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MicroRNA‑22 regulates autophagy and apoptosis in cisplatin resistance of osteosarcoma

  • Authors:
    • Chen‑Yang Meng
    • Zhen‑Qun Zhao
    • Rui Bai
    • Wei Zhao
    • Yu‑Xing Wang
    • Liang Sun
    • Chao Sun
    • Wei Feng
    • Shi‑Bing Guo
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010030, P.R. China
    Copyright: © Meng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3911-3921
    |
    Published online on: August 20, 2020
       https://doi.org/10.3892/mmr.2020.11447
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Abstract

Osteosarcoma (OS) is a primary malignant tumor of bone tissue. Effective chemotherapy may improve the survival of patients with OS. MicroRNAs (miRs) serve significant roles in the regulatory function of tumorigenesis and chemosensitivity of different types of cancer. miR‑22 has been revealed to inhibit the proliferation and migration of OS cells, as well as increasing their sensitivity to cisplatin (CDDP). The mechanisms of action behind the functions of miR‑22 in OS drug resistance require investigation. Therefore, in the present study, the human OS cell lines (MG‑63, U2OS, Saos2 and OS9901) and a drug‑resistant cell line (MG‑63/CDDP) were cultured. Cell proliferation, apoptosis and autophagy assays were performed to investigate the proliferation, apoptosis and autophagy of cell lines transfected with miR‑22 mimic. Reverse transcription‑quantitative polymerase chain reaction and western blot analysis were performed to investigate the expression levels of associated genes. The results revealed that miR‑22 inhibited the proliferation of MG‑63 cells and MG‑63/CDDP cells, and enhanced the anti‑proliferative ability of CDDP. miR‑22 induced apoptosis and inhibited autophagy of MG‑63 cells and MG‑63/CDDP cells. Apoptosis‑related genes, including caspase‑3 and Bcl‑2‑associated X protein were upregulated, while B‑cell lymphoma‑2 was downregulated in both cell lines transfected with the miR‑22 mimic. Autophagy protein 5, beclin1 and microtubules‑associated protein 1 light chain 3 were downregulated in both cell lines transfected with miR‑22 mimic. Furthermore, the in vitro and in vivo expression levels of metadherin (MTDH) in the OS/OS‑CDDP‑resistant models were downregulated following transfection with the miR‑22 mimic. Therefore, the results of the present study suggested that miR‑22 promoted CDDP sensitivity by inhibiting autophagy and inducing apoptosis in OS cells, while MTDH may serve a positive role in inducing CDDP resistance of OS cells.
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View References

1 

Sissons HA: The WHO classification of bone tumors. Recent Results Cancer Res. 54:104–108. 1976.

2 

Mckenna R: Sarcomata of the osteogenic series (osteosarcoma, fibrosarcoma, chondrosarcoma, parosteal osteogenic sarcoma, and sarcomata arising in abnormal bone): An analysis of 552 cases. J Bone Joint Surg Am. 48:1–26. 1966. View Article : Google Scholar

3 

Ries LAG, Smith MA, Gurney JG, Linet M, Tamra T, Young JL and Bunin GR: Cancer incidence and survival among children and adolescents: United States SEER Program, 1975–1995. Bethesda, MD: 1999

4 

Stiller CA, Bielack SS, Jundt G and Steliarova-Foucher E: Bone tumours in European children and adolescents, 1978–1997. Report from the automated childhood cancer information system project. Eur J Cancer. 42:2124–2135. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Anninga JK, Gelderblom H, Fiocco M, Kroep JR, Taminiau AH, Hogendoorn PC and Egeler RM: Chemotherapeutic adjuvant treatment for osteosarcoma: Where do we stand? Eur J Cancer. 47:2431–2445. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Marina N, Gebhardt M, Teot L and Gorlick R: Biology and therapeutic advances for pediatric osteosarcoma. Oncologist. 9:422–441. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Lee RC, Feinbaum RL and Ambros V: The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 75:843–854. 1993. View Article : Google Scholar : PubMed/NCBI

8 

Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, et al: Identification of hundreds of conserved and nonconserved human microRNAs. Nat Genet. 37:766–770. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Djebali S, Davis CA, Merkel A, Dobin A, Lassmann T, Mortazavi A, Tanzer A, Lagarde J, Lin W, Schlesinger F, et al: Landscape of transcription in human cells. Nature. 489:101–108. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Zhong X, Coukos G and Zhang L: miRNAs in human cancer. J Pathol. 223:102–115. 2015.

11 

He L and Hannon GJ: MicroRNAs: Small RNAs with a big role in gene regulation. Nat Rev Genet. 5:522–531. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Xie L, Jing R, Qi J, Lin Z and Ju S: Drug resistance-related microRNAs in hematological malignancies: Translating basic evidence into therapeutic strategies. Blood Rev. 29:33–44. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Torreggiani E, Roncuzzi L, Perut F, Zini N and Baldini N: Multimodal transfer of MDR by exosomes in human osteosarcoma. Int J Oncol. 49:1892016. View Article : Google Scholar : PubMed/NCBI

14 

Duan Z, Gao Y, Shen J, Choy E, Cote G, Harmon D, Bernstein K, Lozano-Calderon S, Mankin H and Hornicek FJ: miR-15b modulates multidrug resistance in human osteosarcoma in vitro and in vivo. Mol Oncol. 11:151–166. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Guo S, Bai R, Liu W, Zhao A, Zhao Z, Wang Y, Wang Y, Zhao W and Wang W: miR-22 inhibits osteosarcoma cell proliferation and migration by targeting HMGB1 and inhibiting HMGB1-mediated autophagy. Tumor Biol. 35:7025–7034. 2014. View Article : Google Scholar

16 

Zhou J, Wu S, Chen Y, Zhao J, Zhang K, Wang J and Chen S: microRNA-143 is associated with the survival of ALDH1+CD133+ osteosarcoma cells and the chemoresistance of osteosarcoma. Exp Biol Med. 240:867–875. 2015. View Article : Google Scholar

17 

Zhao G, Cai C, Yang T, Qiu X, Liao B, Li W, Ji Z, Zhao J, Zhao H, Guo M, et al: MicroRNA-221 induces cell survival and cisplatin resistance through PI3K/Akt pathway in human osteosarcoma. PLoS One. 8:e539062013. View Article : Google Scholar : PubMed/NCBI

18 

Ouyang L, Shi Z, Zhao S, Wang FT, Zhou TT, Liu B and Bao JK: Programmed cell death pathways in cancer: A review of apoptosis, autophagy and programmed necrosis. Cell Prolif. 90:487–498. 2012. View Article : Google Scholar

19 

Lagos-Quintana M, Rauhut R, Lendeckel W and Tuschl T: Identification of novel genes coding for small expressed RNAs. Science. 294:853–858. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Knyazev EN, Samatov TR, Fomicheva KA, Nyushko KM, Alekseev BY and Shkurnikov MY: MicroRNA hsa-miR-4674 in hemolysis-free blood plasma is associated with distant metastases of prostatic cancer. Bull Exp Biol Med. 161:112–115. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Damavandi Z, Torkashvand S, Vasei M, Soltani BM, Tavallaei M and Mowla SJ: Aberrant expression of breast development-related MicroRNAs, miR-22, miR-132, and miR-212, in breast tumor tissues. J Breast Cancer. 19:148–155. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Wang P, Zhao ZQ, Guo SB, Yang TY, Chang ZQ, Li DH, Zhao W, Wang YX, Sun C, Wang Y and Feng W: Roles of microRNA-22 in suppressing proliferation and promoting sensitivity of osteosarcoma cells via metadherin-mediated autophagy. Orthop Surg. 11:285–293. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Wan L, Hu G, Wei Y, Yuan M, Bronson RT, Yang Q, Siddiqui J, Pienta KJ and Kang Y: Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis. Cancer Res. 74:5336–5347. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Zhou X, Natino D, Zhai X, Gao Z and He X: MicroRNA-22 inhibits the proliferation and migration, and increases the cisplatin sensitivity, of osteosarcoma cells. Mol Med Rep. 17:7209–7217. 2018.PubMed/NCBI

25 

Li Y, Geng P, Jiang W, Wang Y, Yao J, Lin X, Liu J, Huang L, Su B and Chen H: Enhancement of radiosensitivity by 5-Aza-CdR through activation of G2/M checkpoint response and apoptosis in osteosarcoma cells. Tumour Biol. 35:4831–4839. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Yang TM, Guo SF, Chen CR, Zhang XY and Li WG: Anti-Osteosarcom aeffects and mechanisms of 4-O-amino- phenol-4′-demethylepipodophyllotoxin ether. J Pharm Pharmacol. 60:179–188. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Tang J, Shen L, Yang Q and Zhang C: Overexpression of metadherin mediates metastasis of osteosarcoma by regulating epithelial-mesenchymal transition. Cell Prolif. 47:427–434. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Ye H, Lin J, Yao X, Li Y, Lin X and Lu H: Overexpression of long non-coding RNA NNT-AS1 correlates with tumor progression and poor prognosis in osteosarcoma. Cell Physiol Biochem. 45:1904–1914. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Zhao S, Chen C, Chang K, Karnad A, Jagirdar J, Kumar AP and Freeman JW: CD44 expression level and isoform contributes to pancreatic cancer cell plasticity, invasiveness, and response to therapy. Clin Cancer Res. 22:5592–5604. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Meng CY, Zhao ZQ, Bai R, Zhao W, Wang YX, Xue HQ, Sun L, Sun C, Feng W and Guo SB: MicroRNA-22 mediates the cisplatin resistance of osteosarcoma cells by inhibiting autophagy via the PI3K/Akt/mTOR pathway. Oncol Rep. 43:1169–1186. 2020.PubMed/NCBI

31 

Zou Y, Yang J, Wu J, Luo C and Huang Y: miR?133b induces chemoresistance of osteosarcoma cells to cisplatin treatment by promoting cell death, migration and invasion. Oncol Lett. 15:1097–1102. 2018.PubMed/NCBI

32 

Vanas V, Haigl B, Stockhammer V and Sutterlüty-Fall H: MicroRNA-21 increases proliferation and cisplatin sensitivity of osteosarcoma-derived cells. PLoS One. 11:e01610232016. View Article : Google Scholar : PubMed/NCBI

33 

Karpel-Massler G, Shu C, Chau L, Banu M, Halatsch ME, Westhoff MA, Ramirez Y, Ross AH, Bruce JN, Canoll P and Siegelin MD: Combined inhibition of Bcl-2/Bcl-xL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo. Oncotarget. 6:14507–14521. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Zhu Z, Tang J, Wang J, Duan G, Zhou L and Zhou X: miR-138 acts as a tumor suppressor by targeting EZH2 and enhances cisplatin-induced apoptosis in osteosarcoma cells. PLoS One. 11:e01500262016. View Article : Google Scholar : PubMed/NCBI

35 

Ziyan W and Yang L: MicroRNA-21 regulates the sensitivity to cisplatin in a human osteosarcoma cell line. Ir J Med Sci. 185:85–91. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Gai P, Sun H, Wang G, Xu Q and Jiang L: miR-22 promotes apoptosis of osteosarcoma cells via inducing cell cycle arrest. Oncol Lett. 13:2354–2358. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Li X, Wang S, Chen Y, Liu G and Yang X: miR-22 targets the 3′ UTR of HMGB1 and inhibits the HMGB1-associated autophagy in osteosarcoma cells during chemotherapy. Tumor Biol. 35:6021–6028. 2014. View Article : Google Scholar

38 

Yan J, Zhang J, Zhang X, Li X, Li L, Li Z, Chen R, Zhang L, Wu J, Wang X, et al: AEG-1 is involved in hypoxia-induced autophagy and decreases chemosensitivity in T-cell lymphoma. Mol Med. 24:352018. View Article : Google Scholar : PubMed/NCBI

39 

Zou M, Zhu W, Wang L, Shi L and Hu G: AEG-1/MTDH-activated autophagy enhances human malignant glioma susceptibility to TGF-β1-triggered epithelial-mesenchymal transition. Oncotarget. 7:13122–13138. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Pei G, Luo M, Ni X, Wu J, Wang S, Ma Y and Yu J: Autophagy facilitates metadherin-induced chemotherapy resistance through the AMPK/ATG5 pathway in gastric cancer. Cell Physiol Biochem. 46:847–859. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Meng CY, Zhao ZQ, Bai R, Zhao W, Wang YX, Sun L, Sun C, Feng W and Guo SB: MicroRNA‑22 regulates autophagy and apoptosis in cisplatin resistance of osteosarcoma. Mol Med Rep 22: 3911-3921, 2020.
APA
Meng, C., Zhao, Z., Bai, R., Zhao, W., Wang, Y., Sun, L. ... Guo, S. (2020). MicroRNA‑22 regulates autophagy and apoptosis in cisplatin resistance of osteosarcoma. Molecular Medicine Reports, 22, 3911-3921. https://doi.org/10.3892/mmr.2020.11447
MLA
Meng, C., Zhao, Z., Bai, R., Zhao, W., Wang, Y., Sun, L., Sun, C., Feng, W., Guo, S."MicroRNA‑22 regulates autophagy and apoptosis in cisplatin resistance of osteosarcoma". Molecular Medicine Reports 22.5 (2020): 3911-3921.
Chicago
Meng, C., Zhao, Z., Bai, R., Zhao, W., Wang, Y., Sun, L., Sun, C., Feng, W., Guo, S."MicroRNA‑22 regulates autophagy and apoptosis in cisplatin resistance of osteosarcoma". Molecular Medicine Reports 22, no. 5 (2020): 3911-3921. https://doi.org/10.3892/mmr.2020.11447
Copy and paste a formatted citation
x
Spandidos Publications style
Meng CY, Zhao ZQ, Bai R, Zhao W, Wang YX, Sun L, Sun C, Feng W and Guo SB: MicroRNA‑22 regulates autophagy and apoptosis in cisplatin resistance of osteosarcoma. Mol Med Rep 22: 3911-3921, 2020.
APA
Meng, C., Zhao, Z., Bai, R., Zhao, W., Wang, Y., Sun, L. ... Guo, S. (2020). MicroRNA‑22 regulates autophagy and apoptosis in cisplatin resistance of osteosarcoma. Molecular Medicine Reports, 22, 3911-3921. https://doi.org/10.3892/mmr.2020.11447
MLA
Meng, C., Zhao, Z., Bai, R., Zhao, W., Wang, Y., Sun, L., Sun, C., Feng, W., Guo, S."MicroRNA‑22 regulates autophagy and apoptosis in cisplatin resistance of osteosarcoma". Molecular Medicine Reports 22.5 (2020): 3911-3921.
Chicago
Meng, C., Zhao, Z., Bai, R., Zhao, W., Wang, Y., Sun, L., Sun, C., Feng, W., Guo, S."MicroRNA‑22 regulates autophagy and apoptosis in cisplatin resistance of osteosarcoma". Molecular Medicine Reports 22, no. 5 (2020): 3911-3921. https://doi.org/10.3892/mmr.2020.11447
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