Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
November-2020 Volume 22 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2020 Volume 22 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Sufentanil attenuates inflammation and oxidative stress in sepsis-induced acute lung injury by downregulating KNG1 expression

  • Authors:
    • Quan Hu
    • Qin Wang
    • Chuangang Han
    • Yan Yang
  • View Affiliations / Copyright

    Affiliations: Intensive Care Unit, The First People's Hospital, Wuhan, Hubei 430200, P.R. China, Department of Pathology, Hubei Women and Children Health Care Hospital, Wuhan, Hubei 430200, P.R. China, Department of Anesthesiology, The First People's Hospital, Wuhan, Hubei 430200, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4298-4306
    |
    Published online on: September 18, 2020
       https://doi.org/10.3892/mmr.2020.11526
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to investigate the effects of sufentanil on sepsis-induced acute lung injury (ALI), and identify the potential molecular mechanisms underlying its effect. In order to achieve this, a rat sepsis model was established. Following treatment with sufentanil, the lung wet/dry (W/D) weight ratio was calculated. Histopathological analysis was performed via hematoxylin and eosin staining. Levels of inflammatory factors in bronchoalveolar lavage fluid were determined via ELISA. Furthermore, malondialdehyde (MDA) content and the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in tissue homogenates were assessed using commercial kits. Western blot analysis was performed to determine kininogen-1 (KNG1) protein expression. In addition, alveolar epithelial type II cells (AEC II) were stimulated with lipopolysaccharide (LPS) to mimic ALI. The levels of inflammation and oxidative stress were evaluated following overexpression of KNG1. Protein expression levels of nuclear factor-κB (NF-κB) and nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling were determined via western blot analysis. The results of the present study demonstrated that sufentanil alleviated histopathological injury and the W/D ratio in lung tissue. Following treatment with sufentanil, levels of inflammatory factors also decreased, accompanied by decreased concentrations of MDA, and increased activities of SOD, CAT and GSH-Px. Notably, KNG1 was decreased in lung tissues following treatment with sufentanil. Furthermore, overexpression of KNG1 attenuated the inhibitory effects of sufentanil on LPS-induced inflammation and oxidative stress in AEC II. Sufentanil markedly downregulated NF-κB expression, while upregulating Nrf2 and HO-1 expression levels, which was reversed following overexpression of KNG1. Taken together, the results of the present study suggested that sufentanil may alleviate inflammation and oxidative stress in sepsis-induced ALI by downregulating KNG1 expression.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, Gattinoni L, van Haren F, Larsson A, McAuley DF, et al: Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA. 315:788–800. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Peng LY, Yuan M, Shi HT, Li JH, Song K, Huang JN, Yi PF, Fu BD and Shen HQ: Protective effect of piceatannol against acute lung injury through protecting the integrity of air-blood barrier and modulating the TLR4/NF-κB signaling pathway activation. Front Pharmacol. 10:16132019. View Article : Google Scholar : PubMed/NCBI

3 

Villar J, Sulemanji D and Kacmarek RM: The acute respiratory distress syndrome: Incidence and mortality, has it changed? Current Opin Crit Care. 20:3–9. 2014. View Article : Google Scholar

4 

Dong Y, Zhang L, Jiang Y, Dai J, Tang L and Liu G: Emodin reactivated autophagy and alleviated inflammatory lung injury in mice with lethal endotoxemia. Exp Anim. 68:559–568. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Wu B, Miao X, Ye J and Pu X: The protective effects of protease inhibitor MG-132 on sepsis-induced acute lung rats and its possible mechanisms. Med Sci Monit. 25:5690–5699. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Chen L, Lin X, Xiao J, Tian Y, Zheng B and Teng H: Sonchus oleraceus Linn protects against LPS-induced sepsis and inhibits inflammatory responses in RAW264.7 cells. J Ethnopharmacol. 236:63–69. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Guo K and Jin F: Dipeptidyl peptidase-4 (DPP-4) inhibitor saxagliptin alleviates lipopolysaccharide-induced acute lung injury via regulating the Nrf-2/HO-1 and NF-κB pathways. J Invest Surg. 1–8. 2019. View Article : Google Scholar

8 

Zhang Y, Li RM, Wang C, Liu N, Lv S and Xiong JY: Etomidate inhibits nuclear factor-kappaB through decreased expression of glucocorticoid receptor in septic rats. Mol Med Rep. 14:5760–5766. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Liu J, Huang X, Hu S, He H and Meng Z: Dexmedetomidine attenuates lipopolysaccharide induced acute lung injury in rats by inhibition of caveolin-1 downstream signaling. Biomed Pharmacother. 118:1093142019. View Article : Google Scholar : PubMed/NCBI

10 

Lian YH, Fang J, Zhou HD, Jiang HF and Xie KJ: Sufentanil preconditioning protects against hepatic ischemia-reperfusion injury by suppressing inflammation. Med Sci Monit. 25:2265–2273. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Zhang CM, Yu JL, Zhang Y, Chen LX, Cao HJ and Wang YY: The effect of sufentanil on acute lung injury in rabbits. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 20:108–110. 2008.(In Chinese). PubMed/NCBI

12 

Reupke V, Walliser K, Perl T, Kimmina S, Schraepler A, Quintel M and Kunze-Szikszay N: Total intravenous anaesthesia using propofol and sufentanil allows controlled long-term ventilation in rabbits without neuromuscular blocking agents. Lab Anim. 51:284–291. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Furniss SK, Yao R and Gonzalez G: Automatic gene prioritization in support of the inflammatory contribution to Alzheimer's disease. AMIA Jt Summits Transl Sci Proc. 2014:42–47. 2014.PubMed/NCBI

14 

Wu D, Huo M, Chen X, Zhang Y and Qiao Y: Mechanism of tanshinones and phenolic acids from Danshen in the treatment of coronary heart disease based on co-expression network. BMC Complement Med Ther. 20:282020. View Article : Google Scholar : PubMed/NCBI

15 

Qin S, Wang H, Liu G, Mei H and Chen M: miR215p ameliorates hyperoxic acute lung injury and decreases apoptosis of AEC II cells via PTEN/AKT signaling in rats. Mol Med Rep. 20:4953–4962. 2019.PubMed/NCBI

16 

Kata D, Foldesi I, Feher LZ, Hackler L Jr, Puskas LG and Gulya K: A novel pleiotropic effect of aspirin: Beneficial regulation of pro- and anti-inflammatory mechanisms in microglial cells. Brain Res Bull. 132:61–74. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Li R, Ren T and Zeng J: Mitochondrial coenzyme Q protects sepsis-induced acute lung injury by activating PI3K/Akt/GSK-3β/mTOR pathway in rats. BioMed Res Int. 2019:52408982019. View Article : Google Scholar : PubMed/NCBI

18 

Hu HY, Shi D, Hu CL, Yuan X, Zhang J and Sun H: Dexmedetomidine mitigates CLP-stimulated acute lung injury via restraining the RAGE pathway. Am J Transl Res. 9:5245–5258. 2017.PubMed/NCBI

19 

Wu B, Miao X, Ye J and Pu X: The protective effects of protease inhibitor MG-132 on sepsis-induced acute lung rats and its possible mechanisms. Med Sci Monitor. 25:5690–5699. 2019. View Article : Google Scholar

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Xu C, Guo Z, Zhao C, Zhang X and Wang Z: Potential mechanism and drug candidates for sepsis-induced acute lung injury. Exp Ther Med. 15:4689–4696. 2018.PubMed/NCBI

22 

Shen N, Cheng A, Qiu M and Zang G: Allicin improves lung injury induced by sepsis via regulation of the toll-like receptor 4 (TLR4)/myeloid differentiation primary response 88 (MYD88)/nuclear factor kappa B (NF-κB) pathway. Med Sci Monit. 25:2567–2576. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Zhou J, Fu Y, Liu K, Hou L and Zhang W: miR-206 regulates alveolar type II epithelial cell Cx43 expression in sepsis-induced acute lung injury. Exp Ther Med. 18:296–304. 2019.PubMed/NCBI

24 

Patel M, Chignalia AZ, Isbatan A, Bommakanti N and Dull RO: Ropivacaine inhibits pressure-induced lung endothelial hyperpermeability in models of acute hypertension. Life Sci. 222:22–28. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Strosing KM, Faller S, Gyllenram V, Engelstaedter H, Buerkle H, Spassov S and Hoetzel A: Inhaled anesthetics exert different protective properties in a mouse model of ventilator-induced lung injury. Anesth Analg. 123:143–151. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Lin X, Ju YN, Gao W, Li DM and Guo CC: Desflurane attenuates ventilator-induced lung injury in rats with acute respiratory distress syndrome. Biomed Res Int. 2018:75073142018. View Article : Google Scholar : PubMed/NCBI

27 

Ji S and Wang L: µ-Opioid receptor signalling via PI3K/Akt pathway ameliorates lipopolysaccharide-induced acute respiratory distress syndrome. Exp Physiol. 104:1555–1561. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Dong S, Liu J, Li L, Wang H, Ma H, Zhao Y and Zhao J: The HECT ubiquitin E3 ligase Smurf2 degrades µ-opioid receptor 1 in the ubiquitin-proteasome system in lung epithelial cells. Am J Physiol Cell Physiol. 316:C632–C640. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Chen Q, Liu J, Wang W, Liu S, Yang X, Chen M, Cheng L, Lu J, Guo T and Huang F: Sini decoction ameliorates sepsis-induced acute lung injury via regulating ACE2-Ang (1–7)-Mas axis and inhibiting the MAPK signaling pathway. Biomed Pharmacother. 115:1089712019. View Article : Google Scholar : PubMed/NCBI

30 

Qiu N, Xu X and He Y: LncRNA TUG1 alleviates sepsis-induced acute lung injury by targeting miR-34b-5p/GAB1. BMC Pulm Med. 20:492020. View Article : Google Scholar : PubMed/NCBI

31 

Wang XH, Zeng JF, Lin C and Chen SB: Effects of morphine and sufentanil preconditioning against myocardial ischemic-reperfusion injury in rabbits. Int J Clin Exp Med. 8:15692–15699. 2015.PubMed/NCBI

32 

Wang H, Tan X, Xu J, Li H, Wang M, Chen S, Yang X, Liu Y and Wang F: Negative correlation between CSF lactate levels and MoCA scores in male Chinese subjects. Psychiatry Res. 255:49–51. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Langhauser F, Göb E, Kraft P, Geis C, Schmitt J, Brede M, Göbel K, Helluy X, Pham M, Bendszus M, et al: Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation. Blood. 120:4082–4092. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Shi K, Chen X, Xie B, Yang SS, Liu D, Dai G and Chen Q: Celastrol alleviates chronic obstructive pulmonary disease by inhibiting cellular inflammation induced by cigarette smoke via the Ednrb/Kng1 signaling pathway. Front Pharmacol. 9:12762018. View Article : Google Scholar : PubMed/NCBI

35 

Xu M, Cao FL, Zhang YF, Shan L, Jiang XL, An XJ, Xu W, Liu XZ and Wang XY: Tanshinone IIA therapeutically reduces LPS-induced acute lung injury by inhibiting inflammation and apoptosis in mice. Acta Pharmacol Sin. 36:179–187. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Qing R, Huang Z, Tang Y, Xiang Q and Yang F: Cordycepin alleviates lipopolysaccharide-induced acute lung injury via Nrf(2)/HO-1 pathway. Int Immunopharmacol. 60:18–25. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Zhao B, Gao W, Gao X, Leng Y, Liu M, Hou J and Wu Y: Sulforaphane attenuates acute lung injury by inhibiting oxidative stress via Nrf2/HO-1 pathway in a rat sepsis model. Int J Clin Exp Pathol. 10:9021–9028. 2017.PubMed/NCBI

38 

Xu J, Li HB, Chen L, Wang YX, Lu S, Li SN, Cui SN, Xiao HR, Qin L, Hu H, et al: BML-111 accelerates the resolution of inflammation by modulating the Nrf2/HO-1 and NF-κB pathways in rats with ventilator-induced lung injury. Int Immunopharmacol. 69:289–298. 2019. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hu Q, Wang Q, Han C and Yang Y: Sufentanil attenuates inflammation and oxidative stress in sepsis-induced acute lung injury by downregulating KNG1 expression. Mol Med Rep 22: 4298-4306, 2020.
APA
Hu, Q., Wang, Q., Han, C., & Yang, Y. (2020). Sufentanil attenuates inflammation and oxidative stress in sepsis-induced acute lung injury by downregulating KNG1 expression. Molecular Medicine Reports, 22, 4298-4306. https://doi.org/10.3892/mmr.2020.11526
MLA
Hu, Q., Wang, Q., Han, C., Yang, Y."Sufentanil attenuates inflammation and oxidative stress in sepsis-induced acute lung injury by downregulating KNG1 expression". Molecular Medicine Reports 22.5 (2020): 4298-4306.
Chicago
Hu, Q., Wang, Q., Han, C., Yang, Y."Sufentanil attenuates inflammation and oxidative stress in sepsis-induced acute lung injury by downregulating KNG1 expression". Molecular Medicine Reports 22, no. 5 (2020): 4298-4306. https://doi.org/10.3892/mmr.2020.11526
Copy and paste a formatted citation
x
Spandidos Publications style
Hu Q, Wang Q, Han C and Yang Y: Sufentanil attenuates inflammation and oxidative stress in sepsis-induced acute lung injury by downregulating KNG1 expression. Mol Med Rep 22: 4298-4306, 2020.
APA
Hu, Q., Wang, Q., Han, C., & Yang, Y. (2020). Sufentanil attenuates inflammation and oxidative stress in sepsis-induced acute lung injury by downregulating KNG1 expression. Molecular Medicine Reports, 22, 4298-4306. https://doi.org/10.3892/mmr.2020.11526
MLA
Hu, Q., Wang, Q., Han, C., Yang, Y."Sufentanil attenuates inflammation and oxidative stress in sepsis-induced acute lung injury by downregulating KNG1 expression". Molecular Medicine Reports 22.5 (2020): 4298-4306.
Chicago
Hu, Q., Wang, Q., Han, C., Yang, Y."Sufentanil attenuates inflammation and oxidative stress in sepsis-induced acute lung injury by downregulating KNG1 expression". Molecular Medicine Reports 22, no. 5 (2020): 4298-4306. https://doi.org/10.3892/mmr.2020.11526
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team