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miR‑26a‑5p alleviates lipopolysaccharide‑induced acute lung injury by targeting the connective tissue growth factor

  • Authors:
    • Hongyan Li
    • Tingting Yang
    • Zhaoxia Fei
  • View Affiliations / Copyright

    Affiliations: Department of Child Healthcare, Zibo Women & Children Hospital, Zibo, Shandong 255000, P.R. China, General Internal Medicine, Qingdao Hospital of Traditional Chinese Medicine (Qingdao Hiser Hospital), Qingdao, Shandong 266033, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 5
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    Published online on: November 3, 2020
       https://doi.org/10.3892/mmr.2020.11643
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Abstract

The aim of the present study was to investigate the regulatory functions of microRNA (miR)‑26a‑5p on lipopolysaccharide (LPS)‑induced acute lung injury (ALI) and its molecular mechanisms. The role of miR‑26a‑5p on an ALI mouse model was evaluated by examining the histological changes, wet/dry (W/D) ratio, myeloperoxidase (MPO) activity, malondialdehyde (MDA) expression levels in lung tissues and the survival of ALI mice. Moreover, the protein concentration and the number of neutrophils and lymphocytes in bronchoalveolar lavage fluid (BALF) was analyzed. To explore the effect of miR‑26a‑5p on inflammatory responses and apoptosis, the expression levels of tumour necrosis factor‑α (TNF‑α), interleukin (IL)‑1β and IL‑6 and apoptosis were measured by ELISA, terminal deoxynucleotidyl transferase‑mediated dUTP nick end labelling staining and flow cytometry in BALF, A549 cells and lung tissues. B‑cell lymphoma‑2 (Bcl‑2), Bax and cleaved caspase‑3 in lung tissues were measured by western blotting and reverse transcription‑quantitative PCR. Connective tissue growth factor (CTGF) was predicted as a direct target of miR‑26a‑5p using dual luciferase reporter assay. The present study sought to determine whether CTGF overexpression reversed the effect of miR‑26a‑5p on apoptosis and inflammatory responses in LPS‑induced A549 cells. The data revealed that miR‑26a‑5p overexpression ameliorated LPS‑induced ALI, which was implicated by fewer histopathological changes, W/D ratio, apoptosis in lung tissues and the survival of ALI mice. Moreover, miR‑26a‑5p overexpression alleviated LPS‑induced inflammatory responses in ALI mice via the reduction of total protein, neutrophil and lymphocyte counts and the expression levels of TNF‑α, IL‑1β, IL‑6, MDA and MPO activity in BALF. Similarly, miR‑26a‑5p overexpression decreased apoptosis and the expression of TNF‑α, IL‑1β and IL‑6 in LPS‑induced A549 cells. CTGF was a direct target of miR‑26a‑5p. CTGF overexpression reversed the effect of miR‑26a‑5p on cell apoptosis and inflammatory responses in LPS‑induced A549 cells. The present study demonstrated that miR‑26a‑5p could attenuate lung inflammation and apoptosis in LPS‑induced ALI by targeting CTGF.
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1 

Needham DM, Wozniak AW, Hough CL, Morris PE, Dinglas VD, Jackson JC, Mendez-Tellez PA, Shanholtz C, Ely EW, Colantuoni E, et al: Risk factors for physical impairment after acute lung injury in a national, multicenter study. Am J Respir Crit Care Med. 189:1214–1224. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Pan C, Liu L, Xie JF and Qiu HB: Acute respiratory distress syndrome: Challenge for diagnosis and therapy. Chin Med J (Engl). 131:1220–1224. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Bartel DP: MicroRNAs: Target recognition and regulatory functions. Cell. 136:215–233. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Pattarayan D, Thimmulappa RK, Ravikumar V and Rajasekaran S: Diagnostic Potential of extracellular microRNA in respiratory diseases. Clin Rev Allergy Immunol. 54:480–492. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Yang Y, Liu D, Xi Y, Li J and Liu B: Upregulation of miRNA-140-5p inhibits inflammatory cytokines in acute lung injury through the MyD88/NF-κB signaling pathway by targeting TLR4. Exp Ther Med. 16:3913–3920. 2018.PubMed/NCBI

6 

Xie W, Lu Q, Wang K, Lu J, Gu X, Zhu D, Liu F and Guo Z: miR-34b-5p inhibition attenuates lung inflammation and apoptosis in an LPS-induced acute lung injury mouse model by targeting progranulin. J Cell Physiol. 233:6615–6631. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Bradham DM, Igarashi A, Potter RL and Grotendorst GR: Connective tissue growth factor: A cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J Cell Biol. 114:1285–1294. 1991. View Article : Google Scholar : PubMed/NCBI

8 

Blom IE, Goldschmeding R and Leask A: Gene regulation of connective tissue growth factor: New targets for antifibrotic therapy? Matrix Biol. 21:473–482. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Alapati D, Rong M, Chen S, Hehre D, Rodriguez MM, Lipson KE and Wu S: Connective tissue growth factor antibody therapy attenuates hyperoxia-induced lung injury in neonatal rats. Am J Respir Cell Mol Biol. 45:1169–1177. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Guo H, Ji F, Liu B, Chen X, He J and Gong J: Peiminine ameliorates bleomycin-induced acute lung injury in rats. Mol Med Rep. 7:1103–1110. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Zhou T, Yu Q, Lin H, Wang Z, Fu G, Lei L, Shi Y, Zhang L, Qin L and Liu Y: The Role of CTGF in inflammatory responses induced by silica particles in human bronchial epithelial cells. Lung. 197:783–791. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Yang H, Li W, Zhang Y, Li M, Gao Y, Lao C and Shi B: Regulatory role of miR-18a to CCN2 by TGF-β1 signaling pathway in pulmonary injury induced by nano-SiO2. Environ Sci Pollut Res Int. 25:867–876. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Qi D, He J, Wang D, Deng W, Zhao Y, Ye Y and Feng L: 17β-estradiol suppresses lipopolysaccharide-induced acute lung injury through PI3K/Akt/SGK1 mediated up-regulation of epithelial sodium channel (ENaC) in vivo and in vitro. Respir Res. 15:1592014. View Article : Google Scholar : PubMed/NCBI

14 

Agarwal V, Bell GW, Nam JW and Bartel DP: Predicting effective microRNA target sites in mammalian mRNAs. Elife. 4:e050052015. View Article : Google Scholar

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Leung WS, Yang ML, Lee SS, Kuo CW, Ho YC, Huang-Liu R, Lin HW and Kuan YH: Protective effect of zerumbone reduces lipopolysaccharide-induced acute lung injury via antioxidative enzymes and Nrf2/HO-1 pathway. Int Immunopharmacol. 46:194–200. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Wang Q and Xiao L: Isochlorogenic acid A attenuates acute lung injury induced by LPS via Nf-κB/NLRP3 signaling pathway. Am J Transl Res. 11:7018–7026. 2019.PubMed/NCBI

18 

Guo H, Ingolia NT, Weissman JS and Bartel DP: Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature. 466:835–840. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Li W, Qiu X, Jiang H, Han Y, Wei D and Liu J: Downregulation of miR-181a protects mice from LPS-induced acute lung injury by targeting Bcl-2. Biomed Pharmacother. 84:1375–1382. 2016. View Article : Google Scholar : PubMed/NCBI

20 

You Q, Wang J, Jia D, Jiang L, Chang Y and Li W: MiR-802 alleviates lipopolysaccharide-induced acute lung injury by targeting Peli2. Inflamm Res. 69:75–85. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Meng L, Cao H, Wan C and Jiang L: MiR-539-5p alleviates sepsis-induced acute lung injury by targeting ROCK1. Folia Histochem Cytobiol. 57:168–178. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Wei R, Zhang L, Hu W, Wu J and Zhang W: Long non-coding RNA AK038897 aggravates cerebral ischemia/reperfusion injury via acting as a ceRNA for miR-26a-5p to target DAPK1. Exp Neurol. 314:100–110. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Xing X, Guo S, Zhang G, Liu Y, Bi S, Wang X and Lu Q: miR-26a-5p protects against myocardial ischemia/reperfusion injury by regulating the PTEN/PI3K/AKT signaling pathway. Braz J Med Biol Res. 53:e91062020. View Article : Google Scholar : PubMed/NCBI

24 

Cox R Jr, Phillips O, Fukumoto J, Fukumoto I, Parthasarathy PT, Arias S, Cho Y, Lockey RF and Kolliputi N: Enhanced resolution of hyperoxic acute lung injury as a result of aspirin triggered resolvin D1 treatment. Am J Respir Cell Mol Biol. 53:422–435. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Liu F, Zhang W, Yang F, Feng T, Zhou M, Yu Y, Yu X, Zhao W, Yi F, Tang W and Lu Y: Interleukin-6-stimulated progranulin expression contributes to the malignancy of hepatocellular carcinoma cells by activating mTOR signaling. Sci Rep. 6:212602016. View Article : Google Scholar : PubMed/NCBI

26 

Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, et al: Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Circ Res. 102:804–812. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Lv H, Liu Q, Wen Z, Feng H, Deng X and Ci X: Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis. Redox Biol. 12:311–324. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Ju M, Liu B, He H, Gu Z, Liu Y, Su Y, Zhu D, Cang J and Luo Z: MicroRNA-27a alleviates LPS-induced acute lung injury in mice via inhibiting in flammation and apoptosis through modulating TLR4/MyD88/NF-κB pathway. Cell Cycle. 17:2001–2018. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Suo T, Chen GZ, Huang Y, Zhao KC, Wang T and Hu K: miRNA-1246 suppresses acute lung injury-induced inflammation and apoptosis via the NF-κB and Wnt/β-catenin signal pathways. Biomed Pharmacother. 108:783–791. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Zhang Y, Su Z, Liu HL, Li L, Wei M, Ge DJ and Zhang ZJ: Effects of miR-26a-5p on neuropathic pain development by targeting MAPK6 in in CCI rat models. Biomed Pharmacother. 107:644–649. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Wen X, Yin Y, Li X, He T, Wang P, Song M and Gao J: Effect of miR-26a-5p targeting ADAM17 gene on apoptosis, inflammatory factors and oxidative stress response of myocardial cells in hypoxic model. J Bioenerg Biomembr. 52:83–92. 2020. View Article : Google Scholar : PubMed/NCBI

32 

Cicha I and Goppelt-Struebe M: Connective tissue growth factor: Context-dependent functions and mechanisms of regulation. Biofactors. 35:200–208. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Gressner OA and Gressner AM: Connective tissue growth factor: A fibrogenic master switch in fibrotic liver diseases. Liver Int. 28:1065–1079. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Kim JW, Rhee CK, Kim TJ, Kim YH, Lee SH, Yoon HK, Kim SC, Lee SY, Kwon SS, Kim KH and Kim YK: Effect of pravastatin on bleomycin-induced acute lung injury and pulmonary fibrosis. Clin Exp Pharmacol Physiol. 37:1055–1063. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Ponticos M, Holmes AM, Shi-wen X, Leoni P, Khan K, Rajkumar VS, Hoyles RK, Bou-Gharios G, Black CM, Denton CP, et al: Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen. Arthritis Rheum. 60:2142–2155. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Li X, Liu L, Shen Y, Wang T, Chen L, Xu D and Wen F: MicroRNA-26a modulates transforming growth factor beta-1-induced proliferation in human fetal lung fibroblasts. Biochem Biophys Res Commun. 454:512–517. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Li C, Han T, Li R, Fu L and Yue L: miR-26a-5p mediates TLR signaling pathway by targeting CTGF in LPS-induced alveolar macrophage. Biosci Rep. 40:BSR201925982020. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li H, Yang T and Fei Z: miR‑26a‑5p alleviates lipopolysaccharide‑induced acute lung injury by targeting the connective tissue growth factor. Mol Med Rep 23: 5, 2021.
APA
Li, H., Yang, T., & Fei, Z. (2021). miR‑26a‑5p alleviates lipopolysaccharide‑induced acute lung injury by targeting the connective tissue growth factor. Molecular Medicine Reports, 23, 5. https://doi.org/10.3892/mmr.2020.11643
MLA
Li, H., Yang, T., Fei, Z."miR‑26a‑5p alleviates lipopolysaccharide‑induced acute lung injury by targeting the connective tissue growth factor". Molecular Medicine Reports 23.1 (2021): 5.
Chicago
Li, H., Yang, T., Fei, Z."miR‑26a‑5p alleviates lipopolysaccharide‑induced acute lung injury by targeting the connective tissue growth factor". Molecular Medicine Reports 23, no. 1 (2021): 5. https://doi.org/10.3892/mmr.2020.11643
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Yang T and Fei Z: miR‑26a‑5p alleviates lipopolysaccharide‑induced acute lung injury by targeting the connective tissue growth factor. Mol Med Rep 23: 5, 2021.
APA
Li, H., Yang, T., & Fei, Z. (2021). miR‑26a‑5p alleviates lipopolysaccharide‑induced acute lung injury by targeting the connective tissue growth factor. Molecular Medicine Reports, 23, 5. https://doi.org/10.3892/mmr.2020.11643
MLA
Li, H., Yang, T., Fei, Z."miR‑26a‑5p alleviates lipopolysaccharide‑induced acute lung injury by targeting the connective tissue growth factor". Molecular Medicine Reports 23.1 (2021): 5.
Chicago
Li, H., Yang, T., Fei, Z."miR‑26a‑5p alleviates lipopolysaccharide‑induced acute lung injury by targeting the connective tissue growth factor". Molecular Medicine Reports 23, no. 1 (2021): 5. https://doi.org/10.3892/mmr.2020.11643
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