Open Access

Mouse model of menstruation: An indispensable tool to investigate the mechanisms of menstruation and gynaecological diseases (Review)

  • Authors:
    • Ting Liu
    • Fuli Shi
    • Ying Ying
    • Qiongfeng Chen
    • Zhimin Tang
    • Hui Lin
  • View Affiliations

  • Published online on: October 7, 2020     https://doi.org/10.3892/mmr.2020.11567
  • Pages: 4463-4474
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Abnormal menstruation may result in several pathological alterations and gynaecological diseases, including endometriosis, menstrual pain and miscarriage. However, the pathogenesis of menstruation remains unclear due to the limited number of animal models available to study the menstrual cycle. In recent years, an effective, reproducible, and highly adaptive mouse model to study menstruation has been developed. In this model, progesterone and oestrogen were administered in cycles following the removal of ovaries. Subsequently, endometrial decidualisation was induced using sesame oil, followed by withdrawal of progesterone administration. Vaginal bleeding in mice is similar to that in humans. Therefore, the use of mice as a model organism to study the mechanism of menstruation and gynaecological diseases may prove to be an important breakthrough. The present review is focussed ond the development and applications of a mouse model of menstruation. Furthermore, various studies have been described to improve this model and the research findings that may aid in the treatment of menstrual disorders in women are presented.
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December-2020
Volume 22 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Liu T, Shi F, Ying Y, Chen Q, Tang Z and Lin H: Mouse model of menstruation: An indispensable tool to investigate the mechanisms of menstruation and gynaecological diseases (Review). Mol Med Rep 22: 4463-4474, 2020
APA
Liu, T., Shi, F., Ying, Y., Chen, Q., Tang, Z., & Lin, H. (2020). Mouse model of menstruation: An indispensable tool to investigate the mechanisms of menstruation and gynaecological diseases (Review). Molecular Medicine Reports, 22, 4463-4474. https://doi.org/10.3892/mmr.2020.11567
MLA
Liu, T., Shi, F., Ying, Y., Chen, Q., Tang, Z., Lin, H."Mouse model of menstruation: An indispensable tool to investigate the mechanisms of menstruation and gynaecological diseases (Review)". Molecular Medicine Reports 22.6 (2020): 4463-4474.
Chicago
Liu, T., Shi, F., Ying, Y., Chen, Q., Tang, Z., Lin, H."Mouse model of menstruation: An indispensable tool to investigate the mechanisms of menstruation and gynaecological diseases (Review)". Molecular Medicine Reports 22, no. 6 (2020): 4463-4474. https://doi.org/10.3892/mmr.2020.11567