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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January-2021 Volume 23 Issue 1

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Astragaloside IV attenuates hypoxia‑induced pulmonary vascular remodeling via the Notch signaling pathway Corrigendum in /10.3892/mmr.2021.12547

Jiamei Yao, Xia Fang, Cui Zhang, Yushu Yang, Dongsheng Wang, Qiong Chen, Guangwei Zhong
Article Number: 89
Published online on: 24 November 2020

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Article Open Access

Metformin induces apoptosis and inhibits migration by activating the AMPK/p53 axis and suppressing PI3K/AKT signaling in human cervical cancer cells

Ya-Hui Chen, Shun-Fa Yang, Chueh-Ko Yang, Horng-Der Tsai, Tze-Ho Chen, Ming-Chih Chou, Yi-Hsuan Hsiao
Article Number: 88
Published online on: 24 November 2020

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Article Open Access

STAT3 enhances radiation-induced tumor migration, invasion and stem-like properties of bladder cancer

Fang Wang, Xiangli Ma, Guangmin Mao, Xiangyan Zhang, Zhaolu Kong
Article Number: 87
Published online on: 24 November 2020

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Article Open Access

Chloroform extract of Citrus unshiu Markovich peel induces apoptosis and inhibits stemness in HeLa human cervical cancer cells

Ye Seul Choi, Jang Mi Han, Yue Jai Kang, Hye Jin Jung
Article Number: 86
Published online on: 24 November 2020

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Article Open Access

lncRNA SNHG4 promotes cell proliferation, migration, invasion and the epithelial-mesenchymal transition process via sponging miR-204-5p in gastric cancer

Shimei Wang, Wei Zhu, Ji Qiu, Fei Chen
Article Number: 85
Published online on: 23 November 2020

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Article Open Access

Exosomal‑miR‑10a derived from colorectal cancer cells suppresses migration of human lung fibroblasts, and expression of IL‑6, IL‑8 and IL‑1β

Jian Wang, Yuanting Liu, Ying Li, Xuan Zheng, Jianhui Gan, Zhaoyuan Wan, Jun Zhang, Yan Liu, Yaqi Wang, Wanning Hu, Yufeng Li, Yankun Liu
Article Number: 84
Published online on: 23 November 2020

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Article

Scutellarin regulates osteoarthritis in vitro by inhibiting the PI3K/AKT/mTOR signaling pathway

Shao-Hua Ju, Li-Rong Tan, Pan-Wang Liu, You-Li Tan, Yuan-Ting Zhang, Xiao-Hong Li, Ming-Jian Wang, Ben-Xiang He
Article Number: 83
Published online on: 23 November 2020

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Article

Nardostachin from Nardostachys jatamansi exerts anti‑neuroinflammatory effects through TLR4/MyD88‑related suppression of the NF‑κB and JNK MAPK signaling pathways in lipopolysaccharide‑induced BV2 and primary microglial cells

Dong-Cheol Kim, Jin-Soo Park, Chi-Su Yoon, Youn-Chul Kim, Hyuncheol Oh
Article Number: 82
Published online on: 23 November 2020

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Article

miR‑576‑3p overexpression enhances cisplatin sensitivity of ovarian cancer cells by dysregulating PD‑L1 and cyclin D1

Ying Zuo, Wei Zheng, Qing Tang, Jing Liu, Shanshan Wang, Chunxia Xin
Article Number: 81
Published online on: 23 November 2020

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Article Open Access

Oncogenic potential of macrophage‑capping protein in clear cell renal cell carcinoma

Zhuang-Fei Chen, Ze-Hai Huang, Shi-Jun Chen, Yao-Dong Jiang, Zi-Ke Qin, Shao-Bin Zheng, Tong Chen
Article Number: 80
Published online on: 23 November 2020

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Article Open Access

miR‑18a‑5p promotes melanoma cell proliferation and inhibits apoptosis and autophagy by targeting EPHA7 signaling

Yunlong Guo, Wenli Shi, Ruihua Fang
Article Number: 79
Published online on: 23 November 2020

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Correction Open Access

[Corrigendum] Molecular mechanism of extracellular matrix disorder in pelvic organ prolapses

Liping Zhang, Fangfang Dai, Gantao Chen, Yanqing Wang, Shiyi Liu, Li Zhang, Shu Xian, Mengqin Yuan, Dongyong Yang, Yajing Zheng, Zhimin Deng, Yanxiang Cheng, Xiaofeng Yang
Article Number: 78
Published online on: 23 November 2020

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Article Open Access

Inonotus obliquus extract alleviates myocardial ischemia/reperfusion injury by suppressing endoplasmic reticulum stress

Yi Wu, Heming Cui, Yuying Zhang, Ping Yu, Yuangeng Li, Dan Wu, Yan Xue, Wenwen Fu
Article Number: 77
Published online on: 23 November 2020

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Article Open Access

lncRNA EZR‑AS1 knockdown represses proliferation, migration and invasion of cSCC via the PI3K/AKT signaling pathway

Di Lu, Lingling Sun, Zhengjun Li, Zhen Mu
Article Number: 76
Published online on: 23 November 2020

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Case Report

PARP inhibitor resistance and TP53 mutations in patients treated with olaparib for BRCA-mutated cancer: Four case reports

Thomas Collot, Julie Niogret, Marion Carnet, Sandy Chevrier, Etienne Humblin, Laure Favier, Leila Bengrine-Lefevre, Isabelle Desmoulins, Laurent Arnould, Romain Boidot
Article Number: 75
Published online on: 23 November 2020

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Article Open Access

Platelet isoform of phosphofructokinase promotes aerobic glycolysis and the progression of non‑small cell lung cancer

Fuan Wang, Ling Li, Zhen Zhang
Article Number: 74
Published online on: 20 November 2020

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Article Open Access

Resveratrol alleviates oxygen/glucose deprivation/reoxygenation‑induced neuronal damage through induction of mitophagy

Ming Ye, Hui Wu, Shuguo Li
Article Number: 73
Published online on: 20 November 2020

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Article Open Access

Acarbose ameliorates spontaneous type‑2 diabetes in db/db mice by inhibiting PDX‑1 methylation

Diyi Zhou, Lijun Chen, Xin Mou
Article Number: 72
Published online on: 20 November 2020

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Article Open Access

Glutathione S‑transferase ω 1 promotes the proliferation, migration and invasion, and inhibits the apoptosis of non‑small cell lung cancer cells, via the JAK/STAT3 signaling pathway

Kai Wang, Fu-Lian Zhang, Wei Jia
Article Number: 71
Published online on: 20 November 2020

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Review Open Access

Different roles of matrix metalloproteinase 2 in osteolysis of skeletal dysplasia and bone metastasis (Review)

Xiumao Li, Libin Jin, Yanbin Tan
Article Number: 70
Published online on: 20 November 2020

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Article Open Access

Bone marrow stem cells therapy alleviates vascular injury in a chronic obstructive pulmonary disease‑obstructive sleep apnea overlap syndrome rat model

Hong Bi, Jian He, Xu He, Junyi Du, Min Chen, Zhaoming Huang, Chao Yang, Lijuan Yang, Hang Li, Kaihua Zhou, Qing Wang, Lewei He, Zhixian Jin
Article Number: 69
Published online on: 20 November 2020

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Article Open Access

HIF‑3α affects preeclampsia development by regulating EVT growth via activation of the Flt‑1/JAK/STAT signaling pathway in hypoxia

Hongmei Qu, Qun Yu, Bei Jia, Wenzhe Zhou, Yinghong Zhang, Linsong Mu
Article Number: 68
Published online on: 19 November 2020

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Article Open Access

Exogenous sodium hydrosulfide protects against high glucose‑induced injury and inflammation in human umbilical vein endothelial cells by inhibiting necroptosis via the p38 MAPK signaling pathway

Jiaqiong Lin, Xiaoyong Li, Yan Lin, Zena Huang, Wen Wu
Article Number: 67
Published online on: 19 November 2020

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Article Open Access

Klotho attenuates angiotensin II‑induced cardiotoxicity through suppression of necroptosis and oxidative stress

Shasha Yu, Hongmei Yang, Xiaofan Guo, Yingxian Sun
Article Number: 66
Published online on: 19 November 2020

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Article

Osteoglycin knockdown promotes vascular smooth muscle cell proliferation and migration in aortic dissection via the VEGF/VEGFR2 axis

Zanxin Wang, Xianmian Zhuang, Bailang Chen, Minxin Wei
Article Number: 65
Published online on: 19 November 2020

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Article Open Access

S100a8 silencing attenuates inflammation, oxidative stress and apoptosis in BV2 cells induced by oxygen‑glucose deprivation and reoxygenation by upregulating GAB1 expression

Wenguang Hu, Caimei Lin
Article Number: 64
Published online on: 19 November 2020

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Article Open Access

Effects and molecular mechanism of pachymic acid on ferroptosis in renal ischemia reperfusion injury

Gui-Ping Jiang, Yue-Juan Liao, Li-Li Huang, Xu-Jia Zeng, Xiao-Hui Liao
Article Number: 63
Published online on: 19 November 2020

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Article Open Access

Hyperoxia sensitizes hypoxic HeLa cells to ionizing radiation by downregulating HIF‑1α and VEGF expression

Dan Dong, Yan Fu, Feng Chen, Jing Zhang, Haiyan Jia, Jia Li, Huailin Wang, Jihong Wen
Article Number: 62
Published online on: 18 November 2020

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Article

Recombinant stromal cell‑derived factor‑1 protein promotes neurite outgrowth in PC‑12 cells

Ye-Rang Yun, Jun-Hyeog Jang
Article Number: 61
Published online on: 18 November 2020

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Article Open Access

Long non‑coding RNA JPX promotes gastric cancer progression by regulating CXCR6 and autophagy via inhibiting miR‑197

Xuejing Han, Zheng Liu
Article Number: 60
Published online on: 18 November 2020

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Article Open Access

Lung cancer‑associated transcript 1 facilitates tumorigenesis in laryngeal squamous cell carcinoma through the targeted inhibition of miR‑493

Zhen Zhao, Yan Xing, Yan Liu, Shanghua Jing
Article Number: 59
Published online on: 18 November 2020

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Article Open Access

Construction of tissue engineering bone with the co‑culture system of ADSCs and VECs on partially deproteinized biologic bone in vitro: A preliminary study

Guiran Yang, Fuke Wang, Yanlin Li, Jianfei Hou, Dejian Liu
Article Number: 58
Published online on: 18 November 2020

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Article

miR-194-5p serves a suppressive role in human keloid fibroblasts via targeting NR2F2

Qijun Xu, Shengjun Jiang
Article Number: 57
Published online on: 17 November 2020

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Article Open Access

AMPK‑SIRT1 pathway dysfunction contributes to neuron apoptosis and cognitive impairment induced by sevoflurane

Liwei Liu, Chao Liu, Lin Fang
Article Number: 56
Published online on: 17 November 2020

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Article Open Access

Treatment of keloids through Runx2 siRNA‑induced inhibition of the PI3K/AKT signaling pathway

Wenchang Lv, Min Wu, Yuping Ren, Xiao Luo, Weijie Hu, Qi Zhang, Yiping Wu
Article Number: 55
Published online on: 16 November 2020

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Article Open Access

MicroRNA‑744‑5p is downregulated in colorectal cancer and targets SEPT2 to suppress the malignant phenotype

Wei Zhang, Kai Liao, Dongning Liu
Article Number: 54
Published online on: 16 November 2020

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Article Open Access

miR‑140‑5p inhibits the proliferation of multiple myeloma cells by targeting VEGFA

Min Liu, Huimin Liu, Jing Zhou, Zhuojun Yu
Article Number: 53
Published online on: 16 November 2020

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Article Open Access

Regulation of ABCG2 expression by Wnt5a through FZD7 in human pancreatic cancer cells

Zhongbo Zhang, Shuang Gao, Yuanhong Xu, Chenghai Zhao
Article Number: 52
Published online on: 16 November 2020

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Article Open Access

MicroRNA‑21‑5p protects melanocytes via targeting STAT3 and modulating Treg/Teff balance to alleviate vitiligo

Jing Huo, Taibin Liu, Fenghua Li, Xinfeng Song, Xiuli Hou
Article Number: 51
Published online on: 16 November 2020

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Article Open Access

Cardiac‑specific deletion of natriuretic peptide receptor A induces differential myocardial expression of circular RNA and mRNA molecules involved in metabolism in mice

Baoying Chen, Pan Chang, Xi Shen, Xiaomeng Zhang, Jing Zhang, Xihui Wang, Jun Yu
Article Number: 50
Published online on: 13 November 2020

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Article Open Access

C-C chemokine receptor 5 signaling contributes to cardiac remodeling and dysfunction under pressure overload

Xiaomin Wang, Wei Li, Qiang Yue, Wei Du, Yongming Li, Fu Liu, Liu Yang, Lijuan Xu, Ruiping Zhao, Jiang Hu
Article Number: 49
Published online on: 13 November 2020

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Article Open Access

Inhibition of Bcl-2 and Bcl-xL overcomes the resistance to the third-generation EGFR tyrosine kinase inhibitor osimertinib in non-small cell lung cancer

Yingjie Lu, Dongliang Bian, Xuelin Zhang, Huibiao Zhang, Zhenghong Zhu
Article Number: 48
Published online on: 12 November 2020

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Article Open Access

Differentiation potential and mRNA profiles of human dedifferentiated adipose cells and adipose‑derived stem cells from young donors

Fangfei Nie, Hongsen Bi, Chen Zhang, Pengbing Ding
Article Number: 47
Published online on: 12 November 2020

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Article Open Access

CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression

Hangwei Fu, Yida Zhang, Yin Chen, Junying Chen, Ping Chen
Article Number: 46
Published online on: 12 November 2020

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Article Open Access

Long non‑coding RNA TTN‑AS1 regulates the proliferation, invasion and migration of triple‑negative breast cancer by targeting miR‑211‑5p

Erhu Sun, Xiaofeng Liu, Cheng Lu, Kangsheng Liu
Article Number: 45
Published online on: 10 November 2020

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Article Open Access

Bioinformatics analysis of the microRNA-mRNA network in sebaceous gland carcinoma of the eyelid

Tetsushi Hirano, Tatsuya Yunoki, Yukihiro Furusawa, Yoshiaki Tabuchi, Atsushi Hayashi
Article Number: 44
Published online on: 10 November 2020

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Article Open Access

Mesenchymal stem cells negatively regulate CD4+ T cell activation in patients with primary Sjögren syndrome through the miRNA‑125b and miRNA‑155 TCR pathway

Bangdong Gong, Ling Zheng, Zhenhao Lu, Jiashu Huang, Jincheng Pu, Shengnan Pan, Min Zhang, Jie Liu, Jianping Tang
Article Number: 43
Published online on: 10 November 2020

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Article Open Access

miR-31 attenuates murine allergic rhinitis by suppressing interleukin-13-induced nasal epithelial inflammatory responses

Fangwei Zhou, Peiqiang Liu, Hao Lv, Ziang Gao, Wenchuan Chang, Yu Xu
Article Number: 42
Published online on: 10 November 2020

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Article Open Access

Reoxygenation induces reactive oxygen species production and ferroptosis in renal tubular epithelial cells by activating aryl hydrocarbon receptor

Theodoros Eleftheriadis, Georgios Pissas, Georgios Filippidis, Vassilios Liakopoulos, Ioannis Stefanidis
Article Number: 41
Published online on: 10 November 2020

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Article Open Access

Tanshinone I and simvastatin inhibit melanoma tumour cell growth by regulating poly (ADP ribose) polymerase 1 expression

Yuyan Zhang, Jiusui Huang, Yapeng Huang, Shike Zhang, Weizhou Wu, Hui Long, Xiaolu Duan, Yongchang Lai, Wenqi Wu
Article Number: 40
Published online on: 10 November 2020

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Article Open Access

PDGF mediates pulmonary arterial smooth muscle cell proliferation and migration by regulating NFATc2

Fang-Yun Zhao, Shuang-Lan Xu, Chun-Fang Zhang, Jie Liu, Yue Zhang, Jiao Yang, Xi-Qian Xing
Article Number: 39
Published online on: 10 November 2020

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Article Open Access

Dexmedetomidine attenuates sevoflurane‑induced neurocognitive impairment through α2‑adrenoceptors

Yufeng Zhang, Mao Li, Enhui Cui, Hao Zhang, Xiaozhong Zhu, Jing Zhou, Ming Yan, Jian Sun
Article Number: 38
Published online on: 10 November 2020

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Article Open Access

Ginsenoside Rg1 improves pathological damages by activating the p21‑p53‑STK pathway in ovary and Bax‑Bcl2 in the uterus in premature ovarian insufficiency mouse models

Lianli He, Xiaojuan Wang, Daigang Cheng, Zhengai Xiong, Xiaoyun Liu
Article Number: 37
Published online on: 10 November 2020

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Retraction Open Access

[Retracted] Effects of botulinum toxin A on endometriosis‑associated pain and its related mechanism

Fubo Tian, Wuzhong Cheng, Jianying Hu, Shaoqiang Huang, Shen Sun
Article Number: 36
Published online on: 09 November 2020

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Article Open Access

Rosiglitazone affects the progression of surgically‑induced endometriosis in a rat model

Shun Zhang, Lingling Zhuang, Qian Liu, Xiaolin Yu, Qinghua Min, Minjie Chen, Qi Chen
Article Number: 35
Published online on: 09 November 2020

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Article Open Access

Curcumin ameliorates DSS‑induced colitis in mice by regulating the Treg/Th17 signaling pathway

Cheng Wei, Jian-Yao Wang, Feng Xiong, Ben-Hua Wu, Ming-Han Luo, Zhi-Chao Yu, Ting-Ting Liu, De-Feng Li, Qi Tang, Ying-Xue Li, Ding-Guo Zhang, Zheng-Lei Xu, Hong-Tao Jin, Li-Sheng Wang, Jun Yao
Article Number: 34
Published online on: 09 November 2020

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Article Open Access

Hyperoxia induces endoplasmic reticulum stress‑associated apoptosis via the IRE1α pathway in rats with bronchopulmonary dysplasia

Xin Tong, Mengyun Li, Na Liu, Wanjie Huang, Xindong Xue, Jianhua Fu
Article Number: 33
Published online on: 09 November 2020

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Review Open Access

Neuromodulation of bone: Role of different peptides and their interactions (Review)

Xiaoyu Wang, Jia Xu, Qinglin Kang
Article Number: 32
Published online on: 05 November 2020

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Article Open Access

Long non‑coding RNA SNHG20 promotes colorectal cancer cell proliferation, migration and invasion via miR‑495/STAT3 axis

Yu Wang, Jianying Fu, Lili Yang, Zhi Liang
Article Number: 31
Published online on: 05 November 2020

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Article Open Access

Effects of miR‑93 on epithelial‑to‑mesenchymal transition and vasculogenic mimicry in triple‑negative breast cancer cells

Gaili An, Feng Lu, Shangke Huang, Jun Bai, Li He, Yi Liu, Lei Hou
Article Number: 30
Published online on: 04 November 2020

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Article Open Access

Catalpol inhibits the proliferation, migration and metastasis of HCC cells by regulating miR‑140‑5p expression

Linsheng Wu, Haoxia Li, Shengyou Chen, Xiaoqiang Wu, Xiaomin Chen, Fangping Wang
Article Number: 29
Published online on: 04 November 2020

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Article Open Access

Effects and mechanism of microRNA‑218 against lung cancer

Yan Chen, Ji-Lin Yang, Zhen-Zhen Xue, Qiu-Chen Cai, Chun Hou, Hong-Juan Li, Liu-Xin Zhao, Yin Zhang, Cheng-Wei Gao, Li Cong, Tian-Zuo Wang, Dong-Mei Chen, Guo-Sheng Li, Shi-Qing Luo, Qian Yao, Chan-Juan Yang, Qi-Shun Zhu, Chuan-Hai Cao
Article Number: 28
Published online on: 04 November 2020

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Review

Calcitonin gene‑related peptide‑mediated pharmacological effects in cardiovascular and gastrointestinal diseases (Review)

Wan-Jun Ma, You-Cong Yin, Bi-Kui Zhang, Yuan-Jian Li, Wen-Qun Li
Article Number: 27
Published online on: 04 November 2020

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Review

Functions, pathophysiology and current insights of exosomal endocrinology (Review)

Dimitrios Vlachakis, Τhanasis Mitsis, Nicolas Nicolaides, Aspasia Efthimiadou, Antonis Giannakakis, Flora Bacopoulou, George P. Chrousos
Article Number: 26
Published online on: 04 November 2020

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Article Open Access

A transcriptome profile in gallbladder cancer based on annotation analysis of microarray studies

Chunlin Ge, Xuan Zhu, Xing Niu, Bingye Zhang, Lijie Chen
Article Number: 25
Published online on: 03 November 2020

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LINC00861 inhibits the progression of cervical cancer cells by functioning as a ceRNA for miR‑513b‑5p and regulating the PTEN/AKT/mTOR signaling pathway

Hui Liu, Ling Zhang, Xiaoling Ding, Xuezuo Sui
Article Number: 24
Published online on: 03 November 2020

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CUL4A regulates endometrial cancer cell proliferation, invasion and migration by interacting with CSN6

Xiangrong Wang, Tianquan Chen
Article Number: 23
Published online on: 03 November 2020

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Involvement of Klotho, TNF‑α and ADAMs in radiation‑induced senescence of renal epithelial cells

Da Yeon Kim, Minyoung Lee, Eun Ju Kim
Article Number: 22
Published online on: 03 November 2020

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Obesity related microRNA‑424 is regulated by TNF‑α in adipocytes

Qin-Zhi Xiao, Li-Jun Zhu, Zi-Yi Fu, Xi-Rong Guo, Xia Chi
Article Number: 21
Published online on: 03 November 2020

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Role of the SIRT1/p53 regulatory axis in oxidative stress‑mediated granulosa cell apoptosis

Sang-Ah Park, Na-Rae Joo, Jung-Hwan Park, Sang-Muk Oh
Article Number: 20
Published online on: 03 November 2020

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Astragaloside‑IV modulates NGF‑induced osteoblast differentiation via the GSK3β/β‑catenin signalling pathway

Nan-Yang Sun, Xiao-Lan Liu, Juan Gao, Xiao-Hui Wu, Ben Dou
Article Number: 19
Published online on: 03 November 2020

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Long non‑coding RNA MEG3 knockdown alleviates hypoxia‑induced injury in rat cardiomyocytes via the miR‑325‑3p/TRPV4 axis

Ya Zhou, Xianguo Li, Dong Zhao, Xinya Li, Jianjun Dai
Article Number: 18
Published online on: 03 November 2020

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Role of hypoxia inducible factor-1 in cancer stem cells (Review)

Qi Zhang, Zhenzhen Han, Yanbo Zhu, Jingcheng Chen, Wei Li
Article Number: 17
Published online on: 03 November 2020

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In vitro analysis of hepatic stellate cell activation influenced by transmembrane 6 superfamily 2 polymorphism

Songyao Liu, Eisuke Murakami, Takashi Nakahara, Kazuki Ohya, Yuji Teraoka, Grace Naswa Makokha, Takuro Uchida, Kei Morio, Hatsue Fujino, Atsushi Ono, Masami Yamauchi, Tomokazu Kawaoka, Daiki Miki, Masataka Tsuge, Akira Hiramatsu, Hiromi Abe‑Chayama, Nelson C. Hayes, Michio Imamura, Hiroshi Aikata, Kazuaki Chayama
Article Number: 16
Published online on: 03 November 2020

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Astragalus polysaccharide has a protective effect on hematopoiesis in an irradiated mouse model and decreases apoptosis in megakaryocytes

Liang Li, Wanhua Xu, Chenju Yi, Yucai Cheng, Hongwu Xin, Hongman Xue, Chi-Kong Li, Xiaoyi Fang, Liuming Yang, Chun Chen, Mo Yang
Article Number: 15
Published online on: 03 November 2020

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miR‑449a‑5p suppresses CDK6 expression to inhibit cardiomyocyte proliferation

Bing Li, Zhi Wang, Fan Yang, Jing Huang, Xingwei Hu, Shiyan Deng, Maobo Tian, Xiaoyun Si
Article Number: 14
Published online on: 03 November 2020

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Curcumin attenuates lncRNA H19‑induced epithelial‑mesenchymal transition in tamoxifen‑resistant breast cancer cells

Jiaqin Cai, Hong Sun, Bin Zheng, Mumu Xie, Chenxia Xu, Guifeng Zhang, Xuhui Huang, Jie Zhuang
Article Number: 13
Published online on: 03 November 2020

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High expression of CIN85 promotes proliferation and invasion of human esophageal squamous cell carcinoma

Xiao-Yang Hua, Xing-Xing Bie, Xi Cheng, Shu-Guang Zhang
Article Number: 12
Published online on: 03 November 2020

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Laminin‑332 mediates proliferation, apoptosis, invasion, migration and epithelial‑to‑mesenchymal transition in pancreatic ductal adenocarcinoma

Caiqun Huang, Jun Chen
Article Number: 11
Published online on: 03 November 2020

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Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial‑mesenchymal transition in the valvular damage due to rheumatic heart disease

Shenglin Xian, Ang Chen, Xiaodan Wu, Chuanghong  Lu, Yunjiao Wu, Feng Huang, Zhiyu Zeng
Article Number: 10
Published online on: 03 November 2020

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Effects of signaling pathway inhibitors on hematopoietic stem cells

Yuyu Jiang, Zhaofeng Xu, Na Ma, Lizhi Yin, Caiqin Hao, Jing Li
Article Number: 9
Published online on: 03 November 2020

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WJ‑MSCs intervention may relieve intrauterine adhesions in female rats via TGF‑β1‑mediated Rho/ROCK signaling inhibition

Jun Li, Bo Huang, Lan Dong, Yajuan Zhong, Zhixin Huang
Article Number: 8
Published online on: 03 November 2020

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Developments in the production of platelets from stem cells (Review)

Jie Yang, Jianfeng Luan, Yanfei Shen, Baoan Chen
Article Number: 7
Published online on: 03 November 2020

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Apelin‑36 protects against lipopolysaccharide‑induced acute lung injury by inhibiting the ASK1/MAPK signaling pathway

Qiong He, Yuqiao Wang, Hua Yang, Jianmin Wang, Jia Zhang, Danni Liu
Article Number: 6
Published online on: 03 November 2020

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miR‑26a‑5p alleviates lipopolysaccharide‑induced acute lung injury by targeting the connective tissue growth factor

Hongyan Li, Tingting Yang, Zhaoxia Fei
Article Number: 5
Published online on: 03 November 2020

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Proteins involved in oxidative stress in leiomyoma tissues treated with ulipristal acetate

Blendi Ura, Lorenzo Monasta, Yeraldin Chiquinquira Castillo De Spelorzi, Giorgio Arrigoni, Cinzia Franchin, Stefania Biffi, Michelangelo Aloisio, Bartolomea Gaita, Danilo Licastro, Emmanouil Athanasakis, Federica Scrimin, Guglielmo Stabile, Federico Romano, Giovanni Di Lorenzo, Giuseppe Ricci
Article Number: 4
Published online on: 02 November 2020

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Berberine alleviates palmitic acid‑induced podocyte apoptosis by reducing reactive oxygen species‑mediated endoplasmic reticulum stress

Xing-Yang Xiang, Ting Liu, Yue Wu, Xu-Shun Jiang, Jun-Ling He, Xue-Mei Chen, Xiao-Gang Du
Article Number: 3
Published online on: 02 November 2020

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Downregulation of lncRNA ZFAS1 inhibits the hallmarks of thyroid carcinoma via the regulation of miR‑302‑3p on cyclin D1

Wenjing Chen, Lili Zhai, Huiming Liu, Yuting Li, Qi Zhang, Dandan Xu, Weiye Fan
Article Number: 2
Published online on: 02 November 2020

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Expression profile and diagnostic value of circRNAs in peripheral blood from patients with systemic lupus erythematosus

Qing Luo, Xue Li, Biqi Fu, Lu Zhang, Le Fang, Cheng Qing, Yang Guo, Zikun Huang, Junming Li
Article Number: 1
Published online on: 02 November 2020

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August-2026 Volume 34 Issue 2

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Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Regulatory function of ten‑eleven translocation‑2 in transcriptional mechanisms of demethylated myeloma cells

Lenka Slavickova, Michaela Nemcova, Dominika Svehlova, Veronika Frybortova, Jirina Manakova, Eva Kriegova, Jiri Minarik, Katerina Smesny Trtkova
Article Number: 237
Published online on: 25 June 2026

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Mulberroside A attenuates H2O2‑induced oxidative stress and barrier dysfunction in Caco‑2 cells through Nrf2/HO‑1‑associated antioxidant signaling

Jianxin Chen, Xiufeng Huang, Xi Chen, Wenhai Jin, Dawei Lin
Article Number: 236
Published online on: 25 June 2026

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[Retracted] Puerarin promotes DUSP1 expression by regulating miR‑133a‑3p in breast cancer

Zhifeng Li, Weiwei Xu, Xiaoyan Ren, Jinhua Xu, Jianxin Chen
Article Number: 235
Published online on: 23 June 2026

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Sulforaphane attenuates cisplatin‑induced acute kidney injury by inhibiting oxidative stress, inflammation and apoptosis via regulation of NRF2

Zeyu Wu, Mengting Lu, Lei Xu, Ming Luo, Limei Shan, Hongxia Xing, Wenwen Li, Junling Qian
Article Number: 234
Published online on: 19 June 2026

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Effects of β‑hydroxybutyrate on restoring autophagic flux and mitochondrial function in macrophages exposed to oxidized low‑density lipoprotein

Weiguang Luo, Mei He, Huiling Wang
Article Number: 233
Published online on: 19 June 2026

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Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review)

Xiaokang Wang, Qiwen Tan, Jingcheng Xu, Yunlin Yang, Haoyue Huang, Xiaomei Teng, Weihua Wu
Article Number: 232
Published online on: 18 June 2026

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Degraded sulfated galactan derived from Gracilaria fisheri induces immunogenic cell death in MDA‑MB‑231 cells

Tawut Rudtanatip, Yada Polsan, Waraporn Sakaew, Somsuda Somintara, Jenjiralai Phanphak, Jamal El‑Abid, Kanokpan Wongprasert, Choowadee Pariwatthanakun
Article Number: 231
Published online on: 17 June 2026

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Irbesartan ameliorates high‑glucose‑induced epithelial‑mesenchymal transition by downregulating the expression of NLRP3 in HK‑2 cells

Qing Deng, Xiujuan Liu, Dan Wen, Yuhua Cheng, Qing Zhao, Yu Wang, Yu Xiang, Qinkai Chen, Jinlei Lv
Article Number: 230
Published online on: 17 June 2026

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A β‑1,3‑1,6‑glucan from Aureobasidium pullulans enhances apoptotic and autophagic pathways in colorectal cancer cells

Ji-Won Park, Gyeong Mim Mun, Tae Min Jo, Ji A Shin, Takao Kuge, Hisashi Kimoto, Jin-Kyung Kim
Article Number: 229
Published online on: 16 June 2026

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Growth pattern and molecular biological analysis of primary meningioma cell cultures under different conditions

Stefan Linsler, Anna-Lena Moroldo, Walter Schulz‑Schaeffer, Ralf Ketter, Joachim Oertel, Steffi Urbschat
Article Number: 228
Published online on: 12 June 2026

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Melatonin alleviates mitochondrial damage by regulating SIRT3‑mediated mitochondrial dynamics in granulosa cells under PCOS‑like conditions

Congcong Xie, Zehao Liu, Tong Chen, Hui Lu, Xiujia Zhang, Wenbo Yu, Jiaxin Zhang, Dandan Shang, Xueying Wang
Article Number: 227
Published online on: 11 June 2026

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Strontium‑based metal‑organic framework/alendronate‑silk fibroin hydrogels promote tendon‑bone interface healing

Tao Yang, Hanji Zhang, Mingjun Li, Yiming Ren, Yunbo Sun, Weiyu Hou, Mengqiang Tian
Article Number: 226
Published online on: 11 June 2026

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[Retracted] Tripterygium glycoside suppresses epithelial‑to‑­­ mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway

Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He
Article Number: 225
Published online on: 08 June 2026

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Gut microbiota‑derived metabolites in cardiovascular disease: Focus on trimethylamine N‑oxide, short‑chain fatty acids and bile acids (Review)

Meizhu Gao, Zhenming Hao, Yiling Li, Weixue Liu, Fubao Zhang
Article Number: 224
Published online on: 08 June 2026

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Fucoxanthin alleviates chondrocyte inflammation and osteoarthritis by modulating the JAK2/STAT3 signaling pathway

Miradj Siddick Adam, Huangming Zhuang, Xunshan Ren, Yuelong Zhang, Panghu Zhou
Article Number: 223
Published online on: 08 June 2026

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Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer

Huaiyong Li, Lili Liu, Qingzhu Yang, Yao Li, Yongli Song, Jing Jiang, Zhenzhong Wu, Weiwei Zhang, Baisong Lou
Article Number: 222
Published online on: 08 June 2026

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Molecular mechanisms of iron metabolism and ferroptosis in cardiovascular diseases and intervention strategies targeting natural products (Review)

Liangqing Ge, Tianqing Zhang, Jiangbiao Yu, Sijie Xiao, Yu Zhou, Li Luo
Article Number: 221
Published online on: 05 June 2026

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Correction Open Access

[Corrigendum] Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis

Ruiqiao Guan, Zhihao Li, Xiaohong Dai, Wei Zou, Xueping Yu, Hao Liu, Qiuxin Chen, Wei Teng, Peng Liu, Xiaoying Liu, Shanshan Dong
Article Number: 220
Published online on: 03 June 2026

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LINC01117 promotes the malignant proliferation of lung adenocarcinoma by increasing HOXD8 mRNA stability

Lizhong Zeng, Jie Shi, Cai Zhang, Yujiao Dong, Yang Chen, Qiuhong Zhang, Long Zhang, Shuanying Yang
Article Number: 219
Published online on: 03 June 2026

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Targeting regulatory T cells in the prostate cancer microenvironment: From mechanisms to therapeutics (Review)

Hua Luo
Article Number: 218
Published online on: 03 June 2026

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Dapagliflozin alleviates heart failure with preserved ejection fraction potentially by regulating the AIM2/caspase‑1/GSDMD pathway and attenuating pyroptosis

Sailiang Ding, Hao Yang, Ting Lu, Yibin Luo, Liang Xu, Xianghui Zeng
Article Number: 217
Published online on: 03 June 2026

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[Retracted] Carnosic acid alleviates brain injury through NF‑κB‑regulated inflammation and Caspase‑3‑associated apoptosis in high fat‑induced mouse models

Yong Liu, Yan Zhang, Ming Hu, Yu-Hu Li, Xing-Hua Cao
Article Number: 216
Published online on: 02 June 2026

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SIRT1/AMPK/PGC1α pathway in ischemic stroke: Elucidating neuroprotective strategies (Review)

Irum Naz Abbasi, Nashwa Amin, Qiaolu Xu, Azhar Badry Hussain, Fei Wu, Xia Yuan, Yang Yang, Suhong Ye, Marong Fang, Yihua Jiang
Article Number: 215
Published online on: 02 June 2026

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Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review)

Yinhuan Wang, Jiefang Guan
Article Number: 214
Published online on: 29 May 2026

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Journal Cover
September-2026 Volume 34 Issue 3

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Sedanolide alleviates LPS‑induced depressive‑like behaviors by modulating the C3a/C3aR signaling axis and microglial glycolysis

Shaocong Lu, Fangla Luo, Niqi Chen, Gongde Shi, Yeru Chen
Article Number: 257
Published online on: 16 July 2026

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[Expression of Concern] Chrysophanol inhibits proliferation and induces apoptosis through NF‑κB/cyclin D1 and NF‑κB/Bcl‑2 signaling cascade in breast cancer cell lines

Li Ren, Zhouping Li, Chunmei Dai, Danyu Zhao, Yanjie Wang, Chunyu Ma, Chun Liu
Article Number: 256
Published online on: 15 July 2026

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PCSK9 alleviates doxorubicin‑induced pyroptosis of cardiomyocytes

Chaochu Cui, Jinyu Zhao, Xiaoqian Li, Shengming Huang, Gang Liu, Xinhui Xu, Can Guo, Tiesuo Zhao, Jiang Du, Shipeng Li, Xianwei Wang, Jianbo Yang
Article Number: 255
Published online on: 14 July 2026

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From cell to disease: Regulatory networks and mechanisms of super‑enhancers in aging (Review)

Xiaodan Wang, Weiqian Deng, Shuangxi Tu, Haojun Tang, Kai Yin, Xiao Zhu
Article Number: 254
Published online on: 14 July 2026

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[Retracted] Matrine‑induced apoptosis in Hep3B cells via the inhibition of MDM2

Ning Zhou, Jiequn Li, Ting Li, Guangshun Chen, Zhongqiang Zhang, Zhongzhou Si
Article Number: 253
Published online on: 13 July 2026

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Role of PANoptosis in the development of gastric immunity and related gastric mucosal disease (Review)

Lan Wang, Zhiyuan Ma, Bei Ji, Shuhui Liu, Shuji Terai, Biguang Tuo, Taolang Li, Xuemei Liu
Article Number: 252
Published online on: 09 July 2026

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Article

Leonurine inhibits the proliferation and metastasis of liver cancer cells by regulating the PI3K/AKT signaling pathway via epithelial‑mesenchymal transition

Bowen Hu, Maher Al Hussan, Jiakai Zhang, Peihao Wen, Changjun Huang, Yang Chen, Huanfei Ding
Article Number: 251
Published online on: 08 July 2026

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[Corrigendum] Resistin aggravates the expression of proinflammatory cytokines in cerulein‑stimulated AR42J pancreatic acinar cells

Chong-Yi Jiang, Wei Wang
Article Number: 250
Published online on: 08 July 2026

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A‑Raf: A serine/threonine protein kinase with important biological functions (Review)

Muhan Yang, Mengying Chen, Jinmei Wei, Yanling Li, Chen Long, Yan Lei, Yanhong Zhou
Article Number: 249
Published online on: 07 July 2026

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Gut dysbiosis‑derived butyrate loss predicts feeding intolerance: Multiomics evidence guiding nurse‑driven microbiota‑supportive interventions (Review)

Ling Wei, Xiaohua Kong, Yuying Li, Huixia Wu, Yirong Gan, Fang Sun
Article Number: 248
Published online on: 07 July 2026

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[Retracted] Network pharmacology combined with experimental validation to investigate the effect of Rongjin Niantong Fang on chondrocyte apoptosis in knee osteoarthritis

Jun Chen, Ting Zhang, Qingqing Luo, Ruyi Wang, Yuting Dai, Zhenyuan Chen, Chutian Zhang, Xuzheng Chen, Guangwen Wu
Article Number: 247
Published online on: 06 July 2026

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Laggera alata attenuates LPS‑induced systemic inflammation and hepatic‑pulmonary injury by regulating PINK1/Parkin-associated mitophagy and macrophage polarization

Jiangcun Wei, Wen Zhong, Guangyun Zhou, Mingtao Huang, Xiaodong Huang, Jing Liang
Article Number: 246
Published online on: 02 July 2026

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Proteolysis‑targeting chimeras in oral squamous cell carcinoma: Current evidence, translational challenges and future directions (Review)

Yun Bai, Danhua Ma, Xi Yang, Min Wang
Article Number: 245
Published online on: 02 July 2026

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Evolving role of biomarkers beyond prostate‑specific antigen in refining prostate cancer screening: From blood‑based tests to urinary and genetic markers (Review)

Luxi Li, Linyue Zhang, Zehong Li, Keqiang Chai, Weidong Ren
Article Number: 244
Published online on: 02 July 2026

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Nanocurcumin attenuates brain injury in rats with desert dry‑heat‑induced exertional heat stroke by suppressing TLR4/MyD88/NF‑κB signaling

Lisong Su, Jinquan Qu, Jiajia Li, Wenhui Shi, Laiyang Song, Feixing Liang, Jiangwei Liu
Article Number: 243
Published online on: 02 July 2026

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TREM2 in glioma: Reprogramming the immune microenvironment from mechanistic understanding to clinical translation (Review)

Junqi Fan, Hongyan Shen, Dan Liu, Songbai Luo, Qingqing Huang, Yi Wen, Libang Yuan
Article Number: 242
Published online on: 02 July 2026

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Human parvovirus B19 VP1u‑induced osteoclastogenesis is enhanced by RANKL in RAW264.7 macrophage cells

Chun-Yu Lin, Bor-Show Tzang, Yi-Hsuan Lin, Chih-Chen Tzang, Tsai-Ching Hsu
Article Number: 241
Published online on: 30 June 2026

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Retraction Open Access

[Retracted] Anti‑tumor peptide AP25 decreases cyclin D1 expression and inhibits MGC‑803 proliferation via phospho­extracellular signal‑regulated kinase‑, Src‑, c‑Jun N‑terminal kinase‑ and phosphoinositide 3­-kinase‑associated pathways  

Jialiang Hu, Tao Cheng, Lijun Zhang, Beicheng Sun, Lei Deng, Hanmei Xu
Article Number: 240
Published online on: 29 June 2026

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Aspirin prevents postoperative peritoneal adhesions by inhibiting the TGF‑β1/Smad signaling pathway in rats

Siqi Yan, Yuan Ren, Bingyan Liu, Pai Xiong, Yimin Sun
Article Number: 239
Published online on: 29 June 2026

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Morinda officinalis oligosaccharides ameliorate corticosterone‑induced depression‑like behaviour in mice by modulating the BDNF signalling pathway and gut microbiota

Mengjie He, Zixuan Liu, Yuxin Chen, Xiaoru Wu, Xueling Dai, Qian Liu, Shuo Wang, Zeping Zuo, Yaxuan Sun
Article Number: 238
Published online on: 29 June 2026

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