1
|
Shlush LI, Zandi S, Mitchell A, Chen WC,
Brandwein JM, Gupta V, Kennedy JA, Schimmer AD, Schuh AC, Yee KW,
et al: Identification of pre-leukaemic haematopoietic stem cells in
acute leukaemia. Nature. 506:328–333. 2014. View Article : Google Scholar : PubMed/NCBI
|
2
|
Tijaro-Ovalle NM, Karantanos T, Wang HT
and Boussiotis VA: Metabolic targets for improvement of allogeneic
hematopoietic stem cell transplantation and graft-vs.-host disease.
Front Immunol. 10:2952019. View Article : Google Scholar : PubMed/NCBI
|
3
|
Cui P, Zhang Y, Cui M, Li Z, Ma G, Wang R,
Wang N, Huang S and Gao J: Leukemia cells impair normal
hematopoiesis and induce functionally loss of hematopoietic stem
cells through immune cells and inflammation. Leuk Res. 65:49–54.
2018. View Article : Google Scholar : PubMed/NCBI
|
4
|
Clements WK and Traver D: Signalling
pathways that control vertebrate haematopoietic stem cell
specification. Nat Rev Immunol. 13:336–348. 2013. View Article : Google Scholar : PubMed/NCBI
|
5
|
Harada K, Fuji S, Seo S, Kanda J, Ueki T,
Kimura F, Kato K, Uchida N, Ikegame K, Onizuka M, et al: Comparison
of the outcomes after haploidentical and cord blood salvage
transplantations for graft failure following allogeneic
hematopoietic stem cell transplantation. Bone Marrow Transplant.
55:1784–1795. 2020. View Article : Google Scholar : PubMed/NCBI
|
6
|
Ozdemir ZN and Civriz Bozdag S: Graft
failure after allogeneic hematopoietic stem cell transplantation.
Transfus Apher Sci. 57:163–167. 2018. View Article : Google Scholar : PubMed/NCBI
|
7
|
Karigane D, Kobayashi H, Morikawa T,
Ootomo Y, Sakai M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M,
Nishimura EK, et al: p38α activates purine metabolism to initiate
hematopoietic stem/progenitor cell cycling in response to stress.
Cell stem cell. 19:192–204. 2016. View Article : Google Scholar : PubMed/NCBI
|
8
|
Guezguez B, Almakadi M, Benoit YD,
Shapovalova Z, Rahmig S, Fiebig-Comyn A, Casado FL, Tanasijevic B,
Bresolin S, Masetti R, et al: GSK3 deficiencies in hematopoietic
stem cells initiate pre-neoplastic state that is predictive of
clinical outcomes of human acute leukemia. Cancer Cell. 29:61–74.
2016. View Article : Google Scholar : PubMed/NCBI
|
9
|
Zhou F, Li X, Wang W, Zhu P, Zhou J, He W,
Ding M, Xiong F, Zheng X, Li Z, et al: Tracing haematopoietic stem
cell formation at single-cell resolution. Nature. 533:487–492.
2016. View Article : Google Scholar : PubMed/NCBI
|
10
|
Hinge A, Xu J, Javier J, Mose E, Kumar S,
Kapur R, Srour EF, Malik P, Aronow BJ and Filippi MD: p190-B RhoGAP
and intracellular cytokine signals balance hematopoietic stem and
progenitor cell self-renewal and differentiation. Nat Commun.
8:143822017. View Article : Google Scholar : PubMed/NCBI
|
11
|
Kwon B: p38α-mediated purine metabolism is
linked to exit from quiescence of hematopoietic stem cells. Stem
Cell Investig. 3:692016. View Article : Google Scholar : PubMed/NCBI
|
12
|
Ito K, Hirao A, Arai F, Takubo K, Matsuoka
S, Miyamoto K, Ohmura M, Naka K, Hosokawa K, Ikeda Y and Suda T:
Reactive oxygen species act through p38 MAPK to limit the lifespan
of hematopoietic stem cells. Nat Med. 12:446–451. 2006. View Article : Google Scholar : PubMed/NCBI
|
13
|
Ratajczak MZ and Suszynska M: Emerging
strategies to enhance homing and engraftment of hematopoietic stem
cells. Stem Cell Rev Rep. 12:121–128. 2016. View Article : Google Scholar : PubMed/NCBI
|
14
|
Abdelbaset-Ismail A, Borkowska-Rzeszotek
S, Kubis E, Bujko K, Brzeźniakiewicz-Janus K, Bolkun L, Kloczko J,
Moniuszko M, Basak GW, Wiktor-Jedrzejczak W and Ratajczak MZ:
Activation of the complement cascade enhances motility of leukemic
cells by downregulating expression of heme oxygenase 1 (HO-1).
Leukemia. 31:446–458. 2016. View Article : Google Scholar : PubMed/NCBI
|
15
|
Gao F and Liu WJ: Advance in the study on
p38 MAPK mediated drug resistance in leukemia. Eur Rev Med
Pharmacol Sci. 20:1064–1070. 2016.PubMed/NCBI
|
16
|
Ko KH, Holmes T, Palladinetti P, Song E,
Nordon R, O'Brien TA and Dolnikov A: GSK-3β inhibition promotes
engraftment of ex vivo-expanded hematopoietic stem cells and
modulates gene expression. Stem Cells. 29:108–118. 2011. View Article : Google Scholar : PubMed/NCBI
|
17
|
Huang J, Zhang Y, Bersenev A, O'Brien WT,
Tong W, Emerson SG and Klein PS: Pivotal role for glycogen synthase
kinase-3 in hematopoietic stem cell homeostasis in mice. J Clin
Invest. 119:3519–3529. 2009.PubMed/NCBI
|
18
|
Li H, Feng J, Zhang Y, Feng J, Wang Q,
Zhao S, Meng P and Li J: Mst1 deletion attenuates renal
ischaemia-reperfusion injury: The role of microtubule cytoskeleton
dynamics, mitochondrial fission and the GSK3β-p53 signalling
pathway. Redox Biol. 20:261–274. 2019. View Article : Google Scholar : PubMed/NCBI
|
19
|
Lechman ER, Gentner B, van Galen P,
Giustacchini A, Saini M, Boccalatte FE, Hiramatsu H, Restuccia U,
Bachi A, Voisin V, et al: Attenuation of miR-126 activity expands
HSC in vivo without exhaustion. Cell Stem Cell. 11:799–811. 2012.
View Article : Google Scholar : PubMed/NCBI
|
20
|
Lapid K, Itkin T, D'Uva G, Ovadya Y, Ludin
A, Caglio G, Kalinkovich A, Golan K, Porat Z, Zollo M and Lapidot
T: GSK3β regulates physiological migration of stem/progenitor cells
via cytoskeletal rearrangement. J Clin Invest. 123:1705–1717. 2013.
View Article : Google Scholar : PubMed/NCBI
|
21
|
Gatla HR, Muniraj N, Thevkar P, Yavvari S,
Sukhavasi S and Makena MR: Regulation of chemokines and cytokines
by histone deacetylases and an update on histone decetylase
inhibitors in human diseases. Int J Mol Sci. 20:11102019.
View Article : Google Scholar
|
22
|
Stahl M, Gore SD, Vey N and Prebet T: Lost
in translation? Ten years of development of histone deacetylase
inhibitors in acute myeloid leukemia and myelodysplastic syndromes.
Expert Opin Investig Drugs. 25:307–317. 2016. View Article : Google Scholar : PubMed/NCBI
|
23
|
Jabbour E and Garcia-Manero G: Deacetylase
inhibitors for the treatment of myelodysplastic syndromes. Leuk
Lymphoma. 56:1205–1212. 2015. View Article : Google Scholar : PubMed/NCBI
|
24
|
Liu Z, Ding K, Li L, Liu H, Wang Y, Liu C
and Fu R: A novel histone deacetylase inhibitor Chidamide induces
G0/G1 arrest and apoptosis in myelodysplastic syndromes. Biomed
Pharmacother. 83:1032–1037. 2016. View Article : Google Scholar : PubMed/NCBI
|
25
|
Heuser M, Yun H and Thol F: Epigenetics in
myelodysplastic syndromes. Semin Cancer Biol. 51:170–179. 2018.
View Article : Google Scholar : PubMed/NCBI
|
26
|
Mao J, Li S, Zhao H, Zhu Y, Hong M, Zhu H,
Qian S and Li J: Effects of chidamide and its combination with
decitabine on proliferation and apoptosis of leukemia cell lines.
Am J Transl Res. 10:2567–2578. 2018.PubMed/NCBI
|
27
|
Qi J, Singh S, Hua WK, Cai Q, Chao SW, Li
L, Liu H, Ho Y, McDonald T, Lin A, et al: HDAC8 inhibition
specifically targets Inv (16) acute myeloid leukemic stem cells by
restoring p53 acetylation. Cell Stem Cell. 17:597–610. 2015.
View Article : Google Scholar : PubMed/NCBI
|
28
|
Chen C, Liu Y, Liu Y and Zheng P: mTOR
regulation and therapeutic rejuvenation of aging hematopoietic stem
cells. Sci Signal. 2:ra752009. View Article : Google Scholar : PubMed/NCBI
|
29
|
Cao D, Song J, Ling S, Niu S, Lu L, Cui Z,
Li Y, Hao S, Zhong G, Qi Z, et al: Hematopoietic stem cells and
lineage cells undergo dynamic alterations under microgravity and
recovery conditions. FASEB J. 33:6904–6918. 2019. View Article : Google Scholar : PubMed/NCBI
|
30
|
Kassim AA and Savani BN: Hematopoietic
stem cell transplantation for acute myeloid leukemia: A review.
Hematol Oncol Stem Cell Ther. 10:245–251. 2017. View Article : Google Scholar : PubMed/NCBI
|
31
|
Chhabra A, Ring AM, Weiskopf K, Schnorr
PJ, Gordon S, Le AC, Kwon HS, Ring NG, Volkmer J, Ho PY, et al:
Hematopoietic stem cell transplantation in immunocompetent hosts
without radiation or chemotherapy. Sci Transl Med. 8:351ra1052016.
View Article : Google Scholar : PubMed/NCBI
|
32
|
De Meyts P: The Insulin Receptor and Its
Signal Transduction Network. Endotext. Feingold KR, Anawalt B,
Boyce A, et al: MDText.com, Inc.; South Dartmouth, MA: 2000
|
33
|
Bari S, Zhong Q, Fan X, Poon Z, Lim AST,
Lim TH, Dighe N, Li S, Chiu GNC, Chai CLL and Hwang WYK: Ex vivo
expansion of CD34+ CD90+ CD49f+
hematopoietic stem and progenitor cells from non-enriched umbilical
cord blood with azole compounds. Stem Cells Transl Med. 7:376–393.
2018. View Article : Google Scholar : PubMed/NCBI
|
34
|
Cao R, Li L, Ying Z, Cao Z, Ma Y, Mao X,
Li J, Qi X, Zhang Z and Wang X: A small molecule protects
mitochondrial integrity by inhibiting mTOR activity. Proc Natl Acad
Sci USA. 116:23332–23338. 2019. View Article : Google Scholar : PubMed/NCBI
|
35
|
Dong G, Chen W, Wang X, Yang X, Xu T, Wang
P, Zhang W, Rao Y, Miao C and Sheng C: Small molecule inhibitors
simultaneously targeting cancer metabolism and epigenetics:
Discovery of novel nicotinamide phosphoribosyltransferase (NAMPT)
and histone deacetylase (HDAC) dual inhibitors. J Med Chem.
60:7965–7983. 2017. View Article : Google Scholar : PubMed/NCBI
|
36
|
Yu VW and Scadden DT: Hematopoietic stem
cell and its bone marrow niche. Curr Top Dev Biol. 118:21–44. 2016.
View Article : Google Scholar : PubMed/NCBI
|
37
|
Wilkinson AC, Ishida R, Kikuchi M, Sudo K,
Morita M, Crisostomo RV, Yamamoto R, Loh KM, Nakamura Y, Watanabe
M, et al: Long-term ex vivo haematopoietic-stem-cell expansion
allows nonconditioned transplantation. Nature. 571:117–121. 2019.
View Article : Google Scholar : PubMed/NCBI
|
38
|
Höfer T and Rodewald HR:
Differentiation-based model of hematopoietic stem cell functions
and lineage pathways. Blood. 132:1106–1113. 2018. View Article : Google Scholar : PubMed/NCBI
|
39
|
Xu ZY, Chai S, Zhang XQ, Cao Y, Lian CQ,
Wu WJ and Li YY: Influence of BMP4 on regulation of cell cycle and
apoptosis of hematopoietic stem cells/progenitor cells and its
mechanism in chemotherapy-induced myelosuppression. Zhongguo Shi
Yan Xue Ye Xue Za Zhi. 27:1265–1271. 2019.(in Chinese). PubMed/NCBI
|
40
|
Morcos MNF, Schoedel KB, Hoppe A, Behrendt
R, Basak O, Clevers HC, Roers A and Gerbaulet A: SCA-1 expression
level identifies quiescent hematopoietic stem and progenitor cells.
Stem Cell Rep. 8:1472–1478. 2017. View Article : Google Scholar
|
41
|
Wang Y, Kellner J, Liu L and Zhou D:
Inhibition of p38 mitogen-activated protein kinase promotes ex vivo
hematopoietic stem cell expansion. Stem Cells Dev. 20:1143–1152.
2011. View Article : Google Scholar : PubMed/NCBI
|
42
|
Cirillo PF, Pargellis C and Regan J: The
non-diaryl heterocycle classes of p38 MAP kinase inhibitors. Curr
Top Med Chem. 2:1021–1035. 2002. View Article : Google Scholar : PubMed/NCBI
|
43
|
Gao LY, Zhao MY, Li P, Kong J, Liu Z, Chen
Y, Huang R, Chu J, Quan J and Zeng R: Glycogen synthase kinase 3
(GSK3)-inhibitor SB216763 promotes the conversion of human
umbilical cord mesenchymal stem cells into neural precursors in
adherent culture. Hum Cell. 30:11–22. 2017. View Article : Google Scholar : PubMed/NCBI
|
44
|
Zeng J, Liu X, Li X, Zheng Y, Liu B and
Xiao Y: Daucosterol inhibits the proliferation, migration, and
invasion of hepatocellular carcinoma cells via Wnt/β-catenin
signaling. Molecules. 22:8622017. View Article : Google Scholar
|
45
|
Cheng T, Zhai K, Chang Y, Yao G, He J,
Wang F, Kong H, Xin H, Wang H, Jin M, et al: CHIR99021 combined
with retinoic acid promotes the differentiation of primordial germ
cells from human embryonic stem cells. Oncotarget. 8:7814–7826.
2017. View Article : Google Scholar : PubMed/NCBI
|
46
|
Dobzanski A, Khalil SM and Lane AP: Nasal
polyp fibroblasts modulate epithelial characteristics via Wnt
signaling. Int Forum Allergy Rhinol. 8:1412–1420. 2018. View Article : Google Scholar : PubMed/NCBI
|
47
|
Wu Y, Ai Z, Yao K, Cao L, Du J, Shi X, Guo
Z and Zhang Y: CHIR99021 promotes self-renewal of mouse embryonic
stem cells by modulation of protein-encoding gene and long
intergenic non-coding RNA expression. Exp Cell Res. 319:2684–2699.
2013. View Article : Google Scholar : PubMed/NCBI
|
48
|
Mahajan MM, Cheng B, Beyer AI, Mulvaney
US, Wilkinson MB, Fomin ME and Muench MO: A quantitative assessment
of the content of hematopoietic stem cells in mouse and human
endosteal-bone marrow: A simple and rapid method for the isolation
of mouse central bone marrow. BMC Hematol. 15:92015. View Article : Google Scholar : PubMed/NCBI
|
49
|
DiNardo CD and Cortes JE: Mutations in
AML: Prognostic and therapeutic implications. Hematology Am Soc
Hematol Educ Program. 2016:348–355. 2016. View Article : Google Scholar : PubMed/NCBI
|
50
|
Cornelissen JJ and Blaise D: Hematopoietic
stem cell transplantation for patients with AML in first complete
remission. Blood. 127:62–70. 2016. View Article : Google Scholar : PubMed/NCBI
|
51
|
Richter J, Traver D and Willert K: The
role of Wnt signaling in hematopoietic stem cell development. Crit
Rev Biochem Mol Biol. 52:414–424. 2017. View Article : Google Scholar : PubMed/NCBI
|
52
|
de Jamblinne Y, Baudoux E, Delo C and
Coppieters Y: Influence of obstetric factors on characteristics of
umbilical cord blood transplants. Gynecol Obstet Fertil Senol.
46:639–644. 2018.(In French). PubMed/NCBI
|
53
|
Lou X, Zhao C and Chen H: Unrelated donor
umbilical cord blood transplant versus unrelated hematopoietic stem
cell transplant in patients with acute leukemia: A meta-analysis
and systematic review. Blood Rev. 32:192–202. 2018. View Article : Google Scholar : PubMed/NCBI
|
54
|
Tong J, Xuan L, Sun Y, Huang D, Liu H,
Zheng C, Zhu X, Tang B, Song K, Zhang X, et al: Umbilical cord
blood transplantation without antithymocyte globulin results in
similar survival but better quality of life compared with unrelated
peripheral blood stem cell transplantation for the treatment of
acute leukemia-a retrospective study in China. Biol Blood Marrow
Transplant. 23:1541–1548. 2017. View Article : Google Scholar : PubMed/NCBI
|
55
|
Kaushansky K and Zhan H: The regulation of
normal and neoplastic hematopoiesis is dependent on
microenvironmental cells. Adv Biol Regul. 69:11–15. 2018.
View Article : Google Scholar : PubMed/NCBI
|
56
|
Lucas D: The bone marrow microenvironment
for hematopoietic stem cells. Adv Exp Med Biol. 1041:5–18. 2017.
View Article : Google Scholar : PubMed/NCBI
|
57
|
Dzierzak E and Bigas A: Blood development:
Hematopoietic stem cell dependence and independence. Cell Stem
Cell. 22:639–651. 2018. View Article : Google Scholar : PubMed/NCBI
|
58
|
Derakhshani M, Abbaszadeh H, Movassaghpour
AA, Mehdizadeh A, Ebrahimi-Warkiani M and Yousefi M: Strategies for
elevating hematopoietic stem cells expansion and engraftment
capacity. Life Sci. 232:1165982019. View Article : Google Scholar : PubMed/NCBI
|
59
|
Hua Y, Wang C, Jiang H, Wang Y, Liu C, Li
L, Liu H, Shao Z and Fu R: Iron overload may promote alteration of
NK cells and hematopoietic stem/progenitor cells by JNK and p38
pathway in myelodysplastic syndromes. Int J Hematol. 106:248–257.
2017. View Article : Google Scholar : PubMed/NCBI
|
60
|
Tesio M, Tang Y, Mudder K, Saini M, von
Paleske L, Macintyre E, Pasparakis M, Waisman A and Trumpp A:
Hematopoietic stem cell quiescence and function are controlled by
the CYLD-TRAF2-p38MAPK pathway. J Exp Med. 212:525–538. 2015.
View Article : Google Scholar : PubMed/NCBI
|
61
|
Peng H, Kasada A, Ueno M, Hoshii T,
Tadokoro Y, Nomura N, Ito C, Takase Y, Vu HT, Kobayashi M, et al:
Distinct roles of Rheb and Raptor in activating mTOR complex 1 for
the self-renewal of hematopoietic stem cells. Biochem Biophys Res
Commun. 495:1129–1135. 2018. View Article : Google Scholar : PubMed/NCBI
|
62
|
Oburoglu L, Romano M, Taylor N and Kinet
S: Metabolic regulation of hematopoietic stem cell commitment and
erythroid differentiation. Curr Opin Hematol. 23:198–205. 2016.
View Article : Google Scholar : PubMed/NCBI
|
63
|
Trowbridge JJ, Xenocostas A, Moon RT and
Bhatia M: Glycogen synthase kinase-3 is an in vivo regulator of
hematopoietic stem cell repopulation. Nature Med. 12:89–98. 2006.
View Article : Google Scholar : PubMed/NCBI
|
64
|
Dhoke NR, Kalabathula E, Kaushik K,
Geesala R, Sravani B and Das A: Histone deacetylases differentially
regulate the proliferative phenotype of mouse bone marrow stromal
and hematopoietic stem/progenitor cells. Stem Cell Res. 17:170–180.
2016. View Article : Google Scholar : PubMed/NCBI
|
65
|
Papa L, Djedaini M and Hoffman R: Ex vivo
expansion of hematopoietic stem cells from human umbilical cord
blood-derived CD34+ cells using valproic acid. J Vis
Exp. 2019. View
Article : Google Scholar : PubMed/NCBI
|
66
|
Aztopal N, Erkisa M, Erturk E, Ulukaya E,
Tokullugil AH and Ari F: Valproic acid, a histone deacetylase
inhibitor, induces apoptosis in breast cancer stem cells. Chem Biol
Interact. 280:51–58. 2018. View Article : Google Scholar : PubMed/NCBI
|
67
|
Zhang M, Liu F, Zhou P, Wang Q, Xu C, Li
Y, Bian L, Liu Y, Zhou J, Wang F, et al: The mTOR signaling pathway
regulates macrophage differentiation from mouse myeloid progenitors
by inhibiting autophagy. Autophagy. 15:1150–1162. 2019. View Article : Google Scholar : PubMed/NCBI
|
68
|
Mossmann D, Park S and Hall MN: mTOR
signalling and cellular metabolism are mutual determinants in
cancer. Nat Rev Cancer. 18:744–757. 2018. View Article : Google Scholar : PubMed/NCBI
|
69
|
Luo Y, Li L, Zou P, Wang J, Shao L, Zhou D
and Liu L: Rapamycin enhances long-term hematopoietic
reconstitution of ex vivo expanded mouse hematopoietic stem cells
by inhibiting senescence. Transplantation. 97:20–29. 2014.
View Article : Google Scholar : PubMed/NCBI
|
70
|
Anastas JN, Zee BM, Kalin JH, Kim M, Guo
R, Alexandrescu S, Blanco MA, Giera S, Gillespie SM, Das J, et al:
Re-programing chromatin with a bifunctional LSD1/HDAC inhibitor
induces therapeutic differentiation in DIPG. Cancer Cell.
36:528–544.e10. 2019. View Article : Google Scholar : PubMed/NCBI
|