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Docosahexaenoic acid inhibits vascular smooth muscle cell migration and proliferation by decreasing microRNA‑155 expression levels

  • Authors:
    • Xiaoliang Yin
    • Chunbo Xu
    • Qiyang Xu
    • Dehai Lang
  • View Affiliations / Copyright

    Affiliations: Department of Vascular Surgery, Hwa Mei Hospital, University of Chinese Academy of Sciences (Ningbo No. 2 Hospital), Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, Zhejiang 315010, P.R. China
    Copyright: © Yin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3396-3404
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    Published online on: August 3, 2020
       https://doi.org/10.3892/mmr.2020.11404
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Abstract

Vascular smooth muscle cell (VSMC) hyperplasia is a common cause of carotid restenosis. In the present study, the potential protective effects of docosahexaenoic acid (DHA) in carotid restenosis and the underlying mechanism of its effects were examined. VSMCs were treated with DHA, a polyunsaturated ω‑3 fatty acid. Cell migration and proliferation were assessed using wound healing and Cell Counting Kit‑8 assays and by measuring Ki‑67 protein levels. Additionally, the expression levels of microRNA‑155 were determined by reverse transcription‑quantitative PCR (RT‑qPCR). The involvement of microRNA‑155 in the regulation of migration and proliferation was evaluated by transfecting VSMCs with microRNA mimics and inhibitors. Moreover, the reversal of migration and proliferation after transfection of VSMCs with the microRNA mimics and subsequent treatment with DHA was investigated. A target gene of microRNA‑155 was identified using RT‑qPCR and luciferase assays. The migration and proliferation of VSMCs, as well as the expression of microRNA‑155 was inhibited by DHA stimulation. MicroRNA‑155 regulated the migration and proliferation of VSMCs. Finally, proliferation and migration of VSMCs were reduced following DHA treatment, which was mediated by an increase in the expression levels of microRNA‑155. Suppressor of cytokine signalling 1 (Socs1) was the target gene of microRNA‑155. In conclusion, DHA inhibited VSMC migration and proliferation by reducing microRNA‑155 expression. This effect may be caused by the microRNA‑155 target gene Socs1.
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View References

1 

Bonati LH, Ederle J, Dobson J, Engelter S, Featherstone RL, Gaines PA, Beard JD, Venables GS, Markus HS, Clifton A, et al: Length of carotid stenosis predicts peri-procedural stroke or death and restenosis in patients randomized to endovascular treatment or endarterectomy. Int J Stroke. 9:3396–305. 2014. View Article : Google Scholar

2 

Plummer C, Henderson RD, O'Sullivan JD and Read SJ: Ischemic stroke and transient ischemic attack after head and neck radiotherapy: A review. Stroke. 42:2410–2418. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Schunck WH, Konkel A, Fischer R and Weylandt KH: Therapeutic potential of omega-3 fatty acid-derived epoxyeicosanoids in cardiovascular and inflammatory diseases. Pharmacol Ther. 183:177–204. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Iverson C, Bacong A, Liu S, Baumgartner S, Lundstrom T, Oscarsson J and Miner JN: Omega-3-carboxylic acids provide efficacious anti-inflammatory activity in models of crystal-mediated inflammation. Sci Rep. 8:12172018. View Article : Google Scholar : PubMed/NCBI

5 

Trattner S, Ruyter B, Ostbye TK, Kamal-Eldin A, Moazzami A, Pan J, Gjoen T, Brännäs E, Zlabek V and Pickova J: Influence of dietary sesamin, a bioactive compound on fatty acids and expression of some lipid regulating genes in Baltic Atlantic salmon (Salmo salar L.) juveniles. Physiol Res. 60:125–137. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Hirafuji M, Machida T, Tsunoda M, Miyamoto A and Minami M: Docosahexaenoic acid potentiates interleukin-1beta induction of nitric oxide synthase through mechanism involving p44/42 MAPK activation in rat vascular smooth muscle cells. Br J Pharmacol. 136:613–619. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Zhang J, Zhao F, Yu X, Lu X and Zheng G: MicroRNA-155 modulates the proliferation of vascular smooth muscle cells by targeting endothelial nitric oxide synthase. Int J Mol Med. 35:1708–1714. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Delbosc S, Glorian M, Le Port AS, Bereziat G, Andreani M and Limon I: The benefit of docosahexanoic acid on the migration of vascular smooth muscle cells is partially dependent on Notch regulation of MMP-2/-9. Am J Pathol. 172:1430–1440. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Terano T, Tanaka T, Tamura Y, Kitagawa M, Higashi H, Saito Y and Hirai A: Eicosapentaenoic acid and docosahexaenoic acid inhibit vascular smooth muscle cell proliferation by inhibiting phosphorylation of Cdk2-cyclinE complex. Biochem Biophys Res Commun. 254:502–506. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Newell M, Baker K, Postovit LM and Field CJ: A critical review on the effect of docosahexaenoic acid (DHA) on cancer cell cycle progression. Int J Mol Sci. 18:17842017. View Article : Google Scholar

11 

Rani K and Aung NY: Docosahexaenoic acid inhibits vascular smooth muscle cell proliferation induced by glucose variability. Open Biochem J. 11:56–65. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Oono K, Takahashi K, Sukehara S, Kurosawa H, Matsumura T, Taniguchi S and Ohta S: Inhibition of PC3 human prostate cancer cell proliferation, invasion and migration by eicosapentaenoic acid and docosahexaenoic acid. Mol Clin Oncol. 7:217–220. 2017.PubMed/NCBI

13 

Geng L, Zhou W, Liu B, Wang X and Chen B: DHA induces apoptosis of human malignant breast cancer tissues by the TLR-4/PPAR-α pathways. Oncol Lett. 15:2967–2977. 2018.PubMed/NCBI

14 

Sun Y, Wang K, Ye P, Wu J, Ren L, Zhang A, Huang X, Deng P, Wu C, Yue Z, et al: MicroRNA-155 promotes the directional migration of resident smooth muscle progenitor cells by regulating monocyte chemoattractant protein 1 in transplant arteriosclerosis. Arterioscler Thromb Vasc Biol. 36:1230–1239. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Li X, Kong D, Chen H, Liu S, Hu H, Wu T, Wang J, Chen W, Ning Y, Li Y and Lu Z: miR-155 acts as an anti-inflammatory factor in atherosclerosis-associated foam cell formation by repressing calcium-regulated heat stable protein 1. Sci Rep. 6:217892016. View Article : Google Scholar : PubMed/NCBI

16 

Jin C, Cheng L, Lu X, Xie T, Wu H and Wu N: Elevated expression of miR-155 is associated with the differentiation of CD8+ T cells in patients with HIV-1. Mol Med Rep. 16:1584–1589. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Pacurari M and Tchounwou PB: Role of MicroRNAs in renin-angiotensin-aldosterone system-mediated cardiovascular inflammation and remodeling. Int J Inflam. 2015:1015272015. View Article : Google Scholar : PubMed/NCBI

18 

Izzard L, Dlugolenski D, Xia Y, McMahon M, Middleton D, Tripp RA and Stambas J: Enhanced immunogenicity following miR-155 incorporation into the influenza a virus genome. Virus Res. 235:115–120. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Heymans S, Corsten MF, Verhesen W, Carai P, van Leeuwen RE, Custers K, Peters T, Hazebroek M, Stöger L, Wijnands E, et al: Macrophage microRNA-155 promotes cardiac hypertrophy and failure. Circulation. 128:1420–1432. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Bhattacharya S, Chalk AM, Ng AJ, Martin TJ, Zannettino AC, Purton LE, Lu J, Baker EK and Walkley CR: Increased miR-155-5p and reduced miR-148a-3p contribute to the suppression of osteosarcoma cell death. Oncogene. 35:5282–5294. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Ji Y, Wrzesinski C, Yu Z, Hu J, Gautam S, Hawk NV, Telford WG, Palmer DC, Franco Z, Sukumar M, et al: miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic gammac cytokines. Proc Natl Acad Sci USA. 112:476–481. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Kim S, Lee E, Jung J, Lee JW, Kim HJ, Kim J, Yoo HJ, Lee HJ, Chae SY, Jeon SM, et al: microRNA-155 positively regulates glucose metabolism via PIK3R1-FOXO3a-cMYC axis in breast cancer. Oncogene. 37:2982–2991. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Yang LX, Liu G, Zhu GF, Liu H, Guo RW, Qi F and Zou JH: MicroRNA-155 inhibits angiotensin II-induced vascular smooth muscle cell proliferation. J Renin Angiotensin Aldosterone Syst. 15:109–116. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Zhang G, Zhong L, Luo H and Wang S: MicroRNA-155-3p promotes breast cancer progression through down-regulating CADM1. Onco Targets Ther. 12:7993–8002. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Wang CR, Zhu HF and Zhu Y: Knockout of microRNA-155 ameliorates the Th17/Th9 immune response and promotes wound healing. Curr Med Sci. 39:954–964. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Knolle MD, Chin SB, Rana BMJ, Englezakis A, Nakagawa R, Fallon PG, Git A and McKenzie ANJ: MicroRNA-155 protects group 2 innate lymphoid cells from apoptosis to promote type-2 immunity. Front Immunol. 9:22322018. View Article : Google Scholar : PubMed/NCBI

28 

Saleh M, Friedl A, Srivastava M, Soliman H, Secombes CJ and El-Matbouli M: STAT3/SOCS3 axis contributes to the outcome of salmonid whirling disease. PLoS One. 15:e02344792020. View Article : Google Scholar : PubMed/NCBI

29 

Oono K, Ohtake K, Watanabe C, Shiba S, Sekiya T and Kasono K: Contribution of Pyk2 pathway and reactive oxygen species (ROS) to the anti-cancer effects of eicosapentaenoic acid (EPA) in PC3 prostate cancer cells. Lipids Health Dis. 19:152020. View Article : Google Scholar : PubMed/NCBI

30 

Watanabe Y and Tatsuno I: Prevention of cardiovascular events with omega-3 polyunsaturated fatty acids and the mechanism involved. J Atheroscler Thromb. 27:183–198. 2020. View Article : Google Scholar : PubMed/NCBI

31 

Farina FM, Hall IF, Serio S, Zani S, Climent M, Salvarani N, Carullo P, Civilini E, Condorelli G, Elia L and Quintavalle M: miR-128-3p is a novel regulator of vascular smooth muscle cell phenotypic switch and vascular diseases. Circ Res. 126:e120–e135. 2020. View Article : Google Scholar : PubMed/NCBI

32 

Nakagawa I, Park HS, Yokoyama S, Wada T, Yamada S, Motoyama Y, Kichikawa K and Nakase H: Pretreatment with and ongoing use of omega-3 fatty acid ethyl esters reduce the slow-flow phenomenon and prevent in-stent restenosis in patients undergoing carotid artery stenting. J Vasc Surg. 66:122–129. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Ding X, Ge L, Yan A, Ding Y, Tao J, Liu Q and Qiao C: Docosahexaenoic acid serving as sensitizing agents and gefitinib resistance revertants in EGFR targeting treatment. Onco Targets Ther. 12:10547–10558. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Song TJ, Chang Y, Shin MJ, Heo JH and Kim YJ: Low levels of plasma omega 3-polyunsaturated fatty acids are associated with cerebral small vessel diseases in acute ischemic stroke patients. Nutr Res. 35:368–374. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Morin C, Rousseau E, Blier PU and Fortin S: Effect of docosahexaenoic acid monoacylglyceride on systemic hypertension and cardiovascular dysfunction. Am J Physiol Heart Circ Physiol. 309:H93–H102. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Yee D, Shah KM, Coles MC, Sharp TV and Lagos D: MicroRNA-155 induction via TNF-α and IFN-γ suppresses expression of programmed death ligand-1 (PD-L1) in human primary cells. J Biol Chem. 292:20683–20693. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Xu L and Leng H, Shi X, Ji J, Fu J and Leng H: miR-155 promotes cell proliferation and inhibits apoptosis by PTEN signaling pathway in the psoriasis. Biomed Pharmacother. 90:524–530. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Seok HY, Chen J, Kataoka M, Huang ZP, Ding J, Yan J, Hu X and Wang DZ: Loss of MicroRNA-155 protects the heart from pathological cardiac hypertrophy. Circ Res. 114:1585–1595. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Wang J, Yu F, Jia X, Iwanowycz S, Wang Y, Huang S, Ai W and Fan D: MicroRNA-155 deficiency enhances the recruitment and functions of myeloid-derived suppressor cells in tumor microenvironment and promotes solid tumor growth. Int J Cancer. 136:E602–E613. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Wan YC, Li T, Han YD, Zhang HY, Lin H and Zhang B: MicroRNA-155 enhances the activation of Wnt/β-catenin signaling in colorectal carcinoma by suppressing HMG-box transcription factor 1. Mol Med Rep. 13:2221–2228. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Tu YX, Wang SB, Fu LQ, Li SS, Guo QP, Wu Y, Mou XZ and Tong XM: Ovatodiolide targets chronic myeloid leukemia stem cells by epigenetically upregulating hsa-miR-155, suppressing the BCR-ABL fusion gene and dysregulating the PI3K/AKT/mTOR pathway. Oncotarget. 9:3267–3277. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Zhang L, Wang W, Li X, He S, Yao J, Wang X, Zhang D and Sun X: MicroRNA-155 promotes tumor growth of human hepatocellular carcinoma by targeting ARID2. Int J Oncol. 48:2425–2434. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Liu D, Han P, Gao C, Gao W, Yao X and Liu S: microRNA-155 modulates hepatic stellate cell proliferation, apoptosis, and cell cycle progression in rats with alcoholic hepatitis via the MAPK signaling pathway through targeting SOCS1. Front Pharmacol. 11:2702020. View Article : Google Scholar : PubMed/NCBI

44 

Chen L, Ming X, Li W, Bi M, Yan B, Wang X, Yang P and Yang B: The microRNA-155 mediates hepatitis B virus replication by reinforcing SOCS1 signalling-induced autophagy. Cell Biochem Funct. 38:436–442. 2020. View Article : Google Scholar : PubMed/NCBI

45 

Ye J, Guo R, Shi Y, Qi F, Guo C and Yang L: miR-155 regulated inflammation response by the SOCS1-STAT3-PDCD4 axis in Atherogenesis. Mediators Inflamm. 2016:80601822016. View Article : Google Scholar : PubMed/NCBI

46 

Yang Y, Yang L, Liang X and Zhu G: MicroRNA-155 promotes atherosclerosis inflammation via targeting SOCS1. Cell Physiol Biochem. 36:1371–1381. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Bouamar H, Jiang D, Wang L, Lin AP, Ortega M and Aguiar RC: MicroRNA 155 control of p53 activity is context dependent and mediated by Aicda and Socs1. Mol Cell Biol. 35:1329–1340. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yin X, Xu C, Xu Q and Lang D: Docosahexaenoic acid inhibits vascular smooth muscle cell migration and proliferation by decreasing microRNA‑155 expression levels. Mol Med Rep 22: 3396-3404, 2020.
APA
Yin, X., Xu, C., Xu, Q., & Lang, D. (2020). Docosahexaenoic acid inhibits vascular smooth muscle cell migration and proliferation by decreasing microRNA‑155 expression levels. Molecular Medicine Reports, 22, 3396-3404. https://doi.org/10.3892/mmr.2020.11404
MLA
Yin, X., Xu, C., Xu, Q., Lang, D."Docosahexaenoic acid inhibits vascular smooth muscle cell migration and proliferation by decreasing microRNA‑155 expression levels". Molecular Medicine Reports 22.4 (2020): 3396-3404.
Chicago
Yin, X., Xu, C., Xu, Q., Lang, D."Docosahexaenoic acid inhibits vascular smooth muscle cell migration and proliferation by decreasing microRNA‑155 expression levels". Molecular Medicine Reports 22, no. 4 (2020): 3396-3404. https://doi.org/10.3892/mmr.2020.11404
Copy and paste a formatted citation
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Spandidos Publications style
Yin X, Xu C, Xu Q and Lang D: Docosahexaenoic acid inhibits vascular smooth muscle cell migration and proliferation by decreasing microRNA‑155 expression levels. Mol Med Rep 22: 3396-3404, 2020.
APA
Yin, X., Xu, C., Xu, Q., & Lang, D. (2020). Docosahexaenoic acid inhibits vascular smooth muscle cell migration and proliferation by decreasing microRNA‑155 expression levels. Molecular Medicine Reports, 22, 3396-3404. https://doi.org/10.3892/mmr.2020.11404
MLA
Yin, X., Xu, C., Xu, Q., Lang, D."Docosahexaenoic acid inhibits vascular smooth muscle cell migration and proliferation by decreasing microRNA‑155 expression levels". Molecular Medicine Reports 22.4 (2020): 3396-3404.
Chicago
Yin, X., Xu, C., Xu, Q., Lang, D."Docosahexaenoic acid inhibits vascular smooth muscle cell migration and proliferation by decreasing microRNA‑155 expression levels". Molecular Medicine Reports 22, no. 4 (2020): 3396-3404. https://doi.org/10.3892/mmr.2020.11404
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