Mannose shows antitumour properties against lung cancer via inhibiting proliferation, promoting cisplatin‑mediated apoptosis and reducing metastasis
- Youyu Wang
- Shenglong Xie
- Bin He
Affiliations: Department of Thoracic Surgery, Sichuan Academy Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610000, P.R. China
- Published online on: July 23, 2020 https://doi.org/10.3892/mmr.2020.11354
Copyright: © Wang
et al. This is an open access article distributed under the
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Commons Attribution License.
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It has been reported that mannose exerts antitumour effects against certain types of cancer. The present study was designed to evaluate whether mannose exerted potential anticancer effects on A549 and H1299 non‑small cell lung cancer (NSCLC) cells in vitro, which has not been reported previously. A Cell Counting Kit‑8 cell viability assay was used to assess the antiproliferative effects of mannose on NSCLC cells. Flow cytometry‑based methods were used to evaluate the effects of mannose on the cell cycle distribution and cisplatin‑mediated apoptosis of NSCLC cells. Transwell migration and invasion assays were conducted to examine whether mannose could inhibit the invasive abilities of NSCLC cells. The effects of mannose on the PI3K/AKT and ERK signalling pathways were explored through western blot analysis assessing the expression of phosphorylated (p)‑AKT and p‑ERK1/2. It was found that mannose showed potential anticancer effects against NSCLC cells in vitro by inhibiting proliferation, inducing G0/G1 cell cycle arrest, promoting cisplatin‑induced apoptosis and decreasing the invasive abilities. These data indicate the potential anticancer properties of mannose and suggest the application of mannose‑based therapies to treat NSCLC.