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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January-2021 Volume 23 Issue 1

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Astragaloside IV attenuates hypoxia‑induced pulmonary vascular remodeling via the Notch signaling pathway Corrigendum in /10.3892/mmr.2021.12547

Jiamei Yao, Xia Fang, Cui Zhang, Yushu Yang, Dongsheng Wang, Qiong Chen, Guangwei Zhong
Article Number: 89
Published online on: 24 November 2020

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Article Open Access

Metformin induces apoptosis and inhibits migration by activating the AMPK/p53 axis and suppressing PI3K/AKT signaling in human cervical cancer cells

Ya-Hui Chen, Shun-Fa Yang, Chueh-Ko Yang, Horng-Der Tsai, Tze-Ho Chen, Ming-Chih Chou, Yi-Hsuan Hsiao
Article Number: 88
Published online on: 24 November 2020

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Article Open Access

STAT3 enhances radiation-induced tumor migration, invasion and stem-like properties of bladder cancer

Fang Wang, Xiangli Ma, Guangmin Mao, Xiangyan Zhang, Zhaolu Kong
Article Number: 87
Published online on: 24 November 2020

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Article Open Access

Chloroform extract of Citrus unshiu Markovich peel induces apoptosis and inhibits stemness in HeLa human cervical cancer cells

Ye Seul Choi, Jang Mi Han, Yue Jai Kang, Hye Jin Jung
Article Number: 86
Published online on: 24 November 2020

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Article Open Access

lncRNA SNHG4 promotes cell proliferation, migration, invasion and the epithelial-mesenchymal transition process via sponging miR-204-5p in gastric cancer

Shimei Wang, Wei Zhu, Ji Qiu, Fei Chen
Article Number: 85
Published online on: 23 November 2020

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Article Open Access

Exosomal‑miR‑10a derived from colorectal cancer cells suppresses migration of human lung fibroblasts, and expression of IL‑6, IL‑8 and IL‑1β

Jian Wang, Yuanting Liu, Ying Li, Xuan Zheng, Jianhui Gan, Zhaoyuan Wan, Jun Zhang, Yan Liu, Yaqi Wang, Wanning Hu, Yufeng Li, Yankun Liu
Article Number: 84
Published online on: 23 November 2020

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Article

Scutellarin regulates osteoarthritis in vitro by inhibiting the PI3K/AKT/mTOR signaling pathway

Shao-Hua Ju, Li-Rong Tan, Pan-Wang Liu, You-Li Tan, Yuan-Ting Zhang, Xiao-Hong Li, Ming-Jian Wang, Ben-Xiang He
Article Number: 83
Published online on: 23 November 2020

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Article

Nardostachin from Nardostachys jatamansi exerts anti‑neuroinflammatory effects through TLR4/MyD88‑related suppression of the NF‑κB and JNK MAPK signaling pathways in lipopolysaccharide‑induced BV2 and primary microglial cells

Dong-Cheol Kim, Jin-Soo Park, Chi-Su Yoon, Youn-Chul Kim, Hyuncheol Oh
Article Number: 82
Published online on: 23 November 2020

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Article

miR‑576‑3p overexpression enhances cisplatin sensitivity of ovarian cancer cells by dysregulating PD‑L1 and cyclin D1

Ying Zuo, Wei Zheng, Qing Tang, Jing Liu, Shanshan Wang, Chunxia Xin
Article Number: 81
Published online on: 23 November 2020

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Article Open Access

Oncogenic potential of macrophage‑capping protein in clear cell renal cell carcinoma

Zhuang-Fei Chen, Ze-Hai Huang, Shi-Jun Chen, Yao-Dong Jiang, Zi-Ke Qin, Shao-Bin Zheng, Tong Chen
Article Number: 80
Published online on: 23 November 2020

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Article Open Access

miR‑18a‑5p promotes melanoma cell proliferation and inhibits apoptosis and autophagy by targeting EPHA7 signaling

Yunlong Guo, Wenli Shi, Ruihua Fang
Article Number: 79
Published online on: 23 November 2020

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Correction Open Access

[Corrigendum] Molecular mechanism of extracellular matrix disorder in pelvic organ prolapses

Liping Zhang, Fangfang Dai, Gantao Chen, Yanqing Wang, Shiyi Liu, Li Zhang, Shu Xian, Mengqin Yuan, Dongyong Yang, Yajing Zheng, Zhimin Deng, Yanxiang Cheng, Xiaofeng Yang
Article Number: 78
Published online on: 23 November 2020

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Article Open Access

Inonotus obliquus extract alleviates myocardial ischemia/reperfusion injury by suppressing endoplasmic reticulum stress

Yi Wu, Heming Cui, Yuying Zhang, Ping Yu, Yuangeng Li, Dan Wu, Yan Xue, Wenwen Fu
Article Number: 77
Published online on: 23 November 2020

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Article Open Access

lncRNA EZR‑AS1 knockdown represses proliferation, migration and invasion of cSCC via the PI3K/AKT signaling pathway

Di Lu, Lingling Sun, Zhengjun Li, Zhen Mu
Article Number: 76
Published online on: 23 November 2020

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Case Report

PARP inhibitor resistance and TP53 mutations in patients treated with olaparib for BRCA-mutated cancer: Four case reports

Thomas Collot, Julie Niogret, Marion Carnet, Sandy Chevrier, Etienne Humblin, Laure Favier, Leila Bengrine-Lefevre, Isabelle Desmoulins, Laurent Arnould, Romain Boidot
Article Number: 75
Published online on: 23 November 2020

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Article Open Access

Platelet isoform of phosphofructokinase promotes aerobic glycolysis and the progression of non‑small cell lung cancer

Fuan Wang, Ling Li, Zhen Zhang
Article Number: 74
Published online on: 20 November 2020

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Article Open Access

Resveratrol alleviates oxygen/glucose deprivation/reoxygenation‑induced neuronal damage through induction of mitophagy

Ming Ye, Hui Wu, Shuguo Li
Article Number: 73
Published online on: 20 November 2020

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Article Open Access

Acarbose ameliorates spontaneous type‑2 diabetes in db/db mice by inhibiting PDX‑1 methylation

Diyi Zhou, Lijun Chen, Xin Mou
Article Number: 72
Published online on: 20 November 2020

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Article Open Access

Glutathione S‑transferase ω 1 promotes the proliferation, migration and invasion, and inhibits the apoptosis of non‑small cell lung cancer cells, via the JAK/STAT3 signaling pathway

Kai Wang, Fu-Lian Zhang, Wei Jia
Article Number: 71
Published online on: 20 November 2020

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Review Open Access

Different roles of matrix metalloproteinase 2 in osteolysis of skeletal dysplasia and bone metastasis (Review)

Xiumao Li, Libin Jin, Yanbin Tan
Article Number: 70
Published online on: 20 November 2020

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Article Open Access

Bone marrow stem cells therapy alleviates vascular injury in a chronic obstructive pulmonary disease‑obstructive sleep apnea overlap syndrome rat model

Hong Bi, Jian He, Xu He, Junyi Du, Min Chen, Zhaoming Huang, Chao Yang, Lijuan Yang, Hang Li, Kaihua Zhou, Qing Wang, Lewei He, Zhixian Jin
Article Number: 69
Published online on: 20 November 2020

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Article Open Access

HIF‑3α affects preeclampsia development by regulating EVT growth via activation of the Flt‑1/JAK/STAT signaling pathway in hypoxia

Hongmei Qu, Qun Yu, Bei Jia, Wenzhe Zhou, Yinghong Zhang, Linsong Mu
Article Number: 68
Published online on: 19 November 2020

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Article Open Access

Exogenous sodium hydrosulfide protects against high glucose‑induced injury and inflammation in human umbilical vein endothelial cells by inhibiting necroptosis via the p38 MAPK signaling pathway

Jiaqiong Lin, Xiaoyong Li, Yan Lin, Zena Huang, Wen Wu
Article Number: 67
Published online on: 19 November 2020

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Article Open Access

Klotho attenuates angiotensin II‑induced cardiotoxicity through suppression of necroptosis and oxidative stress

Shasha Yu, Hongmei Yang, Xiaofan Guo, Yingxian Sun
Article Number: 66
Published online on: 19 November 2020

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Article

Osteoglycin knockdown promotes vascular smooth muscle cell proliferation and migration in aortic dissection via the VEGF/VEGFR2 axis

Zanxin Wang, Xianmian Zhuang, Bailang Chen, Minxin Wei
Article Number: 65
Published online on: 19 November 2020

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Article Open Access

S100a8 silencing attenuates inflammation, oxidative stress and apoptosis in BV2 cells induced by oxygen‑glucose deprivation and reoxygenation by upregulating GAB1 expression

Wenguang Hu, Caimei Lin
Article Number: 64
Published online on: 19 November 2020

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Article Open Access

Effects and molecular mechanism of pachymic acid on ferroptosis in renal ischemia reperfusion injury

Gui-Ping Jiang, Yue-Juan Liao, Li-Li Huang, Xu-Jia Zeng, Xiao-Hui Liao
Article Number: 63
Published online on: 19 November 2020

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Article Open Access

Hyperoxia sensitizes hypoxic HeLa cells to ionizing radiation by downregulating HIF‑1α and VEGF expression

Dan Dong, Yan Fu, Feng Chen, Jing Zhang, Haiyan Jia, Jia Li, Huailin Wang, Jihong Wen
Article Number: 62
Published online on: 18 November 2020

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Article

Recombinant stromal cell‑derived factor‑1 protein promotes neurite outgrowth in PC‑12 cells

Ye-Rang Yun, Jun-Hyeog Jang
Article Number: 61
Published online on: 18 November 2020

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Article Open Access

Long non‑coding RNA JPX promotes gastric cancer progression by regulating CXCR6 and autophagy via inhibiting miR‑197

Xuejing Han, Zheng Liu
Article Number: 60
Published online on: 18 November 2020

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Article Open Access

Lung cancer‑associated transcript 1 facilitates tumorigenesis in laryngeal squamous cell carcinoma through the targeted inhibition of miR‑493

Zhen Zhao, Yan Xing, Yan Liu, Shanghua Jing
Article Number: 59
Published online on: 18 November 2020

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Article Open Access

Construction of tissue engineering bone with the co‑culture system of ADSCs and VECs on partially deproteinized biologic bone in vitro: A preliminary study

Guiran Yang, Fuke Wang, Yanlin Li, Jianfei Hou, Dejian Liu
Article Number: 58
Published online on: 18 November 2020

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Article

miR-194-5p serves a suppressive role in human keloid fibroblasts via targeting NR2F2

Qijun Xu, Shengjun Jiang
Article Number: 57
Published online on: 17 November 2020

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Article Open Access

AMPK‑SIRT1 pathway dysfunction contributes to neuron apoptosis and cognitive impairment induced by sevoflurane

Liwei Liu, Chao Liu, Lin Fang
Article Number: 56
Published online on: 17 November 2020

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Article Open Access

Treatment of keloids through Runx2 siRNA‑induced inhibition of the PI3K/AKT signaling pathway

Wenchang Lv, Min Wu, Yuping Ren, Xiao Luo, Weijie Hu, Qi Zhang, Yiping Wu
Article Number: 55
Published online on: 16 November 2020

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Article Open Access

MicroRNA‑744‑5p is downregulated in colorectal cancer and targets SEPT2 to suppress the malignant phenotype

Wei Zhang, Kai Liao, Dongning Liu
Article Number: 54
Published online on: 16 November 2020

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Article Open Access

miR‑140‑5p inhibits the proliferation of multiple myeloma cells by targeting VEGFA

Min Liu, Huimin Liu, Jing Zhou, Zhuojun Yu
Article Number: 53
Published online on: 16 November 2020

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Article Open Access

Regulation of ABCG2 expression by Wnt5a through FZD7 in human pancreatic cancer cells

Zhongbo Zhang, Shuang Gao, Yuanhong Xu, Chenghai Zhao
Article Number: 52
Published online on: 16 November 2020

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Article Open Access

MicroRNA‑21‑5p protects melanocytes via targeting STAT3 and modulating Treg/Teff balance to alleviate vitiligo

Jing Huo, Taibin Liu, Fenghua Li, Xinfeng Song, Xiuli Hou
Article Number: 51
Published online on: 16 November 2020

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Article Open Access

Cardiac‑specific deletion of natriuretic peptide receptor A induces differential myocardial expression of circular RNA and mRNA molecules involved in metabolism in mice

Baoying Chen, Pan Chang, Xi Shen, Xiaomeng Zhang, Jing Zhang, Xihui Wang, Jun Yu
Article Number: 50
Published online on: 13 November 2020

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Article Open Access

C-C chemokine receptor 5 signaling contributes to cardiac remodeling and dysfunction under pressure overload

Xiaomin Wang, Wei Li, Qiang Yue, Wei Du, Yongming Li, Fu Liu, Liu Yang, Lijuan Xu, Ruiping Zhao, Jiang Hu
Article Number: 49
Published online on: 13 November 2020

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Article Open Access

Inhibition of Bcl-2 and Bcl-xL overcomes the resistance to the third-generation EGFR tyrosine kinase inhibitor osimertinib in non-small cell lung cancer

Yingjie Lu, Dongliang Bian, Xuelin Zhang, Huibiao Zhang, Zhenghong Zhu
Article Number: 48
Published online on: 12 November 2020

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Article Open Access

Differentiation potential and mRNA profiles of human dedifferentiated adipose cells and adipose‑derived stem cells from young donors

Fangfei Nie, Hongsen Bi, Chen Zhang, Pengbing Ding
Article Number: 47
Published online on: 12 November 2020

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Article Open Access

CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression

Hangwei Fu, Yida Zhang, Yin Chen, Junying Chen, Ping Chen
Article Number: 46
Published online on: 12 November 2020

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Article Open Access

Long non‑coding RNA TTN‑AS1 regulates the proliferation, invasion and migration of triple‑negative breast cancer by targeting miR‑211‑5p

Erhu Sun, Xiaofeng Liu, Cheng Lu, Kangsheng Liu
Article Number: 45
Published online on: 10 November 2020

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Article Open Access

Bioinformatics analysis of the microRNA-mRNA network in sebaceous gland carcinoma of the eyelid

Tetsushi Hirano, Tatsuya Yunoki, Yukihiro Furusawa, Yoshiaki Tabuchi, Atsushi Hayashi
Article Number: 44
Published online on: 10 November 2020

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Article Open Access

Mesenchymal stem cells negatively regulate CD4+ T cell activation in patients with primary Sjögren syndrome through the miRNA‑125b and miRNA‑155 TCR pathway

Bangdong Gong, Ling Zheng, Zhenhao Lu, Jiashu Huang, Jincheng Pu, Shengnan Pan, Min Zhang, Jie Liu, Jianping Tang
Article Number: 43
Published online on: 10 November 2020

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Article Open Access

miR-31 attenuates murine allergic rhinitis by suppressing interleukin-13-induced nasal epithelial inflammatory responses

Fangwei Zhou, Peiqiang Liu, Hao Lv, Ziang Gao, Wenchuan Chang, Yu Xu
Article Number: 42
Published online on: 10 November 2020

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Article Open Access

Reoxygenation induces reactive oxygen species production and ferroptosis in renal tubular epithelial cells by activating aryl hydrocarbon receptor

Theodoros Eleftheriadis, Georgios Pissas, Georgios Filippidis, Vassilios Liakopoulos, Ioannis Stefanidis
Article Number: 41
Published online on: 10 November 2020

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Article Open Access

Tanshinone I and simvastatin inhibit melanoma tumour cell growth by regulating poly (ADP ribose) polymerase 1 expression

Yuyan Zhang, Jiusui Huang, Yapeng Huang, Shike Zhang, Weizhou Wu, Hui Long, Xiaolu Duan, Yongchang Lai, Wenqi Wu
Article Number: 40
Published online on: 10 November 2020

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Article Open Access

PDGF mediates pulmonary arterial smooth muscle cell proliferation and migration by regulating NFATc2

Fang-Yun Zhao, Shuang-Lan Xu, Chun-Fang Zhang, Jie Liu, Yue Zhang, Jiao Yang, Xi-Qian Xing
Article Number: 39
Published online on: 10 November 2020

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Article Open Access

Dexmedetomidine attenuates sevoflurane‑induced neurocognitive impairment through α2‑adrenoceptors

Yufeng Zhang, Mao Li, Enhui Cui, Hao Zhang, Xiaozhong Zhu, Jing Zhou, Ming Yan, Jian Sun
Article Number: 38
Published online on: 10 November 2020

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Article Open Access

Ginsenoside Rg1 improves pathological damages by activating the p21‑p53‑STK pathway in ovary and Bax‑Bcl2 in the uterus in premature ovarian insufficiency mouse models

Lianli He, Xiaojuan Wang, Daigang Cheng, Zhengai Xiong, Xiaoyun Liu
Article Number: 37
Published online on: 10 November 2020

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Retraction Open Access

[Retracted] Effects of botulinum toxin A on endometriosis‑associated pain and its related mechanism

Fubo Tian, Wuzhong Cheng, Jianying Hu, Shaoqiang Huang, Shen Sun
Article Number: 36
Published online on: 09 November 2020

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Article Open Access

Rosiglitazone affects the progression of surgically‑induced endometriosis in a rat model

Shun Zhang, Lingling Zhuang, Qian Liu, Xiaolin Yu, Qinghua Min, Minjie Chen, Qi Chen
Article Number: 35
Published online on: 09 November 2020

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Article Open Access

Curcumin ameliorates DSS‑induced colitis in mice by regulating the Treg/Th17 signaling pathway

Cheng Wei, Jian-Yao Wang, Feng Xiong, Ben-Hua Wu, Ming-Han Luo, Zhi-Chao Yu, Ting-Ting Liu, De-Feng Li, Qi Tang, Ying-Xue Li, Ding-Guo Zhang, Zheng-Lei Xu, Hong-Tao Jin, Li-Sheng Wang, Jun Yao
Article Number: 34
Published online on: 09 November 2020

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Article Open Access

Hyperoxia induces endoplasmic reticulum stress‑associated apoptosis via the IRE1α pathway in rats with bronchopulmonary dysplasia

Xin Tong, Mengyun Li, Na Liu, Wanjie Huang, Xindong Xue, Jianhua Fu
Article Number: 33
Published online on: 09 November 2020

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Review Open Access

Neuromodulation of bone: Role of different peptides and their interactions (Review)

Xiaoyu Wang, Jia Xu, Qinglin Kang
Article Number: 32
Published online on: 05 November 2020

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Article Open Access

Long non‑coding RNA SNHG20 promotes colorectal cancer cell proliferation, migration and invasion via miR‑495/STAT3 axis

Yu Wang, Jianying Fu, Lili Yang, Zhi Liang
Article Number: 31
Published online on: 05 November 2020

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Article Open Access

Effects of miR‑93 on epithelial‑to‑mesenchymal transition and vasculogenic mimicry in triple‑negative breast cancer cells

Gaili An, Feng Lu, Shangke Huang, Jun Bai, Li He, Yi Liu, Lei Hou
Article Number: 30
Published online on: 04 November 2020

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Article Open Access

Catalpol inhibits the proliferation, migration and metastasis of HCC cells by regulating miR‑140‑5p expression

Linsheng Wu, Haoxia Li, Shengyou Chen, Xiaoqiang Wu, Xiaomin Chen, Fangping Wang
Article Number: 29
Published online on: 04 November 2020

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Article Open Access

Effects and mechanism of microRNA‑218 against lung cancer

Yan Chen, Ji-Lin Yang, Zhen-Zhen Xue, Qiu-Chen Cai, Chun Hou, Hong-Juan Li, Liu-Xin Zhao, Yin Zhang, Cheng-Wei Gao, Li Cong, Tian-Zuo Wang, Dong-Mei Chen, Guo-Sheng Li, Shi-Qing Luo, Qian Yao, Chan-Juan Yang, Qi-Shun Zhu, Chuan-Hai Cao
Article Number: 28
Published online on: 04 November 2020

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Review

Calcitonin gene‑related peptide‑mediated pharmacological effects in cardiovascular and gastrointestinal diseases (Review)

Wan-Jun Ma, You-Cong Yin, Bi-Kui Zhang, Yuan-Jian Li, Wen-Qun Li
Article Number: 27
Published online on: 04 November 2020

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Review

Functions, pathophysiology and current insights of exosomal endocrinology (Review)

Dimitrios Vlachakis, Τhanasis Mitsis, Nicolas Nicolaides, Aspasia Efthimiadou, Antonis Giannakakis, Flora Bacopoulou, George P. Chrousos
Article Number: 26
Published online on: 04 November 2020

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Article Open Access

A transcriptome profile in gallbladder cancer based on annotation analysis of microarray studies

Chunlin Ge, Xuan Zhu, Xing Niu, Bingye Zhang, Lijie Chen
Article Number: 25
Published online on: 03 November 2020

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LINC00861 inhibits the progression of cervical cancer cells by functioning as a ceRNA for miR‑513b‑5p and regulating the PTEN/AKT/mTOR signaling pathway

Hui Liu, Ling Zhang, Xiaoling Ding, Xuezuo Sui
Article Number: 24
Published online on: 03 November 2020

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CUL4A regulates endometrial cancer cell proliferation, invasion and migration by interacting with CSN6

Xiangrong Wang, Tianquan Chen
Article Number: 23
Published online on: 03 November 2020

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Involvement of Klotho, TNF‑α and ADAMs in radiation‑induced senescence of renal epithelial cells

Da Yeon Kim, Minyoung Lee, Eun Ju Kim
Article Number: 22
Published online on: 03 November 2020

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Obesity related microRNA‑424 is regulated by TNF‑α in adipocytes

Qin-Zhi Xiao, Li-Jun Zhu, Zi-Yi Fu, Xi-Rong Guo, Xia Chi
Article Number: 21
Published online on: 03 November 2020

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Role of the SIRT1/p53 regulatory axis in oxidative stress‑mediated granulosa cell apoptosis

Sang-Ah Park, Na-Rae Joo, Jung-Hwan Park, Sang-Muk Oh
Article Number: 20
Published online on: 03 November 2020

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Astragaloside‑IV modulates NGF‑induced osteoblast differentiation via the GSK3β/β‑catenin signalling pathway

Nan-Yang Sun, Xiao-Lan Liu, Juan Gao, Xiao-Hui Wu, Ben Dou
Article Number: 19
Published online on: 03 November 2020

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Long non‑coding RNA MEG3 knockdown alleviates hypoxia‑induced injury in rat cardiomyocytes via the miR‑325‑3p/TRPV4 axis

Ya Zhou, Xianguo Li, Dong Zhao, Xinya Li, Jianjun Dai
Article Number: 18
Published online on: 03 November 2020

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Role of hypoxia inducible factor-1 in cancer stem cells (Review)

Qi Zhang, Zhenzhen Han, Yanbo Zhu, Jingcheng Chen, Wei Li
Article Number: 17
Published online on: 03 November 2020

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In vitro analysis of hepatic stellate cell activation influenced by transmembrane 6 superfamily 2 polymorphism

Songyao Liu, Eisuke Murakami, Takashi Nakahara, Kazuki Ohya, Yuji Teraoka, Grace Naswa Makokha, Takuro Uchida, Kei Morio, Hatsue Fujino, Atsushi Ono, Masami Yamauchi, Tomokazu Kawaoka, Daiki Miki, Masataka Tsuge, Akira Hiramatsu, Hiromi Abe‑Chayama, Nelson C. Hayes, Michio Imamura, Hiroshi Aikata, Kazuaki Chayama
Article Number: 16
Published online on: 03 November 2020

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Astragalus polysaccharide has a protective effect on hematopoiesis in an irradiated mouse model and decreases apoptosis in megakaryocytes

Liang Li, Wanhua Xu, Chenju Yi, Yucai Cheng, Hongwu Xin, Hongman Xue, Chi-Kong Li, Xiaoyi Fang, Liuming Yang, Chun Chen, Mo Yang
Article Number: 15
Published online on: 03 November 2020

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miR‑449a‑5p suppresses CDK6 expression to inhibit cardiomyocyte proliferation

Bing Li, Zhi Wang, Fan Yang, Jing Huang, Xingwei Hu, Shiyan Deng, Maobo Tian, Xiaoyun Si
Article Number: 14
Published online on: 03 November 2020

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Curcumin attenuates lncRNA H19‑induced epithelial‑mesenchymal transition in tamoxifen‑resistant breast cancer cells

Jiaqin Cai, Hong Sun, Bin Zheng, Mumu Xie, Chenxia Xu, Guifeng Zhang, Xuhui Huang, Jie Zhuang
Article Number: 13
Published online on: 03 November 2020

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High expression of CIN85 promotes proliferation and invasion of human esophageal squamous cell carcinoma

Xiao-Yang Hua, Xing-Xing Bie, Xi Cheng, Shu-Guang Zhang
Article Number: 12
Published online on: 03 November 2020

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Laminin‑332 mediates proliferation, apoptosis, invasion, migration and epithelial‑to‑mesenchymal transition in pancreatic ductal adenocarcinoma

Caiqun Huang, Jun Chen
Article Number: 11
Published online on: 03 November 2020

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Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial‑mesenchymal transition in the valvular damage due to rheumatic heart disease

Shenglin Xian, Ang Chen, Xiaodan Wu, Chuanghong  Lu, Yunjiao Wu, Feng Huang, Zhiyu Zeng
Article Number: 10
Published online on: 03 November 2020

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Effects of signaling pathway inhibitors on hematopoietic stem cells

Yuyu Jiang, Zhaofeng Xu, Na Ma, Lizhi Yin, Caiqin Hao, Jing Li
Article Number: 9
Published online on: 03 November 2020

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WJ‑MSCs intervention may relieve intrauterine adhesions in female rats via TGF‑β1‑mediated Rho/ROCK signaling inhibition

Jun Li, Bo Huang, Lan Dong, Yajuan Zhong, Zhixin Huang
Article Number: 8
Published online on: 03 November 2020

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Developments in the production of platelets from stem cells (Review)

Jie Yang, Jianfeng Luan, Yanfei Shen, Baoan Chen
Article Number: 7
Published online on: 03 November 2020

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Apelin‑36 protects against lipopolysaccharide‑induced acute lung injury by inhibiting the ASK1/MAPK signaling pathway

Qiong He, Yuqiao Wang, Hua Yang, Jianmin Wang, Jia Zhang, Danni Liu
Article Number: 6
Published online on: 03 November 2020

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miR‑26a‑5p alleviates lipopolysaccharide‑induced acute lung injury by targeting the connective tissue growth factor

Hongyan Li, Tingting Yang, Zhaoxia Fei
Article Number: 5
Published online on: 03 November 2020

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Proteins involved in oxidative stress in leiomyoma tissues treated with ulipristal acetate

Blendi Ura, Lorenzo Monasta, Yeraldin Chiquinquira Castillo De Spelorzi, Giorgio Arrigoni, Cinzia Franchin, Stefania Biffi, Michelangelo Aloisio, Bartolomea Gaita, Danilo Licastro, Emmanouil Athanasakis, Federica Scrimin, Guglielmo Stabile, Federico Romano, Giovanni Di Lorenzo, Giuseppe Ricci
Article Number: 4
Published online on: 02 November 2020

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Berberine alleviates palmitic acid‑induced podocyte apoptosis by reducing reactive oxygen species‑mediated endoplasmic reticulum stress

Xing-Yang Xiang, Ting Liu, Yue Wu, Xu-Shun Jiang, Jun-Ling He, Xue-Mei Chen, Xiao-Gang Du
Article Number: 3
Published online on: 02 November 2020

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Downregulation of lncRNA ZFAS1 inhibits the hallmarks of thyroid carcinoma via the regulation of miR‑302‑3p on cyclin D1

Wenjing Chen, Lili Zhai, Huiming Liu, Yuting Li, Qi Zhang, Dandan Xu, Weiye Fan
Article Number: 2
Published online on: 02 November 2020

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Expression profile and diagnostic value of circRNAs in peripheral blood from patients with systemic lupus erythematosus

Qing Luo, Xue Li, Biqi Fu, Lu Zhang, Le Fang, Cheng Qing, Yang Guo, Zikun Huang, Junming Li
Article Number: 1
Published online on: 02 November 2020

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October-2026 Volume 34 Issue 4

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Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Licoisoflavone A ameliorates adipose tissue dysfunction in diet‑induced obesity by promoting METTL3 expression

Shuangxi Tu, Xiaodan Wang, Zhenbo Wang, Haojun Tang, Kai Yin, Xiao Zhu
Article Number: 296
Published online on: 03 September 2026

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Interaction of circular RNAs with splicing factors in cervical cancer: Modulation, interplay and theranostics (Review)

Amahle Nyalambisa, Afra Basera, Ntombikayise Xelwa, Olalekan Fadebi, Zodwa Dlamini, Rahaba Marima
Article Number: 295
Published online on: 03 September 2026

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From oxidative stress to epigenetic regulation: Molecular mechanisms of preterm brain injury and neuroprotective strategies (Review)

Yuying Li, Ling Wei, Fang Sun, Huixia Wu, Xijun Sun, Yirong Gan, Xiaohua Kong
Article Number: 294
Published online on: 03 September 2026

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Resurrection biology: Melatonin as a modulator of anastasis (Review)

Alexandros Georgiou, Russel J. Reiter, Vassilis Zoumpourlis, Demetrios A. Spandidos
Article Number: 293
Published online on: 02 September 2026

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[Corrigendum] CLEC4M overexpression inhibits progression and is associated with a favorable prognosis in hepatocellular carcinoma

Qianle Yu, Kai Gao
Article Number: 292
Published online on: 01 September 2026

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Natural medicine‑empowered treatment of depression via restoring neurogenesis (Review)

Xiufen Zhong, Jingtao Gui
Article Number: 291
Published online on: 28 August 2026

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POU2F1 promotes hypertensive cardiac fibrosis by regulating mitochondrial homeostasis through PINK1/Parkin‑dependent mitophagy

Yongbo Ma, Xiaozhe Chen, Zixian Liu, Yulong Ma, Chunlei Hou, Yunfeng Li, Mingtai Gui, Bo Lu, Deyu Fu, Mingzhu Wang
Article Number: 290
Published online on: 26 August 2026

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[Corrigendum] Human cytomegalovirus RL13 protein interacts with host NUDT14 protein affecting viral DNA replication

Guili Wang, Gaowei Ren, Xin Cui, Zhitao Lu, Yanping Ma, Ying Qi, Yujing Huang, Zhongyang Liu, Zhengrong Sun, Qiang Ruan
Article Number: 289
Published online on: 24 August 2026

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Autophagy: Mechanisms and therapeutic perspectives in intestinal metaplasia (Review)

Laifeng Wu, Lingchen Liao, Ziwei Xia, Qiao Zeng, An Huang, Zhiyong Cao
Article Number: 288
Published online on: 21 August 2026

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Unlocking the potential of microRNA as predictive biomarkers for efficacy and adverse events in immune checkpoint inhibitor therapy (Review)

Xi Wang, Baojun Duan, Jun Bai, Huitong Liu
Article Number: 287
Published online on: 20 August 2026

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Mitochondrial dysfunction‑driven ferroptosis in cerebral ischemia‑reperfusion injury: Mechanisms and therapeutic strategies (Review)

Jianhui Li, Annan Liu, Wei Gao, Liping Xing, Peihan Duan, Honglin Li
Article Number: 286
Published online on: 20 August 2026

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Inhibition of Dyrk1a attenuates type 1 diabetic cardiomyopathy via anti‑ferroptosis

Junjian Chen, Wanyi Zhang, Tao Hong, Junsheng Wang, Chuan Chen, Ying Zhang, Mi Hu, Ning You, Jietao Huang
Article Number: 285
Published online on: 20 August 2026

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[Corrigendum] Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons 

Man Yang, Naqi Lian, Yang Yu, Yaoqi Wang, Keliang Xie, Yonghao Yu
Article Number: 284
Published online on: 20 August 2026

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Deubiquitinating enzymes in kidney diseases: Molecular mechanisms, pathological roles and therapeutic opportunities (Review)

Qianqian Li, Yufang Ni, Zhaoyang Li, Jianchun Li, Li Wang
Article Number: 283
Published online on: 18 August 2026

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Biological mechanisms of atropine in myopia control (Review)

Qin Zhu, Guanglong Zhou, Lingguo Wang, Xuejiao Li, Zhijuan Hua, Jie Yin, Jieying Zhang, Yuan Zhou, Xiaofan Zhang, Allison Wilde, Yingting Zhu, Liping Xue
Article Number: 282
Published online on: 18 August 2026

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6'‑O‑Caffeoylarbutin attenuates experimental hyperuricemia by regulating renal and intestinal urate transport, intestinal barrier integrity, and gut microbiota

Xuezhi Yu, Yang Zhang, Konchun Sun, Rui Yang, Xingde Li, Xiuzhen Chen, Tiantian Li, Xiaolei Yang, Ming Li, Lu Liu, Fei Li, Baochun Shen
Article Number: 281
Published online on: 18 August 2026

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Retraction Open Access

[Retracted] Aberrant expression of miR‑130a‑3p in ankylosing spondylitis and its role in regulating T‑cell survival  

Fengju Li, Dingran Si, Xuejun Guo, Ningru Guo, Dandan Li, Liujing Zhang, Xianan Jian, Jiasheng Ma
Article Number: 280
Published online on: 17 August 2026

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Uric acid enhances tumor stemness in breast cancer cells by upregulating GMPS

Zhiying Wang, Mingzhang Huang, Yuanqi Zhang, Siqi Huang, Wei Lei, Xiaorong Shui
Article Number: 279
Published online on: 13 August 2026

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Construction and validation of a nomogram for the diagnosis of postmenopausal osteoporosis

Le-Yi Huang, Yao Chen, Lin-Ran Song, Zhuo-Lin Zhong, Kamran Ali, Hui-Min Li, Qing-Feng Hu, Hong-Hua Hu
Article Number: 278
Published online on: 13 August 2026

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Expression of Concern Open Access

[Expression of Concern] MicroRNA‑145‑5p suppresses fascin to inhibit the invasion and migration of cervical carcinoma cells

Shufang He, Guiyuan Yu, Ke Peng, Sisun Liu
Article Number: 277
Published online on: 12 August 2026

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Review

Research progress on drugs targeting mitochondria‑associated membranes for the treatment of atherosclerosis (Review)

Shaoying An, Wenhui Sun, Lizhou Shi, Hai Chen, Zhongcheng Mo
Article Number: 276
Published online on: 11 August 2026

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Retraction Open Access

[Retracted] A study of Sirt1 regulation and the effect of resveratrol on synoviocyte invasion and associated joint destruction in rheumatoid arthritis

Liang Hao, Yuying Wan, Juhua Xiao, Qiang Tang, Huan Deng, Lu Chen
Article Number: 275
Published online on: 10 August 2026

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Histone deacetylase 3‑mediated histone deacetylation combined with activating transcription factor 3 promotes renal fibrosis by inhibiting Klotho

Zhiying Yang, Xueling Wang, Wenhong Li, Hao Chen, Gang Liu
Article Number: 274
Published online on: 06 August 2026

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Mitochondrial quality control in acute liver injury and its therapeutic implications (Review)

Ziqiang Chen, Yunhe Wang, Yijing Li, Gang Cong, Yunhang Chu, Yunhui Bai, Yishuo Zhang, Liya Zhou
Article Number: 273
Published online on: 05 August 2026

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STC1 promotes osteogenic differentiation and represses inflammation via inhibition of NF‑κB signaling in mesenchymal stromal cells

Chen Yang, Xin Li, Peng Wang, Yitong Chen, Erli Wu, Qian Chen, Jing Hu, Fu Zheng, Lamu Gongsang, Jiayu Li, Mengyuan Zhang, Jing Zhou, Bing Han, Amr A. Badreldin, Yuka Miyamoto, Jin Koo Kim, Insoon Chang, Jia Chang, Paul H. Krebsbach, Liyuan Huang, Xiaoping Xu, Xiaoyan Chen, Peng Deng, Qianming Chen, Lijie Fan
Article Number: 272
Published online on: 05 August 2026

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Research progress on the protective effect and oxidative stress mechanism of rutin against liver injury (Review)

Teng Sun, Lei Ye
Article Number: 271
Published online on: 04 August 2026

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Role of microbial metabolites in the pathogenesis of hypertensive disorders of pregnancy: From short‑chain fatty acids to tryptophan metabolites (Review)

Fengyun Gao, Lili Wang, Guiyun Teng, Liqiong Shang
Article Number: 270
Published online on: 03 August 2026

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Retraction Open Access

[Retracted] Tumor promoter role of miR‑647 in gastric cancer via repression of TP73

Xiangqian Zhang, Min Zhang, Guifeng Wang, Ye Tian, Xiaolong He
Article Number: 269
Published online on: 03 August 2026

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Gut microbiota‑immune crosstalk in recurrent pregnancy loss: Mechanisms and therapeutic perspectives (Review)

Nanjian Luo, Han Hu, Xiaoting Zeng, Yi Huan Zhang, Qi Deng, En Ni Tang, Yu Hu
Article Number: 268
Published online on: 31 July 2026

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Integrating gut‑brain axis insights into bundled nutrition care for critically ill patients: From mechanisms to implementation (Review)

Liqi Zhang, Shuxia Yang, Huiyan Wu, Hong Zhou
Article Number: 267
Published online on: 30 July 2026

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Role of CMTM6 in disease pathogenesis and clinical translation potential (Review)

Rongtou Huang, Danning Mo, Huitian Huang, Minmin Zhang, Wenhong Yu, Buqing Cao
Article Number: 266
Published online on: 29 July 2026

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Correction Open Access

[Corrigendum] Identification of key differentially expressed genes associated with non‑small cell lung cancer by bioinformatics analyses

Yubo Xiao, Min Feng, Haiying Ran, Xiao Han, Xuegang Li
Article Number: 265
Published online on: 29 July 2026

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Advances in miR‑200c regulation of apoptosis, pyroptosis and autophagy in disease (Review)

Xiaona Wang, Hua Du, Yingxu Shi
Article Number: 264
Published online on: 28 July 2026

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Association between periodontitis and heart failure: Mechanisms and clinical implications (Review)

Xinyue Zhang, Xiaoli An
Article Number: 263
Published online on: 28 July 2026

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Article Open Access

Ginsenosides alleviate the progression of hepatic fibrosis by targeting the liver circadian clock gene CLOCK

Jiawen Yu, Chunmei Qian, Renye Que, Yi Zhou
Article Number: 262
Published online on: 28 July 2026

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Retraction Open Access

[Retracted] PPM1A as a key target of the application of Jiawei‑Maxing‑Shigan decoction for the attenuation of radiation‑induced epithelial‑mesenchymal transition in type II alveolar epithelial cells

Jinhua Lu, Shengyou Lin, Zechen Lin, Xianlei Lin, Yuezhong Shen, Jingyang Su
Article Number: 261
Published online on: 27 July 2026

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UBE2A as a prognostic indicator across human cancers: Insights from multi‑omics and immune landscape analyses

Yun Wen, Pengfei Luo
Article Number: 260
Published online on: 23 July 2026

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Journal Cover
November-2026 Volume 34 Issue 5

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

KIF4A drives esophageal squamous cell carcinoma via Wnt/β‑catenin signaling and predicts poor prognosis

Jialong Chen, Tong Wang, Da Wang, Weiguo Liu, Chunlai Liu, Yang Yang, Xiangfu Sun, Lei Zhou
Article Number: 302
Published online on: 08 September 2026

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Research progress of aptamers in the diagnosis and treatment of colorectal cancer (Review)

Yiwen Li, Penghui Yan, Ji Zhang, Binghui Wu, Min Li, Baoliang Bao
Article Number: 301
Published online on: 08 September 2026

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Role of the circadian rhythm in squamous cell carcinoma: From molecular mechanism to therapy (Review)

Mary-Lyn Eichhorn, Anna M. Dmitrieva, Lydia Meder
Article Number: 300
Published online on: 08 September 2026

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Expression of Concern Open Access

[Expression of Concern] Ganoderma lucidum polysaccharide inhibits prostate cancer cell migration via the protein arginine methyltransferase 6 signaling pathway

Xiaohui Zhao, Dayu Zhou, Yunen Liu, Chun Li, Xiaoguang Zhao, Ying Li, Wei Li
Article Number: 299
Published online on: 07 September 2026

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Multi‑omics approaches to decipher the molecular mechanisms of exercise‑mediated bone protection: From mechanistic insights to personalized exercise prescription (Review)

Bin Tian, Xuesong Chen, Xin Kang
Article Number: 298
Published online on: 03 September 2026

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Retraction Open Access

[Retracted] MicroRNA‑27a promotes tumorigenesis via targeting AKT in triple negative breast cancer

Jing Wu, Zhihui Sun, Huijie Sun, Yanhua Li
Article Number: 297
Published online on: 03 September 2026

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