Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September-2020 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2020 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

lncRNA‑MM2P downregulates the production of pro‑inflammatory cytokines in acute gouty arthritis

  • Authors:
    • Xifeng Zhang
    • Ying Zou
    • Jiangxia Zheng
    • Senguo Ji
    • Xiuzhen Wen
    • Feng Ye
    • Ju Liu
    • Xueyong Li
    • Jin Lei
    • Mingliang Qiu
  • View Affiliations / Copyright

    Affiliations: Department of Rheumatism and Immunology of The First People’s Hospital, Jiujiang, Jiangxi 332000, P.R. China, Department of Rheumatology, Xuzhou Hospital of Traditional Chinese Medicine, Xuzhou, Jiangsu 221009, P.R. China, Department of Rheumatology, The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2227-2234
    |
    Published online on: July 9, 2020
       https://doi.org/10.3892/mmr.2020.11314
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Acute gouty arthritis (AGA) is characterized by the accumulation of pro‑inflammatory cytokines, which are immunological responses to monosodium urate (MSU) crystals. It has been demonstrated that long non‑coding RNA (lncRNA)‑MM2P is a novel regulator of M2 polarization of macrophages. The aim of the present study was to investigate whether lncRNA‑MM2P regulates the MSU‑induced inflammatory process. In cell models of RAW 264.7 and THP‑1‑derived macrophages, decreased expression of lncRNA‑MM2P was observed in lipopolysaccharide‑ and MSU‑treated macrophages, which was accompanied with obvious inflammatory responses. Using small interfering RNA to knockdown lncRNA‑MM2P led to the upregulation of MSU‑mediated inflammatory responses, both in RAW 264.7 and THP‑1‑derived macrophages. In conclusion, lncRNA‑MM2P could be an important regulator of MSU‑induced inflammation, and therefore could be involved in the development of AGA.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Cimmino MA, Zampogna G, Parodi M, Andracco R, Barbieri F, Paparo F, Ferrero G and Garlaschi G: MRI synovitis and bone lesions are common in acute gouty arthritis of the wrist even during the first attack. Ann Rheum Dis. 70:2238–2239. 2011. View Article : Google Scholar : PubMed/NCBI

2 

VanItallie TB: Gout: Epitome of painful arthritis. Metabolism. 59 (Suppl 1):S32–S36. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Schauer C, Janko C, Munoz LE, Zhao Y, Kienhöfer D, Frey B, Lell M, Manger B, Rech J, Naschberger E, et al: Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines. Nat Med. 20:511–517. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Manger B, Lell M, Wacker J, Schett G and Rech J: Detection of periarticular urate deposits with dual energy CT in patients with acute gouty arthritis. Ann Rheum Dis. 71:470–472. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Chen YH, Hsieh SC, Chen WY, Li KJ, Wu CH, Wu PC, Tsai CY and Yu CL: Spontaneous resolution of acute gouty arthritis is associated with rapid induction of the anti-inflammatory factors TGFβ1, IL-10 and soluble TNF receptors and the intracellular cytokine negative regulators CIS and SOCS3. Ann Rheum Dis. 70:1655–1663. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Joosten LA, Crişan TO, Azam T, Cleophas MC, Koenders MI, van de Veerdonk FL, Netea MG, Kim S and Dinarello CA: Alpha-1-anti-trypsin-Fc fusion protein ameliorates gouty arthritis by reducing release and extracellular processing of IL-1β and by the induction of endogenous IL-1Ra. Ann Rheum Dis. 75:1219–1227. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Jha AK, Huang SC, Sergushichev A, Lampropoulou V, Ivanova Y, Loginicheva E, Chmielewski K, Stewart KM, Ashall J, Everts B, et al: Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization. Immunity. 42:419–430. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Wang J, Yang Q, Zhang Q, Yin C, Zhou L, Zhou J, Wang Y and Mi QS: Invariant natural killer T cells ameliorate monosodium urate crystal-induced gouty inflammation in mice. Front Immunol. 8:17102017. View Article : Google Scholar : PubMed/NCBI

9 

Liu L, Zhu X, Zhao T, Yu Y, Xue Y and Zou H: Sirt1 ameliorates monosodium urate crystal-induced inflammation by altering macrophage polarization via the PI3K/Akt/STAT6 pathway. Rheumatology (Oxford). 58:1674–1683. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Liu Y, Tang H, Liu X, Chen H, Feng N, Zhang J, Wang C, Qiu M, Yang J and Zhou X: Frontline Science: Reprogramming COX-2, 5-LOX, and CYP4A-mediated arachidonic acid metabolism in macrophages by salidroside alleviates gouty arthritis. J Leukoc Biol. 105:11–24. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Mei J, Zhou F, Qiao H, Li H and Tang T: Nerve modulation therapy in gouty arthritis: Targeting increased sFRP2 expression in dorsal root ganglion regulates macrophage polarization and alleviates endothelial damage. Theranostics. 9:3707–3722. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Cao J, Dong R, Jiang L, Gong Y, Yuan M, You J, Meng W, Chen Z, Zhang N, Weng Q, et al: LncRNA-MM2P Identified as a Modulator of Macrophage M2 Polarization. Cancer Immunol Res. 7:292–305. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Dhanasekar C, Kalaiselvanand S and Rasool M: Morin, a bioflavonoid suppresses monosodium urate crystal-induced inflammatory immune response in RAW 264.7 Macrophages through the inhibition of inflammatory mediators, intracellular ROS levels and NF-kappaB activation. PLoS One. 10:e01450932015. View Article : Google Scholar : PubMed/NCBI

14 

Li H, Ou G, He Y, Ren L, Yang X and Zeng M: Resveratrol attenuates the MSU crystal-induced inflammatory response through the inhibition of TAK1 activity. Int Immunopharmacol. 67:62–68. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Jhang JJ, Cheng YT, Ho CY and Yen GC: Monosodium urate crystals trigger Nrf2-and heme oxygenase-1-dependent inflammation in THP-1 cells. Cell Mol Immunol. 12:424–434. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Liu R, Aupperle K and Terkeltaub R: Src family protein tyrosine kinase signaling mediates monosodium urate crystal-induced IL-8 expression by monocytic THP-1 cells. J Leukoc Biol. 70:961–968. 2001.PubMed/NCBI

17 

Zeng M, Dang W, Chen B, Qing Y, Xie W, Zhao M and Zhou J: IL-37 inhibits the production of pro-inflammatory cytokines in MSU crystal-induced inflammatory response. Clin Rheumatol. 35:2251–2258. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Pisanu A, Lecca D, Mulas G, Wardas J, Simbula G, Spiga S and Carta AR: Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-γagonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson's disease. Neurobiol Dis. 71:280–291. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Oishi S, Takano R, Tamura S, Tani S, Iwaizumi M, Hamaya Y, Takagaki K, Nagata T, et al: M2 polarization of murine peritoneal macrophages induces regulatory cytokine production and suppresses T-cell proliferation. Immunology. 149:320–328. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Chi X, Ding B, Zhang L, Zhang J, Wang J and Zhang W: lncRNA GAS5 promotes M1 macrophage polarization via miR-455-5p/SOCS3 pathway in childhood pneumonia. J Cell Physiol. 234:13242–13251. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Cui H, Banerjee S, Guo S, Xie N, Ge J, Jiang D, Zornig M, Thannickaland VJ and Liu G: Long noncoding RNA Malat1 regulates differential activation of macrophages and response to lung injury. JCI Insight. 4:e1245222019. View Article : Google Scholar

23 

Li N, Liu Y and Cai J: LncRNA MIR155HG regulates M1/M2 macrophage polarization in chronic obstructive pulmonary disease. Biomed Pharmacother. 117:1090152019. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Zou Y, Zheng J, Ji S, Wen X, Ye F, Liu J, Li X, Lei J, Qiu M, Qiu M, et al: lncRNA‑MM2P downregulates the production of pro‑inflammatory cytokines in acute gouty arthritis. Mol Med Rep 22: 2227-2234, 2020.
APA
Zhang, X., Zou, Y., Zheng, J., Ji, S., Wen, X., Ye, F. ... Qiu, M. (2020). lncRNA‑MM2P downregulates the production of pro‑inflammatory cytokines in acute gouty arthritis. Molecular Medicine Reports, 22, 2227-2234. https://doi.org/10.3892/mmr.2020.11314
MLA
Zhang, X., Zou, Y., Zheng, J., Ji, S., Wen, X., Ye, F., Liu, J., Li, X., Lei, J., Qiu, M."lncRNA‑MM2P downregulates the production of pro‑inflammatory cytokines in acute gouty arthritis". Molecular Medicine Reports 22.3 (2020): 2227-2234.
Chicago
Zhang, X., Zou, Y., Zheng, J., Ji, S., Wen, X., Ye, F., Liu, J., Li, X., Lei, J., Qiu, M."lncRNA‑MM2P downregulates the production of pro‑inflammatory cytokines in acute gouty arthritis". Molecular Medicine Reports 22, no. 3 (2020): 2227-2234. https://doi.org/10.3892/mmr.2020.11314
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Zou Y, Zheng J, Ji S, Wen X, Ye F, Liu J, Li X, Lei J, Qiu M, Qiu M, et al: lncRNA‑MM2P downregulates the production of pro‑inflammatory cytokines in acute gouty arthritis. Mol Med Rep 22: 2227-2234, 2020.
APA
Zhang, X., Zou, Y., Zheng, J., Ji, S., Wen, X., Ye, F. ... Qiu, M. (2020). lncRNA‑MM2P downregulates the production of pro‑inflammatory cytokines in acute gouty arthritis. Molecular Medicine Reports, 22, 2227-2234. https://doi.org/10.3892/mmr.2020.11314
MLA
Zhang, X., Zou, Y., Zheng, J., Ji, S., Wen, X., Ye, F., Liu, J., Li, X., Lei, J., Qiu, M."lncRNA‑MM2P downregulates the production of pro‑inflammatory cytokines in acute gouty arthritis". Molecular Medicine Reports 22.3 (2020): 2227-2234.
Chicago
Zhang, X., Zou, Y., Zheng, J., Ji, S., Wen, X., Ye, F., Liu, J., Li, X., Lei, J., Qiu, M."lncRNA‑MM2P downregulates the production of pro‑inflammatory cytokines in acute gouty arthritis". Molecular Medicine Reports 22, no. 3 (2020): 2227-2234. https://doi.org/10.3892/mmr.2020.11314
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team