Open Access

NDRG2 attenuates ischemia-induced astrocyte necroptosis via the repression of RIPK1

  • Authors:
    • Jie Zhu
    • Li-Kun Yang
    • Qiu-Hong Wang
    • Wei Lin
    • Yi Feng
    • Ye-Ping Xu
    • Wei-Liang Chen
    • Kun Xiong
    • Yu-Hai Wang
  • View Affiliations

  • Published online on: August 7, 2020     https://doi.org/10.3892/mmr.2020.11421
  • Pages: 3103-3110
  • Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cerebral ischemia results in severe brain damage, and is a leading cause of death and long-term disability. Previous studies have investigated methods to activate astrocytes in order to promote repair in injured brain tissue and inhibit cell death. It has previously been shown that N-myc downstream-regulated gene 2 (NDRG2) was highly expressed in astrocytes and associated with cell activity, but the underlying mechanism is largely unknown. The present study generated NDRG2 conditional knockout (Ndrg2-/-) mice to investigate whether NDRG2 can block ischemia-induced astrocyte necroptosis by suppressing receptor interacting protein kinase 1 (RIPK1) expression. This study investigated astrocyte activity in cerebral ischemia, and identified that ischemic brain injuries could trigger RIP-dependent astrocyte necroptosis. The depletion of NDRG2 was found to accelerate permanent middle cerebral artery occlusion-induced necroptosis in the brain tissue of Ndrg2-/- mice, indicating that NDRG2 may act as a neuroprotector during cerebral ischemic injury. The present study suggested that NDRG2 attenuated astrocytic cell death via the suppression of RIPK1. The pharmacological inhibition of astrocyte necroptosis by necrostatin-1 provided neuroprotection against ischemic brain injuries after NDRG2 knockdown. Therefore, NDRG2 could be considered as a potential target for the treatment of cerebral ischemia.
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October-2020
Volume 22 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhu J, Yang L, Wang Q, Lin W, Feng Y, Xu Y, Chen W, Xiong K and Wang Y: NDRG2 attenuates ischemia-induced astrocyte necroptosis via the repression of RIPK1 . Mol Med Rep 22: 3103-3110, 2020
APA
Zhu, J., Yang, L., Wang, Q., Lin, W., Feng, Y., Xu, Y. ... Wang, Y. (2020). NDRG2 attenuates ischemia-induced astrocyte necroptosis via the repression of RIPK1 . Molecular Medicine Reports, 22, 3103-3110. https://doi.org/10.3892/mmr.2020.11421
MLA
Zhu, J., Yang, L., Wang, Q., Lin, W., Feng, Y., Xu, Y., Chen, W., Xiong, K., Wang, Y."NDRG2 attenuates ischemia-induced astrocyte necroptosis via the repression of RIPK1 ". Molecular Medicine Reports 22.4 (2020): 3103-3110.
Chicago
Zhu, J., Yang, L., Wang, Q., Lin, W., Feng, Y., Xu, Y., Chen, W., Xiong, K., Wang, Y."NDRG2 attenuates ischemia-induced astrocyte necroptosis via the repression of RIPK1 ". Molecular Medicine Reports 22, no. 4 (2020): 3103-3110. https://doi.org/10.3892/mmr.2020.11421