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Article Open Access

Pinealectomy increases thermogenesis and decreases lipogenesis

  • Authors:
    • Mikyung Kim
    • So Min Lee
    • Jeeyoun Jung
    • Yun Jin Kim
    • Kyo Chul Moon
    • Ji Hae Seo
    • Tae Kyung Ha
    • Eunyoung Ha
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea, Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea, Department of Surgery, Hanyang University College of Medicine, Seoul 04763, Republic of Korea
    Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4289-4297
    |
    Published online on: September 23, 2020
       https://doi.org/10.3892/mmr.2020.11534
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Abstract

The present study was designed to determine the effects of pineal gland‑derived melatonin on obesity by employing a rat pinealectomy (Pnx) model. After 10 weeks of a high‑fat diet, rats received sham or Pnx surgery followed by a normal chow diet for 10 weeks. Reverse transcription‑quantitative PCR, western blotting analysis, immunohistochemistry and ELISA were used to determine the effects of Pnx. Pnx decreased the expression of melatonin receptor (MTNR)1A and MTNR1B, in brown adipose tissues (BAT) and white adipose tissues (WAT). Pnx rats showed increased insulin sensitivity compared with those that received sham surgery. Leptin levels were significantly decreased in the serum of the Pnx group. In addition, Pnx stimulated thermogenic genes in BAT and attenuated lipogenic genes in both WAT and the liver. Histological analyses revealed a marked decrease in the size of lipid droplets and increased expression of uncoupling protein 1 in BAT. In the liver of the Pnx group, the size and number of lipid droplets had also decreased. In conclusion, the results presented in the current study suggested that Pnx increases thermogenesis in BAT and decreases lipogenesis in WAT and the liver.
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Copy and paste a formatted citation
Spandidos Publications style
Kim M, Lee SM, Jung J, Kim YJ, Moon KC, Seo JH, Ha TK and Ha E: Pinealectomy increases thermogenesis and decreases lipogenesis. Mol Med Rep 22: 4289-4297, 2020.
APA
Kim, M., Lee, S.M., Jung, J., Kim, Y.J., Moon, K.C., Seo, J.H. ... Ha, E. (2020). Pinealectomy increases thermogenesis and decreases lipogenesis. Molecular Medicine Reports, 22, 4289-4297. https://doi.org/10.3892/mmr.2020.11534
MLA
Kim, M., Lee, S. M., Jung, J., Kim, Y. J., Moon, K. C., Seo, J. H., Ha, T. K., Ha, E."Pinealectomy increases thermogenesis and decreases lipogenesis". Molecular Medicine Reports 22.5 (2020): 4289-4297.
Chicago
Kim, M., Lee, S. M., Jung, J., Kim, Y. J., Moon, K. C., Seo, J. H., Ha, T. K., Ha, E."Pinealectomy increases thermogenesis and decreases lipogenesis". Molecular Medicine Reports 22, no. 5 (2020): 4289-4297. https://doi.org/10.3892/mmr.2020.11534
Copy and paste a formatted citation
x
Spandidos Publications style
Kim M, Lee SM, Jung J, Kim YJ, Moon KC, Seo JH, Ha TK and Ha E: Pinealectomy increases thermogenesis and decreases lipogenesis. Mol Med Rep 22: 4289-4297, 2020.
APA
Kim, M., Lee, S.M., Jung, J., Kim, Y.J., Moon, K.C., Seo, J.H. ... Ha, E. (2020). Pinealectomy increases thermogenesis and decreases lipogenesis. Molecular Medicine Reports, 22, 4289-4297. https://doi.org/10.3892/mmr.2020.11534
MLA
Kim, M., Lee, S. M., Jung, J., Kim, Y. J., Moon, K. C., Seo, J. H., Ha, T. K., Ha, E."Pinealectomy increases thermogenesis and decreases lipogenesis". Molecular Medicine Reports 22.5 (2020): 4289-4297.
Chicago
Kim, M., Lee, S. M., Jung, J., Kim, Y. J., Moon, K. C., Seo, J. H., Ha, T. K., Ha, E."Pinealectomy increases thermogenesis and decreases lipogenesis". Molecular Medicine Reports 22, no. 5 (2020): 4289-4297. https://doi.org/10.3892/mmr.2020.11534
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