Open Access

Neuromodulation of bone: Role of different peptides and their interactions (Review)

  • Authors:
    • Xiaoyu Wang
    • Jia Xu
    • Qinglin Kang
  • View Affiliations

  • Published online on: November 5, 2020     https://doi.org/10.3892/mmr.2020.11670
  • Article Number: 32
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Our understanding of the skeletal system has been expanded upon the recognition of several neural pathways that serve important roles in bone metabolism and skeletal homeostasis, as bone tissue is richly innervated. Considerable evidence provided by in vitro, animal and human studies have further elucidated the importance of a host of hormones and local factors, including neurotransmitters, in modulating bone metabolism and osteo‑chondrogenic differentiation, both peripherally and centrally. Various cells of the musculoskeletal system not only express receptors for these neurotransmitters, but also influence their endogenous levels in the skeleton. As with a number of physiological systems in nature, a neuronal pathway regulating bone turnover will be neutralized by another pathway exerting an opposite effect. These neuropeptides are also critically involved in articular cartilage homeostasis and pathogenesis of degenerative joint disorders, such as osteoarthritis. In the present Review, data on the role of several neuronal populations in nerve‑dependent skeletal metabolism is examined, and the molecular events involved are explored, which may reveal broader relationships between two apparently unrelated organs.
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January-2021
Volume 23 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang X, Xu J and Kang Q: Neuromodulation of bone: Role of different peptides and their interactions (Review). Mol Med Rep 23: 32, 2021
APA
Wang, X., Xu, J., & Kang, Q. (2021). Neuromodulation of bone: Role of different peptides and their interactions (Review). Molecular Medicine Reports, 23, 32. https://doi.org/10.3892/mmr.2020.11670
MLA
Wang, X., Xu, J., Kang, Q."Neuromodulation of bone: Role of different peptides and their interactions (Review)". Molecular Medicine Reports 23.1 (2021): 32.
Chicago
Wang, X., Xu, J., Kang, Q."Neuromodulation of bone: Role of different peptides and their interactions (Review)". Molecular Medicine Reports 23, no. 1 (2021): 32. https://doi.org/10.3892/mmr.2020.11670