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NDRG2 attenuates ischemia-induced astrocyte necroptosis via the repression of RIPK1

  • Authors:
    • Jie Zhu
    • Li-Kun Yang
    • Qiu-Hong Wang
    • Wei Lin
    • Yi Feng
    • Ye-Ping Xu
    • Wei-Liang Chen
    • Kun Xiong
    • Yu-Hai Wang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The 101 Hospital of PLA, School of Medicine, Anhui Medical University, Wuxi, Jiangsu 214044, P.R. China, Department of Ophthalmology, Wuxi Second Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214002, P.R. China, Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, Hunan 410013, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3103-3110
    |
    Published online on: August 7, 2020
       https://doi.org/10.3892/mmr.2020.11421
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Abstract

Cerebral ischemia results in severe brain damage, and is a leading cause of death and long-term disability. Previous studies have investigated methods to activate astrocytes in order to promote repair in injured brain tissue and inhibit cell death. It has previously been shown that N-myc downstream-regulated gene 2 (NDRG2) was highly expressed in astrocytes and associated with cell activity, but the underlying mechanism is largely unknown. The present study generated NDRG2 conditional knockout (Ndrg2-/-) mice to investigate whether NDRG2 can block ischemia-induced astrocyte necroptosis by suppressing receptor interacting protein kinase 1 (RIPK1) expression. This study investigated astrocyte activity in cerebral ischemia, and identified that ischemic brain injuries could trigger RIP-dependent astrocyte necroptosis. The depletion of NDRG2 was found to accelerate permanent middle cerebral artery occlusion-induced necroptosis in the brain tissue of Ndrg2-/- mice, indicating that NDRG2 may act as a neuroprotector during cerebral ischemic injury. The present study suggested that NDRG2 attenuated astrocytic cell death via the suppression of RIPK1. The pharmacological inhibition of astrocyte necroptosis by necrostatin-1 provided neuroprotection against ischemic brain injuries after NDRG2 knockdown. Therefore, NDRG2 could be considered as a potential target for the treatment of cerebral ischemia.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu J, Yang L, Wang Q, Lin W, Feng Y, Xu Y, Chen W, Xiong K and Wang Y: NDRG2 attenuates ischemia-induced astrocyte necroptosis via the repression of RIPK1 . Mol Med Rep 22: 3103-3110, 2020.
APA
Zhu, J., Yang, L., Wang, Q., Lin, W., Feng, Y., Xu, Y. ... Wang, Y. (2020). NDRG2 attenuates ischemia-induced astrocyte necroptosis via the repression of RIPK1 . Molecular Medicine Reports, 22, 3103-3110. https://doi.org/10.3892/mmr.2020.11421
MLA
Zhu, J., Yang, L., Wang, Q., Lin, W., Feng, Y., Xu, Y., Chen, W., Xiong, K., Wang, Y."NDRG2 attenuates ischemia-induced astrocyte necroptosis via the repression of RIPK1 ". Molecular Medicine Reports 22.4 (2020): 3103-3110.
Chicago
Zhu, J., Yang, L., Wang, Q., Lin, W., Feng, Y., Xu, Y., Chen, W., Xiong, K., Wang, Y."NDRG2 attenuates ischemia-induced astrocyte necroptosis via the repression of RIPK1 ". Molecular Medicine Reports 22, no. 4 (2020): 3103-3110. https://doi.org/10.3892/mmr.2020.11421
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu J, Yang L, Wang Q, Lin W, Feng Y, Xu Y, Chen W, Xiong K and Wang Y: NDRG2 attenuates ischemia-induced astrocyte necroptosis via the repression of RIPK1 . Mol Med Rep 22: 3103-3110, 2020.
APA
Zhu, J., Yang, L., Wang, Q., Lin, W., Feng, Y., Xu, Y. ... Wang, Y. (2020). NDRG2 attenuates ischemia-induced astrocyte necroptosis via the repression of RIPK1 . Molecular Medicine Reports, 22, 3103-3110. https://doi.org/10.3892/mmr.2020.11421
MLA
Zhu, J., Yang, L., Wang, Q., Lin, W., Feng, Y., Xu, Y., Chen, W., Xiong, K., Wang, Y."NDRG2 attenuates ischemia-induced astrocyte necroptosis via the repression of RIPK1 ". Molecular Medicine Reports 22.4 (2020): 3103-3110.
Chicago
Zhu, J., Yang, L., Wang, Q., Lin, W., Feng, Y., Xu, Y., Chen, W., Xiong, K., Wang, Y."NDRG2 attenuates ischemia-induced astrocyte necroptosis via the repression of RIPK1 ". Molecular Medicine Reports 22, no. 4 (2020): 3103-3110. https://doi.org/10.3892/mmr.2020.11421
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