Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
December-2020 Volume 22 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2020 Volume 22 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Identification of inflammation‑associated circulating long non‑coding RNAs and genes in intracranial aneurysm rupture‑induced subarachnoid hemorrhage

  • Authors:
    • Lifa Huang
    • Xu Li
    • Zupeng Chen
    • Yajun Liu
    • Xin Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Zhejiang Provincial Hospital of Traditional Chinese Medicine, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4541-4550
    |
    Published online on: September 25, 2020
       https://doi.org/10.3892/mmr.2020.11540
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Ruptured intracranial aneurysm (IA)‑induced subarachnoid hemorrhage (SAH) triggers a series of immune responses and inflammation in the brain and body. The present study was conducted to identify additional circulating biomarkers that may serve as potential therapeutic targets for SAH‑induced inflammation. Differentially expressed (DE) long non‑coding RNAs (lncRNAs; DElncRNAs) and genes (DEGs) in the peripheral blood mononuclear cells between patients with IA rupture‑induced SAH and healthy controls were identified in the GSE36791 dataset. DEGs were used for weighted gene co‑expression network analysis (WGCNA), and SAH‑associated WGCNA modules were identified. Subsequently, an lncRNA‑mRNA regulatory network was constructed using the DEGs in SAH‑associated WGCNA modules. A total of 25 DElncRNAs and 1,979 DEGs were screened from patients with IA‑induced SAH in the GSE36791 dataset compared with the controls. A total of 11 WGCNA modules, including four upregulated modules significantly associated with IA rupture‑induced SAH were obtained. The DEGs in the SAH‑associated modules were associated with Gene Ontology biological processes such as ‘regulation of programmed cell death’, ‘apoptosis’ and ‘immune response’. The subsequent lncRNA‑mRNA regulatory network included seven upregulated lncRNAs [HCG27, ZNFX1 antisense RNA 1, long intergenic non‑protein coding RNA (LINC)00265, murine retrovirus integration site 1 homolog‑antisense RNA 1, cytochrome P450 1B1‑AS1, LINC01347 and LINC02193] and 375 DEGs. Functional enrichment analysis and screening in the Comparative Toxicogenomics Database demonstrated that SAH‑associated DEGs, including neutrophil cytosolic factor (NCF)2 and NCF4, were enriched in ‘chemokine signaling pathway’ (hsa04062), ‘leukocyte transendothelial migration’ (hsa04670) and ‘Fc gamma R‑mediated phagocytosis’ (hsa04666). The upregulated lncRNAs and genes, including NCF2 and NCF4, in patients with IA rupture‑induced SAH indicated their respective potentials as anti‑inflammatory therapeutic targets.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Garg K, Sinha S, Kale SS, Chandra PS, Suri A, Singh MM, Kumar R, Sharma MS, Pandey RM, Sharma BS and Mahapatra AK: Role of simvastatin in prevention of vasospasm and improving functional outcome after aneurysmal sub-arachnoid hemorrhage: A prospective, randomized, double-blind, placebo-controlled pilot trial. Br J Neurosurg. 27:181–186. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Wesali S, Persson HC, Cederin B and Sunnerhagen KS: Improved survival after non-traumatic subarachnoid haemorrhage with structured care pathways and modern intensive care. Clin Neurol Neurosurg. 138:52–58. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Banki NM, Alexander K, Dae MW, Miss J, Tung P, Lawton MT, Drew BJ, Foster E, Smith W, Parmley WW and Zaroff JG: Acute neurocardiogenic injury after subarachnoid hemorrhage. Circulation. 112:3314–3319. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Johnston SC, Selvin S and Gress DR: The burden, trends, and demographics of mortality from subarachnoid hemorrhage. Neurology. 50:1413–1418. 1998. View Article : Google Scholar : PubMed/NCBI

5 

Suarez JI, Tarr RW and Selman WR: Aneurysmal subarachnoid hemorrhage. N Engl J Med. 354:387–396. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Zumofen DW, Roethlisberger M, Achermann R, Bawarjan S, Stienen MN, Fung C, D'Alonzo D, Maldaner N, Ferrari A, Corniola MV, et al: Factors associated with clinical and radiological status on admission in patients with aneurysmal subarachnoid hemorrhage. Neurosurg Rev. 41:1059–1069. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Hendrix P, Foreman PM, Harrigan MR, Fisher WS Rd, Vyas NA, Lipsky RH, Lin M, Walters BC, Tubbs RS, Shoja MM, et al: The role of endothelial nitric oxide synthase-786 T/C polymorphism in cardiac instability following aneurysmal subarachnoid hemorrhage. Nitric Oxide. 71:52–56. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Liang Z, Chi YJ, Lin GQ, Xiao LF, Su GL and Yang LM: LncRNA MEG3 participates in neuronal cell injury induced by subarachnoid hemorrhage via inhibiting the Pi3k/Akt pathway. Eur Rev Med Pharmacol Sci. 22:2824–2831. 2018.PubMed/NCBI

9 

Santiago-Sim T, Fang X, Hennessy ML, Nalbach SV, DePalma SR, Lee MS, Greenway SC, McDonough B, Hergenroeder GW, Patek KJ, et al: THSD1 (thrombospondin type 1 domain containing protein 1) mutation in the pathogenesis of intracranial aneurysm and subarachnoid hemorrhage. Stroke. 47:3005–3013. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Pawlowska E, Szczepanska J, Wisniewski K, Tokarz P, Jaskólski DJ and Blasiak J: NF-κB-mediated inflammation in the pathogenesis of intracranial aneurysm and subarachnoid hemorrhage. Does autophagy play a role? Int J Mol Sci. 19:12452018.

11 

Zhao L, Liu H, Yue L, Zhang J, Li X, Wang B, Lin Y and Qu Y: Melatonin attenuates early brain injury via the melatonin receptor/Sirt1/NF-κB signaling pathway following subarachnoid hemorrhage in mice. Mol Neurobiol. 54:1612–1621. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Ma C, Zhou W, Yan Z, Qu M and Bu X: Toll-like receptor 4 (TLR4) is associated with cerebral vasospasm and delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage. Neurol Med Chir (Tokyo). 55:878–884. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Okada T and Suzuki H: Toll-like receptor 4 as a possible therapeutic target for delayed brain injuries after aneurysmal subarachnoid hemorrhage. Neural Regen Res. 12:193–196. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Pera J, Korostynski M, Golda S, Piechota M, Dzbek J, Krzyszkowski T, Dziedzic T, Moskala M, Przewlocki R, Szczudlik A and Slowik A: Gene expression profiling of blood in ruptured intracranial aneurysms: In search of biomarkers. J Cereb Blood Flow Metab. 33:1025–1031. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

16 

Yates B, Braschi B, Gray KA, Seal RL, Tweedie S and Bruford EA: Genenames.org: The HGNC and VGNC resources in 2017. Nucleic Acids Res. 45(D1): D619–D625. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Szekely GJ and Rizzo ML: Hierarchical clustering via joint between-within distances: Extending ward's minimum variance method. J Classif. 22:151–183. 2005. View Article : Google Scholar

18 

Wright RM, Aglyamova GV, Meyer E and Matz MV: Variance stabilized gene expression data for WGCNA. Comput Graph. 29:805–817. 2015.

19 

Langfelder P and Horvath S: WGCNA: An R package for weighted correlation network analysis. BMC Bioinformatics. 9:5592008. View Article : Google Scholar : PubMed/NCBI

20 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The gene ontology consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

21 

The Gene Ontology Consortium: The gene ontology resource: 20 Years and still GOing strong. Nucleic Acids Res. 47(D1): D330–D338. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Huang da W, Sherman BT and Lempicki RA: Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37:1–13. 2009. View Article : Google Scholar : PubMed/NCBI

23 

R Core Team: R: A language and environment for statistical computing. R Foundation for Statistical Computing; Vienna, Austria: 2015

24 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Davis AP, Grondin CJ, Johnson RJ, Sciaky D, McMorran R, Wiegers J, Wiegers TC and Mattingly CJ: The comparative toxicogenomics database: Update 2019. Nucleic Acids Res. 47(D1): D948–D954. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Kurki MI, Häkkinen SK, Frösen J, Tulamo R, von und zu Fraunberg M, Wong G, Tromp G, Niemelä M, Hernesniemi J, Jääskeläinen JE and Ylä-Herttuala S: Upregulated signaling pathways in ruptured human saccular intracranial aneurysm wall: An emerging regulative role of Toll-like receptor signaling and nuclear factor-κB, hypoxia-inducible factor-1A, and ETS transcription factors. Neurosurgery. 68:1667–1676. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Guo J, Qi J, He K, Wu J, Bai S, Zhang T, Zhao J and Wang Z: The Asian corn borer Ostrinia furnacalis feeding increases the direct and indirect defense of mid-whorl stage commercial maize in the field. Plant Biotechnol J. 17:88–102. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Diringer MN and Zazulia AR: Aneurysmal subarachnoid hemorrhage: Strategies for preventing vasospasm in the intensive care unit. Semin Respir Crit Care Med. 38:760–767. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Leclerc JL, Blackburn S, Neal D, Mendez NV, Wharton JA, Waters MF and Doré S: Haptoglobin phenotype predicts the development of focal and global cerebral vasospasm and may influence outcomes after aneurysmal subarachnoid hemorrhage. Proc Natl Acad Sci USA. 112:1155–1160. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Li YC, Zhao L, Wu JP, Qu CX, Song QK and Wang RB: Cytokine-induced killer cell infusion combined with conventional treatments produced better prognosis for hepatocellular carcinoma patients with barcelona clinic liver cancer B or earlier stage: A systematic review and meta-analysis. Cytotherapy. 18:1525–1531. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Denson LA, Jurickova I, Karns R, Shaw KA, Cutler DJ, Okou DT, Dodd A, Quinn K, Mondal K, Aronow BJ, et al: Clinical and genomic correlates of neutrophil reactive oxygen species production in pediatric patients with Crohn's disease. Gastroenterology. 154:2097–2110. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Armstrong DL, Miriam E, Raphael Z and Jacob CO: Systemic lupus erythematosus-associated neutrophil cytosolic factor 2 mutation affects the structure of NADPH oxidase complex. J Biol Chem. 290:12595–12602. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Winter S, Hultqvist Hopkins M, Laulund F and Holmdahl R: A reduction in intracellular reactive oxygen species due to a mutation in NCF4 promotes autoimmune arthritis in mice. Antioxid Redox Signal. 25:983–996. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Gauss KA, Bunger PL, Larson TC, Young CJ, Nelson-Overton LK, Siemsen DW and Quinn MT: Identification of a novel tumor necrosis factor alpha-responsive region in the NCF2 promoter. J Leukoc Biol. 77:267–278. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Cunninghame Graham DS, Morris DL, Bhangale TR, Criswell LA, Syvänen AC, Rönnblom L, Behrens TW, Graham RR and Vyse TJ: Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus. PLoS Genet. 7:e10023412011. View Article : Google Scholar : PubMed/NCBI

37 

Li SL, Valente AJ, Wang L, Gamez MJ and Clark RA: Transcriptional regulation of the p67phox gene: Role of AP-1 in concert with myeloid-specific transcription factors. J Biol Chem. 276:39368–39378. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Gupta JW, Kubin M, Hartman L, Cassatella M and Trinchieri G: Induction of expression of genes encoding components of the respiratory burst oxidase during differentiation of human myeloid cell lines induced by tumor necrosis factor and gamma-interferon. Cancer Res. 52:2530–2537. 1992.PubMed/NCBI

39 

Wisdom R: AP-1: One switch for many signals. Exp Cell Res. 253:180–185. 1999. View Article : Google Scholar : PubMed/NCBI

40 

Cohen M, Meisser A, Haenggeli L and Bischof P: Involvement of MAPK pathway in TNF-alpha-induced MMP-9 expression in human trophoblastic cells. Mol Hum Reprod. 12:225–232. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Robinson SC, Scott KA and Balkwill FR: Chemokine stimulation of monocyte matrix metalloproteinase-9 requires endogenous TNF-alpha. Eur J Immunol. 32:404–412. 2002. View Article : Google Scholar : PubMed/NCBI

42 

Soumyarani VS and Jayakumari N: Oxidatively modified high density lipoprotein promotes inflammatory response in human monocytes-macrophages by enhanced production of ROS, TNF-α, MMP-9, and MMP-2. Mol Cell Biochem. 366:277–285. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Chen J, Yang X, Zhang W, Peng D, Xia Y, Lu Y, Han X, Song G, Zhu J and Liu R: Therapeutic effects of resveratrol in a mouse model of LPS and cigarette smoke-induced COPD. Inflammation. 39:1949–1959. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Higgins KA, Park D, Lee GY, Curran WJ and Deng X: Exercise-induced lung cancer regression: Mechanistic findings from a mouse model. Cancer. 120:3302–3310. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Li BS, Zuo QF, Zhao YL, Xiao B, Zhuang Y, Mao XH, Wu C, Yang SM, Zeng H, Zou QM and Guo G: MicroRNA-25 promotes gastric cancer migration, invasion and proliferation by directly targeting transducer of ERBB2, 1 and correlates with poor survival. Oncogene. 34:2556–2565. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Qian Y, Cao L, Guan T, Chen L, Xin H, Li Y, Zheng R and Yu D: Protection by genistein on cortical neurons against oxidative stress injury via inhibition of NF-kappaB, JNK and ERK signaling pathway. Pharm Biol. 53:1124–1132. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Wu JS, Tsai HD, Cheung WM, Hsu CY and Lin TN: PPAR-γ ameliorates neuronal apoptosis and ischemic brain injury via suppressing NF-κB-driven p22phox transcription. Mol Neurobiol. 53:3626–3645. 2016. View Article : Google Scholar : PubMed/NCBI

48 

Pan W, Lin L, Zhang N, Yuan F, Hua X, Wang Y and Mo L: Neuroprotective effects of dexmedetomidine against hypoxia-induced nervous system injury are related to inhibition of NF-κB/COX-2 pathways. Cell Mol Neurobiol. 36:1179–1188. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Joosten LA, Helsen MM, Saxne T, van De Loo FA, Heinegard D and van Den Berg WB: IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation. J Immunol. 163:5049–5055. 1999.PubMed/NCBI

50 

Charrad R, Berraïes A, Hamdi B, Ammar J, Hamzaoui K and Hamzaoui A: Anti-inflammatory activity of IL-37 in asthmatic children: Correlation with inflammatory cytokines TNF-α, IL-β, IL-6 and IL-17A. Immunobiology. 221:182–187. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Su Y, Hu J, Lan H, Chen Y and Wei X: Long non-coding RNA LINC00265 promotes inflammation via sponging miR-let-7a in abdominal aortic aneurysm. Aging. 11:4463–4477. 2019. View Article : Google Scholar : PubMed/NCBI

52 

Malaplate-Armand C, Ferrari L, Masson C, Siest G and Batt AM: Astroglial CYP1B1 up-regulation in inflammatory/oxidative toxic conditions: IL-1beta effect and protection by N-acetylcysteine. Toxicol Lett. 138:243–251. 2003. View Article : Google Scholar : PubMed/NCBI

53 

Smerdová L, Šmerdová J, Kabátková M, Kohoutek J, Blažek D, Machala M and Vondráček J: Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway. Carcinogenesis. 35:2534–2543. 2014. View Article : Google Scholar : PubMed/NCBI

54 

Fan W, Fnag R, Feng M, Dai G and Wu G: Microarray expression profile of long non-coding RNAs in human endothelial cells exposed to atheroprotective shear stress. J Am Coll Cardiol. 66:C67–C68. 2015. View Article : Google Scholar

55 

Leng L, Zhang C, Ren L and Li Q: Construction of a long non-coding RNA-mediated competitive endogenous RNA network reveals global patterns and regulatory markers in gestational diabetes. Int J Mol Med. 43:927–935. 2019.PubMed/NCBI

56 

Ye Y, Gao X and Yang N: LncRNA ZFAS1 promotes cell migration and invasion of fibroblast-like synoviocytes by suppression of miR-27a in rheumatoid arthritis. Human Cell. 31:14–21. 2018. View Article : Google Scholar : PubMed/NCBI

57 

Marcos V, Zhou Z, Yildirim AO, Bohla A, Hector A, Vitkov L, Wiedenbauer EM, Krautgartner WD, Stoiber W, Belohradsky BH, et al: CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation. Nat Med. 16:1018–1023. 2010. View Article : Google Scholar : PubMed/NCBI

58 

Bertini R, Allegretti M, Bizzarri C, Moriconi A, Locati M, Zampella G, Cervellera MN, Di Cioccio V, Cesta MC, Galliera E, et al: Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: Prevention of reperfusion injury. Proc Natl Acad Sci USA. 101:11791–11796. 2004. View Article : Google Scholar : PubMed/NCBI

59 

Wuyts A, Van Osselaer N, Haelens A, Samson I, Herdewijn P, Ben-Baruch A, Oppenheim JJ, Proost P and Van Damme J: Characterization of synthetic human granulocyte chemotactic protein 2: Usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties. Biochemistry. 36:2716–2723. 1997. View Article : Google Scholar : PubMed/NCBI

60 

De Paola M, Buanne P, Biordi L, Bertini R, Ghezzi P and Mennini T: Chemokine MIP-2/CXCL2, acting on CXCR2, induces motor neuron death in primary cultures. Neuroimmunomodulation. 14:310–316. 2007. View Article : Google Scholar : PubMed/NCBI

61 

Du SH, Zhang W, Yue X, Luo XQ, Tan XH, Liu C, Qiao DF and Wang H: Role of CXCR1 and interleukin-8 in methamphetamine-induced neuronal apoptosis. Front Cell Neurosci. 12:2302018. View Article : Google Scholar : PubMed/NCBI

62 

Zhou Y, Li RJ, Li M, Liu X, Zhu HY, Ju Z, Miao X and Xu GY: Overexpression of GRK6 attenuates neuropathic pain via suppression of CXCR2 in rat dorsal root ganglion. Mol Pain. 12:17448069166463812016. View Article : Google Scholar : PubMed/NCBI

63 

Lopes AH, Brandolini L, Aramini A, Bianchini G, Silva RL, Zaperlon AC, Verri WA Jr, Alves-Filho JC, Cunha FQ, Teixeira MM, et al: DF2755A, a novel non-competitive allosteric inhibitor of CXCR1/2, reduces inflammatory and post-operative pain. Pharmacol Res. 103:69–79. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Huang L, Li X, Chen Z, Liu Y and Zhang X: Identification of inflammation‑associated circulating long non‑coding RNAs and genes in intracranial aneurysm rupture‑induced subarachnoid hemorrhage. Mol Med Rep 22: 4541-4550, 2020.
APA
Huang, L., Li, X., Chen, Z., Liu, Y., & Zhang, X. (2020). Identification of inflammation‑associated circulating long non‑coding RNAs and genes in intracranial aneurysm rupture‑induced subarachnoid hemorrhage. Molecular Medicine Reports, 22, 4541-4550. https://doi.org/10.3892/mmr.2020.11540
MLA
Huang, L., Li, X., Chen, Z., Liu, Y., Zhang, X."Identification of inflammation‑associated circulating long non‑coding RNAs and genes in intracranial aneurysm rupture‑induced subarachnoid hemorrhage". Molecular Medicine Reports 22.6 (2020): 4541-4550.
Chicago
Huang, L., Li, X., Chen, Z., Liu, Y., Zhang, X."Identification of inflammation‑associated circulating long non‑coding RNAs and genes in intracranial aneurysm rupture‑induced subarachnoid hemorrhage". Molecular Medicine Reports 22, no. 6 (2020): 4541-4550. https://doi.org/10.3892/mmr.2020.11540
Copy and paste a formatted citation
x
Spandidos Publications style
Huang L, Li X, Chen Z, Liu Y and Zhang X: Identification of inflammation‑associated circulating long non‑coding RNAs and genes in intracranial aneurysm rupture‑induced subarachnoid hemorrhage. Mol Med Rep 22: 4541-4550, 2020.
APA
Huang, L., Li, X., Chen, Z., Liu, Y., & Zhang, X. (2020). Identification of inflammation‑associated circulating long non‑coding RNAs and genes in intracranial aneurysm rupture‑induced subarachnoid hemorrhage. Molecular Medicine Reports, 22, 4541-4550. https://doi.org/10.3892/mmr.2020.11540
MLA
Huang, L., Li, X., Chen, Z., Liu, Y., Zhang, X."Identification of inflammation‑associated circulating long non‑coding RNAs and genes in intracranial aneurysm rupture‑induced subarachnoid hemorrhage". Molecular Medicine Reports 22.6 (2020): 4541-4550.
Chicago
Huang, L., Li, X., Chen, Z., Liu, Y., Zhang, X."Identification of inflammation‑associated circulating long non‑coding RNAs and genes in intracranial aneurysm rupture‑induced subarachnoid hemorrhage". Molecular Medicine Reports 22, no. 6 (2020): 4541-4550. https://doi.org/10.3892/mmr.2020.11540
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team