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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January-2021 Volume 23 Issue 1

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Astragaloside IV attenuates hypoxia‑induced pulmonary vascular remodeling via the Notch signaling pathway Corrigendum in /10.3892/mmr.2021.12547

Jiamei Yao, Xia Fang, Cui Zhang, Yushu Yang, Dongsheng Wang, Qiong Chen, Guangwei Zhong
Article Number: 89
Published online on: 24 November 2020

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Article Open Access

Metformin induces apoptosis and inhibits migration by activating the AMPK/p53 axis and suppressing PI3K/AKT signaling in human cervical cancer cells

Ya-Hui Chen, Shun-Fa Yang, Chueh-Ko Yang, Horng-Der Tsai, Tze-Ho Chen, Ming-Chih Chou, Yi-Hsuan Hsiao
Article Number: 88
Published online on: 24 November 2020

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Article Open Access

STAT3 enhances radiation-induced tumor migration, invasion and stem-like properties of bladder cancer

Fang Wang, Xiangli Ma, Guangmin Mao, Xiangyan Zhang, Zhaolu Kong
Article Number: 87
Published online on: 24 November 2020

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Article Open Access

Chloroform extract of Citrus unshiu Markovich peel induces apoptosis and inhibits stemness in HeLa human cervical cancer cells

Ye Seul Choi, Jang Mi Han, Yue Jai Kang, Hye Jin Jung
Article Number: 86
Published online on: 24 November 2020

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Article Open Access

lncRNA SNHG4 promotes cell proliferation, migration, invasion and the epithelial-mesenchymal transition process via sponging miR-204-5p in gastric cancer

Shimei Wang, Wei Zhu, Ji Qiu, Fei Chen
Article Number: 85
Published online on: 23 November 2020

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Article Open Access

Exosomal‑miR‑10a derived from colorectal cancer cells suppresses migration of human lung fibroblasts, and expression of IL‑6, IL‑8 and IL‑1β

Jian Wang, Yuanting Liu, Ying Li, Xuan Zheng, Jianhui Gan, Zhaoyuan Wan, Jun Zhang, Yan Liu, Yaqi Wang, Wanning Hu, Yufeng Li, Yankun Liu
Article Number: 84
Published online on: 23 November 2020

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Article

Scutellarin regulates osteoarthritis in vitro by inhibiting the PI3K/AKT/mTOR signaling pathway

Shao-Hua Ju, Li-Rong Tan, Pan-Wang Liu, You-Li Tan, Yuan-Ting Zhang, Xiao-Hong Li, Ming-Jian Wang, Ben-Xiang He
Article Number: 83
Published online on: 23 November 2020

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Article

Nardostachin from Nardostachys jatamansi exerts anti‑neuroinflammatory effects through TLR4/MyD88‑related suppression of the NF‑κB and JNK MAPK signaling pathways in lipopolysaccharide‑induced BV2 and primary microglial cells

Dong-Cheol Kim, Jin-Soo Park, Chi-Su Yoon, Youn-Chul Kim, Hyuncheol Oh
Article Number: 82
Published online on: 23 November 2020

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Article

miR‑576‑3p overexpression enhances cisplatin sensitivity of ovarian cancer cells by dysregulating PD‑L1 and cyclin D1

Ying Zuo, Wei Zheng, Qing Tang, Jing Liu, Shanshan Wang, Chunxia Xin
Article Number: 81
Published online on: 23 November 2020

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Article Open Access

Oncogenic potential of macrophage‑capping protein in clear cell renal cell carcinoma

Zhuang-Fei Chen, Ze-Hai Huang, Shi-Jun Chen, Yao-Dong Jiang, Zi-Ke Qin, Shao-Bin Zheng, Tong Chen
Article Number: 80
Published online on: 23 November 2020

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Article Open Access

miR‑18a‑5p promotes melanoma cell proliferation and inhibits apoptosis and autophagy by targeting EPHA7 signaling

Yunlong Guo, Wenli Shi, Ruihua Fang
Article Number: 79
Published online on: 23 November 2020

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Correction Open Access

[Corrigendum] Molecular mechanism of extracellular matrix disorder in pelvic organ prolapses

Liping Zhang, Fangfang Dai, Gantao Chen, Yanqing Wang, Shiyi Liu, Li Zhang, Shu Xian, Mengqin Yuan, Dongyong Yang, Yajing Zheng, Zhimin Deng, Yanxiang Cheng, Xiaofeng Yang
Article Number: 78
Published online on: 23 November 2020

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Article Open Access

Inonotus obliquus extract alleviates myocardial ischemia/reperfusion injury by suppressing endoplasmic reticulum stress

Yi Wu, Heming Cui, Yuying Zhang, Ping Yu, Yuangeng Li, Dan Wu, Yan Xue, Wenwen Fu
Article Number: 77
Published online on: 23 November 2020

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Article Open Access

lncRNA EZR‑AS1 knockdown represses proliferation, migration and invasion of cSCC via the PI3K/AKT signaling pathway

Di Lu, Lingling Sun, Zhengjun Li, Zhen Mu
Article Number: 76
Published online on: 23 November 2020

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Case Report

PARP inhibitor resistance and TP53 mutations in patients treated with olaparib for BRCA-mutated cancer: Four case reports

Thomas Collot, Julie Niogret, Marion Carnet, Sandy Chevrier, Etienne Humblin, Laure Favier, Leila Bengrine-Lefevre, Isabelle Desmoulins, Laurent Arnould, Romain Boidot
Article Number: 75
Published online on: 23 November 2020

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Article Open Access

Platelet isoform of phosphofructokinase promotes aerobic glycolysis and the progression of non‑small cell lung cancer

Fuan Wang, Ling Li, Zhen Zhang
Article Number: 74
Published online on: 20 November 2020

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Article Open Access

Resveratrol alleviates oxygen/glucose deprivation/reoxygenation‑induced neuronal damage through induction of mitophagy

Ming Ye, Hui Wu, Shuguo Li
Article Number: 73
Published online on: 20 November 2020

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Article Open Access

Acarbose ameliorates spontaneous type‑2 diabetes in db/db mice by inhibiting PDX‑1 methylation

Diyi Zhou, Lijun Chen, Xin Mou
Article Number: 72
Published online on: 20 November 2020

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Article Open Access

Glutathione S‑transferase ω 1 promotes the proliferation, migration and invasion, and inhibits the apoptosis of non‑small cell lung cancer cells, via the JAK/STAT3 signaling pathway

Kai Wang, Fu-Lian Zhang, Wei Jia
Article Number: 71
Published online on: 20 November 2020

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Review Open Access

Different roles of matrix metalloproteinase 2 in osteolysis of skeletal dysplasia and bone metastasis (Review)

Xiumao Li, Libin Jin, Yanbin Tan
Article Number: 70
Published online on: 20 November 2020

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Article Open Access

Bone marrow stem cells therapy alleviates vascular injury in a chronic obstructive pulmonary disease‑obstructive sleep apnea overlap syndrome rat model

Hong Bi, Jian He, Xu He, Junyi Du, Min Chen, Zhaoming Huang, Chao Yang, Lijuan Yang, Hang Li, Kaihua Zhou, Qing Wang, Lewei He, Zhixian Jin
Article Number: 69
Published online on: 20 November 2020

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Article Open Access

HIF‑3α affects preeclampsia development by regulating EVT growth via activation of the Flt‑1/JAK/STAT signaling pathway in hypoxia

Hongmei Qu, Qun Yu, Bei Jia, Wenzhe Zhou, Yinghong Zhang, Linsong Mu
Article Number: 68
Published online on: 19 November 2020

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Article Open Access

Exogenous sodium hydrosulfide protects against high glucose‑induced injury and inflammation in human umbilical vein endothelial cells by inhibiting necroptosis via the p38 MAPK signaling pathway

Jiaqiong Lin, Xiaoyong Li, Yan Lin, Zena Huang, Wen Wu
Article Number: 67
Published online on: 19 November 2020

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Article Open Access

Klotho attenuates angiotensin II‑induced cardiotoxicity through suppression of necroptosis and oxidative stress

Shasha Yu, Hongmei Yang, Xiaofan Guo, Yingxian Sun
Article Number: 66
Published online on: 19 November 2020

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Article

Osteoglycin knockdown promotes vascular smooth muscle cell proliferation and migration in aortic dissection via the VEGF/VEGFR2 axis

Zanxin Wang, Xianmian Zhuang, Bailang Chen, Minxin Wei
Article Number: 65
Published online on: 19 November 2020

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Article Open Access

S100a8 silencing attenuates inflammation, oxidative stress and apoptosis in BV2 cells induced by oxygen‑glucose deprivation and reoxygenation by upregulating GAB1 expression

Wenguang Hu, Caimei Lin
Article Number: 64
Published online on: 19 November 2020

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Article Open Access

Effects and molecular mechanism of pachymic acid on ferroptosis in renal ischemia reperfusion injury

Gui-Ping Jiang, Yue-Juan Liao, Li-Li Huang, Xu-Jia Zeng, Xiao-Hui Liao
Article Number: 63
Published online on: 19 November 2020

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Article Open Access

Hyperoxia sensitizes hypoxic HeLa cells to ionizing radiation by downregulating HIF‑1α and VEGF expression

Dan Dong, Yan Fu, Feng Chen, Jing Zhang, Haiyan Jia, Jia Li, Huailin Wang, Jihong Wen
Article Number: 62
Published online on: 18 November 2020

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Article

Recombinant stromal cell‑derived factor‑1 protein promotes neurite outgrowth in PC‑12 cells

Ye-Rang Yun, Jun-Hyeog Jang
Article Number: 61
Published online on: 18 November 2020

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Article Open Access

Long non‑coding RNA JPX promotes gastric cancer progression by regulating CXCR6 and autophagy via inhibiting miR‑197

Xuejing Han, Zheng Liu
Article Number: 60
Published online on: 18 November 2020

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Article Open Access

Lung cancer‑associated transcript 1 facilitates tumorigenesis in laryngeal squamous cell carcinoma through the targeted inhibition of miR‑493

Zhen Zhao, Yan Xing, Yan Liu, Shanghua Jing
Article Number: 59
Published online on: 18 November 2020

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Article Open Access

Construction of tissue engineering bone with the co‑culture system of ADSCs and VECs on partially deproteinized biologic bone in vitro: A preliminary study

Guiran Yang, Fuke Wang, Yanlin Li, Jianfei Hou, Dejian Liu
Article Number: 58
Published online on: 18 November 2020

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Article

miR-194-5p serves a suppressive role in human keloid fibroblasts via targeting NR2F2

Qijun Xu, Shengjun Jiang
Article Number: 57
Published online on: 17 November 2020

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Article Open Access

AMPK‑SIRT1 pathway dysfunction contributes to neuron apoptosis and cognitive impairment induced by sevoflurane

Liwei Liu, Chao Liu, Lin Fang
Article Number: 56
Published online on: 17 November 2020

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Article Open Access

Treatment of keloids through Runx2 siRNA‑induced inhibition of the PI3K/AKT signaling pathway

Wenchang Lv, Min Wu, Yuping Ren, Xiao Luo, Weijie Hu, Qi Zhang, Yiping Wu
Article Number: 55
Published online on: 16 November 2020

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Article Open Access

MicroRNA‑744‑5p is downregulated in colorectal cancer and targets SEPT2 to suppress the malignant phenotype

Wei Zhang, Kai Liao, Dongning Liu
Article Number: 54
Published online on: 16 November 2020

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Article Open Access

miR‑140‑5p inhibits the proliferation of multiple myeloma cells by targeting VEGFA

Min Liu, Huimin Liu, Jing Zhou, Zhuojun Yu
Article Number: 53
Published online on: 16 November 2020

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Article Open Access

Regulation of ABCG2 expression by Wnt5a through FZD7 in human pancreatic cancer cells

Zhongbo Zhang, Shuang Gao, Yuanhong Xu, Chenghai Zhao
Article Number: 52
Published online on: 16 November 2020

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Article Open Access

MicroRNA‑21‑5p protects melanocytes via targeting STAT3 and modulating Treg/Teff balance to alleviate vitiligo

Jing Huo, Taibin Liu, Fenghua Li, Xinfeng Song, Xiuli Hou
Article Number: 51
Published online on: 16 November 2020

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Article Open Access

Cardiac‑specific deletion of natriuretic peptide receptor A induces differential myocardial expression of circular RNA and mRNA molecules involved in metabolism in mice

Baoying Chen, Pan Chang, Xi Shen, Xiaomeng Zhang, Jing Zhang, Xihui Wang, Jun Yu
Article Number: 50
Published online on: 13 November 2020

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Article Open Access

C-C chemokine receptor 5 signaling contributes to cardiac remodeling and dysfunction under pressure overload

Xiaomin Wang, Wei Li, Qiang Yue, Wei Du, Yongming Li, Fu Liu, Liu Yang, Lijuan Xu, Ruiping Zhao, Jiang Hu
Article Number: 49
Published online on: 13 November 2020

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Article Open Access

Inhibition of Bcl-2 and Bcl-xL overcomes the resistance to the third-generation EGFR tyrosine kinase inhibitor osimertinib in non-small cell lung cancer

Yingjie Lu, Dongliang Bian, Xuelin Zhang, Huibiao Zhang, Zhenghong Zhu
Article Number: 48
Published online on: 12 November 2020

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Article Open Access

Differentiation potential and mRNA profiles of human dedifferentiated adipose cells and adipose‑derived stem cells from young donors

Fangfei Nie, Hongsen Bi, Chen Zhang, Pengbing Ding
Article Number: 47
Published online on: 12 November 2020

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Article Open Access

CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression

Hangwei Fu, Yida Zhang, Yin Chen, Junying Chen, Ping Chen
Article Number: 46
Published online on: 12 November 2020

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Article Open Access

Long non‑coding RNA TTN‑AS1 regulates the proliferation, invasion and migration of triple‑negative breast cancer by targeting miR‑211‑5p

Erhu Sun, Xiaofeng Liu, Cheng Lu, Kangsheng Liu
Article Number: 45
Published online on: 10 November 2020

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Article Open Access

Bioinformatics analysis of the microRNA-mRNA network in sebaceous gland carcinoma of the eyelid

Tetsushi Hirano, Tatsuya Yunoki, Yukihiro Furusawa, Yoshiaki Tabuchi, Atsushi Hayashi
Article Number: 44
Published online on: 10 November 2020

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Article Open Access

Mesenchymal stem cells negatively regulate CD4+ T cell activation in patients with primary Sjögren syndrome through the miRNA‑125b and miRNA‑155 TCR pathway

Bangdong Gong, Ling Zheng, Zhenhao Lu, Jiashu Huang, Jincheng Pu, Shengnan Pan, Min Zhang, Jie Liu, Jianping Tang
Article Number: 43
Published online on: 10 November 2020

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Article Open Access

miR-31 attenuates murine allergic rhinitis by suppressing interleukin-13-induced nasal epithelial inflammatory responses

Fangwei Zhou, Peiqiang Liu, Hao Lv, Ziang Gao, Wenchuan Chang, Yu Xu
Article Number: 42
Published online on: 10 November 2020

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Article Open Access

Reoxygenation induces reactive oxygen species production and ferroptosis in renal tubular epithelial cells by activating aryl hydrocarbon receptor

Theodoros Eleftheriadis, Georgios Pissas, Georgios Filippidis, Vassilios Liakopoulos, Ioannis Stefanidis
Article Number: 41
Published online on: 10 November 2020

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Article Open Access

Tanshinone I and simvastatin inhibit melanoma tumour cell growth by regulating poly (ADP ribose) polymerase 1 expression

Yuyan Zhang, Jiusui Huang, Yapeng Huang, Shike Zhang, Weizhou Wu, Hui Long, Xiaolu Duan, Yongchang Lai, Wenqi Wu
Article Number: 40
Published online on: 10 November 2020

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Article Open Access

PDGF mediates pulmonary arterial smooth muscle cell proliferation and migration by regulating NFATc2

Fang-Yun Zhao, Shuang-Lan Xu, Chun-Fang Zhang, Jie Liu, Yue Zhang, Jiao Yang, Xi-Qian Xing
Article Number: 39
Published online on: 10 November 2020

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Article Open Access

Dexmedetomidine attenuates sevoflurane‑induced neurocognitive impairment through α2‑adrenoceptors

Yufeng Zhang, Mao Li, Enhui Cui, Hao Zhang, Xiaozhong Zhu, Jing Zhou, Ming Yan, Jian Sun
Article Number: 38
Published online on: 10 November 2020

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Article Open Access

Ginsenoside Rg1 improves pathological damages by activating the p21‑p53‑STK pathway in ovary and Bax‑Bcl2 in the uterus in premature ovarian insufficiency mouse models

Lianli He, Xiaojuan Wang, Daigang Cheng, Zhengai Xiong, Xiaoyun Liu
Article Number: 37
Published online on: 10 November 2020

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Retraction Open Access

[Retracted] Effects of botulinum toxin A on endometriosis‑associated pain and its related mechanism

Fubo Tian, Wuzhong Cheng, Jianying Hu, Shaoqiang Huang, Shen Sun
Article Number: 36
Published online on: 09 November 2020

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Article Open Access

Rosiglitazone affects the progression of surgically‑induced endometriosis in a rat model

Shun Zhang, Lingling Zhuang, Qian Liu, Xiaolin Yu, Qinghua Min, Minjie Chen, Qi Chen
Article Number: 35
Published online on: 09 November 2020

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Article Open Access

Curcumin ameliorates DSS‑induced colitis in mice by regulating the Treg/Th17 signaling pathway

Cheng Wei, Jian-Yao Wang, Feng Xiong, Ben-Hua Wu, Ming-Han Luo, Zhi-Chao Yu, Ting-Ting Liu, De-Feng Li, Qi Tang, Ying-Xue Li, Ding-Guo Zhang, Zheng-Lei Xu, Hong-Tao Jin, Li-Sheng Wang, Jun Yao
Article Number: 34
Published online on: 09 November 2020

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Article Open Access

Hyperoxia induces endoplasmic reticulum stress‑associated apoptosis via the IRE1α pathway in rats with bronchopulmonary dysplasia

Xin Tong, Mengyun Li, Na Liu, Wanjie Huang, Xindong Xue, Jianhua Fu
Article Number: 33
Published online on: 09 November 2020

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Review Open Access

Neuromodulation of bone: Role of different peptides and their interactions (Review)

Xiaoyu Wang, Jia Xu, Qinglin Kang
Article Number: 32
Published online on: 05 November 2020

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Article Open Access

Long non‑coding RNA SNHG20 promotes colorectal cancer cell proliferation, migration and invasion via miR‑495/STAT3 axis

Yu Wang, Jianying Fu, Lili Yang, Zhi Liang
Article Number: 31
Published online on: 05 November 2020

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Article Open Access

Effects of miR‑93 on epithelial‑to‑mesenchymal transition and vasculogenic mimicry in triple‑negative breast cancer cells

Gaili An, Feng Lu, Shangke Huang, Jun Bai, Li He, Yi Liu, Lei Hou
Article Number: 30
Published online on: 04 November 2020

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Article Open Access

Catalpol inhibits the proliferation, migration and metastasis of HCC cells by regulating miR‑140‑5p expression

Linsheng Wu, Haoxia Li, Shengyou Chen, Xiaoqiang Wu, Xiaomin Chen, Fangping Wang
Article Number: 29
Published online on: 04 November 2020

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Article Open Access

Effects and mechanism of microRNA‑218 against lung cancer

Yan Chen, Ji-Lin Yang, Zhen-Zhen Xue, Qiu-Chen Cai, Chun Hou, Hong-Juan Li, Liu-Xin Zhao, Yin Zhang, Cheng-Wei Gao, Li Cong, Tian-Zuo Wang, Dong-Mei Chen, Guo-Sheng Li, Shi-Qing Luo, Qian Yao, Chan-Juan Yang, Qi-Shun Zhu, Chuan-Hai Cao
Article Number: 28
Published online on: 04 November 2020

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Review

Calcitonin gene‑related peptide‑mediated pharmacological effects in cardiovascular and gastrointestinal diseases (Review)

Wan-Jun Ma, You-Cong Yin, Bi-Kui Zhang, Yuan-Jian Li, Wen-Qun Li
Article Number: 27
Published online on: 04 November 2020

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Review

Functions, pathophysiology and current insights of exosomal endocrinology (Review)

Dimitrios Vlachakis, Τhanasis Mitsis, Nicolas Nicolaides, Aspasia Efthimiadou, Antonis Giannakakis, Flora Bacopoulou, George P. Chrousos
Article Number: 26
Published online on: 04 November 2020

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A transcriptome profile in gallbladder cancer based on annotation analysis of microarray studies

Chunlin Ge, Xuan Zhu, Xing Niu, Bingye Zhang, Lijie Chen
Article Number: 25
Published online on: 03 November 2020

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LINC00861 inhibits the progression of cervical cancer cells by functioning as a ceRNA for miR‑513b‑5p and regulating the PTEN/AKT/mTOR signaling pathway

Hui Liu, Ling Zhang, Xiaoling Ding, Xuezuo Sui
Article Number: 24
Published online on: 03 November 2020

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CUL4A regulates endometrial cancer cell proliferation, invasion and migration by interacting with CSN6

Xiangrong Wang, Tianquan Chen
Article Number: 23
Published online on: 03 November 2020

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Involvement of Klotho, TNF‑α and ADAMs in radiation‑induced senescence of renal epithelial cells

Da Yeon Kim, Minyoung Lee, Eun Ju Kim
Article Number: 22
Published online on: 03 November 2020

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Obesity related microRNA‑424 is regulated by TNF‑α in adipocytes

Qin-Zhi Xiao, Li-Jun Zhu, Zi-Yi Fu, Xi-Rong Guo, Xia Chi
Article Number: 21
Published online on: 03 November 2020

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Role of the SIRT1/p53 regulatory axis in oxidative stress‑mediated granulosa cell apoptosis

Sang-Ah Park, Na-Rae Joo, Jung-Hwan Park, Sang-Muk Oh
Article Number: 20
Published online on: 03 November 2020

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Astragaloside‑IV modulates NGF‑induced osteoblast differentiation via the GSK3β/β‑catenin signalling pathway

Nan-Yang Sun, Xiao-Lan Liu, Juan Gao, Xiao-Hui Wu, Ben Dou
Article Number: 19
Published online on: 03 November 2020

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Long non‑coding RNA MEG3 knockdown alleviates hypoxia‑induced injury in rat cardiomyocytes via the miR‑325‑3p/TRPV4 axis

Ya Zhou, Xianguo Li, Dong Zhao, Xinya Li, Jianjun Dai
Article Number: 18
Published online on: 03 November 2020

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Role of hypoxia inducible factor-1 in cancer stem cells (Review)

Qi Zhang, Zhenzhen Han, Yanbo Zhu, Jingcheng Chen, Wei Li
Article Number: 17
Published online on: 03 November 2020

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In vitro analysis of hepatic stellate cell activation influenced by transmembrane 6 superfamily 2 polymorphism

Songyao Liu, Eisuke Murakami, Takashi Nakahara, Kazuki Ohya, Yuji Teraoka, Grace Naswa Makokha, Takuro Uchida, Kei Morio, Hatsue Fujino, Atsushi Ono, Masami Yamauchi, Tomokazu Kawaoka, Daiki Miki, Masataka Tsuge, Akira Hiramatsu, Hiromi Abe‑Chayama, Nelson C. Hayes, Michio Imamura, Hiroshi Aikata, Kazuaki Chayama
Article Number: 16
Published online on: 03 November 2020

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Astragalus polysaccharide has a protective effect on hematopoiesis in an irradiated mouse model and decreases apoptosis in megakaryocytes

Liang Li, Wanhua Xu, Chenju Yi, Yucai Cheng, Hongwu Xin, Hongman Xue, Chi-Kong Li, Xiaoyi Fang, Liuming Yang, Chun Chen, Mo Yang
Article Number: 15
Published online on: 03 November 2020

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miR‑449a‑5p suppresses CDK6 expression to inhibit cardiomyocyte proliferation

Bing Li, Zhi Wang, Fan Yang, Jing Huang, Xingwei Hu, Shiyan Deng, Maobo Tian, Xiaoyun Si
Article Number: 14
Published online on: 03 November 2020

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Curcumin attenuates lncRNA H19‑induced epithelial‑mesenchymal transition in tamoxifen‑resistant breast cancer cells

Jiaqin Cai, Hong Sun, Bin Zheng, Mumu Xie, Chenxia Xu, Guifeng Zhang, Xuhui Huang, Jie Zhuang
Article Number: 13
Published online on: 03 November 2020

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High expression of CIN85 promotes proliferation and invasion of human esophageal squamous cell carcinoma

Xiao-Yang Hua, Xing-Xing Bie, Xi Cheng, Shu-Guang Zhang
Article Number: 12
Published online on: 03 November 2020

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Laminin‑332 mediates proliferation, apoptosis, invasion, migration and epithelial‑to‑mesenchymal transition in pancreatic ductal adenocarcinoma

Caiqun Huang, Jun Chen
Article Number: 11
Published online on: 03 November 2020

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Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial‑mesenchymal transition in the valvular damage due to rheumatic heart disease

Shenglin Xian, Ang Chen, Xiaodan Wu, Chuanghong  Lu, Yunjiao Wu, Feng Huang, Zhiyu Zeng
Article Number: 10
Published online on: 03 November 2020

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Effects of signaling pathway inhibitors on hematopoietic stem cells

Yuyu Jiang, Zhaofeng Xu, Na Ma, Lizhi Yin, Caiqin Hao, Jing Li
Article Number: 9
Published online on: 03 November 2020

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WJ‑MSCs intervention may relieve intrauterine adhesions in female rats via TGF‑β1‑mediated Rho/ROCK signaling inhibition

Jun Li, Bo Huang, Lan Dong, Yajuan Zhong, Zhixin Huang
Article Number: 8
Published online on: 03 November 2020

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Developments in the production of platelets from stem cells (Review)

Jie Yang, Jianfeng Luan, Yanfei Shen, Baoan Chen
Article Number: 7
Published online on: 03 November 2020

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Apelin‑36 protects against lipopolysaccharide‑induced acute lung injury by inhibiting the ASK1/MAPK signaling pathway

Qiong He, Yuqiao Wang, Hua Yang, Jianmin Wang, Jia Zhang, Danni Liu
Article Number: 6
Published online on: 03 November 2020

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miR‑26a‑5p alleviates lipopolysaccharide‑induced acute lung injury by targeting the connective tissue growth factor

Hongyan Li, Tingting Yang, Zhaoxia Fei
Article Number: 5
Published online on: 03 November 2020

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Proteins involved in oxidative stress in leiomyoma tissues treated with ulipristal acetate

Blendi Ura, Lorenzo Monasta, Yeraldin Chiquinquira Castillo De Spelorzi, Giorgio Arrigoni, Cinzia Franchin, Stefania Biffi, Michelangelo Aloisio, Bartolomea Gaita, Danilo Licastro, Emmanouil Athanasakis, Federica Scrimin, Guglielmo Stabile, Federico Romano, Giovanni Di Lorenzo, Giuseppe Ricci
Article Number: 4
Published online on: 02 November 2020

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Berberine alleviates palmitic acid‑induced podocyte apoptosis by reducing reactive oxygen species‑mediated endoplasmic reticulum stress

Xing-Yang Xiang, Ting Liu, Yue Wu, Xu-Shun Jiang, Jun-Ling He, Xue-Mei Chen, Xiao-Gang Du
Article Number: 3
Published online on: 02 November 2020

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Downregulation of lncRNA ZFAS1 inhibits the hallmarks of thyroid carcinoma via the regulation of miR‑302‑3p on cyclin D1

Wenjing Chen, Lili Zhai, Huiming Liu, Yuting Li, Qi Zhang, Dandan Xu, Weiye Fan
Article Number: 2
Published online on: 02 November 2020

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Expression profile and diagnostic value of circRNAs in peripheral blood from patients with systemic lupus erythematosus

Qing Luo, Xue Li, Biqi Fu, Lu Zhang, Le Fang, Cheng Qing, Yang Guo, Zikun Huang, Junming Li
Article Number: 1
Published online on: 02 November 2020

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January-2026 Volume 33 Issue 1

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CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Non‑coding RNAs in epithelial‑mesenchymal transition of renal cell carcinoma (Review)

Ziqiao Liu, Hanshen Zhou, Junxiao Shen, Yiming Qi, Xuke Gong, Cheng Zhang
Article Number: 51
Published online on: 24 November 2025

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FOXJ3 drives mesenchymal stem cell osteogenic differentiation via the Wnt/β‑catenin pathway: A novel regulator implicated in osteoporosis

Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
Published online on: 21 November 2025

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NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head

Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
Published online on: 21 November 2025

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Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway

Chih-Hsuan Hsia, Chun-Ming Yang, Chao-Chien Chang, Ting-Lin Yen, Arief Gunawan Darmanto, Chi-Chang Huang, Joen-Rong Sheu
Article Number: 48
Published online on: 21 November 2025

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Research progress on molecular therapy for glaucoma (Review)

Weiwei Wang, Gangwei Cheng, Qi Zhou, Sheng Wang, Linyi Zhang
Article Number: 47
Published online on: 21 November 2025

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Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut‑joint axis’ (Review)

Wenjie Hu, Rui Li, Zhongming Zhang
Article Number: 46
Published online on: 20 November 2025

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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

Pan Guo, Mengke Sun, Jingyu Zhang, Qianshu Yuan, Hong Cui, Junkai Huang, Jing Luo, Qianyu Zhu, Bingxin Zhang, Lizhi Hu
Article Number: 45
Published online on: 20 November 2025

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

Banghao Sun, Zhenyu Zhao, Qingyu Meng, Luya Pu, Xingyu Jiang, Shuai Li, Fadi Cao, Fan Li
Article Number: 44
Published online on: 20 November 2025

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
Published online on: 18 November 2025

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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
Published online on: 12 November 2025

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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
Published online on: 12 November 2025

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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
Published online on: 12 November 2025

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Article

Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 33 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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