Calcitonin gene‑related peptide‑mediated pharmacological effects in cardiovascular and gastrointestinal diseases (Review)

  • Authors:
    • Wan-Jun Ma
    • You-Cong Yin
    • Bi-Kui Zhang
    • Yuan-Jian Li
    • Wen-Qun Li
  • View Affiliations

  • Published online on: November 4, 2020     https://doi.org/10.3892/mmr.2020.11665
  • Article Number: 27
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Abstract

Calcitonin gene‑related peptide (CGRP) is the predominant neurotransmitter located in sensory nerves. This peptide is extensively distributed in central and peripheral tissues. CGRP causes relaxation of cardiovascular smooth muscle cells and confers protection against ischaemic myocardium and cardiac remodeling. The pharmacological effects of nitroglycerine and rutaecarpine have been demonstrated to be associated with an increase in the synthesis and release of CGRP. In the gastrointestinal tissues, CGRP participates in the regulation of gastrointestinal function, and exerts protective effects on gastric mucosa. Rutaecarpine, capsaicin and its derivatives, such as evodiamine, decrease gastric mucosal damage induced by several factors, including increased synthesis and release of CGRP. Taken together, this review focuses on the pharmacological effects of several CGRP related canonical drugs and suggests that synthesis and secretion of CGRP exhibit significant therapeutic effects in the occurrence and development of cardiovascular and gastrointestinal diseases.
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January-2021
Volume 23 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Ma W, Yin Y, Zhang B, Li Y and Li W: Calcitonin gene‑related peptide‑mediated pharmacological effects in cardiovascular and gastrointestinal diseases (Review). Mol Med Rep 23: 27, 2021
APA
Ma, W., Yin, Y., Zhang, B., Li, Y., & Li, W. (2021). Calcitonin gene‑related peptide‑mediated pharmacological effects in cardiovascular and gastrointestinal diseases (Review). Molecular Medicine Reports, 23, 27. https://doi.org/10.3892/mmr.2020.11665
MLA
Ma, W., Yin, Y., Zhang, B., Li, Y., Li, W."Calcitonin gene‑related peptide‑mediated pharmacological effects in cardiovascular and gastrointestinal diseases (Review)". Molecular Medicine Reports 23.1 (2021): 27.
Chicago
Ma, W., Yin, Y., Zhang, B., Li, Y., Li, W."Calcitonin gene‑related peptide‑mediated pharmacological effects in cardiovascular and gastrointestinal diseases (Review)". Molecular Medicine Reports 23, no. 1 (2021): 27. https://doi.org/10.3892/mmr.2020.11665