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Article

Effects of hot‑water extracts from 26 herbs on α‑glucosidase activity

  • Authors:
    • Hidetomo Kikuchi
    • Nana Toyoda
    • Satoko Ezawa
    • Shiori  Yoshida
    • Yasuhide Hibino
    • Katsuyoshi Sunaga
  • View Affiliations / Copyright

    Affiliations: Laboratory of Pharmacotherapy, Clinical Dietetics and Human Nutrition, Master's Program, Josai University Graduate School of Pharmaceutical Sciences, Sakado, Saitama 350‑0295, Japan, SunagaLaboratory of Pharmacotherapy, Clinical Dietetics and Human Nutrition, Master's Program, Josai University Graduate School of Pharmaceutical Sciences, Sakado, Saitama 350‑0295, Japan
  • Pages: 3525-3532
    |
    Published online on: July 31, 2020
       https://doi.org/10.3892/mmr.2020.11397
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Abstract

α‑glucosidase is a key enzyme that plays a role in glucose absorption in the gastrointestinal tract, and the inhibition of its activity induces the prevention of postprandial hyperglycemia. Several α‑glucosidase inhibitors have been used as medicines for type 2 diabetes, but a similar effect is observed in natural resources, including traditional herbs and their phytochemicals. To identify the presence of the α‑glucosidase inhibitory activity in herbs, in which various functional effects have been known to occur, the present study investigated the effects of hot‑water extracts of 26 types of herbs on α‑glucosidase activity in an in vitro assay. The results indicated significant increases in the inhibition of α‑glucosidase activity in 1,000 µg/ml olive (P<0.01), white willow (P<0.01) and red rooibos hot‑water extracts. Furthermore, ≥50% inhibition of α‑glucosidase activity was determined to be significant in 1,000 µg/ml coltsfoot, green tea and bearberry hot‑water extracts. In addition, the effects of bearberry, green tea and coltsfoot hot‑water extracts on α‑glucosidase activity in vivo were evaluated according to the blood glucose levels (BGLs) in maltose and glucose load model rats. It was indicated that the administration of these three herb extracts significantly reduced the increasing BGLs after maltose loading until 0.5 h compared with the control group. However, only coltsfoot extract significantly reduced the increasing BGLs after glucose loading until 0.5 h compared with the control group. Thus, the present results may facilitate the understanding of a novel functionality in traditional herbs, which could be useful for the prevention of disease onset and progression, such as in hyperglycemia and type 2 diabetes.
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Copy and paste a formatted citation
Spandidos Publications style
Kikuchi H, Toyoda N, Ezawa S, Yoshida S, Hibino Y and Sunaga K: Effects of hot‑water extracts from 26 herbs on α‑glucosidase activity. Mol Med Rep 22: 3525-3532, 2020.
APA
Kikuchi, H., Toyoda, N., Ezawa, S., Yoshida, S., Hibino, Y., & Sunaga, K. (2020). Effects of hot‑water extracts from 26 herbs on α‑glucosidase activity. Molecular Medicine Reports, 22, 3525-3532. https://doi.org/10.3892/mmr.2020.11397
MLA
Kikuchi, H., Toyoda, N., Ezawa, S., Yoshida, S., Hibino, Y., Sunaga, K."Effects of hot‑water extracts from 26 herbs on α‑glucosidase activity". Molecular Medicine Reports 22.4 (2020): 3525-3532.
Chicago
Kikuchi, H., Toyoda, N., Ezawa, S., Yoshida, S., Hibino, Y., Sunaga, K."Effects of hot‑water extracts from 26 herbs on α‑glucosidase activity". Molecular Medicine Reports 22, no. 4 (2020): 3525-3532. https://doi.org/10.3892/mmr.2020.11397
Copy and paste a formatted citation
x
Spandidos Publications style
Kikuchi H, Toyoda N, Ezawa S, Yoshida S, Hibino Y and Sunaga K: Effects of hot‑water extracts from 26 herbs on α‑glucosidase activity. Mol Med Rep 22: 3525-3532, 2020.
APA
Kikuchi, H., Toyoda, N., Ezawa, S., Yoshida, S., Hibino, Y., & Sunaga, K. (2020). Effects of hot‑water extracts from 26 herbs on α‑glucosidase activity. Molecular Medicine Reports, 22, 3525-3532. https://doi.org/10.3892/mmr.2020.11397
MLA
Kikuchi, H., Toyoda, N., Ezawa, S., Yoshida, S., Hibino, Y., Sunaga, K."Effects of hot‑water extracts from 26 herbs on α‑glucosidase activity". Molecular Medicine Reports 22.4 (2020): 3525-3532.
Chicago
Kikuchi, H., Toyoda, N., Ezawa, S., Yoshida, S., Hibino, Y., Sunaga, K."Effects of hot‑water extracts from 26 herbs on α‑glucosidase activity". Molecular Medicine Reports 22, no. 4 (2020): 3525-3532. https://doi.org/10.3892/mmr.2020.11397
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