R, Abraham P, Awad ME, Kurago Z, Baladhandayutham B, Whitford GM, Pashley DH, McKenna CE and Elsalanty ME: Removal of matrix-bound zoledronate prevents post-extraction osteonecrosis of the jaw by rescuing osteoclast function. Bone. 110:141–149. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Schwartz HC: American association of oral and maxillofacial surgeons position paper on medication-related osteonecrosis of the jaw-2014 update and CTX. J Oral Maxillofac Surg. 73:3772015. View Article : Google Scholar : PubMed/NCBI

6 

Marx RE: Oral and intravenous bisphosphonate-induced osteonecrosis of the jaws: History etiology, prevention, and treatment. Royal College of Surgeons of England. 2009.

7 

Aghaloo TL, Kang B, Sung EC, Shoff M, Ronconi M, Gotcher JE, Bezouglaia O, Dry SM and Tetradis S: Periodontal disease and bisphosphonates induce osteonecrosis of the jaws in the rat. J Bone Miner Res. 26:1871–1882. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Oteri G, Bramanti E, Nigrone V and Cicciù M: Periodontal health in osteoporotic patients affected by BRONJ: An observational study. J Osteoporos. 2013:2312892013. View Article : Google Scholar : PubMed/NCBI

9 

Li CL, Lu WW, Seneviratne CJ, Leung WK, Zwahlen RA and Zheng LW: Role of periodontal disease in bisphosphonate-related osteonecrosis of the jaws in ovariectomized rats. Clin Oral Implants Res. 27:1–6. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Thumbigere-Math V, Michalowicz BS, Hodges JS, Tsai ML, Swenson KK, Rockwell L and Gopalakrishnan R: Periodontal disease as a risk factor for bisphosphonate-related osteonecrosis of the jaw. J Periodontol. 85:226–233. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Krimmel M, Ripperger J, Hairass M, Hoefert S, Kluba S and Reinert S: Does dental and oral health influence the development and course of bisphosphonate-related osteonecrosis of the jaws (BRONJ)? Oral Maxillofac Surg. 18:213–218. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Li M, Yu Y, Shi Y, Yuqiong Zhou Y, Zhang W, Hua H, Ge J, Zhang Z, Ye D, Yang C and Wang S: Decreased osteogenic ability of periodontal ligament stem cells leading to impaired periodontal tissue repair in BRONJ patients. Stem Cells Dev. 29:156–168. 2020. View Article : Google Scholar : PubMed/NCBI

13 

Russell RGG, Watts NB, Ebetino FH and Rogers MJ: Mechanisms of action of bisphosphonates: Similarities and differences and their potential influence on clinical efficacy. Osteoporos Int. 19:733–759. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Otto S, Pautke C, Opelz C, Westphal I, Drosse I, Schwager J, Bauss F, Ehrenfeld M and Schieker M: Osteonecrosis of the jaw: Effect of bisphosphonate type, local concentration, and acidic milieu on the pathomechanism. J Oral Maxillofac Surg. 68:2837–2845. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

16 

R Core Team: R: A language and environment for statistical computing. R Foundation for Statistical Computing. (Vienna, Austria). 2019.

17 

Raivo Kolde: Pheatmap: Pretty Heatmaps. R package version 1.0.8. 2018.

18 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Yu G, Wang LG, Han Y and He QY: clusterProfiler: An R package for comparing biological themes among gene clusters. OMICS. 16:284–287. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Chatr-aryamontri A, Oughtred R, Boucher L, Rust J, Chang C, Kolas NK, O'Donnell L, Oster S, Theesfeld C, Sellam A, et al: The BioGRID interaction database: 2017 update. Nucleic Acids Res. 45:D369–D379. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Katz J, Gong Y, Salmasinia D, Hou W, Burkley B, Ferreira P, Casanova O, Langaee TY and Moreb JS: Genetic polymorphisms and other risk factors associated with bisphosphonate induced osteonecrosis of the jaw. Int J Oral Maxillofac Surg. 40:605–611. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Franchi L, Eigenbrod T, Muñoz-Planillo R and Nuñez G: The inflammasome: A caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol. 10:241–247. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Chellaiah MA, Kizer N, Biswas R, Alvarez U, Strauss-Schoenberger J, Rifas L, Rittling SR, Denhardt DT and Hruska KA: Osteopontin deficiency produces osteoclast dysfunction due to reduced CD44 surface expression. Mol Biol Cell. 14:173–189. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Falet H, Pollitt AY, Begonja AJ, Weber SE, Duerschmied D, Wagner DD, Watson SP and Hartwig JH: A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. J Exp Med. 207:1967–1979. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Khosla S, Burr D, Cauley J, Dempster DW, Ebeling PR, Felsenberg D, Gagel RF, Gilsanz V, Guise T, Koka S, et al: Bisphosphonate-associated osteonecrosis of the jaw: Report of a task force of the American Society for bone and mineral research. J Bone Miner Res. 22:1479–1491. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Aghaloo T, Hazboun R and Tetradis S: Pathophysiology of osteonecrosis of the jaws. Oral Maxillofac Surg Clin North Am. 27:489–496. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Lorenzo-Pouso AI, Pérez-Sayáns M, González-Palanca S, Chamorro-Petronacci C, Bagán J and García-García A: Biomarkers to predict the onset of biphosphonate-related osteonecrosis of the jaw: A systematic review. Med Oral Patol Oral Cir Bucal. 24:e26–e36. 2019.PubMed/NCBI

29 

Coleman RE, Major P, Lipton A, Brown JE, Lee KA, Smith M, Saad F, Zheng M, Hei YJ, Seaman J and Cook R: Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid. J Clin Oncol. 23:4925–4935. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B and O'Ryan F; American Association of Oral and Maxillofacial Surgeons, : American association of oral and maxillofacial surgeons position paper on medication-related osteonecrosis of the jaw-2014 update. J Oral Maxillofac Surg. 72:1938–1956. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Allen MR and Burr DB: The pathogenesis of bisphosphonate-related osteonecrosis of the jaw: So many hypotheses, so few data. J Oral Maxillofac Surg. 67 (Suppl 5):S61–S70. 2009. View Article : Google Scholar

32 

Reid IR and Cornish J: Epidemiology and pathogenesis of osteonecrosis of the jaw. Nat Rev Rheumatol. 8:90–96. 2012. View Article : Google Scholar

33 

Zhu X, Ma X and Hu Y: PARP1: A promising target for the development of PARP1-based candidates for anticancer intervention. Curr Med Chem. 23:1756–1774. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Mathis BJ, Lai Y, Qu C, Janicki JS and Cui T: CYLD-mediated signaling and diseases. Curr Drug Targets. 16:284–294. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Wang H, Lai Y, Mathis BJ, Wang W, Li S, Qu C, Li B, Shao L, Song H, Janicki JS, et al: Deubiquitinating enzyme CYLD mediates pressure overload-induced cardiac maladaptive remodeling and dysfunction via downregulating Nrf2. J Mol Cell Cardiol. 84:143–153. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Vriend J and Reiter RJ: Melatonin, bone regulation and the ubiquitin-proteasome connection: A review. Life Sci. 145:152–160. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Rodriguez-Pascual F and Slatter DA: Collagen cross-linking: Insights on the evolution of metazoan extracellular matrix. Sci Rep. 6:373742016. View Article : Google Scholar : PubMed/NCBI

38 

Saito M and Marumo K: Effects of collagen crosslinking on bone material properties in health and disease. Calcif Tissue Int. 97:242–261. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Shi Y, Li M, Yu Y, Zhou Y, Zhang W, Hua H and Wang S: Stress response in periodontal ligament stem cells may contribute to bisphosphonate‑associated osteonecrosis of the jaw: A gene expression array analysis. Mol Med Rep 22: 2043-2051, 2020.
APA
Shi, Y., Li, M., Yu, Y., Zhou, Y., Zhang, W., Hua, H., & Wang, S. (2020). Stress response in periodontal ligament stem cells may contribute to bisphosphonate‑associated osteonecrosis of the jaw: A gene expression array analysis. Molecular Medicine Reports, 22, 2043-2051. https://doi.org/10.3892/mmr.2020.11276
MLA
Shi, Y., Li, M., Yu, Y., Zhou, Y., Zhang, W., Hua, H., Wang, S."Stress response in periodontal ligament stem cells may contribute to bisphosphonate‑associated osteonecrosis of the jaw: A gene expression array analysis". Molecular Medicine Reports 22.3 (2020): 2043-2051.
Chicago
Shi, Y., Li, M., Yu, Y., Zhou, Y., Zhang, W., Hua, H., Wang, S."Stress response in periodontal ligament stem cells may contribute to bisphosphonate‑associated osteonecrosis of the jaw: A gene expression array analysis". Molecular Medicine Reports 22, no. 3 (2020): 2043-2051. https://doi.org/10.3892/mmr.2020.11276
Copy and paste a formatted citation
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Spandidos Publications style
Shi Y, Li M, Yu Y, Zhou Y, Zhang W, Hua H and Wang S: Stress response in periodontal ligament stem cells may contribute to bisphosphonate‑associated osteonecrosis of the jaw: A gene expression array analysis. Mol Med Rep 22: 2043-2051, 2020.
APA
Shi, Y., Li, M., Yu, Y., Zhou, Y., Zhang, W., Hua, H., & Wang, S. (2020). Stress response in periodontal ligament stem cells may contribute to bisphosphonate‑associated osteonecrosis of the jaw: A gene expression array analysis. Molecular Medicine Reports, 22, 2043-2051. https://doi.org/10.3892/mmr.2020.11276
MLA
Shi, Y., Li, M., Yu, Y., Zhou, Y., Zhang, W., Hua, H., Wang, S."Stress response in periodontal ligament stem cells may contribute to bisphosphonate‑associated osteonecrosis of the jaw: A gene expression array analysis". Molecular Medicine Reports 22.3 (2020): 2043-2051.
Chicago
Shi, Y., Li, M., Yu, Y., Zhou, Y., Zhang, W., Hua, H., Wang, S."Stress response in periodontal ligament stem cells may contribute to bisphosphonate‑associated osteonecrosis of the jaw: A gene expression array analysis". Molecular Medicine Reports 22, no. 3 (2020): 2043-2051. https://doi.org/10.3892/mmr.2020.11276
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