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Article

Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis

  • Authors:
    • Ruli Li
    • Jianbo Xiao
    • Sufan Tang
    • Xinjing Lin
    • Honglin Xu
    • Bin Han
    • Ming Yang
    • Fu Liu
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China, Department of Medical Imaging, North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China, School of Pharmacy, North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China
  • Pages: 2545-2550
    |
    Published online on: July 10, 2020
       https://doi.org/10.3892/mmr.2020.11327
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Abstract

Ovarian cancer is a serious threat to women's life and health, with a high mortality rate. Therefore, in addition to improving surgery for ovarian cancer, it is particularly important to develop novel drug treatments. In the present study, the anticancer effects of cucurbitacin I, a natural product, were investigated. Cucurbitacin I impaired the viability of SKVO3 cells in a concentration‑ and time‑dependent manner. Apoptosis was involved in the process of cucurbitacin I‑induced cell death, with an increase observed in cleaved‑caspase 3 and BAX, and a decrease in Bcl‑2. Cucurbitacin I caused a notable increase in intracellular reactive oxygen species, and regulated Kelch‑like ECH‑associated protein 1 and nuclear factor erythroid‑derived 2‑like 2 to decrease the expression of antioxidant‑related genes. In addition, Cucurbitacin I induced cell shrinkage by regulating the p190BRhoGAP (p190B)‑Rac1 signaling axis related to the cytoskeleton. In brief, these results suggested that cucurbitacin I induced cell death through oxidative stress and the p190B‑Rac1 signaling axis in SKVO3 cells. The results may provide novel evidence for the treatment of ovarian cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Li R, Xiao J, Tang S, Lin X, Xu H, Han B, Yang M and Liu F: Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis. Mol Med Rep 22: 2545-2550, 2020.
APA
Li, R., Xiao, J., Tang, S., Lin, X., Xu, H., Han, B. ... Liu, F. (2020). Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis. Molecular Medicine Reports, 22, 2545-2550. https://doi.org/10.3892/mmr.2020.11327
MLA
Li, R., Xiao, J., Tang, S., Lin, X., Xu, H., Han, B., Yang, M., Liu, F."Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis". Molecular Medicine Reports 22.3 (2020): 2545-2550.
Chicago
Li, R., Xiao, J., Tang, S., Lin, X., Xu, H., Han, B., Yang, M., Liu, F."Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis". Molecular Medicine Reports 22, no. 3 (2020): 2545-2550. https://doi.org/10.3892/mmr.2020.11327
Copy and paste a formatted citation
x
Spandidos Publications style
Li R, Xiao J, Tang S, Lin X, Xu H, Han B, Yang M and Liu F: Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis. Mol Med Rep 22: 2545-2550, 2020.
APA
Li, R., Xiao, J., Tang, S., Lin, X., Xu, H., Han, B. ... Liu, F. (2020). Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis. Molecular Medicine Reports, 22, 2545-2550. https://doi.org/10.3892/mmr.2020.11327
MLA
Li, R., Xiao, J., Tang, S., Lin, X., Xu, H., Han, B., Yang, M., Liu, F."Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis". Molecular Medicine Reports 22.3 (2020): 2545-2550.
Chicago
Li, R., Xiao, J., Tang, S., Lin, X., Xu, H., Han, B., Yang, M., Liu, F."Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis". Molecular Medicine Reports 22, no. 3 (2020): 2545-2550. https://doi.org/10.3892/mmr.2020.11327
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