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Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury

  • Authors:
    • Changwei Zou
    • Hong Yang
    • Lanyue Cui
    • Xinyi Cao
    • Hong Huang
    • Tingtao Chen
  • View Affiliations / Copyright

    Affiliations: School of Resources Environmental and Chemical Engineering, Key Laboratory of Poyang Lake Environment and Resource Utilization, Ministry of Education, Nanchang University, Nanchang, Jiangxi 330031, P.R. China, Nanchang University Queen Mary School, Nanchang, Jiangxi 330031, P.R. China, National Engineering Research Center for Bioengineering Drugs and The Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330031, P.R. China
    Copyright: © Zou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3213-3224
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    Published online on: July 31, 2020
       https://doi.org/10.3892/mmr.2020.11399
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Abstract

There have been few studies investigating the potential effects of indoor sources of particulate matter on human health. In this study, the effect of different concentrations of fine particulate matter (PM2.5) collected from a printing room on lung health was examined using cultured cells and a mouse model. Further, the mechanism of lung injury was examined. The results indicated that PM2.5 significantly enhanced malondialdehyde activity (P<0.05), decreased superoxide dismutase activity (P<0.05), upregulated the expression of pro‑inflammatory factors including interleukin (IL)‑1β, tumor necrosis factor‑, IL‑6 and downregulated the expression of the inflammatory factor IL‑2 (P<0.05). Western blot analysis indicated that PM2.5 significantly enhanced expression of phosphorylated (p)‑ERK relative to total ERK, cyclooxygenase‑2, p‑anti‑nuclear‑factor‑κB (p‑NF‑κB) relative to NF‑κB, transforming growth factor‑β1 and Bax relative to Bcl‑2 in inflammation (P<0.05), fibrosis and apoptosis signaling pathways. Furthermore, the results revealed that exposure was associated with an increased abundance of pathogens including Burkholderiales, Coriobacteriia, and Betaproteobacteria in in the lungs. In conclusion, exposure to PM2.5 from a printing room significantly increased inflammation, fibrosis, apoptosis and the abundance of pathogenic bacteria, indicating that exposure is potential threat to individuals who spend a significant amount of time in printing rooms.
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Copy and paste a formatted citation
Spandidos Publications style
Zou C, Yang H, Cui L, Cao X, Huang H and Chen T: Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury. Mol Med Rep 22: 3213-3224, 2020.
APA
Zou, C., Yang, H., Cui, L., Cao, X., Huang, H., & Chen, T. (2020). Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury. Molecular Medicine Reports, 22, 3213-3224. https://doi.org/10.3892/mmr.2020.11399
MLA
Zou, C., Yang, H., Cui, L., Cao, X., Huang, H., Chen, T."Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury". Molecular Medicine Reports 22.4 (2020): 3213-3224.
Chicago
Zou, C., Yang, H., Cui, L., Cao, X., Huang, H., Chen, T."Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury". Molecular Medicine Reports 22, no. 4 (2020): 3213-3224. https://doi.org/10.3892/mmr.2020.11399
Copy and paste a formatted citation
x
Spandidos Publications style
Zou C, Yang H, Cui L, Cao X, Huang H and Chen T: Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury. Mol Med Rep 22: 3213-3224, 2020.
APA
Zou, C., Yang, H., Cui, L., Cao, X., Huang, H., & Chen, T. (2020). Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury. Molecular Medicine Reports, 22, 3213-3224. https://doi.org/10.3892/mmr.2020.11399
MLA
Zou, C., Yang, H., Cui, L., Cao, X., Huang, H., Chen, T."Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury". Molecular Medicine Reports 22.4 (2020): 3213-3224.
Chicago
Zou, C., Yang, H., Cui, L., Cao, X., Huang, H., Chen, T."Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury". Molecular Medicine Reports 22, no. 4 (2020): 3213-3224. https://doi.org/10.3892/mmr.2020.11399
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