Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
October-2020 Volume 22 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2020 Volume 22 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

11β‑hydroxysteroid dehydrogenase‑1 is associated with the activation of hepatic stellate cells in the development of hepatic fibrosis

  • Authors:
    • Wei Xiao
    • Meng‑Hou Lu
    • Peng‑Fei Rong
    • Hao‑Ye Zhang
    • Jian Gong
    • Ying‑Qiong Peng
    • Huan‑Yu Gong
    • Zhen‑Guo Liu
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Disease, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China, Department of Infectious Disease, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China
    Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3191-3200
    |
    Published online on: August 7, 2020
       https://doi.org/10.3892/mmr.2020.11423
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hepatic fibrosis (HF) is a common complication of numerous chronic liver diseases, but predominantly results from persistent liver inflammation or injury. If left untreated, HF can progress and develop into liver cirrhosis and even hepatocellular carcinoma. However, the underlying molecular mechanisms of HF remain unknown. The present study aimed to investigate the role of 11β‑hydroxysteroid dehydrogenase‑1 (11β‑HSD1) during the development of hepatic fibrosis. An experimental rat model of liver fibrosis was induced using porcine serum. 11β‑HSD1 gene expression levels and enzyme activity during hepatic fibrogenesis were assessed. 11β‑HSD1 gene knockdown using small interfering RNA and overexpression were performed in LX2‑human hepatic stellate cells (HSCs). HSCs were stimulated with transforming growth factor‑β1 (TGF‑β1). Cell cycle distribution, proliferation, collagen secretion and 11β‑HSD1 gene activity in HSCs were compared before and after stimulation. As hepatic fibrosis progressed, 11β‑HSD1 gene expression and activity increased, indicating a positive correlation with typical markers of liver fibrosis. 11β‑HSD1 inhibition markedly reduced the degree of fibrosis. The cell proliferation was increased, the number of cells in the G0/G1 phase decreased and the number of cells in the S and G2/M phases increased in the pSuper transfected group compared with the N group. In addition, the overexpression of 11β‑HSD1 enhanced the TGF‑β1‑induced activation of LX2‑HSCs and enzyme activity of connective tissue growth factor. 11β‑HSD1 knockdown suppressed cell proliferation by blocking the G0/G1 phase of the cell cycle, which was associated with HSC stimulation and inhibition of 11β‑HSD1 enzyme activity. In conclusion, increased 11β‑HSD1 expression in the liver may be partially responsible for hepatic fibrogenesis, which is potentially associated with HSC activation and proliferation.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Eijken M, Hewison M, Cooper MS, de Jong FH, Chiba H, Stewart PM, Uitterlinden AG, Pols HA and van Leeuwen JP: 11beta-Hydroxysteroid dehydrogenase expression and glucocorticoid synthesis are directed by a molecular switch during osteoblast differentiation. Mol Endocrinol. 19:3191–631. 2005. View Article : Google Scholar

2 

Gyllenhammer LE, Alderete TL, Mahurka S, Allayee H and Goran MI: Adipose tissue 11βHSD1 gene expression, βcell function and ectopic fat in obese African Americans versus Hispanics. Obesity (Silver Spring). 22:14–18. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Tomlinson JW, Walker EA, Bujalska IJ, Draper N, Lavery GG, Cooper MS, Hewison M and Stewart PM: 11beta-hydroxysteroid dehydrogenase type 1: A tissue-specific regulator of glucocorticoid response. Endocr Rev. 25:831–866. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Wake DJ and Walker BR: 11 beta-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome. Mol Cell Endocrinol. 215:45–54. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Chapman K, Holmes M and Seckl J: 11β-hydroxysteroid dehydrogenases: Intracellular gate-keepers of tissue glucocorticoid action. Physiol Rev. 93:1139–1206. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Necela BM and Cidlowski JA: Mechanisms of glucocorticoid receptor action in noninflammatory and inflammatory cells. Proc Am Thorac Soc. 1:239–246. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Rhen T and Cidlowski JA: Antiinflammatory action of glucocorticoids - new mechanisms for old drugs. N Engl J Med. 353:1711–1723. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Zhang TY and Daynes RA: Macrophages from 11beta-hydroxysteroid dehydrogenase type 1-deficient mice exhibit an increased sensitivity to lipopolysaccharide stimulation due to TGF-beta-mediated up-regulation of SHIP1 expression. J Immunol. 179:6325–6335. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Gilmour JS, Coutinho AE, Cailhier JF, Man TY, Clay M, Thomas G, Harris HJ, Mullins JJ, Seckl JR, Savill JS, et al: Local amplification of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes. J Immunol. 176:7605–7611. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Ezhilarasan D, Sokal E and Najimi M: Hepatic fibrosis: It is time to go with hepatic stellate cell-specific therapeutic targets. Hepatobiliary Pancreat Dis Int. 17:192–197. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Koyama Y, Xu J, Liu X and Brenner DA: New Developments on the Treatment of Liver Fibrosis. Dig Dis. 34:589–596. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Schnabl B, Kweon YO, Frederick JP, Wang XF, Rippe RA and Brenner DA: The role of Smad3 in mediating mouse hepatic stellate cell activation. Hepatology. 34:89–100. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Pellicoro A, Ramachandran P, Iredale JP and Fallowfield JA: Liver fibrosis and repair: Immune regulation of wound healing in a solid organ. Nat Rev Immunol. 14:181–194. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Fabris L, Strazzabosco M, Crosby HA, Ballardini G, Hubscher SG, Kelly DA, Neuberger JM, Strain AJ and Joplin R: Characterization and isolation of ductular cells coexpressing neural cell adhesion molecule and Bcl-2 from primary cholangiopathies and ductal plate malformations. Am J Pathol. 156:1599–1612. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Huang YH, Chen YX, Zhang LJ, Chen ZX and Wang XZ: Hydrodynamics-based transfection of rat interleukin-10 gene attenuates porcine serum-induced liver fibrosis in rats by inhibiting the activation of hepatic stellate cells. Int J Mol Med. 34:677–686. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Pereira RM, dos Santos RA, da Costa Dias FL, Teixeira MM and Simões e Silva AC: Renin-angiotensin system in the pathogenesis of liver fibrosis. World J Gastroenterol. 15:2579–2586. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Lam BP, Jeffers T, Younoszai Z, Fazel Y and Younossi ZM: The changing landscape of hepatitis C virus therapy: Focus on interferon-free treatment. Therap Adv Gastroenterol. 8:298–312. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Friedman SL: Liver fibrosis - from bench to bedside. J Hepatol. 38 (Suppl 1):S38–S53. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Inagaki Y and Okazaki I: Emerging insights into Transforming growth factor beta Smad signal in hepatic fibrogenesis. Gut. 56:284–292. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Kluwe J, Mencin A and Schwabe RF: Toll-like receptors, wound healing, and carcinogenesis. J Mol Med (Berl). 87:125–138. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Görbig MN, Ginès P, Bataller R, Nicolás JM, Garcia-Ramallo E, Tobías E, Titos E, Rey MJ, Clària J, Arroyo V, et al: Atrial natriuretic peptide antagonizes endothelin-induced calcium increase and cell contraction in cultured human hepatic stellate cells. Hepatology. 30:501–509. 1999. View Article : Google Scholar : PubMed/NCBI

22 

Grieb G, Steffens G, Pallua N, Bernhagen J and Bucala R: Circulating fibrocytes - biology and mechanisms in wound healing and scar formation. Int Rev Cell Mol Biol. 291:1–19. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Schlernitzauer A, Oiry C, Hamad R, Galas S, Cortade F, Chabi B, Casas F, Pessemesse L, Fouret G, Feillet-Coudray C, et al: Chicoric acid is an antioxidant molecule that stimulates AMP kinase pathway in L6 myotubes and extends lifespan in Caenorhabditis elegans. PLoS One. 8:e787882013. View Article : Google Scholar : PubMed/NCBI

24 

Di Sario A, Bendia E, Svegliati Baroni G, Ridolfi F, Casini A, Ceni E, Saccomanno S, Marzioni M, Trozzi L, Sterpetti P, et al: Effect of pirfenidone on rat hepatic stellate cell proliferation and collagen production. J Hepatol. 37:584–591. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Iredale JP: A cut above the rest? MMP-8 and liver fibrosis gene therapy. Gastroenterology. 126:1199–1201. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Cremer MA, Rosloniec EF and Kang AH: The cartilage collagens: A review of their structure, organization, and role in the pathogenesis of experimental arthritis in animals and in human rheumatic disease. J Mol Med (Berl). 76:275–288. 1998. View Article : Google Scholar : PubMed/NCBI

27 

Bhunchet E, Eishi Y and Wake K: Contribution of immune response to the hepatic fibrosis induced by porcine serum. Hepatology. 23:811–817. 1996. View Article : Google Scholar : PubMed/NCBI

28 

Kim JH, Lee S, Lee MY and Shin HK: Therapeutic effect of Soshiho-tang, a traditional herbal formula, on liver fibrosis or cirrhosis in animal models: A systematic review and meta-analysis. J Ethnopharmacol. 154:1–16. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Andrade RG, Gotardo BM, Assis BC, Mengel J and Andrade ZA: Immunological tolerance to pig-serum partially inhibits the formation of septal fibrosis of the liver in Capillaria hepatica-infected rats. Mem Inst Oswaldo Cruz. 99:703–707. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Cai DY, Zhao G, Chen JC, Ye GM, Bing FH and Fan BW: Therapeutic effect of Zijin capsule in liver fibrosis in rats. World J Gastroenterol. 4:260–263. 1998. View Article : Google Scholar : PubMed/NCBI

31 

Goodman ZD: Grading and staging systems for inflammation and fibrosis in chronic liver diseases. J Hepatol. 47:598–607. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Lee JH, Jang EJ, Seo HL, Ku SK, Lee JR, Shin SS, Park SD, Kim SC and Kim YW: Sauchinone attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway. Chem Biol Interact. 224:58–67. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Yang Y, Wang H, Lv X, Wang Q, Zhao H, Yang F, Yang Y and Li J: Involvement of cAMP-PKA pathway in adenosine A1 and A2A receptor-mediated regulation of acetaldehyde-induced activation of HSCs. Biochimie. 115:59–70. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Legeza B, Marcolongo P, Gamberucci A, Varga V, Bánhegyi G, Benedetti A and Odermatt A: Fructose, Glucocorticoids and Adipose Tissue: Implications for the Metabolic Syndrome. Nutrients. 9:4262017. View Article : Google Scholar

35 

Morton NM, Holmes MC, Fiévet C, Staels B, Tailleux A, Mullins JJ and Seckl JR: Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice. J Biol Chem. 276:41293–41300. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Seckl JR, Morton NM, Chapman KE and Walker BR: Glucocorticoids and 11beta-hydroxysteroid dehydrogenase in adipose tissue. Recent Prog Horm Res. 59:359–393. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Konopelska S, Kienitz T, Hughes B, Pirlich M, Bauditz J, Lochs H, Strasburger CJ, Stewart PM and Quinkler M: Hepatic 11beta-HSD1 mRNA expression in fatty liver and nonalcoholic steatohepatitis. Clin Endocrinol (Oxf). 70:554–560. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Ahmed A, Rabbitt E, Brady T, Brown C, Guest P, Bujalska IJ, Doig C, Newsome PN, Hubscher S, Elias E, et al: A switch in hepatic cortisol metabolism across the spectrum of non alcoholic fatty liver disease. PLoS One. 7:e295312012. View Article : Google Scholar : PubMed/NCBI

39 

Zou X, Ramachandran P, Kendall TJ, Pellicoro A, Dora E, Aucott RL, Manwani K, Man TY, Chapman KE, Henderson NC, et al: 11Beta-hydroxysteroid dehydrogenase-1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis. Hepatology. 67:2167–2181. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Yang R, Xu Y, Dai Z, Lin X and Wang H: The Immunologic Role of Gut Microbiota in Patients with Chronic HBV Infection. J Immunol Res. 2018:23619632018. View Article : Google Scholar : PubMed/NCBI

41 

Chen G, Wang R, Chen H, Wu L, Ge RS and Wang Y: Gossypol ameliorates liver fibrosis in diabetic rats induced by high-fat diet and streptozocin. Life Sci. 149:58–64. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Kottmann RM, Trawick E, Judge JL, Wahl LA, Epa AP, Owens KM, Thatcher TH, Phipps RP and Sime PJ: Pharmacologic inhibition of lactate production prevents myofibroblast differentiation. Am J Physiol Lung Cell Mol Physiol. 309:L1305–L1312. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xiao W, Lu MH, Rong PF, Zhang HY, Gong J, Peng YQ, Gong HY and Liu ZG: 11β‑hydroxysteroid dehydrogenase‑1 is associated with the activation of hepatic stellate cells in the development of hepatic fibrosis. Mol Med Rep 22: 3191-3200, 2020.
APA
Xiao, W., Lu, M., Rong, P., Zhang, H., Gong, J., Peng, Y. ... Liu, Z. (2020). 11β‑hydroxysteroid dehydrogenase‑1 is associated with the activation of hepatic stellate cells in the development of hepatic fibrosis. Molecular Medicine Reports, 22, 3191-3200. https://doi.org/10.3892/mmr.2020.11423
MLA
Xiao, W., Lu, M., Rong, P., Zhang, H., Gong, J., Peng, Y., Gong, H., Liu, Z."11β‑hydroxysteroid dehydrogenase‑1 is associated with the activation of hepatic stellate cells in the development of hepatic fibrosis". Molecular Medicine Reports 22.4 (2020): 3191-3200.
Chicago
Xiao, W., Lu, M., Rong, P., Zhang, H., Gong, J., Peng, Y., Gong, H., Liu, Z."11β‑hydroxysteroid dehydrogenase‑1 is associated with the activation of hepatic stellate cells in the development of hepatic fibrosis". Molecular Medicine Reports 22, no. 4 (2020): 3191-3200. https://doi.org/10.3892/mmr.2020.11423
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao W, Lu MH, Rong PF, Zhang HY, Gong J, Peng YQ, Gong HY and Liu ZG: 11β‑hydroxysteroid dehydrogenase‑1 is associated with the activation of hepatic stellate cells in the development of hepatic fibrosis. Mol Med Rep 22: 3191-3200, 2020.
APA
Xiao, W., Lu, M., Rong, P., Zhang, H., Gong, J., Peng, Y. ... Liu, Z. (2020). 11β‑hydroxysteroid dehydrogenase‑1 is associated with the activation of hepatic stellate cells in the development of hepatic fibrosis. Molecular Medicine Reports, 22, 3191-3200. https://doi.org/10.3892/mmr.2020.11423
MLA
Xiao, W., Lu, M., Rong, P., Zhang, H., Gong, J., Peng, Y., Gong, H., Liu, Z."11β‑hydroxysteroid dehydrogenase‑1 is associated with the activation of hepatic stellate cells in the development of hepatic fibrosis". Molecular Medicine Reports 22.4 (2020): 3191-3200.
Chicago
Xiao, W., Lu, M., Rong, P., Zhang, H., Gong, J., Peng, Y., Gong, H., Liu, Z."11β‑hydroxysteroid dehydrogenase‑1 is associated with the activation of hepatic stellate cells in the development of hepatic fibrosis". Molecular Medicine Reports 22, no. 4 (2020): 3191-3200. https://doi.org/10.3892/mmr.2020.11423
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team