Effects and mechanism of microRNA‑218 against lung cancer
- Authors:
- Yan Chen
- Ji-Lin Yang
- Zhen-Zhen Xue
- Qiu-Chen Cai
- Chun Hou
- Hong-Juan Li
- Liu-Xin Zhao
- Yin Zhang
- Cheng-Wei Gao
- Li Cong
- Tian-Zuo Wang
- Dong-Mei Chen
- Guo-Sheng Li
- Shi-Qing Luo
- Qian Yao
- Chan-Juan Yang
- Qi-Shun Zhu
- Chuan-Hai Cao
-
Affiliations: School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, P.R. China, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650031, P.R. China, School of Chemical Science and Technology, Yunnan University, Kunming, Yunnan 650091, P.R. China, YinMore Biotech Co., Ltd., Kunming, Yunnan 650224, P.R. China, Yunnan Cancer Hospital and The Third Affiliated Hospital of Kunming Medical University and Yunnan Cancer Center, Kunming, Yunnan 650118, P.R. China, Byrd Alzheimer's Institute, University of South Florida, Tampa, FL 33613, USA - Published online on: November 4, 2020 https://doi.org/10.3892/mmr.2020.11666
- Article Number: 28
-
Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
|
Miller KD, Nogueira L, Mariotto AB, Rowland JH, Yabroff KR, Alfano CM, Jemal A, Kramer JL and Siegel RL: Cancer treatment and survivorship statistics, 2019. CA Cancer J Clin. 69:363–385. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Li J, Guo W, Ran J, Tang R, Lin H, Chen X, Ning B, Li J, Zhou Y, Chen LC, et al: Five-year lung cancer mortality risk analysis and topography in Xuan Wei: A spatiotemporal correlation analysis. BMC Public Health. 19:1732019. View Article : Google Scholar : PubMed/NCBI | |
|
Cao Y and Gao H: Prevalence and causes of air pollution and lung cancer in Xuanwei City and Fuyuan County, Yunnan Province, China. Front Med. 6:217–220. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Xiao Y, Shao Y, Yu X and Zhou G: The epidemic status and risk factors of lung cancer in Xuanwei City, Yunnan Province, China. Front Med. 6:388–394. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Wang J, Duan Y, Meng QH, Gong R, Guo C, Zhao Y and Zhang Y: Integrated analysis of DNA methylation profiling and gene expression profiling identifies novel markers in lung cancer in Xuanwei, China. PLoS One. 13:e02031552018. View Article : Google Scholar : PubMed/NCBI | |
|
Li J, Ran J, Chen LC, Costa M, Huang Y, Chen X and Tian L: Bituminous coal combustion and Xuan Wei Lung cancer: A review of the epidemiology, intervention, carcinogens, and carcinogenesis. Arch Toxicol. 93:573–583. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Yang Y, Chen K, Zhou Y, Hu Z, Chen S and Huang Y: Application of serum microRNA-9-5p, 21-5p, and 223-3p combined with tumor markers in the diagnosis of non-small-cell lung cancer in Yunnan in southwestern China. OncoTargets Ther. 11:587–597. 2018. View Article : Google Scholar | |
|
Yan FC, Wang QQ, Ruan YH, Ma LJ, Jia JT, Jin KW and Chin J: Establishment and biological characteristics of lung cancer cell line XWLC-05. Ai Zheng. 26:21–25. 2007.PubMed/NCBI | |
|
Lei J, Li QH, Yang JL, Liu F, Wang L, Xu WM and Zhao WX: The antitumor effects of oncolytic adenovirus H101 against lung cancer. Int J Oncol. 47:555–562. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Xiong G, Chen X, Zhang Q, Fang Y, Chen W, Li C and Zhang J: RNA interference influenced the proliferation and invasion of XWLC-05 lung cancer cells through inhibiting aquaporin 3. Biochem Biophys Res Commun. 485:627–634. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Y, He S, Mei R, Kang Y, Duan J, Wei R, Xiang C, Wu Y, Lu X, Cai Z, et al: miR 29a suppresses IL 13 induced cell invasion by inhibiting YY1 in the AKT pathway in lung adenocarcinoma A549 cells. Oncol Rep. 39:2613–2623. 2018.PubMed/NCBI | |
|
Cai L, Lin S, Girard L, Zhou Y, Yang L, Ci B, Zhou Q, Luo D, Yao B, Tang H, et al: LCE: An open web portal to explore gene expression and clinical associations in lung cancer. Oncogene. 38:2551–2564. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Tie J, Pan Y, Zhao L, Wu K, Liu J, Sun S, Guo X, Wang B, Gang Y, Zhang Y, et al: MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor. PLoS Genet. 6:e10008792010. View Article : Google Scholar : PubMed/NCBI | |
|
Esquela-Kerscher A and Slack FJ: Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer. 6:259–269. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Lee RC, Feinbaum RL and Ambros V: The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 75:843–854. 1993. View Article : Google Scholar : PubMed/NCBI | |
|
Pu M, Chen J, Tao Z, Miao L, Qi X, Wang Y and Ren J: Regulatory network of miRNA on its target: Coordination between transcriptional and post-transcriptional regulation of gene expression. Cell Mol Life Sci. 76:441–451. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Mestdagh P, Boström AK, Impens F, Fredlund E, Van Peer G, De Antonellis P, von Stedingk K, Ghesquière B, Schulte S, Dews M, et al: The miR-17-92 microRNA cluster regulates multiple components of the TGF-β pathway in neuroblastoma. Mol Cell. 40:762–773. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Lewis BP, Burge CB and Bartel DP: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 120:15–20. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Naeli P, Yousefi F, Ghasemi Y, Savardashtaki A and Mirzaei H: The role of microRNAs in lung cancer: Implications for diagnosis and therapy. Curr Mol Med. 20:90–101. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Uddin A and Chakraborty S: Role of miRNAs in lung cancer. J Cell Physiol. April 20–2018.(Epub ahead of print). View Article : Google Scholar | |
|
Lin PY, Yu SL and Yang PC: MicroRNA in lung cancer. Br J Cancer. 103:1144–1148. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Xu LF, Wu ZP, Chen Y, Zhu QS, Hamidi S and Navab R: MicroRNA-21 (miR-21) regulates cellular proliferation, invasion, migration, and apoptosis by targeting PTEN, RECK and Bcl-2 in lung squamous carcinoma, Gejiu City, China. PLoS One. 9:e1036982014. View Article : Google Scholar : PubMed/NCBI | |
|
Deng M, Zeng C, Lu X, He X, Zhang R, Qiu Q, Zheng G, Jia X, Liu H and He Z: miR-218 suppresses gastric cancer cell cycle progression through the CDK6/Cyclin D1/E2F1 axis in a feedback loop. Cancer Lett. 403:175–185. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Guan B, Wu K, Zeng J, Xu S, Mu L, Gao Y, Wang K, Ma Z, Tian J, Shi Q, et al: Tumor-suppressive microRNA-218 inhibits tumor angiogenesis via targeting the mTOR component RICTOR in prostate cancer. Oncotarget. 8:8162–8172. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Jun GJ, Zhong GG and Ming ZS: miR-218 inhibits the proliferation of glioma U87 cells through the inactivation of the CDK6/cyclin D1/p21Cip1/Waf1 pathway. Oncol Lett. 9:2743–2749. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Tu K, Li C, Zheng X, Yang W, Yao Y and Liu Q: Prognostic significance of miR-218 in human hepatocellular carcinoma and its role in cell growth. Oncol Rep. 32:1571–1577. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Liu B, Tian Y, Li F, Zhao Z, Jiang X, Zhai C, Han X and Zhang L: Tumor-suppressing roles of miR-214 and miR-218 in breast cancer. Oncol Rep. 35:3178–3184. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Wang T, Xu L, Jia R and Wei J: MiR-218 suppresses the metastasis and EMT of HCC cells via targeting SERBP1. Acta Biochim Biophys Sin (Shanghai). 49:383–391. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang X, Shi H, Tang H, Fang Z, Wang J and Cui S: miR-218 inhibits the invasion and migration of colon cancer cells by targeting the PI3K/Akt/mTOR signaling pathway. Int J Mol Med. 35:1301–1308. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Davidson MR, Larsen JE, Yang IA, Hayward NK, Clarke BE, Duhig EE, Passmore LH, Bowman RV and Fong KM: MicroRNA-218 is deleted and downregulated in lung squamous cell carcinoma. PLoS One. 5:e125602010. View Article : Google Scholar : PubMed/NCBI | |
|
Wu DW, Cheng YW, Wang J, Chen CY and Lee H: Paxillin predicts survival and relapse in non-small cell lung cancer by microRNA-218 targeting. Cancer Res. 70:10392–10401. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Yang Y, Ding L, Hu Q, Xia J, Sun J, Wang X, Xiong H, Gurbani D, Li L, Liu Y, et al: MicroRNA-218 functions as a tumor suppressor in lung cancer by targeting IL-6/STAT3 and negatively correlates with poor prognosis. Mol Cancer. 16:1412017. View Article : Google Scholar : PubMed/NCBI | |
|
Shi ZM, Wang L, Shen H, Jiang CF, Ge X, Li DM, Wen YY, Sun HR, Pan MH, Li W, et al: Downregulation of miR-218 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer by targeting Slug/ZEB2 signaling. Oncogene. 36:2577–2588. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu K, Ding H, Wang W, Liao Z, Fu Z, Hong Y, Zhou Y, Zhang CY and Chen X: Tumor-suppressive miR-218-5p inhibits cancer cell proliferation and migration via EGFR in non-small cell lung cancer. Oncotarget. 7:28075–28085. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Song L, Li D, Zhao Y, Gu Y, Zhao D, Li X, Bai X, Sun Y, Zhang X, Sun H, et al: miR-218 suppressed the growth of lung carcinoma by reducing MEF2D expression. Tumour Biol. 37:2891–2900. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Chiu KL, Kuo TT, Kuok QY, Lin YS, Hua CH, Lin CY, Su PY, Lai LC and Sher YP: ADAM9 enhances CDCP1 protein expression by suppressing miR-218 for lung tumor metastasis. Sci Rep. 5:164262015. View Article : Google Scholar : PubMed/NCBI | |
|
Xie J, Yu F, Li D, Zhu X, Zhang X and Lv Z: MicroRNA-218 regulates cisplatin (DPP) chemosensitivity in non-small cell lung cancer by targeting RUNX2. Tumour Biol. 37:1197–1204. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang C, Ge S, Hu C, Yang N and Zhang J: MiRNA-218, a new regulator of HMGB1, suppresses cell migration and invasion in non-small cell lung cancer. Acta Biochim Biophys Sin (Shanghai). 45:1055–1061. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Zeng F, Wang Q, Wang S, Liang S, Huang W, Guo Y, Peng J, Li M, Zhu W and Guo L: Linc00173 promotes chemoresistance and progression of small cell lung cancer by sponging miR-218 to regulate Etk expression. Oncogene. 39:293–307. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Jin X, Liu X, Zhang Z and Guan Y: lncRNA CCAT1 acts as a microRNA-218 sponge to increase gefitinib resistance in NSCLC by targeting HOXA1. Mol Ther Nucleic Acids. 19:1266–1275. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Z, Lu C, Zhao G, Han X, Dong K, Wang C, Guan J-Z and Wang Z: Downregulation of miR-218 by nicotine promotes cell proliferation through targeting CDK6 in non-small cell lung cancer. J Cell Biochem. 120:18370–18377. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Li YJ, Zhang W, Xia H, Zhang BS, Chen P, Zhao YL and Li J: miR-218 suppresses epithelial-to-mesenchymal transition by targeting Robo1 and Ecop in lung adenocarcinoma cells. Future Oncol. 13:2571–2582. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Singh R, Letai A and Sarosiek K: Regulation of apoptosis in health and disease: The balancing act of BCL-2 family proteins. Nat Rev Mol Cell Biol. 20:175–193. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Radha G and Raghavan SC: BCL2: A promising cancer therapeutic target. Biochim Biophys Acta Rev Cancer. 1868:309–314. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Hata AN, Engelman JA and Faber AC: The BCL2 family: Key mediators of the apoptotic response to targeted anticancer therapeutics. Cancer Discov. 5:475–487. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Wang M-C, Li C-L, Cui J, Jiao M, Wu T, Jing LI and Nan K-J: BMI-1, a promising therapeutic target for human cancer. Oncol Lett. 10:583–588. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Meng X, Wang Y, Zheng X, Liu C, Su B, Nie H, Zhao B, Zhao X and Yang H: shRNA-mediated knockdown of Bmi-1 inhibit lung adenocarcinoma cell migration and metastasis. Lung Cancer. 77:24–30. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Siddique HR and Saleem M: Role of BMI1, a stem cell factor, in cancer recurrence and chemoresistance: Preclinical and clinical evidences. Stem Cells. 30:372–378. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Gkountakos A, Sartori G, Falcone I, Piro G, Ciuffreda L, Carbone C, Tortora G, Scarpa A, Bria E, Milella M, et al: PTEN in lung cancer: Dealing with the problem, building on new knowledge and turning the game around. Cancers (Basel). 11:11412019. View Article : Google Scholar | |
|
Álvarez-Garcia V, Tawil Y, Wise HM and Leslie NR: Mechanisms of PTEN loss in cancer: It's all about diversity. Semin Cancer Biol. 59:66–79. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Papa A and Pandolfi PP: The PTEN-PI3K axis in cancer. Biomolecules. 9:1532019. View Article : Google Scholar | |
|
Sarvagalla S, Kolapalli SP and Vallabhapurapu S: The two sides of YY1 in cancer: A friend and a foe. Front Oncol. 9:12302019. View Article : Google Scholar : PubMed/NCBI | |
|
Wang CC, Tsai MF, Hong TM, Chang GC, Chen CY, Yang WM, Chen JJW and Yang PC: The transcriptional factor YY1 upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion. Oncogene. 24:4081–4093. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Huang T, Wang G, Yang L, Peng B, Wen Y, Ding G and Wang Z: Transcription factor YY1 modulates lung cancer progression by activating lncRNA-PVT1. DNA Cell Biol. 36:947–958. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Liu J, Blackhall F, Seiden-Long I, Jurisica I, Navab R, Liu N, Radulovich N, Wigle D, Sultan M, Hu J, et al: Modeling of lung cancer by an orthotopically growing H460SM variant cell line reveals novel candidate genes for systemic metastasis. Oncogene. 23:6316–6324. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Li W, Wang W, Ding M, Zheng X, Ma S and Wang X: MiR-1244 sensitizes the resistance of non-small cell lung cancer A549 cell to cisplatin. Cancer Cell Int. 16:302016. View Article : Google Scholar : PubMed/NCBI | |
|
Liang CC, Park AY and Guan JL: In vitro scratch assay: A convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc. 2:329–333. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Vermeulen R, Downward GS, Zhang J, Hu W, Portengen L, Bassig BA, Hammond SK, Wong JYY, Li J, Reiss B, et al: Constituents of household air pollution and risk of lung cancer among never-smoking women in Xuanwei and Fuyuan, China. Environ Health Perspect. 127:970012019. View Article : Google Scholar : PubMed/NCBI | |
|
Chen G, Sun X, Ren H, Wan X, Huang H, Ma X, Ning B, Zou X, Hu W and Yang G: The mortality patterns of lung cancer between 1990 and 2013 in Xuanwei, China. Lung Cancer. 90:155–160. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Shao C, Yang F, Qin Z, Jing X, Shu Y and Shen H: The value of miR-155 as a biomarker for the diagnosis and prognosis of lung cancer: A systematic review with meta-analysis. BMC Cancer. 19:11032019. View Article : Google Scholar : PubMed/NCBI | |
|
Bica-Pop C, Cojocneanu-Petric R, Magdo L, Raduly L, Gulei D and Berindan-Neagoe I: Overview upon miR-21 in lung cancer: Focus on NSCLC. Cell Mol Life Sci. 75:3539–3551. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou B, Yuan W and Li X: Long intergenic noncoding RNA 319 (linc00319) promotes cell proliferation and invasion in lung cancer cells by directly downregulating the tumor suppressor miR-32. Oncol Rese. Aug 11–2017.(Epub ahead of print). View Article : Google Scholar | |
|
Zhang L, Liao Y and Tang L: MicroRNA-34 family: A potential tumor suppressor and therapeutic candidate in cancer. J Exp Clin Cancer Res. 38:532019. View Article : Google Scholar : PubMed/NCBI | |
|
Lu YF, Zhang L, Waye MMY, Fu WM and Zhang JF: MiR-218 mediates tumorigenesis and metastasis: Perspectives and implications. Exp Cell Res. 334:173–182. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
He X, Dong Y, Wu CW, Zhao Z, Ng SSM, Chan FKL, Sung JJY and Yu J: MicroRNA-218 inhibits cell cycle progression and promotes apoptosis in colon cancer by downregulating BMI1 polycomb ring finger oncogene. Mol Med. 18:1491–1498. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Hu Y, Xu K and Yagüe E: miR-218 targets survivin and regulates resistance to chemotherapeutics in breast cancer. Breast Cancer Res Treat. 151:269–280. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Zarogoulidis P, Petanidis S, Kioseoglou E, Domvri K, Anestakis D and Zarogoulidis K: miR-205 and miR-218 expression is associated with carboplatin chemoresistance and regulation of apoptosis via Mcl-1 and Survivin in lung cancer cells. Cell Signal. 27:1576–1588. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Song LB, Li J, Liao WT, Feng Y, Yu CP, Hu LJ, Kong QL, Xu LH, Zhang X, Liu WL, et al: The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest. 119:3626–3636. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Choi Y, Zhang J, Murga C, Yu H, Koller E, Monia BP, Gutkind JS and Li W: PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells. Oncogene. 21:5289–5300. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Lu XX, Cao LY, Chen X, Xiao J, Zou Y and Chen Q: PTEN inhibits cell proliferation, promotes cell apoptosis, and induces cell cycle arrest via downregulating the PI3K/AKT/ hTERT pathway in lung adenocarcinoma A549 cells. BioMed Res Int. 2016:24768422016. View Article : Google Scholar : PubMed/NCBI | |
|
Gao Y, Sun L, Wu Z, Xuan C, Zhang J, You Y and Chen X: miR-218 inhibits the proliferation of human glioma cells through downregulation of Yin Yang 1. Mol Med Rep. 17:1926–1932. 2018.PubMed/NCBI | |
|
Wang CC, Tsai MF, Dai TH, Hong TM, Chan WK, Chen JJW and Yang PC: Synergistic activation of the tumor suppressor, HLJ1, by the transcription factors YY1 and activator protein 1. Cancer Res. 67:4816–4826. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Tan H, Huang S, Zhang Z, Qian X, Sun P and Zhou X: Pan-cancer analysis on microRNA-associated gene activation. EBioMedicine. 43:82–97. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Jacobs JJ, Scheijen B, Voncken JW, Kieboom K, Berns A and van Lohuizen M: Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. Genes Dev. 13:2678–2690. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Shrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP and Calame K: Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc. Science. 262:1889–1892. 1993. View Article : Google Scholar : PubMed/NCBI | |
|
Austen M, Cerni C, Lüscher-Firzlaff JM and Lüscher B: YY1 can inhibit c-Myc function through a mechanism requiring DNA binding of YY1 but neither its transactivation domain nor direct interaction with c-Myc. Oncogene. 17:511–520. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Guo BH, Feng Y, Zhang R, Xu LH, Li MZ, Kung HF, Song LB and Zeng MS: Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer. Mol Cancer. 10:102011. View Article : Google Scholar : PubMed/NCBI | |
|
Xu L, Li Y, Yan D, He J and Liu D: MicroRNA-183 inhibits gastric cancer proliferation and invasion via directly targeting Bmi-1. Oncol Lett. 8:2345–2351. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
He Z, Xia Y, Pan C, Ma T, Liu B, Wang J, Chen L and Chen Y: Up-regulation of miR-452 inhibits metastasis of non-small cell lung cancer by regulating BMI1. Cell Physiol Biochem. 37:387–398. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Guo S, Xu X, Tang Y, Zhang C, Li J, Ouyang Y, Ju J, Bie P and Wang H: miR-15a inhibits cell proliferation and epithelial to mesenchymal transition in pancreatic ductal adenocarcinoma by down-regulating Bmi-1 expression. Cancer Lett. 344:40–46. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Tu Y, Gao X, Li G, Fu H, Cui D, Liu H, Jin W and Zhang Y: MicroRNA-218 inhibits glioma invasion, migration, proliferation, and cancer stem-like cell self-renewal by targeting the polycomb group gene Bmi1. Cancer Res. 73:6046–6055. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Li X, Yang Z, Song W, Zhou L, Li Q, Tao K, Zhou J, Wang X, Zheng Z, You N, et al: Overexpression of Bmi-1 contributes to the invasion and metastasis of hepatocellular carcinoma by increasing the expression of matrix metalloproteinase (MMP) 2, MMP-9 and vascular endothelial growth factor via the PTEN/PI3K/Akt pathway. Int J Oncol. 43:793–802. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou Y, Wang X, Huang Y, Chen Y, Zhao G, Yao Q, Jin C, Huang Y, Liu X and Li G: Down-regulated SOX4 expression suppresses cell proliferation, metastasis and induces apoptosis in Xuanwei female lung cancer patients. J Cell Biochem. 116:1007–1018. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Wang D, Hao T, Pan Y, Qian X and Zhou D: Increased expression of SOX4 is a biomarker for malignant status and poor prognosis in patients with non-small cell lung cancer. Mol Cell Biochem. 402:75–82. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Li R, Liu Y, Wang T, Tang J, Xie L, Yao Z, Li K, Liao Y, Zhou L, Geng Z, et al: The characteristics of lung cancer in Xuanwei County: A review of differentially expressed genes and noncoding RNAs on cell proliferation and migration. Biomed Pharmacother. 119:1093122019. View Article : Google Scholar : PubMed/NCBI | |
|
Hu Z, Wang X, Yang Y, Zhao Y, Shen Z and Huang Y: MicroRNA expression profiling of lung adenocarcinoma in Xuanwei, China: A preliminary study. Medicine (Baltimore). 98:e157172019. View Article : Google Scholar : PubMed/NCBI | |
|
Yu XJ, Yang MJ, Zhou B, Wang GZ, Huang YC, Wu LC, Cheng X, Wen ZS, Huang JY, Zhang YD, et al: Characterization of somatic mutations in air pollution-related lung cancer. EBioMedicine. 2:583–590. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Kanwal M, Ding XJ, Song X, Zhou GB and Cao Y: MUC16 overexpression induced by gene mutations promotes lung cancer cell growth and invasion. Oncotarget. 9:12226–12239. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Pan HL, Wen ZS, Huang YC, Cheng X, Wang GZ, Zhou YC, Wang ZY, Guo YQ, Cao Y and Zhou GB: Down-regulation of microRNA-144 in air pollution-related lung cancer. Sci Rep. 5:143312015. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou G: Tobacco, air pollution, environmental carcinogenesis, and thoughts on conquering strategies of lung cancer. Cancer Biol Med. 16:700–713. 2019.PubMed/NCBI | |
|
Markou A, Zavridou M and Lianidou ES: miRNA-21 as a novel therapeutic target in lung cancer. Lung Cancer (Auckl). 7:19–27. 2016.PubMed/NCBI | |
|
Li YL, Liu XM, Zhang CY, Zhou JB, Shao Y, Liang C, Wang HM, Hua ZY, Lu SD and Ma ZL: MicroRNA-34a/EGFR axis plays pivotal roles in lung tumorigenesis. Oncogenesis. 6:e3722017. View Article : Google Scholar : PubMed/NCBI | |
|
Wu S, Shen W, Pan Y, Zhu M, Xie K, Geng L, Wang Y, Liang Y, Xu J, Cao S, et al: Genetic variations in key MicroRNAs are associated with the survival of nonsmall cell lung cancer. Medicine (Baltimore). 94:e20842015. View Article : Google Scholar : PubMed/NCBI | |
|
Liuxin Z: Role of miR-34a in local lung cancer cell lines XWLC-05 and YTMLC-90 (unpublished PhD thesis). Yunnan University; 2018 |
