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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November-2020 Volume 22 Issue 5

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mutations of the cystic fibrosis transmembrane conductance regulator gene in males with congenital bilateral absence of the vas deferens: Reproductive implications and genetic counseling (Review)

Xiangrong Cui, Xueqing Wu, Qiang Li, Xuan Jing
Pages: 3587-3596
Published online on: 24 August 2020

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Article Open Access

In vivo and in vitro anti‑allergic and anti‑inflammatory effects of Dryopteris crassirhizoma through the modulation of the NF‑ĸB signaling pathway in an ovalbumin‑induced allergic asthma mouse model

Chun Hua Piao, Thi Tho Bui, Yan Jing Fan, Thi Van Nguyen, Dong‑Uk Shin, Chang Ho Song, So‑Young Lee, Hee Soon Shin, Hyoung Tae Kim, Ok Hee Chai
Pages: 3597-3606
Published online on: 25 August 2020

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Article Open Access

iTRAQ‑based proteomic analysis reveals potential regulatory networks in dust mite‑related asthma treated with subcutaneous allergen immunotherapy

Jun Bai, Jia‑Yong Zhong, Wang Liao, Ruo Hu, Liang Chen, Xian‑Jin Wu, Shuang‑Ping Liu
Pages: 3607-3620
Published online on: 01 September 2020

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Article Open Access

MicroRNA‑25‑3p regulates human nucleus pulposus cell proliferation and apoptosis in intervertebral disc degeneration by targeting Bim Retraction in /10.3892/mmr.2026.13845

Zhifang Zhao, Jie Zheng, Youchen Ye, Kefeng Zhao, Ruozhang Wang, Ran Wang
Pages: 3621-3628
Published online on: 02 September 2020

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Article Open Access

Deletion of P110δ promotes the development of myocarditis in ApoE‑deficient mice by increasing mononuclear cell peritoneal infiltration

Qi‑Zhi Zhang, Ai‑Ying Xue, Wei Wei, Ai‑Min Pang, Li‑Na Cao, Fang Liu
Pages: 3629-3634
Published online on: 21 August 2020

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Article Open Access

lncRNA FEZF1‑AS1 promotes migration, invasion and epithelial‑mesenchymal transition of retinoblastoma cells by targeting miR‑1236‑3p

Guanghong Zhang, Wei Yang, Dujun Li, Xiaoyu Li, Juan Huang, Rong Huang, Jihong Luo
Pages: 3635-3644
Published online on: 02 September 2020

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Article Open Access

Differentially expressed genes on the growth of mouse Leydig cells treated with standardised Eurycoma longifolia extract

Nor Amira Khurshid Ahmed, Shern Kwok Lim, Ganesh N. Pandian, Hiroshi Sugiyama, Chong Yew Lee, Boon Yin Khoo, Kit Lam Chan
Pages: 3645-3658
Published online on: 02 September 2020

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Article Open Access

Matrine exerts anti‑breast cancer activity by mediating apoptosis and protective autophagy via the AKT/mTOR pathway in MCF‑7 cells

Jikun Du, Jinwen Li, Daibo Song, Qin Li, Lin Li, Baohong Li, Li Li
Pages: 3659-3666
Published online on: 20 August 2020

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Article Open Access

LncRNA HOTTIP promotes the proliferation and invasion of ovarian cancer cells by activating the MEK/ERK pathway

Jian Liu, Hong‑Bo Hu, Yan‑Ming Liu, Fan‑Xiang Li, Liu‑Ping Zhang, Zong‑Min Liao
Pages: 3667-3676
Published online on: 21 August 2020

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Article Open Access

lncRNA small nucleolar RNA host gene 12 promotes renal cell carcinoma progression by modulating the miR‑200c‑5p/collagen type XI α1 chain pathway

Congjie Xu, Hui Liang, Jiaquan Zhou, Yang Wang, Shuan Liu, Xiaolin Wang, Liangju Su, Xinli Kang
Pages: 3677-3686
Published online on: 02 September 2020

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Article Open Access

Effects of tacrolimus on the TGF‑β1/SMAD signaling pathway in paraquat‑exposed rat alveolar type II epithelial cells

Yingli Ren, Xiangdong Jian, Zhongchen Zhang, Qiong Ning, Baotian Kan, Li Kong
Pages: 3687-3694
Published online on: 21 August 2020

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Article Open Access

miR‑155‑5p downregulation inhibits epithelial‑to‑mesenchymal transition by targeting SIRT1 in human nasal epithelial cells

Niannian Yang, Hao Cheng, Qiao Mo, Xiaobiao Zhou, Minqiang Xie
Pages: 3695-3704
Published online on: 27 August 2020

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Article Open Access

MicroRNA‑23a‑5p mediates the proliferation and differentiation of C2C12 myoblasts

Xue Zhao, Hao Gu, Linghui Wang, Peiwen Zhang, Jingjing Du, Linyuan Shen, Dongmei Jiang, Jinyong Wang, Xuewei Li, Shunhua Zhang, Mingzhou Li, Li Zhu
Pages: 3705-3714
Published online on: 02 September 2020

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Article Open Access

lncRNA SNHG1 attenuates osteogenic differentiation via the miR‑101/DKK1 axis in bone marrow mesenchymal stem cells

Jie Xiang, Hai‑Qing Fu, Zhun Xu, Wei‑Jie Fan, Fei Liu, Bin Chen
Pages: 3715-3722
Published online on: 02 September 2020

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Article Open Access

The AKT inhibitor MK2206 suppresses airway inflammation and the pro‑remodeling pathway in a TDI‑induced asthma mouse model

Haiyan Cui, Yuanxiong Cheng, Yi He, Weiying Cheng, Wenqu Zhao, Haijin Zhao, Fiona H. Zhou, Liping Wang, Jianghui Dong, Shaoxi Cai
Pages: 3723-3734
Published online on: 21 August 2020

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Article Open Access

Expression profile of lncRNAs and mRNAs in intestinal macrophages

Qais Ahmad Naseer, Lulu Liu, Xiaofei Xue, Siche Chen, Jixiang Chen, Jianguo Qu, Lei Cui, Xiaogang Wang, Shengchun Dang
Pages: 3735-3746
Published online on: 28 August 2020

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Article Open Access

Cancer stem cells as a therapeutic target in 3D tumor models of human chondrosarcoma: An encouraging future for proline rich polypeptide‑1

Caroline J. Granger, Aaron K. Hoyt, Alexandra Moran, Beatrice Becker, Anil  Sedani, Shannon Saigh, Sheila A. Conway, Jeffrey Brown, Karina Galoian
Pages: 3747-3758
Published online on: 02 September 2020

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Article Open Access

Osthole inhibits proliferation of kainic acid‑activated BV‑2 cells by modulating the Notch signaling pathway

Yu‑Zhu Li, Zheng Sun, Hong‑Rui Xu, Qing‑Gao Zhang, Chang‑Qian Zeng
Pages: 3759-3766
Published online on: 24 August 2020

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Article Open Access

Ghrelin system is involved in improvements in glucose metabolism mediated by hyperbaric oxygen treatment in a streptozotocin‑induced type 1 diabetes mouse model

Limin Song, Junhua Yuan, Yuan Liu, Di Zhang, Caishun Zhang, Qian Lin, Manwen Li, Kaizhen Su, Yanrun Li, Guangkai Gao, Ruixia Ma, Jing Dong
Pages: 3767-3776
Published online on: 02 September 2020

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Article Open Access

Functional classification of prostate cancer‑associated miRNAs through CRISPR/Cas9‑mediated gene knockout

Fu‑Neng Jiang, Yu‑Xiang Liang, Wang Wei, Cui‑Yun Zou, Guan‑Xing Chen, Yue‑Ping  Wan, Ze‑Zhen Liu, Yang  Yang, Zhao‑Dong Han, Jian‑Guo Zhu, Wei‑De Zhong
Pages: 3777-3784
Published online on: 07 September 2020

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Article Open Access

A novel identified circular RNA, circ_0000491, aggravates the extracellular matrix of diabetic nephropathy glomerular mesangial cells through suppressing miR‑101b by targeting TGFβRI

Xin Mou, Jia Wei Chenv, Di Yi Zhou, Kaiyuan Liu, Li Jun Chen, Danyang Zhou, Yong Bin Hu
Pages: 3785-3794
Published online on: 02 September 2020

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Article Open Access

MicroRNA‑214 promotes the EMT process in melanoma by downregulating CADM1 expression

Shu‑Jun Wang, Wei‑Wei Li, Cong‑Ji Wen, Yong‑Li Diao, Tian‑Lan Zhao
Pages: 3795-3803
Published online on: 20 August 2020

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Article Open Access

miR‑181d promotes cell proliferation via the IGF1/PI3K/AKT axis in glioma

Dong Tang, Wenhong Gao, Jian Yang, Junhui Liu, Jian Zhao, Jian Ge, Qianxue Chen, Baohui Liu
Pages: 3804-3812
Published online on: 26 August 2020

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Article Open Access

Mesenchymal stem cell‑derived extracellular vesicles prevent neural stem cell hypoxia injury via promoting miR‑210‑3p expression

Fang Li, Jie Zhang, Rui Liao, Yongchun Duan, Lili Tao, Yuwei Xu, Anbao Chen
Pages: 3813-3821
Published online on: 21 August 2020

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Article Open Access

Long non‑coding RNA TP73‑AS1 accelerates the progression and cisplatin resistance of non‑small cell lung cancer by upregulating the expression of TRIM29 via competitively targeting microRNA‑34a‑5p

Shunxiang Luo, Ming Shen, Hui Chen, Weiwei Li, Cong Chen
Pages: 3822-3832
Published online on: 01 September 2020

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Article Open Access

Icariin modulates the sirtuin/NF‑κB pathway and exerts anti‑aging effects in human lung fibroblasts

Changqing Xu, Xuqing Huang, Yueyang Tong, Xiaocheng Feng, Yan Wang, Cancan Wang, Yuyue Jiang
Pages: 3833-3839
Published online on: 24 August 2020

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Article Open Access

Differential expression and inhibitory effects of aquaporins on the development of adenomyosis

Liping Jia, Yuzhu Liu, Yixu Han, Xiaofei Zhou, Fahui Wang
Pages: 3840-3850
Published online on: 02 September 2020

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Article Open Access

Cryptotanshinone alleviates polycystic ovary syndrome in rats by regulating the HMGB1/TLR4/NF‑κB signaling pathway

Yijiao Yang, Ling Yang, Cao Qi, Guohua Hu, Longhui Wang, Zhuojun Sun, Xiaorong Ni
Pages: 3851-3861
Published online on: 28 August 2020

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Article Open Access

Analysis of biomarkers and metabolic pathways in patients with unstable angina based on ultra‑high‑performance liquid chromatography‑quadrupole time‑of‑flight mass spectrometry

Yuechen Liu, Yue Li, Tianpu Zhang, Huan Zhao, Simiao Fan, Xuemeng Cai, Yijia Liu, Zhu Li, Shan Gao, Yubo Li, Chunquan Yu
Pages: 3862-3872
Published online on: 02 September 2020

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Article Open Access

Epigallocatechin gallate induces chemopreventive effects on rats with diethylnitrosamine‑induced liver cancer via inhibition of cell division cycle 25A

Yanping Tang, Ji Cao, Zhengmin Cai, Huihua An, Yuqun Li, Yan Peng, Ni Chen, Anqiang Luo, Hao Tao, Kezhi Li
Pages: 3873-3885
Published online on: 26 August 2020

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Article Open Access

SNHG12 inhibits oxygen‑glucose deprivation‑induced neuronal apoptosis via the miR‑181a‑5p/NEGR1 axis

Yangtian Yan, Li Chen, Jiajun Zhou, Liquan Xie
Pages: 3886-3894
Published online on: 24 August 2020

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Article Open Access

KCTD1 mutants in scalp‑ear‑nipple syndrome and AP‑2α P59A in Char syndrome reciprocally abrogate their interactions, but can regulate Wnt/β‑catenin signaling

Lingyu Hu, Li Chen, Liu Yang, Zi Ye, Wenhuan Huang, Xinxin Li, Qing Liu, Junlu Qiu, Xiaofeng Ding
Pages: 3895-3903
Published online on: 24 August 2020

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Article Open Access

MgCl2 promotes mouse mesenchymal stem cell osteogenic differentiation by activating the p38/Osx/Runx2 signaling pathway

Su Ni, Xin‑Bo Xiong, Xin‑Ye Ni
Pages: 3904-3910
Published online on: 02 September 2020

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Article Open Access

MicroRNA‑22 regulates autophagy and apoptosis in cisplatin resistance of osteosarcoma

Chen‑Yang Meng, Zhen‑Qun Zhao, Rui Bai, Wei Zhao, Yu‑Xing Wang, Liang Sun, Chao Sun, Wei Feng, Shi‑Bing Guo
Pages: 3911-3921
Published online on: 20 August 2020

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Article Open Access

Upregulation of centromere protein M promotes tumorigenesis: A potential predictive target for cancer in humans Corrigendum in /10.3892/mmr.2024.13186

Ying Liu, Wenfeng Yu, Peng Ren, Ting Zhang
Pages: 3922-3934
Published online on: 25 August 2020

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Article Open Access

Apatinib sensitizes chemoresistant NSCLC cells to doxetaxel via regulating autophagy and enhances the therapeutic efficacy in advanced and refractory/recurrent NSCLC

Rong Hu, Tao Li, Kaiyuan Hui, Zi Chen, Nan Wang, Xingping Wu, Linyang Ge, Linfu Zhou
Pages: 3935-3943
Published online on: 07 September 2020

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Article Open Access

miR‑183‑5p attenuates cerebral ischemia injury by negatively regulating PTEN

Li Zhu, Xueying Zhou, Shanshan Li, Jianmeng Liu, Jingyan Yang, Xiangyun Fan, Shengnian Zhou
Pages: 3944-3954
Published online on: 07 September 2020

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Article Open Access

Determination of the migration effect and molecular docking of verteporfin in different subtypes of breast cancer cells

Changran Wei, Xiangqi Li
Pages: 3955-3961
Published online on: 02 September 2020

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Article Open Access

Calycosin induces apoptosis via p38‑MAPK pathway‑mediated activation of the mitochondrial apoptotic pathway in human osteosarcoma 143B cells

Wei Tian, Zhi‑Wei Wang, Bao‑Ming Yuan, Yong‑Ge Bao
Pages: 3962-3968
Published online on: 01 September 2020

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Article Open Access

Monoclonal antibody against H1N1 influenza virus hemagglutinin cross reacts with hnRNPA1 and hnRNPA2/B1

Chunyan Guo, Lijun Sun, Shuangping Hao, Xiaoyan Huang, Hanyu Hu, Daoyan Liang, Qing Feng, Yan Li, Yangmeng Feng, Xin Xie, Jun Hu
Pages: 3969-3975
Published online on: 07 September 2020

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Article Open Access

De novo transcriptome sequencing of Paecilomyces tenuipes revealed genes involved in adenosine biosynthesis

Long Han, Yaying Li, Xinyu Meng, Guodong Chu, Yongxin Guo, Muhammad Noman, Yuanyuan Dong, Haiyan Li, Jing Yang, Linna Du
Pages: 3976-3984
Published online on: 02 September 2020

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Article Open Access

Piceatannol suppresses proliferation and induces apoptosis by regulation of the microRNA‑21/phosphatase and tensin homolog/protein kinase B signaling pathway in osteosarcoma cells

Mingyue Zheng, Yaochi Wu
Pages: 3985-3993
Published online on: 02 September 2020

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Article

Gangliosides and CD82 inhibit the motility of colon cancer by downregulating the phosphorylation of EGFR at different tyrosine sites and signaling pathways

Xiaohua Huang, Ying Li, Xin He, Yang Chen, Wei Wei, Xuesong Yang, Keli Ma
Pages: 3994-4002
Published online on: 27 August 2020

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Article

miR‑155 modulates high glucose‑induced cardiac fibrosis via the Nrf2/HO‑1 signaling pathway

Yu Li, Jing‑Zhu Duan, Qian He, Chong‑Quan Wang
Pages: 4003-4016
Published online on: 07 September 2020

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Article

Sox9 promotes renal tubular epithelial‑mesenchymal transition and extracellular matrix aggregation via the PI3K/AKT signaling pathway

Zhiqiang Zhang, Wei Wu, Xiang Fang, Mei Lu, Heyan Wu, Chunlin Gao, Zhengkun Xia
Pages: 4017-4030
Published online on: 02 September 2020

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Article

Histone deacetylase 4 deletion results in abnormal chondrocyte hypertrophy and premature ossification from collagen type 2α1‑expressing cells

Guoqing Du, Chuan Xiang, Xiaowen Sang, Xiang Wang, Ying Shi, Nan Wang, Shaowei Wang, Pengcui Li, Xiaochun Wei, Min Zhang, Lilan Gao, Hongsheng Zhan, Lei Wei
Pages: 4031-4040
Published online on: 27 August 2020

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Article

Histone deacetylase inhibitor valproic acid attenuates high glucose‑induced endoplasmic reticulum stress and apoptosis in NRK‑52E cells

Xinyi Sun, Yuman Sun, Sitong Lin, Yan Xu, Dongming Zhao
Pages: 4041-4047
Published online on: 07 September 2020

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Article

Mutually distinguishing microRNA signatures of breast, ovarian and endometrial cancers in vitro

Marc Hirschfeld, Isabel Ge, Gerta Rücker, Julia Waldschmidt, Sebastian Mayer, Markus Jäger, Matthias Voigt, Bernd Kammerer, Claudia Nöthling, Kai Berner, Daniela Weiss, Jasmin Asberger, Thalia Erbes
Pages: 4048-4060
Published online on: 27 August 2020

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Article

Hydrogen sulfide is a regulator of mammary gland development in prepubescent female mice

Jing Zhang, Jiayi Ye, Cong Yuan, Qin Fu, Fenglin Zhang, Xiaotong Zhu, Lina Wang, Ping Gao, Gang Shu, Songbo Wang, Qiang Liu, Qingyan Jiang
Pages: 4061-4069
Published online on: 25 August 2020

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Article

Astragalin alleviates ischemia/reperfusion‑induced brain injury via suppression of endoplasmic reticulum stress

Desheng Liu, Yuntao Gu, Wenting Wang, Wendao Chen
Pages: 4070-4078
Published online on: 20 August 2020

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Retraction Open Access

[Retracted] p53 suppresses stress‑induced cellular senescence via regulation of autophagy under the deprivation of serum

Xinbing Sui, Yong Fang, Haizhou Lou, Kaifeng Wang, Yu Zheng, Fang Lou, Wei  Jin, Yinghua Xu, Wei Chen, Hongming Pan, Xian Wang, Weidong Han
Pages: 4079-4079
Published online on: 01 September 2020

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Review Open Access

Exosomal non‑coding RNAs: Novel biomarkers with emerging clinical applications in gastric cancer (Review)

Xu Lu, Yu Zhang, Guangfei Xie, Ye Ding, Hui Cong, Shihai Xuan
Pages: 4091-4100
Published online on: 17 September 2020

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Review

YAP‑mediated crosstalk between the Wnt and Hippo signaling pathways (Review)

Liya Jiang, Juan Li, Chenxing Zhang, Yufeng Shang, Jun Lin
Pages: 4101-4106
Published online on: 21 September 2020

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Review Open Access

Tumor‑associated macrophages in lung cancer: Friend or foe? (Review)

Fei Xu, Ying Wei, Zhao Tang, Baojun Liu, Jingcheng Dong
Pages: 4107-4115
Published online on: 17 September 2020

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Review

Progress in evaluating the status of hepatitis C infection based on the functional changes of hepatic stellate cells (Review)

Wei Wang, Xuelian Huang, Xuzhou Fan, Jingmei Yan, Jianfeng Luan
Pages: 4116-4124
Published online on: 17 September 2020

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Article Open Access

Human monoclonal anti‑TLR4 antibody negatively regulates lipopolysaccharide‑induced inflammatory responses in mouse macrophages

Yiwen Wang, Dandan Gong, Chuanxia Yao, Feng Zheng, Tingting Zhou, Qingxin Cao, Xuhui Zhu, Maorong Wang, Jin Zhu
Pages: 4125-4134
Published online on: 09 September 2020

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Article Open Access

Vitamin D receptor knockdown attenuates the antiproliferative, pro‑apoptotic and anti‑invasive effect of vitamin D by activating the Wnt/β‑catenin signaling pathway in papillary thyroid cancer

Rui Pang, Ye Xu, Xiaonan Hu, Bo Liu, Jiawei Yu
Pages: 4135-4142
Published online on: 17 September 2020

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Article Open Access

Weissella cibaria CMU exerts an anti‑inflammatory effect by inhibiting Aggregatibacter actinomycetemcomitans‑induced NF‑κB activation in macrophages

Min‑Jeong Kim, Yong‑Ouk You, Joo‑Yi Kang, Hyun‑Jin Kim, Mi‑Sun Kang
Pages: 4143-4150
Published online on: 15 September 2020

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Protective effects of valsartan administration on doxorubicin‑induced myocardial injury in rats and the role of oxidative stress and NOX2/NOX4 signaling

Dong Cheng, Libo Chen, Wencheng Tu, Haoren Wang, Qinfu Wang, Lili Meng, Zhu Li, Qin Yu
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SDF1/CXCR4 axis facilitates the angiogenesis via activating the PI3K/AKT pathway in degenerated discs Retraction in /10.3892/mmr.2024.13331

Hanxiang Zhang, Peng Wang, Xiang Zhang, Wenrui Zhao, Honglei Ren, Zhenming Hu
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Hypoxia in utero increases the risk of pulmonary hypertension in rat offspring and is associated with vasopressin type‑2 receptor upregulation

Hao Ding, Yuchuan Luo, Ke Hu, Huaying Huang, Pei Liu, Mengqing Xiong, Li Zhu, Jing Yi, Ying Xu
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Effects of PEG anchors in PEGylated siRNA lipoplexes on in vitro gene‑silencing effects and siRNA biodistribution in mice

Yoshiyuki Hattori, Kyoko Tamaki, Sho Sakasai, Kei‑Ichi Ozaki, Hiraku Onishi
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Expression and clinical significance of circular RNA hsa_circ_0079787 in the peripheral blood of patients with axial spondyloarthritis

Qing Luo, Biqi Fu, Lu Zhang, Yang Guo, Zikun Huang, Junming Li
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Microecological investigation and comparison of two clinical methods to evaluate axillary osmidrosis

Hongjiao Du, Shu Ding, Lihua Gao, Jinrong Zeng, Jianyun Lu
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IKKε deficiency inhibits acute lung injury following renal ischemia reperfusion injury

Chao Meng, Yi Qian, Cui Zhang, Han Liu, Xinwei Mu, Aiping Zhang
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Neuropilin‑1 as a new potential SARS‑CoV‑2 infection mediator implicated in the neurologic features and central nervous system involvement of COVID‑19

Julie Davies, Harpal S. Randeva, Kamaljit Chatha, Marcia Hall, Demetrios A. Spandidos, Emmanouil Karteris, Ioannis Kyrou
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Berberine protects against diabetic retinopathy by inhibiting cell apoptosis via deactivation of the NF‑κB signaling pathway

Jiajia Zhai, Zeping Li, Huifeng Zhang, Louyan Ma, Zhengquan Ma, Yi Zhang, Jian Zou, Mo Li, Li Ma, Xin Wang, Xiaomiao Li
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DDX46 silencing inhibits cell proliferation by activating apoptosis and autophagy in cutaneous squamous cell carcinoma

Quan Lin, Hong-Juan Jin, Duo Zhang, Ling Gao
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lncRNA TINCR facilities bladder cancer progression via regulating miR‑7 and mTOR

Guoying Xu, Honglan Yang, Meichun Liu, Jintao Niu, Weidong Chen, Xiaojing Tan, Li Sun
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Published online on: 22 September 2020

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Hyperbaric oxygen protects against myocardial ischemia‑reperfusion injury through inhibiting mitochondria dysfunction and autophagy

Wan Chen, Liwen Lv, Zhihuan Nong, Xiaoyu Chen, Xiaorong Pan, Chunxia Chen
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Potential mechanism and key genes involved in mechanical ventilation and lipopolysaccharide‑induced acute lung injury

Wen‑Wen Dong, Zhou Feng, Yun‑Qian Zhang, Zheng‑Shang Ruan, Lai Jiang
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Effects of ex vivo ischemia time and delayed processing on quality of specimens in tissue biobank

Dan Guo, Anqi Wang, Ting Xie, Sumei Zhang, Dingyan Cao, Jian Sun
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Pinealectomy increases thermogenesis and decreases lipogenesis

Mikyung Kim, So Min Lee, Jeeyoun Jung, Yun Jin Kim, Kyo Chul Moon, Ji Hae Seo, Tae Kyung Ha, Eunyoung Ha
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Published online on: 23 September 2020

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Sufentanil attenuates inflammation and oxidative stress in sepsis-induced acute lung injury by downregulating KNG1 expression

Quan Hu, Qin Wang, Chuangang Han, Yan Yang
Pages: 4298-4306
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ITCH regulates oxidative stress induced by high glucose through thioredoxin interacting protein in cultured human lens epithelial cells

Lingfeng Jiang, Wenkai Zhou, Bo Lu, Qichang Yan
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Caveolin‑1 modulates hypertensive vascular remodeling via regulation of the Notch pathway

Qian Wang, Minxi Lao, Zhen Xu, Meilin Ding, Shaolei Guo, Ling Li
Pages: 4320-4328
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AMP‑activated protein kinase family member 5 is an independent prognostic indicator of pancreatic adenocarcinoma: A study based on The Cancer Genome Atlas

Haokai Xu, Jiayan Mao, Xiaodan Yang, Fei Chen, Zhengwei Song, Jianguo Fei, Wei Chen, Zhengxiang Zhong, Xiaoguang Wang
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Investigating aberrantly expressed microRNAs in peripheral blood mononuclear cells from patients with treatment‑resistant schizophrenia using miRNA sequencing and integrated bioinformatics

Xu You, Yunqiao Zhang, Qing Long, Zijun Liu, Xiao Ma, Zixiang Lu, Wei  Yang, Ziqiao Feng, Wengyu Zhang, Zhaowei Teng, Yong Zeng
Pages: 4340-4350
Published online on: 15 September 2020

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Effects of botulinum toxin A on endometriosis‑associated pain and its related mechanism Retraction in /10.3892/mmr.2020.11674

Fubo Tian, Wuzhong Cheng, Jianying Hu, Shaoqiang Huang, Shen Sun
Pages: 4351-4359
Published online on: 10 September 2020

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Effects of local dexmedetomidine administration on the neurotoxicity of ropivacaine for sciatic nerve block in rats

Xing Xue, Jun Fan, Xiaoli Ma, Yongqiang Liu, Xuena Han, Yufang Leng, Jinjia Yu
Pages: 4360-4366
Published online on: 17 September 2020

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Resveratrol decreases high glucose‑induced apoptosis in renal tubular cells via suppressing endoplasmic reticulum stress

Jing Zhang, Xiong‑Jun Dong, Meng‑Ru Ding, Chun‑Yu You, Xin Lin, Ying Wang, Miao‑Jie‑Yang Wu, Guo‑Fei Xu, Guo‑Dong Wang
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Published online on: 15 September 2020

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Neuropeptide Y upregulates Runx2 and osterix and enhances osteogenesis in mouse MC3T3‑E1 cells via an autocrine mechanism

Bo Zhang, Xiaolei Zhang, Juan Xiao, Xuguang Zhou, Yuan Chen, Chunzheng Gao
Pages: 4376-4382
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Uncovering potential differentially expressed miRNAs and targeted mRNAs in myocardial infarction based on integrating analysis

Shiai Wang, Na Cao
Pages: 4383-4395
Published online on: 17 September 2020

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Clinical characteristics and gene mutation analysis of an adult patient with ETFDH‑related multiple acyl‑CoA dehydrogenase deficiency

Chenyi Wang, Haihong Lv, Xia Xu, Yuping Ma, Qian Li
Pages: 4396-4402
Published online on: 18 September 2020

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Overexpression of G3BP1 facilitates the progression of colon cancer by activating β‑catenin signaling

Yuanzhi Li, Jundong Wang, Sen Zhong, Jun Li, Weiliang Du
Pages: 4403-4411
Published online on: 18 September 2020

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Methylation status of CpG sites in the NOTCH4 promoter region regulates NOTCH4 expression in patients with tetralogy of Fallot

Yanjie Zhu, Ming Ye, Hongfei Xu, Ruoyi Gu, Xiaojing Ma, Mingwu Chen, Xiaodi Li, Wei Sheng, Guoying Huang
Pages: 4412-4422
Published online on: 24 September 2020

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Preparation of T‑2 toxin‑containing pH‑sensitive liposome and its antitumor activity

Yuan Dong, Guixian Meng, Jian Guo, Moli Yin, Huijing Xu, Yujie Li, Jie Zhu, Wenhe Zhu, Mingguang Li, Yan Li, Huiyan Wang
Pages: 4423-4431
Published online on: 22 September 2020

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GSK‑3β inhibition promotes doxorubicin‑induced apoptosis in human cholangiocarcinoma cells via FAK/AKT inhibition

Lei Li, Yuancai Xiang, Yi Zeng, Bin Xiao, Wenjing Yu, Chunyan Duan, Xianming Xia, Ting Zhang, Yongqiu Zeng, Youping Liu, Rongyang Dai
Pages: 4432-4441
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miR‑181b‑5p inhibits trophoblast cell migration and invasion through targeting S1PR1 in multiple abnormal trophoblast invasion‑related events

Juan Miao, Yiqing Zhu, Lei Xu, Xiaohao Huang, Xue Zhou
Pages: 4442-4451
Published online on: 17 September 2020

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[Retracted] Glycogen synthase kinase‑3β is required for epithelial‑mesenchymal transition and barrier dysfunction in mouse podocytes under high glucose conditions

Jia Guo, Lili Yang, Yingjin Qiao, Zhangsuo Liu
Pages: 4452-4452
Published online on: 17 September 2020

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August-2026 Volume 34 Issue 2

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CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Regulatory function of ten‑eleven translocation‑2 in transcriptional mechanisms of demethylated myeloma cells

Lenka Slavickova, Michaela Nemcova, Dominika Svehlova, Veronika Frybortova, Jirina Manakova, Eva Kriegova, Jiri Minarik, Katerina Smesny Trtkova
Article Number: 237
Published online on: 25 June 2026

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Mulberroside A attenuates H2O2‑induced oxidative stress and barrier dysfunction in Caco‑2 cells through Nrf2/HO‑1‑associated antioxidant signaling

Jianxin Chen, Xiufeng Huang, Xi Chen, Wenhai Jin, Dawei Lin
Article Number: 236
Published online on: 25 June 2026

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[Retracted] Puerarin promotes DUSP1 expression by regulating miR‑133a‑3p in breast cancer

Zhifeng Li, Weiwei Xu, Xiaoyan Ren, Jinhua Xu, Jianxin Chen
Article Number: 235
Published online on: 23 June 2026

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Sulforaphane attenuates cisplatin‑induced acute kidney injury by inhibiting oxidative stress, inflammation and apoptosis via regulation of NRF2

Zeyu Wu, Mengting Lu, Lei Xu, Ming Luo, Limei Shan, Hongxia Xing, Wenwen Li, Junling Qian
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Effects of β‑hydroxybutyrate on restoring autophagic flux and mitochondrial function in macrophages exposed to oxidized low‑density lipoprotein

Weiguang Luo, Mei He, Huiling Wang
Article Number: 233
Published online on: 19 June 2026

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Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review)

Xiaokang Wang, Qiwen Tan, Jingcheng Xu, Yunlin Yang, Haoyue Huang, Xiaomei Teng, Weihua Wu
Article Number: 232
Published online on: 18 June 2026

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Degraded sulfated galactan derived from Gracilaria fisheri induces immunogenic cell death in MDA‑MB‑231 cells

Tawut Rudtanatip, Yada Polsan, Waraporn Sakaew, Somsuda Somintara, Jenjiralai Phanphak, Jamal El‑Abid, Kanokpan Wongprasert, Choowadee Pariwatthanakun
Article Number: 231
Published online on: 17 June 2026

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Irbesartan ameliorates high‑glucose‑induced epithelial‑mesenchymal transition by downregulating the expression of NLRP3 in HK‑2 cells

Qing Deng, Xiujuan Liu, Dan Wen, Yuhua Cheng, Qing Zhao, Yu Wang, Yu Xiang, Qinkai Chen, Jinlei Lv
Article Number: 230
Published online on: 17 June 2026

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A β‑1,3‑1,6‑glucan from Aureobasidium pullulans enhances apoptotic and autophagic pathways in colorectal cancer cells

Ji-Won Park, Gyeong Mim Mun, Tae Min Jo, Ji A Shin, Takao Kuge, Hisashi Kimoto, Jin-Kyung Kim
Article Number: 229
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Growth pattern and molecular biological analysis of primary meningioma cell cultures under different conditions

Stefan Linsler, Anna-Lena Moroldo, Walter Schulz‑Schaeffer, Ralf Ketter, Joachim Oertel, Steffi Urbschat
Article Number: 228
Published online on: 12 June 2026

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Melatonin alleviates mitochondrial damage by regulating SIRT3‑mediated mitochondrial dynamics in granulosa cells under PCOS‑like conditions

Congcong Xie, Zehao Liu, Tong Chen, Hui Lu, Xiujia Zhang, Wenbo Yu, Jiaxin Zhang, Dandan Shang, Xueying Wang
Article Number: 227
Published online on: 11 June 2026

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Strontium‑based metal‑organic framework/alendronate‑silk fibroin hydrogels promote tendon‑bone interface healing

Tao Yang, Hanji Zhang, Mingjun Li, Yiming Ren, Yunbo Sun, Weiyu Hou, Mengqiang Tian
Article Number: 226
Published online on: 11 June 2026

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[Retracted] Tripterygium glycoside suppresses epithelial‑to‑­­ mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway

Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He
Article Number: 225
Published online on: 08 June 2026

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Gut microbiota‑derived metabolites in cardiovascular disease: Focus on trimethylamine N‑oxide, short‑chain fatty acids and bile acids (Review)

Meizhu Gao, Zhenming Hao, Yiling Li, Weixue Liu, Fubao Zhang
Article Number: 224
Published online on: 08 June 2026

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Fucoxanthin alleviates chondrocyte inflammation and osteoarthritis by modulating the JAK2/STAT3 signaling pathway

Miradj Siddick Adam, Huangming Zhuang, Xunshan Ren, Yuelong Zhang, Panghu Zhou
Article Number: 223
Published online on: 08 June 2026

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Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer

Huaiyong Li, Lili Liu, Qingzhu Yang, Yao Li, Yongli Song, Jing Jiang, Zhenzhong Wu, Weiwei Zhang, Baisong Lou
Article Number: 222
Published online on: 08 June 2026

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Molecular mechanisms of iron metabolism and ferroptosis in cardiovascular diseases and intervention strategies targeting natural products (Review)

Liangqing Ge, Tianqing Zhang, Jiangbiao Yu, Sijie Xiao, Yu Zhou, Li Luo
Article Number: 221
Published online on: 05 June 2026

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[Corrigendum] Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis

Ruiqiao Guan, Zhihao Li, Xiaohong Dai, Wei Zou, Xueping Yu, Hao Liu, Qiuxin Chen, Wei Teng, Peng Liu, Xiaoying Liu, Shanshan Dong
Article Number: 220
Published online on: 03 June 2026

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LINC01117 promotes the malignant proliferation of lung adenocarcinoma by increasing HOXD8 mRNA stability

Lizhong Zeng, Jie Shi, Cai Zhang, Yujiao Dong, Yang Chen, Qiuhong Zhang, Long Zhang, Shuanying Yang
Article Number: 219
Published online on: 03 June 2026

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Targeting regulatory T cells in the prostate cancer microenvironment: From mechanisms to therapeutics (Review)

Hua Luo
Article Number: 218
Published online on: 03 June 2026

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Dapagliflozin alleviates heart failure with preserved ejection fraction potentially by regulating the AIM2/caspase‑1/GSDMD pathway and attenuating pyroptosis

Sailiang Ding, Hao Yang, Ting Lu, Yibin Luo, Liang Xu, Xianghui Zeng
Article Number: 217
Published online on: 03 June 2026

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[Retracted] Carnosic acid alleviates brain injury through NF‑κB‑regulated inflammation and Caspase‑3‑associated apoptosis in high fat‑induced mouse models

Yong Liu, Yan Zhang, Ming Hu, Yu-Hu Li, Xing-Hua Cao
Article Number: 216
Published online on: 02 June 2026

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SIRT1/AMPK/PGC1α pathway in ischemic stroke: Elucidating neuroprotective strategies (Review)

Irum Naz Abbasi, Nashwa Amin, Qiaolu Xu, Azhar Badry Hussain, Fei Wu, Xia Yuan, Yang Yang, Suhong Ye, Marong Fang, Yihua Jiang
Article Number: 215
Published online on: 02 June 2026

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Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review)

Yinhuan Wang, Jiefang Guan
Article Number: 214
Published online on: 29 May 2026

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September-2026 Volume 34 Issue 3

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Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Sedanolide alleviates LPS‑induced depressive‑like behaviors by modulating the C3a/C3aR signaling axis and microglial glycolysis

Shaocong Lu, Fangla Luo, Niqi Chen, Gongde Shi, Yeru Chen
Article Number: 257
Published online on: 16 July 2026

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[Expression of Concern] Chrysophanol inhibits proliferation and induces apoptosis through NF‑κB/cyclin D1 and NF‑κB/Bcl‑2 signaling cascade in breast cancer cell lines

Li Ren, Zhouping Li, Chunmei Dai, Danyu Zhao, Yanjie Wang, Chunyu Ma, Chun Liu
Article Number: 256
Published online on: 15 July 2026

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PCSK9 alleviates doxorubicin‑induced pyroptosis of cardiomyocytes

Chaochu Cui, Jinyu Zhao, Xiaoqian Li, Shengming Huang, Gang Liu, Xinhui Xu, Can Guo, Tiesuo Zhao, Jiang Du, Shipeng Li, Xianwei Wang, Jianbo Yang
Article Number: 255
Published online on: 14 July 2026

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From cell to disease: Regulatory networks and mechanisms of super‑enhancers in aging (Review)

Xiaodan Wang, Weiqian Deng, Shuangxi Tu, Haojun Tang, Kai Yin, Xiao Zhu
Article Number: 254
Published online on: 14 July 2026

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[Retracted] Matrine‑induced apoptosis in Hep3B cells via the inhibition of MDM2

Ning Zhou, Jiequn Li, Ting Li, Guangshun Chen, Zhongqiang Zhang, Zhongzhou Si
Article Number: 253
Published online on: 13 July 2026

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Role of PANoptosis in the development of gastric immunity and related gastric mucosal disease (Review)

Lan Wang, Zhiyuan Ma, Bei Ji, Shuhui Liu, Shuji Terai, Biguang Tuo, Taolang Li, Xuemei Liu
Article Number: 252
Published online on: 09 July 2026

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Article

Leonurine inhibits the proliferation and metastasis of liver cancer cells by regulating the PI3K/AKT signaling pathway via epithelial‑mesenchymal transition

Bowen Hu, Maher Al Hussan, Jiakai Zhang, Peihao Wen, Changjun Huang, Yang Chen, Huanfei Ding
Article Number: 251
Published online on: 08 July 2026

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[Corrigendum] Resistin aggravates the expression of proinflammatory cytokines in cerulein‑stimulated AR42J pancreatic acinar cells

Chong-Yi Jiang, Wei Wang
Article Number: 250
Published online on: 08 July 2026

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A‑Raf: A serine/threonine protein kinase with important biological functions (Review)

Muhan Yang, Mengying Chen, Jinmei Wei, Yanling Li, Chen Long, Yan Lei, Yanhong Zhou
Article Number: 249
Published online on: 07 July 2026

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Gut dysbiosis‑derived butyrate loss predicts feeding intolerance: Multiomics evidence guiding nurse‑driven microbiota‑supportive interventions (Review)

Ling Wei, Xiaohua Kong, Yuying Li, Huixia Wu, Yirong Gan, Fang Sun
Article Number: 248
Published online on: 07 July 2026

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[Retracted] Network pharmacology combined with experimental validation to investigate the effect of Rongjin Niantong Fang on chondrocyte apoptosis in knee osteoarthritis

Jun Chen, Ting Zhang, Qingqing Luo, Ruyi Wang, Yuting Dai, Zhenyuan Chen, Chutian Zhang, Xuzheng Chen, Guangwen Wu
Article Number: 247
Published online on: 06 July 2026

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Laggera alata attenuates LPS‑induced systemic inflammation and hepatic‑pulmonary injury by regulating PINK1/Parkin-associated mitophagy and macrophage polarization

Jiangcun Wei, Wen Zhong, Guangyun Zhou, Mingtao Huang, Xiaodong Huang, Jing Liang
Article Number: 246
Published online on: 02 July 2026

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Proteolysis‑targeting chimeras in oral squamous cell carcinoma: Current evidence, translational challenges and future directions (Review)

Yun Bai, Danhua Ma, Xi Yang, Min Wang
Article Number: 245
Published online on: 02 July 2026

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Evolving role of biomarkers beyond prostate‑specific antigen in refining prostate cancer screening: From blood‑based tests to urinary and genetic markers (Review)

Luxi Li, Linyue Zhang, Zehong Li, Keqiang Chai, Weidong Ren
Article Number: 244
Published online on: 02 July 2026

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Nanocurcumin attenuates brain injury in rats with desert dry‑heat‑induced exertional heat stroke by suppressing TLR4/MyD88/NF‑κB signaling

Lisong Su, Jinquan Qu, Jiajia Li, Wenhui Shi, Laiyang Song, Feixing Liang, Jiangwei Liu
Article Number: 243
Published online on: 02 July 2026

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TREM2 in glioma: Reprogramming the immune microenvironment from mechanistic understanding to clinical translation (Review)

Junqi Fan, Hongyan Shen, Dan Liu, Songbai Luo, Qingqing Huang, Yi Wen, Libang Yuan
Article Number: 242
Published online on: 02 July 2026

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Human parvovirus B19 VP1u‑induced osteoclastogenesis is enhanced by RANKL in RAW264.7 macrophage cells

Chun-Yu Lin, Bor-Show Tzang, Yi-Hsuan Lin, Chih-Chen Tzang, Tsai-Ching Hsu
Article Number: 241
Published online on: 30 June 2026

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[Retracted] Anti‑tumor peptide AP25 decreases cyclin D1 expression and inhibits MGC‑803 proliferation via phospho­extracellular signal‑regulated kinase‑, Src‑, c‑Jun N‑terminal kinase‑ and phosphoinositide 3­-kinase‑associated pathways  

Jialiang Hu, Tao Cheng, Lijun Zhang, Beicheng Sun, Lei Deng, Hanmei Xu
Article Number: 240
Published online on: 29 June 2026

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Aspirin prevents postoperative peritoneal adhesions by inhibiting the TGF‑β1/Smad signaling pathway in rats

Siqi Yan, Yuan Ren, Bingyan Liu, Pai Xiong, Yimin Sun
Article Number: 239
Published online on: 29 June 2026

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Morinda officinalis oligosaccharides ameliorate corticosterone‑induced depression‑like behaviour in mice by modulating the BDNF signalling pathway and gut microbiota

Mengjie He, Zixuan Liu, Yuxin Chen, Xiaoru Wu, Xueling Dai, Qian Liu, Shuo Wang, Zeping Zuo, Yaxuan Sun
Article Number: 238
Published online on: 29 June 2026

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