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Review Open Access

Cellular senescence: A pathogenic mechanism of pelvic organ prolapse (Review)

  • Authors:
    • Liwei Huang
    • Zhiwei Zhao
    • Jirui Wen
    • Wang Ling
    • Yali Miao
    • Jiang Wu
  • View Affiliations / Copyright

    Affiliations: Deep Underground Space Medical Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2155-2162
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    Published online on: July 13, 2020
       https://doi.org/10.3892/mmr.2020.11339
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Abstract

Pelvic organ prolapse (POP) is a common symptom of pelvic floor disorders which is characterized by the descent of the uterus, bladder or bowel from their normal anatomical position towards or through the vagina. Among the older population, the incidence of POP increases with age. It is becoming necessary to recognize that POP is a degenerative disease that is correlated with age. In recent years, studies have been performed to improve understanding of the cellular and molecular mechanisms concerning senescent fibroblasts in pelvic tissues, which contribute to the loss of structure supporting the pelvic organs. These mechanisms can be classified into gene and mitochondrial dysfunctions, intrinsic senescence processes, protein imbalance and alterations in stem cells. The present review provides an integrated overview of the current research and concepts regarding POP, in addition to discussing how fibroblasts can be targeted to evade the negative impact of senescence on POP. However, it is probable that other mechanisms that can also cause POP exist during cell senescence, which necessitates further research and provides new directions in the development of novel medical treatment, stem cell therapy and non‑surgical interventions for POP.
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Copy and paste a formatted citation
Spandidos Publications style
Huang L, Zhao Z, Wen J, Ling W, Miao Y and Wu J: Cellular senescence: A pathogenic mechanism of pelvic organ prolapse (Review). Mol Med Rep 22: 2155-2162, 2020.
APA
Huang, L., Zhao, Z., Wen, J., Ling, W., Miao, Y., & Wu, J. (2020). Cellular senescence: A pathogenic mechanism of pelvic organ prolapse (Review). Molecular Medicine Reports, 22, 2155-2162. https://doi.org/10.3892/mmr.2020.11339
MLA
Huang, L., Zhao, Z., Wen, J., Ling, W., Miao, Y., Wu, J."Cellular senescence: A pathogenic mechanism of pelvic organ prolapse (Review)". Molecular Medicine Reports 22.3 (2020): 2155-2162.
Chicago
Huang, L., Zhao, Z., Wen, J., Ling, W., Miao, Y., Wu, J."Cellular senescence: A pathogenic mechanism of pelvic organ prolapse (Review)". Molecular Medicine Reports 22, no. 3 (2020): 2155-2162. https://doi.org/10.3892/mmr.2020.11339
Copy and paste a formatted citation
x
Spandidos Publications style
Huang L, Zhao Z, Wen J, Ling W, Miao Y and Wu J: Cellular senescence: A pathogenic mechanism of pelvic organ prolapse (Review). Mol Med Rep 22: 2155-2162, 2020.
APA
Huang, L., Zhao, Z., Wen, J., Ling, W., Miao, Y., & Wu, J. (2020). Cellular senescence: A pathogenic mechanism of pelvic organ prolapse (Review). Molecular Medicine Reports, 22, 2155-2162. https://doi.org/10.3892/mmr.2020.11339
MLA
Huang, L., Zhao, Z., Wen, J., Ling, W., Miao, Y., Wu, J."Cellular senescence: A pathogenic mechanism of pelvic organ prolapse (Review)". Molecular Medicine Reports 22.3 (2020): 2155-2162.
Chicago
Huang, L., Zhao, Z., Wen, J., Ling, W., Miao, Y., Wu, J."Cellular senescence: A pathogenic mechanism of pelvic organ prolapse (Review)". Molecular Medicine Reports 22, no. 3 (2020): 2155-2162. https://doi.org/10.3892/mmr.2020.11339
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