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Article

Preparation of T‑2 toxin‑containing pH‑sensitive liposome and its antitumor activity

  • Authors:
    • Yuan Dong
    • Guixian Meng
    • Jian Guo
    • Moli Yin
    • Huijing Xu
    • Yujie Li
    • Jie Zhu
    • Wenhe Zhu
    • Mingguang Li
    • Yan Li
    • Huiyan Wang
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, Jilin Medical University, Jilin 132013, P.R. China, Jilin Collaborative Innovation Center for Antibody Engineering, Jilin Medical University, Jilin 132013, P.R. China
  • Pages: 4423-4431
    |
    Published online on: September 22, 2020
       https://doi.org/10.3892/mmr.2020.11531
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Abstract

T‑2 toxin is a type A trichothecene mycotoxin. In order to reduce the side effects of T‑2 toxin and increase the tumor targeting ability, a pH‑sensitive liposome of T‑2 toxin (LP‑pHS‑T2) was prepared and characterized in the present study. The cytotoxicity of LP‑pHS‑T2 on A549, Hep‑G2, MKN‑45, K562 and L929 cell lines was tested by 3‑(4,5‑dimethylthiazolyl‑2)‑2,5‑diphenyltetrazolium bromide assay, with T‑2 toxin as the control. The apoptotic and migratory effects of LP‑pHS‑T2 on Hep‑G2 cells were investigated. The preparation process of LP‑pHS‑T2 involved the following parameters: Dipalmitoyl phosphatidylcholine: dioleoylphosphatidylethanolamine, 1:2; total phospholipid concentration, 20 mg/ml; phospholipid:cholesterol, 3:1; 4‑(2‑hydroxyethyl)‑1‑piperazineethanesulfonic acid buffer (pH 7.4), 10 ml; drug:lipid ratio, 2:1; followed by ultrasound for 10 min and extrusion. The encapsulation efficiency reached 95±2.43%. The average particle size of LP‑pHS‑T2 after extrusion was 100 nm; transmission electron microscopy showed that the shape of LP‑pHS‑T2 was round or oval and of uniform size. The release profile demonstrated a two‑phase downward trend, with fast leakage of T‑2 toxin in the first 6 h (~20% released), followed by sustained release up to 48 h (~46% released). From 48‑72 h, the leakage rate increased (~76% released), until reaching a minimum at 72 h. When LP‑pHS‑T2 was immersed in 0.2 mol/l disodium phosphate‑sodium dihydrogen phosphate buffers (pH 6.5), the release speed was significantly increased and the release rate reached 91.2%, demonstrating strong pH sensitivity. Overall, antitumor tests showed that LP‑pHS‑T2 could promote the apoptosis and inhibit the migration of Hep‑G2 cells. The present study provided a new approach for the development of T‑2 toxin‑based anti‑cancer drugs.
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View References

1 

Wu J, Zhou Y, Yuan Z, Yi J, Chen J, Wang N and Tian Y: Autophagy and apoptosis interact to modulate T-2 toxin-induced toxicity in liver cells. Toxins (Basel). 11:452019. View Article : Google Scholar

2 

Yang L, Tu D, Wang N, Deng Z, Zhan Y, Liu W, Hu Y, Liu T, Tan L, Li Y, et al: The protective effects of DL-selenomethionine against T-2/HT-2 toxins-induced cytotoxicity and oxidative stress in broiler hepatocytes. Toxicol In Vitro. 54:137–146. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Meng-Reiterer J, Varga E, Nathanail AV, Bueschl C, Rechthaler J, McCormick SP, Michlmayr H, Malachova A, Fruhmann P, Adam G, et al: Tracing the metabolism of HT-2 toxin and T-2 toxin in barley by isotope-assisted untargeted screening and quantitative LC-HRMS analysis. Anal Bioanal Chem. 407:8019–8033. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Wang Y, Zhang L, Peng D, Xie S, Chen D, Pan Y, Tao Y and Yuan Z: Construction of electrochemical immunosensor based on gold-nanoparticles/carbon nanotubes/chitosan for sensitive determination of T-2 toxin in feed and swine meat. Int J Mol Sci. 19:38952018. View Article : Google Scholar

5 

Seeboth J, Solinhac R, Oswald IP and Guzylack-Piriou L: The fungal T-2 toxin alters the activation of primary macrophages induced by TLR-agonists resulting in a decrease of the inflammatory response in the pig. Vet Res. 43:352012. View Article : Google Scholar : PubMed/NCBI

6 

Osselaere A, Li SJ, De Bock L, Devreese M, Goossens J, Vandenbroucke V, Van Bocxlaer J, Boussery K, Pasmans F, Martel A, et al: Toxic effects of dietary exposure to T-2 toxin on intestinal and hepatic biotransformation enzymes and drug transporter systems in broiler chickens. Food Chem Toxicol. 55:150–155. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Doi K, Ishigami N and Sehata S: T-2 toxin-induced toxicity in pregnant mice and rats. Int J Mol Sci. 9:2146–2158. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Fu YT, Lin WG, BaoCheng Z and Quan G: The effect of T-2 toxin on IL-1beta and IL-6 secretion in human fetal chondrocytes. Int Orthop. 25:199–201. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Chen X, Xu J, Liu D, Sun Y, Qian G, Xu S, Gan F, Pan C and Huang K: The aggravating effect of selenium deficiency on T-2 toxin-induced damage on primary cardiomyocyte results from a reduction of protective autophagy. Chem Biol Interact. 300:27–34. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Huang Z, Wang Y, Qiu M, Sun L, Liao J, Wang R, Sun X, Bi S and Gooneratne R: Effect of T-2 toxin-injected shrimp muscle extracts on mouse macrophage cells (RAW264.7). Drug Chem Toxicol. 41:16–21. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Nathanail AV, Varga E, Meng-Reiterer J, Bueschl C, Michlmayr H, Malachova A, Fruhmann P, Jestoi M, Peltonen K, Adam G, et al: Metabolism of the fusarium mycotoxins T-2 toxin and HT-2 toxin in wheat. J Agric Food Chem. 63:7862–7872. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Wu Q, Huang L, Liu Z, Yao M, Wang Y, Dai M and Yuan Z: A comparison of hepatic in vitro metabolism of T-2 toxin in rats, pigs, chickens, and carp. Xenobiotica. 41:863–873. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Konigs M, Mulac D, Schwerdt G, Gekle M and Humpf HU: Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture. Toxicology. 258:106–115. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Wang J, Yang C, Yuan Z, Yi J and Wu J: T-2 toxin exposure induces apoptosis in TM3 cells by inhibiting mammalian target of rapamycin/serine/threonine protein kinase(mTORC2/AKT) to promote Ca2+production. Int J Mol Sci. 19:33602018. View Article : Google Scholar

15 

Ueno Y, Umemori K, Niimi E, Tanuma S, Nagata S, Sugamata M, Ihara T, Sekijima M, Kawai K, Ueno I, et al: Induction of apoptosis by T-2 toxin and other natural toxins in HL-60 human promyelotic leukemia cells. Nat Toxins. 3:129–137. 1995. View Article : Google Scholar : PubMed/NCBI

16 

Nagase M, Alam MM, Tsushima A, Yoshizawa T and Sakato N: Apoptosis induction by T-2 toxin: Activation of caspase-9, caspase-3, and DFF-40/CAD through cytosolic release of cytochrome c in HL-60 cells. Biosci Biotechnol Biochem. 65:1741–1747. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Chaudhari M, Jayaraj R, Bhaskar AS and Lakshmana Rao PV: Oxidative stress induction by T-2 toxin causes DNA damage and triggers apoptosis via caspase pathway in human cervical cancer cells. Toxicology. 262:153–161. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Gao C and Zhang Y, Chen J, Wang T, Qian Y, Yang B, Dong P and Zhang Y: Targeted drug delivery system for platinum-based anticancer drugs. Mini Rev Med Chem. 16:872–891. 2016. View Article : Google Scholar : PubMed/NCBI

19 

T S A, Shalumon KT and Chen JP: Applications of magnetic liposomes in cancer therapies. Curr Pharm Des. 25:1490–1504. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Paliwal SR, Paliwal R and Vyas SP: A review of mechanistic insight and application of pH-sensitive liposomes in drug delivery. Drug Deliv. 22:231–242. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Shaban N, Abdel-Rahman S, Haggag A, Awad D, Bassiouny A and Talaat I: Combination between taxol-encapsulated liposomes and eruca sativa seed extract suppresses mammary tumors in female rats induced by 7,12 dimethylbenz(α)anthracene. Asian Pac J Cancer Prev. 17:117–123. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Cadinoiu AN, Rata DM, Atanase LI, Daraba OM, Gherghel D, Vochita G and Popa M: Aptamer-functionalized liposomes as a potential treatment for basal cell carcinoma. Polymers (Basel). 11:15152019. View Article : Google Scholar

23 

Yang Y, Yang X, Li H, Li C, Ding H, Zhang M, Guo Y and Sun M: Near-infrared light triggered liposomes combining photodynamic and chemotherapy for synergistic breast tumor therapy. Colloids Surf B Biointerfaces. 173:564–570. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Sadeghi N, Kok RJ, Bos C, Zandvliet M, Geerts WJC, Storm G, Moonen CTW, Lammers T and Deckers R: Hyperthermia-triggered release of hypoxic cell radiosensitizers from temperature-sensitive liposomes improves radiotherapy efficacy in vitro. Nanotechnology. 30:2640012019. View Article : Google Scholar : PubMed/NCBI

25 

Odette WL, Payne NA, Khaliullin RZ and Mauzeroll J: Redox-triggered disassembly of nanosized liposomes containing ferrocene-appended amphiphiles. Langmuir. 35:5608–5616. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Li B, Li B, He D, Feng C, Luo Z and He M: Preparation, characterization, and in vitro pH-sensitivity evaluation of superparamagnetic iron oxide nanoparticle- misonidazole pH-sensitive liposomes. Curr Drug Deliv. 16:254–267. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Chen Y, Du Q, Guo Q, Huang J, Liu L, Shen X and Peng J: A W/O emulsion mediated film dispersion method for curcumin encapsulated pH-sensitive liposomes in the colon tumor treatment. Drug Dev Ind Pharm. 45:282–291. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Duan Y, Wei L, Petryk J and Ruddy TD: Formulation, characterization and tissue distribution of a novel pH-sensitive long-circulating liposome-based theranostic suitable for molecular imaging and drug delivery. Int J Nanomedicine. 11:5697–5708. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Chiang NJ, Chao TY, Hsieh RK, Wang CH, Wang YW, Yeh CG and Chen LT: A phase I dose-escalation study of PEP02 (irinotecan liposome injection) in combination with 5-fluorouracil and leucovorin in advanced solid tumors. BMC Cancer. 16:9072016. View Article : Google Scholar : PubMed/NCBI

30 

Rehman AU, Omran Z, Anton H, Mely Y, Akram S, Vandamme TF and Anton N: Development of doxorubicin hydrochloride loaded pH-sensitive liposomes: Investigation on the impact of chemical nature of lipids and liposome composition on pH-sensitivity. Eur J Pharm Biopharm. 133:331–338. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Riondel J, Jacrot M, Fessi H, Puisieux F and Potier: Effects of free and liposome-encapsulated taxol on two brain tumors xenografted into nude mice. In Vivo. 6:23–27. 1992.PubMed/NCBI

32 

Rubio DP, Roa LG, Soto DA, Velasquez FJ, Gregorcic NA, Soto JA, Martinez MC, Kalergis AM and Vasquez AE: Purification and characterization of saxitoxin from mytilus chilensis of southern chile. Toxicon. 108:147–153. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Shi R, Xu X, Wu J, Wang T, Li Y, Ma B and Ma Y: Hydrophilic interaction chromatography-tandem mass spectrometry based on an amide column for the high-throughput quantification of metformin in rat plasma. RSC Adv. 5:101386–101392. 2015. View Article : Google Scholar

34 

Zhang H: Thin-film hydration followed by extrusion method for liposome preparation. Methods Mol Biol. 1522:17–22. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Liu GX, Fang GQ and Xu W: Dual targeting biomimetic liposomes for paclitaxel/DNA combination cancer treatment. Int J Mol Sci. 15:15287–15303. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Dornetshuber-Fleiss R, Heilos D, Mohr T, Richter L, Sussmuth RD, Zlesak M, Novicky A, Heffeter P, Lemmens-Gruber R and Berger W: The naturally born fusariotoxin enniatin B and sorafenib exert synergistic activity against cervical cancer in vitro and in vivo. Biochem Pharmacol. 93:318–331. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Song J, Wang Y, Teng M, Zhang S, Yin M, Lu J, Liu Y, Lee RJ, Wang D and Teng L: Cordyceps militaris induces tumor cell death via the caspase-dependent mitochondrial pathway in HepG2 and MCF-7 cells. Mol Med Rep. 13:5132–5140. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Ovejero S, Ayala P, Malumbres M, Pimentel-Muinos FX, Bueno A and Sacristan MP: Biochemical analyses reveal amino acid residues critical for cell cycle-dependent phosphorylation of human Cdc14A phosphatase by cyclin-dependent kinase 1. Sci Rep. 8:118712018. View Article : Google Scholar : PubMed/NCBI

39 

Belwal VK and Singh KP: Nanosilica-supported liposome (protocells) as a drug vehicle for cancer therapy. Int J Nanomedicine. 13:125–127. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Soema PC, Willems GJ, Jiskoot W, Amorij JP and Kersten GF: Predicting the influence of liposomal lipid composition on liposome size, zeta potential and liposome-induced dendritic cell maturation using a design of experiments approach. Eur J Pharm Biopharm. 94:427–435. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Zhang X, Wang Y, Velkov T, Tang S and Dai C: T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway. Food Chem Toxicol. 114:88–97. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Yu FF, Lin XL, Yang L, Liu H, Wang X, Fang H, Lammi ZJ and Guo X: Comparison of T-2 toxin and HT-2 toxin distributed in the skeletal system with that in other tissues of rats by acute toxicity test. Biomed Environ Sci. 30:851–854. 2017.PubMed/NCBI

43 

Kojima S, Nakamura N, Ueno Y, Yamaguchi T and Takahashi T: Anti-tumor activity of T-2 toxin-conjugated A7 monoclonal antibody (T-2-A7 MoAb) against human colon carcinoma. Nat Toxins. 1:209–215. 1993. View Article : Google Scholar : PubMed/NCBI

44 

Ferreira Ddos S, Lopes SC, Franco MS and Oliveira MC: pH-sensitive liposomes for drug delivery in cancer treatment. Ther Deliv. 4:1099–1123. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Bellat V, Lee HH, Vahdat L and Law B: Smart nanotransformers with unique enzyme-inducible structural changes and drug release properties. Biomacromolecules. 17:2040–2049. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Yi XQ, Zhang Q, Zhao D, Xu JQ, Zhong ZL, Zhuoa RX and Li F: Preparation of pH and redox dual-sensitive core crosslinked micelles for overcoming drug resistance of DOX. Polym Chem. 7:1719–1729. 2016. View Article : Google Scholar

47 

Ruttala HB, Ramasamy T, Gupta B, Choi HG, Yong CS and Kim JO: Multiple polysaccharide-drug complex-loaded liposomes: A unique strategy in drug loading and cancer targeting. Carbohydr Polym. 173:57–66. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Vlassov A, Khvorova A and Yarus M: Binding and disruption of phospholipid bilayers by supramolecular RNA complexes. Proc Natl Acad Sci USA. 98:7706–7711. 2001. View Article : Google Scholar : PubMed/NCBI

49 

Falck E, Patra M, Karttunen M, Hyvonen MT and Vattulainen I: Impact of cholesterol on voids in phospholipid membranes. J Chem Phys. 121:12676–12689. 2004. View Article : Google Scholar : PubMed/NCBI

50 

Bellavance MA, Poirier MB and Fortin D: Uptake and intracellular release kinetics of liposome formulations in glioma cells. Int J Pharm. 395:251–259. 2010. View Article : Google Scholar : PubMed/NCBI

51 

Drummond DC, Zignani M and Leroux J: Current status of pH-sensitive liposomes in drug delivery. Prog Lipid Res. 39:409–460. 2000. View Article : Google Scholar : PubMed/NCBI

52 

Ramasamy T, Haidar ZS, Tran TH, Choi JY, Jeong JH, Shin BS, Choi HG, Yong CS and Kim JO: Layer-by-layer assembly of liposomal nanoparticles with PEGylated polyelectrolytes enhances systemic delivery of multiple anticancer drugs. Acta Biomater. 10:5116–5127. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Ramasamy T, Ruttala HB, Sundaramoorthy P, Poudel BK, Youn YS, Ku SK, Choi HG, Yong CS and Kim JO: Multimodal selenium nanoshell-capped Au@mSiO2 nanoplatform for NIR-responsive chemo-photothermal therapy against metastatic breast cancer. NPG Asia Mater. 10:197–216. 2018. View Article : Google Scholar

54 

Ramasamy T, Ruttala HB, Kaliraj K, Poudel K, Jin SG, Choi HG, Ku SK, Yong CS and Kim JO: Polypeptide derivative of metformin with the combined advantage of a gene carrier and anticancer activity. ACS Biomater Sci Eng. 5:5159–5168. 2019. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Dong Y, Meng G, Guo J, Yin M, Xu H, Li Y, Zhu J, Zhu W, Li M, Li Y, Li Y, et al: Preparation of T‑2 toxin‑containing pH‑sensitive liposome and its antitumor activity. Mol Med Rep 22: 4423-4431, 2020.
APA
Dong, Y., Meng, G., Guo, J., Yin, M., Xu, H., Li, Y. ... Wang, H. (2020). Preparation of T‑2 toxin‑containing pH‑sensitive liposome and its antitumor activity. Molecular Medicine Reports, 22, 4423-4431. https://doi.org/10.3892/mmr.2020.11531
MLA
Dong, Y., Meng, G., Guo, J., Yin, M., Xu, H., Li, Y., Zhu, J., Zhu, W., Li, M., Li, Y., Wang, H."Preparation of T‑2 toxin‑containing pH‑sensitive liposome and its antitumor activity". Molecular Medicine Reports 22.5 (2020): 4423-4431.
Chicago
Dong, Y., Meng, G., Guo, J., Yin, M., Xu, H., Li, Y., Zhu, J., Zhu, W., Li, M., Li, Y., Wang, H."Preparation of T‑2 toxin‑containing pH‑sensitive liposome and its antitumor activity". Molecular Medicine Reports 22, no. 5 (2020): 4423-4431. https://doi.org/10.3892/mmr.2020.11531
Copy and paste a formatted citation
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Spandidos Publications style
Dong Y, Meng G, Guo J, Yin M, Xu H, Li Y, Zhu J, Zhu W, Li M, Li Y, Li Y, et al: Preparation of T‑2 toxin‑containing pH‑sensitive liposome and its antitumor activity. Mol Med Rep 22: 4423-4431, 2020.
APA
Dong, Y., Meng, G., Guo, J., Yin, M., Xu, H., Li, Y. ... Wang, H. (2020). Preparation of T‑2 toxin‑containing pH‑sensitive liposome and its antitumor activity. Molecular Medicine Reports, 22, 4423-4431. https://doi.org/10.3892/mmr.2020.11531
MLA
Dong, Y., Meng, G., Guo, J., Yin, M., Xu, H., Li, Y., Zhu, J., Zhu, W., Li, M., Li, Y., Wang, H."Preparation of T‑2 toxin‑containing pH‑sensitive liposome and its antitumor activity". Molecular Medicine Reports 22.5 (2020): 4423-4431.
Chicago
Dong, Y., Meng, G., Guo, J., Yin, M., Xu, H., Li, Y., Zhu, J., Zhu, W., Li, M., Li, Y., Wang, H."Preparation of T‑2 toxin‑containing pH‑sensitive liposome and its antitumor activity". Molecular Medicine Reports 22, no. 5 (2020): 4423-4431. https://doi.org/10.3892/mmr.2020.11531
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