Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
January-2021 Volume 23 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2021 Volume 23 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Astragalus polysaccharide has a protective effect on hematopoiesis in an irradiated mouse model and decreases apoptosis in megakaryocytes

  • Authors:
    • Liang Li
    • Wanhua Xu
    • Chenju Yi
    • Yucai Cheng
    • Hongwu Xin
    • Hongman Xue
    • Chi-Kong Li
    • Xiaoyi Fang
    • Liuming Yang
    • Chun Chen
    • Mo Yang
  • View Affiliations / Copyright

    Affiliations: Research Center of The Seventh Affiliated Hospital, Sun Yat‑sen University, Shenzhen, Guangdong 518107, P.R. China, Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Medicine, Lianjiang People's Hospital, Lianjiang, Guangdong 524400, P.R. China, Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong 999077, SAR, P.R. China
  • Article Number: 15
    |
    Published online on: November 3, 2020
       https://doi.org/10.3892/mmr.2020.11653
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Huangqi, the dried root of Radix Astragali, is an essential herb in Traditional Chinese Medicine and has been used to promote hematopoiesis for centuries. Astragalus polysaccharide (ASPS), the bioactive compound of Huangqi, serves a crucial role in hematopoiesis. The aim of the present study was to investigate the hematopoietic effects, in particular the thrombopoietic effects, and the molecular mechanisms of ASPS using an irradiation‑induced myelosuppressive mouse model. Colony‑forming unit assays, flow cytometric analysis of apoptosis, ELISAs, Giemsa staining and western blotting were performed to determine the hematopoietic and anti‑apoptotic effects of ASPS. The results demonstrated that ASPS enhanced the recovery of red blood cells at day 21 following treatment, as well as platelets and white blood cells at day 14. In addition, ASPS promoted colony formation in all lineages (megakaryocytes, granulocyte monocytes, erythroid cells and fibroblasts). The morphological study of the bone marrow demonstrated that tri‑lineage hematopoiesis was preserved in the ASPS‑ and thrombopoietin (TPO)‑treated groups compared with the control group. The overall cellularity (mean total cell count/area) of the ASPS‑treated group was similar to that of the TPO‑treated group. Additionally, in vitro experiments indicated that treatment with 100 µg/ml ASPS exhibited the maximum effect on colony formation. ASPS attenuated cell apoptosis in megakaryocytic cells via inhibiting the mitochondrial caspase‑3 signaling pathway. In conclusion, ASPS promoted hematopoiesis in irradiated myelosuppressive mice possibly via enhancing hematopoietic stem/progenitor cell proliferation and inhibiting megakaryocytes apoptosis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Liebman HA: Thrombocytopenia in cancer patients. Thromb Res. 133 (Suppl 2):S63–S69. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Lieberman L, Bercovitz RS, Sholapur NS, Heddle NM, Stanworth SJ and Arnold DM: Platelet transfusions for critically ill patients with thrombocytopenia. Blood. 123:1146–1151; quiz 1280. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Cines DB, Gernsheimer T, Wasser J, Godeau B, Provan D, Lyons R, Altomare I, Wang X and Lopez A: Integrated analysis of long-term safety in patients with chronic immune thrombocytopaenia (ITP) treated with the thrombopoietin (TPO) receptor agonist romiplostim. Int J Hematol. 102:259–270. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Arnold DM, Vrbensky JR, Karim N, Smith JW, Liu Y, Ivetic N, Kelton JG and Nazy I: The effect of rituximab on anti-platelet autoantibody levels in patients with immune thrombocytopenia. Br J Haematol. 178:302–307. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Aubron C, Flint AW, Bailey M, Pilcher D, Cheng AC, Hegarty C, Martinelli A, Reade MC, Bellomo R and McQuilten Z: Is platelet transfusion associated with hospital-acquired infections in critically ill patients? Crit Care. 21:22017. View Article : Google Scholar : PubMed/NCBI

6 

Scheinberg P, Singulane CC, Barbosa LS and Scheinberg M: Successful platelet count recovery in lupus-associated thrombocytopenia with the thrombopoietin agonist eltrombopag. Clin Rheumatol. 33:1347–1349. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Shin SK, Pack SP, Oh JG, Kang NK, Chang MH, Chung YH, Kim SJ, Lee JW and Heo TH: Anti-erythropoietin and anti-thrombopoietin antibodies induced after administration of recombinant human erythropoietin. Int Immunopharmacol. 11:2237–2241. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Gong AG, Li N, Lau KM, Lee PS, Yan L, Xu ML, Lam CT, Kong AY, Lin HQ, Dong TT, et al: Calycosin orchestrates the functions of Danggui Buxue Tang, a Chinese herbal decoction composing of Astragali Radix and Angelica Sinensis Radix: An evaluation by using calycosin-knock out herbal extract. J Ethnopharmacol. 168:150–157. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Lin HQ, Gong AG, Wang HY, Duan R, Dong TT, Zhao KJ and Tsim KW: Danggui Buxue Tang (Astragali Radix and Angelicae Sinensis Radix) for menopausal symptoms: A review. J Ethnopharmacol. 199:205–210. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Liu C, Li J, Meng FY, Liang SX, Deng R, Li CK, Pong NH, Lau CP, Cheng SW, Ye JY, et al: Polysaccharides from the root of Angelica sinensis promotes hematopoiesis and thrombopoiesis through the PI3K/AKT pathway. BMC Complement Altern Med. 10:792010. View Article : Google Scholar : PubMed/NCBI

11 

Yang M, Chan GC, Deng R, Ng MH, Cheng SW, Lau CP, Ye JY, Wang L and Liu C: An herbal decoction of Radix astragali and Radix angelicae sinensis promotes hematopoiesis and thrombopoiesis. J Ethnopharmacol. 124:87–97. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Zhao M, Zhang ZF, Ding Y, Wang JB and Li Y: Astragalus polysaccharide improves palmitate-induced insulin resistance by inhibiting PTP1B and NF-κB in C2C12 myotubes. Molecules. 17:7083–7092. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Xie JH, Jin ML, Morris GA, Zha XQ, Chen HQ, Yi Y, Li JE, Wang ZJ, Gao J, Nie SP, et al: Advances on bioactive polysaccharides from medicinal plants. Crit Rev Food Sci Nutr. 56 (Suppl 1):S60–S84. 2016. View Article : Google Scholar : PubMed/NCBI

14 

National Research Council, . Guide for the Care and Use of Laboratory Animals. National Academies Press; Washington, DC: 1985

15 

Yuan S, Piao X, Li D, Kim S, Lee H and Guo P: Effects of dietary Astragalus polysaccharide on growth performance and immune function in weaned pigs. Anim Sci. 82:501–507. 2006. View Article : Google Scholar

16 

Staub A: Removeal of protein-Sevag method. Methods Carbohydr Chem. 5:5–6. 1965.

17 

Inagaki K, Oda T, Naka Y, Shinkai H, Komatsu N and Iwamura H: Induction of megakaryocytopoiesis and thrombocytopoiesis by JTZ-132, a novel small molecule with thrombopoietin mimetic activities. Blood. 104:58–64. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Ye JY, Chan GC, Qiao L, Lian Q, Meng FY, Luo XQ, Khachigian LM, Ma M, Deng R, Chen JL, et al: Platelet-derived growth factor enhances platelet recovery in a murine model of radiation-induced thrombocytopenia and reduces apoptosis in megakaryocytes via its receptors and the PI3-k/Akt pathway. Haematologica. 95:1745–1753. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Yang M, Li K, Chui CM, Yuen PM, Chan PK, Chuen CK, Li CK and Fok TF: Expression of interleukin (IL) 1 type I and type II receptors in megakaryocytic cells and enhancing effects of IL-1beta on megakaryocytopoiesis and NF-E2 expression. Br J Haematol. 111:371–380. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Yang M, Li K, Ng PC, Chuen CK, Lau TK, Cheng YS, Liu YS, Li CK, Yuen PM, James AE, et al: Promoting effects of serotonin on hematopoiesis: Ex vivo expansion of cord blood CD34+ stem/progenitor cells, proliferation of bone marrow stromal cells, and antiapoptosis. Stem Cells. 25:1800–1806. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Li K, Sung RY, Huang WZ, Yang M, Pong NH, Lee SM, Chan WY, Zhao H, To MY, Fok TF, et al: Thrombopoietin protects against in vitro and in vivo cardiotoxicity induced by doxorubicin. Circulation. 113:2211–2220. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Porter AG and Jänicke RU: Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 6:99–104. 1999. View Article : Google Scholar : PubMed/NCBI

23 

Zhang J, Zhou S, Zhou Y, Feng F, Wang Q, Zhu X, Zhao J, Fu H, Lv M, Ai H, et al: Adipose-derived mesenchymal stem cells (ADSCs) with the potential to ameliorate platelet recovery, enhance megakaryopoiesis, and inhibit apoptosis of bone marrow cells in a mouse model of radiation-induced thrombocytopenia. Cell Transplant. 25:261–273. 2016. View Article : Google Scholar : PubMed/NCBI

24 

MacVittie TJ, Farese AM, Smith WG, Baum CM, Burton E and McKearn JP: Myelopoietin, an engineered chimeric IL-3 and G-CSF receptor agonist, stimulates multilineage hematopoietic recovery in a nonhuman primate model of radiation-induced myelosuppression. Blood. 95:837–845. 2000. View Article : Google Scholar : PubMed/NCBI

25 

He X, Shu J, Xu L, Lu C and Lu A: Inhibitory effect of Astragalus polysaccharides on lipopolysaccharide-induced TNF-α and IL-1β production in THP-1 cells. Molecules. 17:3155–3164. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Xue H, Gan F, Zhang Z, Hu J, Chen X and Huang K: Astragalus polysaccharides inhibits PCV2 replication by inhibiting oxidative stress and blocking NF-κB pathway. Int J Biol Macromol. 81:22–30. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Han L, Wang HX and Lu MI: Effect of Astragalus polysaccharide on LPS-induced cardiomyocyte apoptosis by inhibiting NF-κB and JNK signaling pathway. Chinese Pharmacol Bull. 34:243–249. 2018.

28 

Chuen CK, Li K, Yang M, Fok TF, Li CK, Chui CM and Yuen PM: Interleukin-1β up-regulates the expression of thrombopoietin and transcription factors c-Jun, c-Fos, GATA-1, and NF-E2 in megakaryocytic cells. J Lab Clin Med. 143:75–88. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Xiao B, Xu Y, He H, Jiang QL, Li SY, Shu HY, Liang EY, Yi ZS, Ye JY, Huang LF, et al: Anti-apoptotic effect of Astragalus Polysaccharide on myeloid cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 21:1243–1247. 2013.(In Chinese). PubMed/NCBI

30 

Yang M, Jiang Q, Xiao B, Liu C, Li S, Huang L, Chong B and Meng F: Astragalus polysaccharide has hematopoietic and thrombopoietic activities in an irradiation mouse model. Blood. 122:42162013. View Article : Google Scholar

31 

Jiang X, Zeng L, Huang J, Zhou H and Liu Y: Arctigenin, a natural lignan compound, induces apoptotic death of hepatocellular carcinoma cells via suppression of PI3-K/Akt signaling. J Biochem Mol Toxicol. 29:458–464. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Liu R, Ding L, Yu MH, Wang HQ, Li WC, Cao Z, Zhang P, Yao BC, Tang J, Ke Q, et al: Effects of dihydrotestosterone on adhesion and proliferation via PI3-K/Akt signaling in endothelial progenitor cells. Endocrine. 46:634–643. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Martini M, De Santis MC, Braccini L, Gulluni F and Hirsch E: PI3K/AKT signaling pathway and cancer: An updated review. Ann Med. 46:372–383. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Hu C, Xu M, Qin R, Chen W and Xu X: Wogonin induces apoptosis and endoplasmic reticulum stress in HL-60 leukemia cells through inhibition of the PI3K-AKT signaling pathway. Oncol Rep. 33:3146–3154. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Ma W, Wang DD, Li L, Feng YK, Gu HM, Zhu GM, Piao JH, Yang Y, Gao X and Zhang PX: Caveolin-1 plays a key role in the oleanolic acid-induced apoptosis of HL-60 cells. Oncol Rep. 32:293–301. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Liu Y, Bi T, Wang G, Dai W, Wu G, Qian L, Gao Q and Shen G: Lupeol inhibits proliferation and induces apoptosis of human pancreatic cancer PCNA-1 cells through AKT/ERK pathways. Naunyn Schmiedebergs Arch Pharmacol. 388:295–304. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Hitchcock IS and Kaushansky K: Thrombopoietin from beginning to end. Br J Haematol. 165:259–268. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Pulikkan JA, Madera D, Xue L, Bradley P, Landrette SF, Kuo YH, Abbas S, Zhu LJ, Valk P and Castilla LH: Thrombopoietin/MPL participates in initiating and maintaining RUNX1-ETO acute myeloid leukemia via PI3K/AKT signaling. Blood. 120:868–879. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Chan KY, Xiang P, Zhou L, Li K, Ng PC, Wang CC, Zhang L, Deng HY, Pong NH, Zhao H, et al: Thrombopoietin protects against doxorubicin-induced cardiomyopathy, improves cardiac function, and reversely alters specific signalling networks. Eur J Heart Fail. 13:366–376. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Su RJ, Zhang XB, Li K, Yang M, Li CK, Fok TF, James AE, Pong H and Yuen PM: Platelet-derived growth factor promotes ex vivo expansion of CD34+ cells from human cord blood and enhances long-term culture-initiating cells, non-obese diabetic/severe combined immunodeficient repopulating cells and formation of adherent cells. Br J Haematol. 117:735–746. 2002. View Article : Google Scholar : PubMed/NCBI

41 

Ye JY, Liang EY, Cheng YS, Chan GC, Ding Y, Meng F, Ng MH, Chong BH, Lian Q and Yang M: Serotonin enhances megakaryopoiesis and proplatelet formation via p-Erk1/2 and F-actin reorganization. Stem Cells. 32:2973–2982. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Kilkenny C, Browne WJ, Cuthill IC, Emerson M and Altman DG: Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. J Pharmacol Pharmacother. 1:94–99. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li L, Xu W, Yi C, Cheng Y, Xin H, Xue H, Li C, Fang X, Yang L, Chen C, Chen C, et al: Astragalus polysaccharide has a protective effect on hematopoiesis in an irradiated mouse model and decreases apoptosis in megakaryocytes. Mol Med Rep 23: 15, 2021.
APA
Li, L., Xu, W., Yi, C., Cheng, Y., Xin, H., Xue, H. ... Yang, M. (2021). Astragalus polysaccharide has a protective effect on hematopoiesis in an irradiated mouse model and decreases apoptosis in megakaryocytes. Molecular Medicine Reports, 23, 15. https://doi.org/10.3892/mmr.2020.11653
MLA
Li, L., Xu, W., Yi, C., Cheng, Y., Xin, H., Xue, H., Li, C., Fang, X., Yang, L., Chen, C., Yang, M."Astragalus polysaccharide has a protective effect on hematopoiesis in an irradiated mouse model and decreases apoptosis in megakaryocytes". Molecular Medicine Reports 23.1 (2021): 15.
Chicago
Li, L., Xu, W., Yi, C., Cheng, Y., Xin, H., Xue, H., Li, C., Fang, X., Yang, L., Chen, C., Yang, M."Astragalus polysaccharide has a protective effect on hematopoiesis in an irradiated mouse model and decreases apoptosis in megakaryocytes". Molecular Medicine Reports 23, no. 1 (2021): 15. https://doi.org/10.3892/mmr.2020.11653
Copy and paste a formatted citation
x
Spandidos Publications style
Li L, Xu W, Yi C, Cheng Y, Xin H, Xue H, Li C, Fang X, Yang L, Chen C, Chen C, et al: Astragalus polysaccharide has a protective effect on hematopoiesis in an irradiated mouse model and decreases apoptosis in megakaryocytes. Mol Med Rep 23: 15, 2021.
APA
Li, L., Xu, W., Yi, C., Cheng, Y., Xin, H., Xue, H. ... Yang, M. (2021). Astragalus polysaccharide has a protective effect on hematopoiesis in an irradiated mouse model and decreases apoptosis in megakaryocytes. Molecular Medicine Reports, 23, 15. https://doi.org/10.3892/mmr.2020.11653
MLA
Li, L., Xu, W., Yi, C., Cheng, Y., Xin, H., Xue, H., Li, C., Fang, X., Yang, L., Chen, C., Yang, M."Astragalus polysaccharide has a protective effect on hematopoiesis in an irradiated mouse model and decreases apoptosis in megakaryocytes". Molecular Medicine Reports 23.1 (2021): 15.
Chicago
Li, L., Xu, W., Yi, C., Cheng, Y., Xin, H., Xue, H., Li, C., Fang, X., Yang, L., Chen, C., Yang, M."Astragalus polysaccharide has a protective effect on hematopoiesis in an irradiated mouse model and decreases apoptosis in megakaryocytes". Molecular Medicine Reports 23, no. 1 (2021): 15. https://doi.org/10.3892/mmr.2020.11653
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team