search button
Open Access

Upregulated lncRNA Pvt1 may be important for cardiac remodeling at the infarct border zone

  • Authors:
    • Baihui Liu
    • Yuanjuan Cheng
    • Jiakun Tian
    • Li Zhang
    • Xiaoqian Cui

  • View Affiliations

  • Published online on: July 28, 2020     https://doi.org/10.3892/mmr.2020.11371
  • Pages: 2605-2616

  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Myocardial infarction (MI) is a leading cause of mortality due to progression to ventricular arrhythmias (VAs) or heart failure (HF). Cardiac remodeling at the infarct border zone (IBZ) is the primary contributor for VAs or HF. Therefore, genes involved in IBZ remodeling may be potential targets for the treatment of MI, but the mechanism remains unclear. The present study aimed to explain the molecular mechanisms of IBZ remodeling based on the roles of long non‑coding RNAs (lncRNAs). After downloading miRNA (GSE76592) and mRNA/lncRNA (GSE52313) datasets from the Gene Expression Omnibus database, 23 differentially expressed miRNAs (DEMs), 2,563 genes (DEGs) and 168 lncRNAs (DELs) were identified between IBZ samples of MI mice and sham controls. A total of 483 DEGs were predicted to be regulated by 23 DEMs, among which Itgam, Met and TNF belonged to hub genes after five topological parameters were calculated for genes in the protein‑protein interaction network. These hub genes‑associated DEMs (mmu‑miR‑181a, mmu‑miR‑762) can also interact with six DELs (Gm15832, Gas5, Gm6634, Pvt1, Gm14636 and A330023F24Rik) to constitute the competing endogenous RNA (ceRNA) axes. Furthermore, a co‑expression network was constructed based on the co‑expression pairs between 44 DELs and 297 DEGs, in which Pvt1 and Bst1 were overlapped with the ceRNA network. Thus, Bst1‑associated ceRNA (Pvt1‑mmu‑miR‑181a‑Bst1) and co‑expression (Pvt‑Bst1) axes were also pivotal for MI. Accordingly, Pvt1 may be a crucial lncRNA for modification of cardiac remodeling in the IBZ after MI and may function by acting as a ceRNA for miR‑181a to regulate TNF/Met/Itgam/Bst1 or by co‑expressing with Bst1.
View Figures
View References

Related Articles

Journal Cover

October-2020
Volume 22 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 3.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 6.9
  • CiteScore Rank: Q2: #98/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.721
  • SCImago Journal Rank (SJR): 0.65
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Liu B, Cheng Y, Tian J, Zhang L and Cui X: Upregulated lncRNA Pvt1 may be important for cardiac remodeling at the infarct border zone. Mol Med Rep 22: 2605-2616, 2020
APA
Liu, B., Cheng, Y., Tian, J., Zhang, L., & Cui, X. (2020). Upregulated lncRNA Pvt1 may be important for cardiac remodeling at the infarct border zone. Molecular Medicine Reports, 22, 2605-2616. https://doi.org/10.3892/mmr.2020.11371
MLA
Liu, B., Cheng, Y., Tian, J., Zhang, L., Cui, X."Upregulated lncRNA Pvt1 may be important for cardiac remodeling at the infarct border zone". Molecular Medicine Reports 22.4 (2020): 2605-2616.
Chicago
Liu, B., Cheng, Y., Tian, J., Zhang, L., Cui, X."Upregulated lncRNA Pvt1 may be important for cardiac remodeling at the infarct border zone". Molecular Medicine Reports 22, no. 4 (2020): 2605-2616. https://doi.org/10.3892/mmr.2020.11371