Open Access

lncRNA‑MM2P downregulates the production of pro‑inflammatory cytokines in acute gouty arthritis

  • Authors:
    • Xifeng Zhang
    • Ying Zou
    • Jiangxia Zheng
    • Senguo Ji
    • Xiuzhen Wen
    • Feng Ye
    • Ju Liu
    • Xueyong Li
    • Jin Lei
    • Mingliang Qiu
  • View Affiliations

  • Published online on: July 9, 2020     https://doi.org/10.3892/mmr.2020.11314
  • Pages: 2227-2234
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Acute gouty arthritis (AGA) is characterized by the accumulation of pro‑inflammatory cytokines, which are immunological responses to monosodium urate (MSU) crystals. It has been demonstrated that long non‑coding RNA (lncRNA)‑MM2P is a novel regulator of M2 polarization of macrophages. The aim of the present study was to investigate whether lncRNA‑MM2P regulates the MSU‑induced inflammatory process. In cell models of RAW 264.7 and THP‑1‑derived macrophages, decreased expression of lncRNA‑MM2P was observed in lipopolysaccharide‑ and MSU‑treated macrophages, which was accompanied with obvious inflammatory responses. Using small interfering RNA to knockdown lncRNA‑MM2P led to the upregulation of MSU‑mediated inflammatory responses, both in RAW 264.7 and THP‑1‑derived macrophages. In conclusion, lncRNA‑MM2P could be an important regulator of MSU‑induced inflammation, and therefore could be involved in the development of AGA.
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September-2020
Volume 22 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang X, Zou Y, Zheng J, Ji S, Wen X, Ye F, Liu J, Li X, Lei J, Qiu M, Qiu M, et al: lncRNA‑MM2P downregulates the production of pro‑inflammatory cytokines in acute gouty arthritis. Mol Med Rep 22: 2227-2234, 2020.
APA
Zhang, X., Zou, Y., Zheng, J., Ji, S., Wen, X., Ye, F. ... Qiu, M. (2020). lncRNA‑MM2P downregulates the production of pro‑inflammatory cytokines in acute gouty arthritis. Molecular Medicine Reports, 22, 2227-2234. https://doi.org/10.3892/mmr.2020.11314
MLA
Zhang, X., Zou, Y., Zheng, J., Ji, S., Wen, X., Ye, F., Liu, J., Li, X., Lei, J., Qiu, M."lncRNA‑MM2P downregulates the production of pro‑inflammatory cytokines in acute gouty arthritis". Molecular Medicine Reports 22.3 (2020): 2227-2234.
Chicago
Zhang, X., Zou, Y., Zheng, J., Ji, S., Wen, X., Ye, F., Liu, J., Li, X., Lei, J., Qiu, M."lncRNA‑MM2P downregulates the production of pro‑inflammatory cytokines in acute gouty arthritis". Molecular Medicine Reports 22, no. 3 (2020): 2227-2234. https://doi.org/10.3892/mmr.2020.11314