Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
October-2020 Volume 22 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2020 Volume 22 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Competing endogenous RNA network analysis for screening inflammation‑related long non‑coding RNAs for acute ischemic stroke

  • Authors:
    • Li Zhang
    • Baihui Liu
    • Jinhua Han
    • Tingting Wang
    • Lin Han
  • View Affiliations / Copyright

    Affiliations: Department of Emergency Medicine, The Second Hospital of Jilin University, Chuangchun, Jilin 130041, P.R. China, Department of Radiotherapy, The Second Hospital of Jilin University, Chuangchun, Jilin 130041, P.R. China, Department of Tumor Hematology, The Second Hospital of Jilin University, Chuangchun, Jilin 130041, P.R. China, Internal Medicine‑Neurology, China‑Japan Union Hospital of Jilin University, Chuangchun, Jilin 130033, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3081-3094
    |
    Published online on: August 4, 2020
       https://doi.org/10.3892/mmr.2020.11415
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Long non‑coding RNAs (lncRNAs) represent potential biomarkers for the diagnosis and treatment of various diseases; however, the role of circulating acute ischemic stroke (AIS)‑related lncRNAs remains relatively unknown. The present study aimed to screen crucial lncRNAs for AIS based on the competing endogenous RNA (ceRNA) hypothesis. The expression profile datasets for one mRNA, accession no. GSE16561, and four microRNAs (miRNAs), accession nos. GSE95204, GSE86291, GSE55937 and GSE110993, were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs), lncRNAs (DELs), and miRNAs (DEMs) were identified, and ClusterProfiler was used to interpret the function of the DEGs. Based on the protein‑protein interaction (PPI) network and module analyses, hub DEGs were identified. A ceRNA network was established based on miRNA‑mRNA or miRNA‑lncRNA interaction pairs. In total, 2,041 DEGs and 5 DELs were identified between the AIS and controls samples in GSE16561, and 10 DEMs between at least two of the four miRNA expression profiles. A PPI network was constructed with 1,235 DEGs, among which 20 genes were suggested to be hub genes. The hub genes paxillin (PXN), FYN‑proto‑oncogene, Src family tyrosine kinase (FYN), ras homolog family member A (RHOA), STAT1, and growth factor receptor‑bound protein 2 (GRB2), were amongst the most significantly enriched modules extracted from the PPI network. Functional analysis revealed that these hub genes were associated with inflammation‑related signaling pathways. An AIS‑related ceRNA network was constructed, in which 4 DELs were predicted to function as ceRNAs for 9 DEMs, to regulate the five identified hub genes; that is, minichromosome maintenance complex component 3 associated protein‑antisense RNA 1 (MCM3AP‑AS1)/long intergenic non‑protein coding RNA 1089 (LINC01089)/hsa‑miRNA (miR)‑125a/FYN, inositol‑tetrakisphosphate 1‑kinase‑antisense RNA 1 (ITPK1‑AS1)/hsa‑let‑7i/RHOA/GRB2/STAT1, and human leukocyte antigen complex group 27 (HCG27)/hsa‑­miR‑19a/PXN interaction axes. In conclusion, MCM3AP‑AS1, LINC01089, ITPK1‑AS1, and HCG27 may represent new biomarkers and underlying targets for the treatment of AIS.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, Moran AE, Sacco RL, Anderson L, Truelsen T, et al: Global and regional burden of stroke during 1990–2010: Findings from the Global Burden of disease study 2010. Lancet. 383:3081–255. 2014. View Article : Google Scholar

2 

Boldsen JK, Engedal TS, Pedraza S, Cho TH, Thomalla G, Nighoghossian N, Baron JC, Fiehler J, Østergaard L and Mouridsen K: Better diffusion segmentation in acute ischemic stroke through automatic tree learning anomaly segmentation. Front Neuroinform. 12:212018. View Article : Google Scholar : PubMed/NCBI

3 

Cassella CR and Jagoda A: Ischemic Stroke: Advances in diagnosis and management. Emerg Med Clin North Am. 35:911–930. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Hasan TF, Rabinstein AA, Middlebrooks EH, Haranhalli N, Silliman SL, Meschia JF and Tawk RG: Diagnosis and management of acute ischemic stroke. Mayo Clin Proc. 93:523–538. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Adams BD, Parsons C, Walker L, Zhang WC and Slack FJ: Targeting noncoding RNAs in disease. J Clin Invest. 127:761–771. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Zhu M, Li N, Luo P, Jing W, Wen X, Liang C and Tu J: Peripheral blood leukocyte expression of lncRNA MIAT and its diagnostic and prognostic value in ischemic stroke. J Stroke Cerebrovasc Dis. 27:326–337. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Feng L, Guo J and Ai F: Circulating long noncoding RNA ANRIL downregulation correlates with increased risk, higher disease severity and elevated pro-inflammatory cytokines in patients with acute ischemic stroke. J Clin Lab Anal. 33:e226292019. View Article : Google Scholar : PubMed/NCBI

8 

Deng QW, Li S, Wang H, Sun HL, Zuo L, Gu ZT, Lu G, Sun CZ, Zhang HQ and Yan FL: Differential long noncoding RNA expressions in peripheral blood mononuclear cells for detection of acute ischemic stroke. Clin Sci. 132:1597–1614. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Sheng Y, Ma J, Zhao J, Qi S, Hu R and Yang Q: Differential expression patterns of specific long noncoding RNAs and competing endogenous RNA network in alopecia areata. J Cell Biochem. 120:10737–10747. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Guo X, Yang J, Liang B, Shen T, Yan Y, Huang S, Zhou J, Huang J, Gu L and Su L: Identification of novel LncRNA biomarkers and construction of LncRNA-related networks in Han Chinese patients with ischemic stroke. Cell Physiol Biochem. 50:2157–2175. 2018. View Article : Google Scholar : PubMed/NCBI

11 

He W, Wei D, Chen S, Li S and Chen W: Altered long non-coding RNA transcriptomic profiles in ischemic stroke. Hum Gene Ther. 29:719–732. 2017. View Article : Google Scholar

12 

Tiedt S, Prestel M, Malik R, Schieferdecker N, Duering M, Kautzky V, Stoycheva I, Böck J, Northoff BH, Klein M, et al: RNA-Seq identifies circulating miR-125a-5p, miR-125b-5p and miR-143-3p as potential biomarkers for acute ischemic stroke. Circ Res. 121:970–980. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Tian C, Li Z, Yang Z, Huang Q, Liu J and Hong B: Plasma MicroRNA-16 is a biomarker for diagnosis, stratification, and prognosis of hyperacute cerebral infarction. PLoS One. 11:e01666882016. View Article : Google Scholar : PubMed/NCBI

14 

Jickling GC, Ander BP, Xinhua Z, Dylan N, Boryana S and Dazhi L: microRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets. PLoS One. 9:e992832014. View Article : Google Scholar : PubMed/NCBI

15 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

16 

Chen S, Yanqing Z, Yaru C and Jia G: Fastp: An ultra-fast all-in-one FASTQ preprocessor. Bioinformatics. 34:i884–i890. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Li B and Dewey CN: RSEM: Accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinformatics. 12:3232011. View Article : Google Scholar : PubMed/NCBI

18 

Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, et al: STRING v10: Protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 43((Database Issue)): D447–D452. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Tang Y, Li M, Wang J, Pan Y and Wu FX: CytoNCA: A cytoscape plugin for centrality analysis and evaluation of protein interaction networks. Biosystems. 127:67–72. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Bader GD and Hogue CW: An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics. 4:22003. View Article : Google Scholar : PubMed/NCBI

21 

Ashwini J, Marks DS and Erik L: miRcode: A map of putative microRNA target sites in the long non-coding transcriptome. Bioinformatics. 28:2062–2063. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Li JH, Liu S, Zhou H, Qu LH and Yang JH: starBase v2.0: Decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res. 42((Database Issue)): D92–D97. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Paraskevopoulou MD, Georgakilas G, Kostoulas N, Reczko M, Maragkakis M, Dalamagas TM and Hatzigeorgiou AG: DIANA-LncBase: Experimentally verified and computationally predicted microRNA targets on long non-coding RNAs. Nucleic Acids Res. 41((Database Issue)): D239–D245. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Dweep H and Gretz N: miRWalk2. 0: A comprehensive atlas of microRNA-target interactions. Nat Methods. 12:6972015. View Article : Google Scholar : PubMed/NCBI

25 

Jin R, Liu L, Zhang S, Nanda A and Li G: Role of inflammation and its mediators in acute ischemic stroke. J Cardiovasc Transl Res. 6:834–851. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Dziedzic T: Systemic inflammation as a therapeutic target in acute ischemic stroke. Expert Rev Neurother. 15:523–531. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Akella A, Bhattarai S and Dharap A: Long noncoding RNAs in the pathophysiology of ischemic stroke. Neuromolecular Med. 21:474–483. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Zhang X, Zhu XL, Ji BY, Cao X, Yu LJ, Zhang Y, Bao XY, Xu Y and Jin JL: LncRNA-1810034E14Rik reduces microglia activation in experimental ischemic stroke. J Neuroinflammation. 16:752019. View Article : Google Scholar : PubMed/NCBI

29 

Wang J, Zhao H, Fan Z, Li G, Ma Q, Tao Z, Wang R, Feng J and Luo Y: Long noncoding RNA H19 promotes neuroinflammation in ischemic stroke by driving histone deacetylase 1-Dependent M1 microglial polarization. Stroke. 48:2211–2221. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Cao DW, Liu MM, Duan R, Tao YF, Zhou JS, Fang WR, Zhu JR, Niu L and Sun JG: The lncRNA Malat1 functions as a ceRNA to contribute to berberine-mediated inhibition of HMGB1 by sponging miR-181c-5p in poststroke inflammation. Acta Pharmacol Sin. 41:22–33. 2020. View Article : Google Scholar : PubMed/NCBI

31 

Wang Y, Luo Y, Yao Y, Ji Y, Feng L, Du F, Zheng X, Tao T, Zhai X, Li Y, et al: Silencing the lncRNA Maclpil in pro-inflammatory macrophages attenuates acute experimental ischemic stroke via LCP1 in mice. J Cereb Blood Flow Metab. 40:747–759. 2020. View Article : Google Scholar : PubMed/NCBI

32 

Zhang K, Qi M, Yang Y, Xu P, Zhua Y and Zhang J: Circulating lncRNA ANRIL in the serum of patients with ischemic stroke. Clin Lab. 652019.doi: 10.7754/Clin.Lab.2019.190143.

33 

Wang Y, Yang L, Chen T, Liu X, Guo Y, Zhu Q, Tong X, Yang W, Xu Q, Huang D and Tu K: A novel lncRNA MCM3AP-AS1 promotes the growth of hepatocellular carcinoma by targeting miR-194-5p/FOXA1 axis. Mol Cancer Res. 18:282019. View Article : Google Scholar

34 

Sas-Chen A, Aure MR, Leibovich L, Carvalho S, Enuka Y, Körner C, Polycarpou-Schwarz M, Lavi S, Nevo N, Kuznetsov Y, et al: LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer. EMBO Mol Med. 8:1052–1064. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Hu Z, Yang D, Tang Y, Zhang X, Wei Z, Fu H, Xu J, Zhu Z and Cai Q: Five-long non-coding RNA risk score system for the effective prediction of gastric cancer patient survival. Oncol Lett. 17:4474–4486. 2019.PubMed/NCBI

36 

Yang C, Zheng J, Xue Y, Yu H, Liu X, Ma J, Liu L, Wang P, Li Z, Cai H and Liu Y: The Effect of MCM3AP-AS1/miR-211/KLF5/AGGF1 axis regulating glioblastoma angiogenesis. Front Mol Neurosci. 10:4372017. View Article : Google Scholar : PubMed/NCBI

37 

Ding H, Gao S, Wang L, Wei Y and Zhang M: Overexpression of miR-582-5p inhibits the apoptosis of neuronal cells after cerebral ischemic stroke through regulating PAR-1/Rho/Rho Axis. J Stroke Cerebrovasc Dis. 28:149–155. 2019. View Article : Google Scholar : PubMed/NCBI

38 

Vesterinen HM, Currie GL, Carter S, Mee S, Watzlawick R, Egan KJ, Macleod MR and Sena ES: Systematic review and stratified meta-analysis of the efficacy of RhoA and Rho kinase inhibitors in animal models of ischaemic stroke. Syst Rev. 2:332013. View Article : Google Scholar : PubMed/NCBI

39 

Schultz NEØ, Hasseldam H, Rasmussen RS, Vindegaard N, Mcwilliam O, Iversen HK and Johansen FF: Statin treatment before stroke reduces pro-inflammatory cytokine levels after stroke. Neurol Res. 41:289–297. 2019. View Article : Google Scholar : PubMed/NCBI

40 

Fard MA, Ebrahimi KB and Miller NR: RhoA activity and post-ischemic inflammation in an experimental model of adult rodent anterior ischemic optic neuropathy. Brain Res. 1534:76–86. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Jin K, Mao X, Mw, Nagayama T, Minami M, Simon R and Greenberg D: Microarray analysis of hippocampal gene expression in global cerebral ischemia. Ann Neurol. 50:93–103. 2010. View Article : Google Scholar

42 

He D, Zhuo Z, Lao J, Meng H, Han L, Fan C, Dan Y, He Z and Yun X: Proteomic analysis of the Peri-infarct area after human umbilical cord mesenchymal stem cell transplantation in experimental stroke. Aging Dis. 7:623–634. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Hou YC, Liou KT, Chern CM, Wang YH, Liao JF, Chang S, Chou YH and Shen YC: Preventive effect of silymarin in cerebral ischemia-reperfusion-induced brain injury in rats possibly through impairing NF-κB and STAT-1 activation. Phytomedicine. 17:963–973. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Xiang W, Tian C, Lin J, Wu X, Pang G, Zhou L, Pan S and Deng Z: Plasma let-7i and miR-15a expression are associated with the effect of recombinant tissue plasminogen activator treatment in acute ischemic stroke patients. Thromb Res. 158:121–125. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Jickling GC, Ander BP, Shroff N, Orantia M, Stamova B, Dykstra-Aiello C, Hull H, Zhan X, Liu D and Sharp FR: Leukocyte response is regulated by microRNA let7i in patients with acute ischemic stroke. Neurology. 87:2198–2205. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Franciska E, Thorsten T, Günter M and Konstantin-A H: Immunohistochemical analysis of protein expression after middle cerebral artery occlusion in mice. Acta Neuropathol. 107:127–136. 2004. View Article : Google Scholar : PubMed/NCBI

47 

Liu J, Zhou CX, Zhang ZJ, Wang LY, Jing ZW and Wang Z: Synergistic mechanism of gene expression and pathways between jasminoidin and ursodeoxycholic acid in treating focal cerebral ischemia-reperfusion injury. CNS Neurosci Ther. 18:674–682. 2012. View Article : Google Scholar : PubMed/NCBI

48 

Tan JR, Tan KS, Yong FL, Armugam A, Wang CW, Jeyaseelan K and Wong PT: MicroRNAs regulating cluster of differentiation 46 (CD46) in cardioembolic and non-cardioembolic stroke. PLoS One. 12:e01721312017. View Article : Google Scholar : PubMed/NCBI

49 

Marie JC, Astier AL, Rivailler P, Rabourdin-Combe C, Wild TF and Horvat B: Linking innate and acquired immunity: Divergent role of CD46 cytoplasmic domains in T cell induced inflammation. Nat Immunol. 3:659–666. 2002. View Article : Google Scholar : PubMed/NCBI

50 

Du CP, Tan R and Hou XY: Fyn kinases play a critical role in neuronal apoptosis induced by oxygen and glucose deprivation or amyloid-β peptide treatment. CNS Neurosci Ther. 18:754–761. 2012. View Article : Google Scholar : PubMed/NCBI

51 

Holmes A, Zhou N, Donahue DL, Balsara R and Castellino FJ: A deficiency of the GluN2C subunit of the N-methyl-D-aspartate receptor is neuroprotective in a mouse model of ischemic stroke. Biochem Biophys Res Commun. 495:136–144. 2018. View Article : Google Scholar : PubMed/NCBI

52 

Lopes F, Wang A, Smyth D, Reyes JL, Doering A, Schenck LP, Beck P, Waterhouse C and McKay DM: The Src kinase Fyn is protective in acute chemical-induced colitis and promotes recovery from disease. J Leukoc Biol. 97:1089–1099. 2015. View Article : Google Scholar : PubMed/NCBI

53 

Maitrias P, Metzinger-Le Meuth V, Massy ZA, M'Baya-Moutoula E, Reix T, Caus T and Metzinger L: MicroRNA deregulation in symptomatic carotid plaque. J Vasc Surg. 62:1245–1250.e1. 2015. View Article : Google Scholar : PubMed/NCBI

54 

Kumar M and Nerurkar VR: Integrated analysis of microRNAs and their disease related targets in the brain of mice infected with West Nile virus. Virology. 452-453:143–151. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Liu B, Han J, Wang T and Han L: Competing endogenous RNA network analysis for screening inflammation‑related long non‑coding RNAs for acute ischemic stroke. Mol Med Rep 22: 3081-3094, 2020.
APA
Zhang, L., Liu, B., Han, J., Wang, T., & Han, L. (2020). Competing endogenous RNA network analysis for screening inflammation‑related long non‑coding RNAs for acute ischemic stroke. Molecular Medicine Reports, 22, 3081-3094. https://doi.org/10.3892/mmr.2020.11415
MLA
Zhang, L., Liu, B., Han, J., Wang, T., Han, L."Competing endogenous RNA network analysis for screening inflammation‑related long non‑coding RNAs for acute ischemic stroke". Molecular Medicine Reports 22.4 (2020): 3081-3094.
Chicago
Zhang, L., Liu, B., Han, J., Wang, T., Han, L."Competing endogenous RNA network analysis for screening inflammation‑related long non‑coding RNAs for acute ischemic stroke". Molecular Medicine Reports 22, no. 4 (2020): 3081-3094. https://doi.org/10.3892/mmr.2020.11415
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Liu B, Han J, Wang T and Han L: Competing endogenous RNA network analysis for screening inflammation‑related long non‑coding RNAs for acute ischemic stroke. Mol Med Rep 22: 3081-3094, 2020.
APA
Zhang, L., Liu, B., Han, J., Wang, T., & Han, L. (2020). Competing endogenous RNA network analysis for screening inflammation‑related long non‑coding RNAs for acute ischemic stroke. Molecular Medicine Reports, 22, 3081-3094. https://doi.org/10.3892/mmr.2020.11415
MLA
Zhang, L., Liu, B., Han, J., Wang, T., Han, L."Competing endogenous RNA network analysis for screening inflammation‑related long non‑coding RNAs for acute ischemic stroke". Molecular Medicine Reports 22.4 (2020): 3081-3094.
Chicago
Zhang, L., Liu, B., Han, J., Wang, T., Han, L."Competing endogenous RNA network analysis for screening inflammation‑related long non‑coding RNAs for acute ischemic stroke". Molecular Medicine Reports 22, no. 4 (2020): 3081-3094. https://doi.org/10.3892/mmr.2020.11415
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team