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Article

Sulforaphane suppresses polyinosinic‑polycytidylic acid‑stimulated release of cytokines, chemokines and MMPs by human corneal fibroblasts

  • Authors:
    • Pingping Liu
    • Ye Liu
    • Hui Zheng
    • Xiaoshuo Zheng
    • Xiuxia Yang
    • Xiaojing Zhao
    • Lin Chen
    • Yang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, The Fifth Affiliated Hospital of Sun Yat‑Sen University, Zhuhai, Guangdong 519000, P.R. China, Department of Pathology, The Fifth Affiliated Hospital of Sun Yat‑Sen University, Zhuhai, Guangdong 519000, P.R. China
  • Pages: 5463-5471
    |
    Published online on: October 26, 2020
       https://doi.org/10.3892/mmr.2020.11633
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Abstract

Viral corneal infection is a common cause of visual impairment and blindness. Polyinosinic‑polycytidylic acid, or poly(I:C), is similar to viral double‑stranded RNA in structure and has been implicated in the release of a variety of cytokines, chemokines and matrix metalloproteinases (MMPs) by corneal fibroblasts. Sulforaphane (SFN) is an isothiocyanate compound found in cruciferous vegetables. The present study investigated the potential effect of SFN on the poly(I:C)‑stimulated release of cytokines, chemokines and MMPs in human corneal fibroblasts (HCFs). ELISA showed that SFN was associated with a time‑ and dose‑dependent reduction in poly(I:C)‑stimulated production of interleukin (IL)‑8, chemoattractant protein‑1, IL‑6, MMP‑1 and MMP‑3 by HCFs. Western blot analysis indicated that SFN suppressed the function of poly(I:C) by modulating mitogen‑activated protein kinases (MAPKs), including p38 and extracellular signal‑regulated kinase (ERK), activator protein‑1 (AP‑1) component c‑Jun and the kinase, Akt, and the phosphorylation and degradation of the nuclear factor (NF)‑κB inhibitor IκB‑α. Immunofluorescence analysis revealed that SFN attenuated the production of poly(I:C)‑induced nuclear translocation of the NF‑κB p65 subunit. Reverse transcription‑quantitative PCR analysis revealed that SFN prevented the poly(I:C)‑induced upregulation of Toll‑like receptor 3 (TLR3) mRNA expression in HCFs. No significant cytotoxic effect of SFN on HCFs was observed. In summary, SFN attenuated the poly(I:C)‑induced production of proinflammatory chemokines, cytokines and MMPs by HCFs, by inhibiting TLR3, MAPK (p38 and ERK), AP‑1, Akt and NF‑κB signaling. SFN may therefore be a potential novel treatment for viral corneal infection by limiting immune cell infiltration.
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1 

Rowe AM, St Leger AJ, Jeon S, Dhaliwal DK, Knickelbein JE and Hendricks RL: Herpes keratitis. Prog Retin Eye Res. 32:88–101. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Farooq AV and Shukla D: Herpes simplex epithelial and stromal keratitis: An epidemiologic update. Surv Ophthalmol. 57:448–462. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Reynaud C, Rousseau A, Kaswin G, M'Garrech M, Barreau E and Labetoulle M: Persistent impairment of quality of life in patients with herpes simplex keratitis. Ophthalmology. 124:160–169. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Biswas PS and Rouse BT: Early events in HSV keratitis-setting the stage for a blinding disease. Microbes Infect. 7:799–810. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Knickelbein JE, Hendricks RL and Charukamnoetkanok P: Management of herpes simplex virus stromal keratitis: An evidence-based review. Surv Ophthalmol. 54:226–234. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Urtti A: Challenges and obstacles of ocular pharmacokinetics and drug delivery. Adv Drug Deliv Rev. 58:1131–1135. 2006. View Article : Google Scholar : PubMed/NCBI

7 

DelMonte DW and Kim T: Anatomy and physiology of the cornea. J Cataract Refract Surg. 37:588–598. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Smith RS, Smith TJ, Blieden TM and Phipps RP: Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation. Am J Pathol. 151:317–322. 1997.PubMed/NCBI

9 

Xi X, McMillan DH, Lehmann GM, Sime PJ, Libby RT, Huxlin KR, Feldon SE and Phipps RP: Ocular fibroblast diversity: Implications for inflammation and ocular wound healing. Invest Ophthalmol Vis Sci. 52:4859–4865. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Lee G, Park JS, Lee EJ, Ahn JH and Kim HS: Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia. Phytomedicine. 55:50–57. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Guan X, Zhang M, Fu M, Luo S and Hu Q: Herpes simplex virus type 2 immediate early protein ICP27 inhibits IFN-beta production in mucosal epithelial cells by antagonizing IRF3 activation. Front Immunol. 10:2902019. View Article : Google Scholar : PubMed/NCBI

12 

Herbert C, Zeng QX, Shanmugasundaram R, Garthwaite L, Oliver BG and Kumar RK: Response of airway epithelial cells to double-stranded RNA in an allergic environment. Transl Respir Med. 2:112014. View Article : Google Scholar : PubMed/NCBI

13 

Liu Y, Kimura K, Yanai R, Chikama T and Nishida T: Cytokine, chemokine, and adhesion molecule expression mediated by MAPKs in human corneal fibroblasts exposed to poly(I:C). Invest Ophthalmol Vis Sci. 49:3336–3344. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Garrington TP and Johnson GL: Organization and regulation of mitogen-activated protein kinase signaling pathways. Curr Opin Cell Biol. 11:211–218. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Matsumoto M, Funami K, Oshiumi H and Seya T: Toll-like receptor 3: A link between toll-like receptor, interferon and viruses. Microbiol Immunol. 48:147–154. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Kimura K, Orita T, Kondo Y, Zhou H and Nishida T: Upregulation of matrix metalloproteinase expression by poly(I:C) in corneal fibroblasts: Role of NF-κB and interleukin-1β. Invest Ophthalmol Vis Sci. 51:5012–5018. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Bazzoni F, Cassatella MA, Rossi F, Ceska M, Dewald B and Baggiolini M: Phagocytosing neutrophils produce and release high amounts of the neutrophil-activating peptide 1/interleukin 8. J Exp Med. 173:771–774. 1991. View Article : Google Scholar : PubMed/NCBI

18 

Bianconi V, Sahebkar A, Atkin SL and Pirro M: The regulation and importance of monocyte chemoattractant protein-1. Curr Opin Hematol. 25:44–51. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Scheller J, Chalaris A, Schmidt-Arras D and Rose-John S: The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta. 1813:878–888. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Thomas J, Kanangat S and Rouse BT: Herpes simplex virus replication-induced expression of chemokines and proinflammatory cytokines in the eye: Implications in herpetic stromal keratitis. J Interferon Cytokine Res. 18:681–690. 1998. View Article : Google Scholar : PubMed/NCBI

21 

Fini ME, Cook JR and Mohan R: Proteolytic mechanisms in corneal ulceration and repair. Arch Dermatol Res. 290 (Suppl):S12–S23. 1998. View Article : Google Scholar : PubMed/NCBI

22 

Matusheski NV, Juvik JA and Jeffery EH: Heating decreases epithiospecifier protein activity and increases sulforaphane formation in broccoli. Phytochemistry. 65:1273–1281. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Lenzi M, Fimognari C and Hrelia P: Sulforaphane as a promising molecule for fighting cancer. Cancer Treat Res. 159:207–223. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Zhou A, Hong Y and Lv Y: Sulforaphane attenuates endometriosis in rat models through inhibiting PI3K/Akt signaling pathway. Dose Response. 17:15593258198555382019. View Article : Google Scholar : PubMed/NCBI

25 

Qi T, Xu F, Yan X, Li S and Li H: Sulforaphane exerts anti-inflammatory effects against lipopolysaccharide-induced acute lung injury in mice through the Nrf2/ARE pathway. Int J Mol Med. 37:182–188. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Qin S, Yang C, Huang W, Du S, Mai H, Xiao J and Lü T: Sulforaphane attenuates microglia-mediated neuronal necroptosis through down-regulation of MAPK/NF-κB signaling pathways in LPS-activated BV-2 microglia. Pharmacol Res. 133:218–235. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Liu H, Smith AJO, Lott MC, Bao Y, Bowater RP, Reddan JR and Wormstone IM: Sulforaphane can protect lens cells against oxidative stress: Implications for cataract prevention. Invest Ophthalmol Vis Sci. 54:5236–5248. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Dulull NK, Dias DA, Thrimawithana TR and Kwa FAA: L-sulforaphane confers protection against oxidative stress in an in vitro model of age-related macular degeneration. Curr Mol Pharmacol. 11:237–253. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Ziaei A, Schmedt T, Chen Y and Jurkunas UV: Sulforaphane decreases endothelial cell apoptosis in fuchs endothelial corneal dystrophy: A novel treatment. Invest Ophthalmol Vis Sci. 54:6724–6734. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Erdinest N, Aviel G, Moallem E, Anteby I, Yahalom C, Mechoulam H, Ovadia H and Solomon A: Expression and activation of toll-like receptor 3 and toll-like receptor 4 on human corneal epithelial and conjunctival fibroblasts. J Inflamm (Lond). 11:32014. View Article : Google Scholar : PubMed/NCBI

31 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Jin X, Qin Q, Chen W and Qu J: Expression of toll-like receptors in the healthy and herpes simplex virus-infected cornea. Cornea. 26:847–852. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Nagel MA, Choe A, Rempel A, Wyborny A, Stenmark K and Gilden D: Differential regulation of matrix metalloproteinases in varicella zoster virus-infected human brain vascular adventitial fibroblasts. J Neurol Sci. 358:444–446. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Prochnau D, Lehmann M, Straube E, Figulla HR and Rödel J: Human cytomegalovirus induces MMP-1 and MMP-3 expression in aortic smooth muscle cells. Acta Microbiol Immunol Hung. 58:303–317. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Caignard G, Leiva-Torres GA, Leney-Greene M, Charbonneau B, Dumaine A, Fodil-Cornu N, Pyzik M, Cingolani P, Schwartzentruber J, Dupaul-Chicoine J, et al: Genome-wide mouse mutagenesis reveals CD45-mediated T cell function as critical in protective immunity to HSV-1. PLoS Pathog. 9:e10036372013. View Article : Google Scholar : PubMed/NCBI

36 

Yang YN, Bauer D, Wasmuth S, Steuhl KP and Heiligenhaus A: Matrix metalloproteinases (MMP-2 and 9) and tissue inhibitors of matrix metalloproteinases (TIMP-1 and 2) during the course of experimental necrotizing herpetic keratitis. Exp Eye Res. 77:227–237. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Heiligenhaus A, Li HF, Yang Y, Wasmuth S, Steuhl KP and Bauer D: Transplantation of amniotic membrane in murine herpes stromal keratitis modulates matrix metalloproteinases in the cornea. Invest Ophthalmol Vis Sci. 46:4079–4085. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Wiegand C, Schönfelder U, Abel M, Ruth P, Kaatz M and Hipler UC: Protease and pro-inflammatory cytokine concentrations are elevated in chronic compared to acute wounds and can be modulated by collagen type I in vitro. Arch Dermatol Res. 302:419–428. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Kimura K, Nomi N, Yan ZH, Orita T and Nishida T: Inhibition of poly(I:C)-induced matrix metalloproteinase expression in human corneal fibroblasts by triptolide. Mol Vis. 17:526–532. 2011.PubMed/NCBI

40 

Chaiprasongsuk A, Lohakul J, Soontrapa K, Sampattavanich S, Akarasereenont P and Panich U: Activation of Nrf2 reduces UVA-mediated MMP-1 upregulation via MAPK/AP-1 signaling cascades: The photoprotective effects of sulforaphane and hispidulin. J Pharmacol Exp Ther. 360:388–398. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Choi YJ, Lee WS, Lee EG, Sung MS and Yoo WH: Sulforaphane inhibits IL-1β-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of MMPs, COX-2, and PGE2. Inflammation. 37:1496–1503. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Meylan E and Tschopp J: Toll-like receptors and RNA helicases: Two parallel ways to trigger antiviral responses. Mol Cell. 22:561–569. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Takeuchi O and Akira S: Toll-like receptors; their physiological role and signal transduction system. Int Immunopharmacol. 1:625–635. 2001. View Article : Google Scholar : PubMed/NCBI

44 

Orita T, Kimura K, Zhou HY and Nishida T: Poly(I:C)-induced adhesion molecule expression mediated by NF-{kappa}B and phosphoinositide 3-kinase-Akt signaling pathways in human corneal fibroblasts. Invest Ophthalmol Vis Sci. 51:5556–5560. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Sweeney SE, Kimbler TB and Firestein GS: Synoviocyte innate immune responses: II. Pivotal role of IFN regulatory factor 3. J Immunol. 184:7162–7168. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Lawrence T: The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol. 1:a0016512009. View Article : Google Scholar : PubMed/NCBI

47 

Hayden MS and Ghosh S: Shared principles in NF-kappaB signaling. Cell. 132:344–362. 2008. View Article : Google Scholar : PubMed/NCBI

48 

Sun Y, Liu WZ, Liu T, Feng X, Yang N and Zhou HF: Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis. J Recept Signal Transduct Res. 35:600–604. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Arthur JS and Ley SC: Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol. 13:679–692. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Hoesel B and Schmid JA: The complexity of NF-κB signaling in inflammation and cancer. Mol Cancer. 12:862013. View Article : Google Scholar : PubMed/NCBI

51 

Trop-Steinberg S and Azar Y: AP-1 expression and its clinical relevance in immune disorders and cancer. Am J Med Sci. 353:474–483. 2017. View Article : Google Scholar : PubMed/NCBI

52 

Bian ZM, Elner SG, Yoshida A and Elner VM: Differential involvement of phosphoinositide 3-kinase/Akt in human RPE MCP-1 and IL-8 expression. Invest Ophthalmol Vis Sci. 45:1887–1896. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu P, Liu Y, Zheng H, Zheng X, Yang X, Zhao X, Chen L and Liu Y: Sulforaphane suppresses polyinosinic‑polycytidylic acid‑stimulated release of cytokines, chemokines and MMPs by human corneal fibroblasts. Mol Med Rep 22: 5463-5471, 2020.
APA
Liu, P., Liu, Y., Zheng, H., Zheng, X., Yang, X., Zhao, X. ... Liu, Y. (2020). Sulforaphane suppresses polyinosinic‑polycytidylic acid‑stimulated release of cytokines, chemokines and MMPs by human corneal fibroblasts. Molecular Medicine Reports, 22, 5463-5471. https://doi.org/10.3892/mmr.2020.11633
MLA
Liu, P., Liu, Y., Zheng, H., Zheng, X., Yang, X., Zhao, X., Chen, L., Liu, Y."Sulforaphane suppresses polyinosinic‑polycytidylic acid‑stimulated release of cytokines, chemokines and MMPs by human corneal fibroblasts". Molecular Medicine Reports 22.6 (2020): 5463-5471.
Chicago
Liu, P., Liu, Y., Zheng, H., Zheng, X., Yang, X., Zhao, X., Chen, L., Liu, Y."Sulforaphane suppresses polyinosinic‑polycytidylic acid‑stimulated release of cytokines, chemokines and MMPs by human corneal fibroblasts". Molecular Medicine Reports 22, no. 6 (2020): 5463-5471. https://doi.org/10.3892/mmr.2020.11633
Copy and paste a formatted citation
x
Spandidos Publications style
Liu P, Liu Y, Zheng H, Zheng X, Yang X, Zhao X, Chen L and Liu Y: Sulforaphane suppresses polyinosinic‑polycytidylic acid‑stimulated release of cytokines, chemokines and MMPs by human corneal fibroblasts. Mol Med Rep 22: 5463-5471, 2020.
APA
Liu, P., Liu, Y., Zheng, H., Zheng, X., Yang, X., Zhao, X. ... Liu, Y. (2020). Sulforaphane suppresses polyinosinic‑polycytidylic acid‑stimulated release of cytokines, chemokines and MMPs by human corneal fibroblasts. Molecular Medicine Reports, 22, 5463-5471. https://doi.org/10.3892/mmr.2020.11633
MLA
Liu, P., Liu, Y., Zheng, H., Zheng, X., Yang, X., Zhao, X., Chen, L., Liu, Y."Sulforaphane suppresses polyinosinic‑polycytidylic acid‑stimulated release of cytokines, chemokines and MMPs by human corneal fibroblasts". Molecular Medicine Reports 22.6 (2020): 5463-5471.
Chicago
Liu, P., Liu, Y., Zheng, H., Zheng, X., Yang, X., Zhao, X., Chen, L., Liu, Y."Sulforaphane suppresses polyinosinic‑polycytidylic acid‑stimulated release of cytokines, chemokines and MMPs by human corneal fibroblasts". Molecular Medicine Reports 22, no. 6 (2020): 5463-5471. https://doi.org/10.3892/mmr.2020.11633
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