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Article

Artesunate inhibits lung cancer cells via regulation of mitochondrial membrane potential and induction of apoptosis

  • Authors:
    • Yan Zhao
    • Jianghui Liu
    • Liang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology and Head and Neck Surgery, Tumor Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Flow Cytometry Analysis, Tumor Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
  • Pages: 3017-3022
    |
    Published online on: July 15, 2020
       https://doi.org/10.3892/mmr.2020.11341
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Abstract

Lung cancer is a common malignant disease with a high incidence rate worldwide, posing a great threat to human health. To date, only a small number of studies have assessed the potential anti‑cancer effect of artesunate (Art) and the associated mechanisms in lung cancer. The present study aimed to investigate the inhibitory effects of Art in human lung cancer cells and investigated the underlying molecular mechanisms. The inhibitory effect of Art on the growth of A549 lung cancer cells was detected by the MTT assay, and flow cytometry was utilized to determine cell cycle progression, apoptosis, mitochondrial membrane potential, as well as the expression of Bcl‑2 and Bax proteins in A549 cells after Art treatment for 24 h. Art inhibited the growth of A549 cells in a dose‑dependent manner, induced cell apoptosis and cell cycle arrest, decreased the expression of Bcl‑2 protein and mitochondrial membrane potential, and increased the expression of Bax protein. In conclusion, Art significantly inhibited the growth of lung cancer cells by preventing cell cycle progression. This phenomenon indicated its promising therapeutic potential in the treatment of lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao Y, Liu J and Liu L: Artesunate inhibits lung cancer cells via regulation of mitochondrial membrane potential and induction of apoptosis. Mol Med Rep 22: 3017-3022, 2020.
APA
Zhao, Y., Liu, J., & Liu, L. (2020). Artesunate inhibits lung cancer cells via regulation of mitochondrial membrane potential and induction of apoptosis. Molecular Medicine Reports, 22, 3017-3022. https://doi.org/10.3892/mmr.2020.11341
MLA
Zhao, Y., Liu, J., Liu, L."Artesunate inhibits lung cancer cells via regulation of mitochondrial membrane potential and induction of apoptosis". Molecular Medicine Reports 22.4 (2020): 3017-3022.
Chicago
Zhao, Y., Liu, J., Liu, L."Artesunate inhibits lung cancer cells via regulation of mitochondrial membrane potential and induction of apoptosis". Molecular Medicine Reports 22, no. 4 (2020): 3017-3022. https://doi.org/10.3892/mmr.2020.11341
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Y, Liu J and Liu L: Artesunate inhibits lung cancer cells via regulation of mitochondrial membrane potential and induction of apoptosis. Mol Med Rep 22: 3017-3022, 2020.
APA
Zhao, Y., Liu, J., & Liu, L. (2020). Artesunate inhibits lung cancer cells via regulation of mitochondrial membrane potential and induction of apoptosis. Molecular Medicine Reports, 22, 3017-3022. https://doi.org/10.3892/mmr.2020.11341
MLA
Zhao, Y., Liu, J., Liu, L."Artesunate inhibits lung cancer cells via regulation of mitochondrial membrane potential and induction of apoptosis". Molecular Medicine Reports 22.4 (2020): 3017-3022.
Chicago
Zhao, Y., Liu, J., Liu, L."Artesunate inhibits lung cancer cells via regulation of mitochondrial membrane potential and induction of apoptosis". Molecular Medicine Reports 22, no. 4 (2020): 3017-3022. https://doi.org/10.3892/mmr.2020.11341
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