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miR-31 attenuates murine allergic rhinitis by suppressing interleukin-13-induced nasal epithelial inflammatory responses

  • Authors:
    • Fangwei Zhou
    • Peiqiang Liu
    • Hao Lv
    • Ziang Gao
    • Wenchuan Chang
    • Yu Xu
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 42
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    Published online on: November 10, 2020
       https://doi.org/10.3892/mmr.2020.11680
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Abstract

The present study aimed to investigate whether microRNA (miR)‑31 exerted therapeutic potential in allergic rhinitis (AR) and to explore its underlying mechanism. Firstly, the expression levels of miR‑31 were detected by reverse transcription‑quantitative PCR in the nasal mucosa of patients and mice. Subsequently, an ovalbumin (OVA)‑induced animal model of AR was constructed. Allergic symptom score, histopathological characteristics, OVA‑specific immunoglobulin E (IgE) titers, and T‑helper (Th)1 and Th2 cell‑related cytokine levels were analyzed in OVA‑sensitized mice, miR‑31‑overexpressing mice, miR‑negative control mice and control mice. Furthermore, interleukin (IL)‑13‑stimulated nasal epithelial cells (NECs) were used to assess the effects of miR‑31 on the production of IL‑13‑induced inflammatory cytokines and mucin 5AC by performing western blotting and ELISA. The expression levels of miR‑31 were significantly decreased in the nasal mucosa of the AR group compared with those in the control group. Moreover, upregulation of miR‑31 markedly attenuated sneezing and nasal rubbing events, reduced nasal eosinophil infiltration and goblet cell hyperplasia, and decreased the levels of OVA‑specific IgE and Th2‑related cytokines. In addition, subsequent in vitro experiments showed that upregulation of miR‑31 inhibited IL‑13 receptor α1 chain expression and signal transducer and activator of transcription 6 phosphorylation in NECs. Furthermore, miR‑31 suppressed IL‑13‑induced expression of thymic stromal lymphopoietin, granulocyte‑macrophage colony‑stimulating factor, eotaxin and mucin 5AC in NECs. In conclusion, these data revealed that miR‑31 could ameliorate AR by suppressing IL‑13‑induced nasal epithelial inflammatory responses, and thus may serve as a novel therapeutic target for AR.
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1 

Brożek JL, Bousquet J, Agache I, Agarwal A, Bachert C, Bosnic-Anticevich S, Brignardello-Petersen R, Canonica GW, Casale T, Chavannes NH, et al: Allergic rhinitis and its impact on asthma (ARIA) guidelines-2016 revision. J Allergy Clin Immunol. 140:950–958. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Katelaris CH, Lee BW, Potter PC, Maspero JF, Cingi C, Lopatin A, Saffer M, Xu G and Walters RD: Prevalence and diversity of allergic rhinitis in regions of the world beyond Europe and North America. Clin Exp Allergy. 42:186–207. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Scadding G: Cytokine profiles in allergic rhinitis. Curr Allergy Asthma Rep. 14:4352014. View Article : Google Scholar : PubMed/NCBI

4 

Almeida MI, Reis RM and Calin GA: MicroRNA history: Discovery, recent applications, and next frontiers. Mutat Res. 717:1–8. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Bartel DP: MicroRNAs: Target recognition and regulatory functions. Cell. 136:215–233. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Li L, Hui Y and Xing C: MicroRNA-31 affects the expression of asthma-related cytokines via regulation of CD44. Int J Clin Exp Med. 9:112016.

7 

Fan W, Liang D, Tang Y, Qu B, Cui H, Luo X, Huang X, Chen S, Higgs BW, Jallal B, et al: Identification of microRNA-31 as a novel regulator contributing to impaired interleukin-2 production in T cells from patients with systemic lupus erythematosus. Arthritis Rheum. 64:3715–3725. 2012. View Article : Google Scholar : PubMed/NCBI

8 

van der Heide V, Möhnle P, Rink J, Briegel J and Kreth S: Down-regulation of MicroRNA-31 in CD4+ T cells contributes to immunosuppression in human sepsis by promoting TH2 skewing. Anesthesiology. 124:908–922. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Whiteoak SR, Claridge A, Balendran CA, Harris RJ, Gwiggner M, Bondanese VP, Erlandsson F, Hansen MB, Cummings JR and Sanchez-Elsner T: MicroRNA-31 targets thymic stromal lymphopoietin in mucosal infiltrated CD4+ T cells: A Role in Achieving Mucosal Healing in Ulcerative Colitis? Inflamm Bowel Dis. 24:2377–2385. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Gwiggner M, Claridge A, Cummings F and Sanchez-Elsner T: OC-162 the role of micrornas miR-31 and miR-155 in the deregulation of the IL-13 pathway in ulcerative colitis. Gut. 61 (Suppl 2):A69–A70. 2012. View Article : Google Scholar

11 

Gwiggner M, Martinez-Nunez RT, Whiteoak SR, Bondanese VP, Claridge A, Collins JE, Cummings JR and Sanchez-Elsner T: MicroRNA-31 and MicroRNA-155 Are Overexpressed in ulcerative colitis and regulate IL-13 signaling by targeting interleukin 13 receptor α-1. Genes (Basel). 9:852018. View Article : Google Scholar

12 

Niu Y, Murata T, Watanabe K, Kawakami K, Yoshimura A, Inoue J, Puri RK and Kobayashi N: MIP-T3 associates with IL-13Ralpha1 and suppresses STAT6 activation in response to IL-13 stimulation. FEBS Lett. 550:139–143. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Ramalingam TR, Pesce JT, Sheikh F, Cheever AW, Mentink-Kane MM, Wilson MS, Stevens S, Valenzuela DM, Murphy AJ, Yancopoulos GD, et al: Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain. Nat Immunol. 9:25–33. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Cheng L, Chen J, Fu Q, He S, Li H, Liu Z, Tan G, Tao Z, Wang D, Wen W, et al: Chinese society of allergy guidelines for diagnosis and treatment of allergic rhinitis. Allergy Asthma Immunol Res. 10:300–353. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Tan L, Qiu T, Xiang R, Cao C, Deng Y, Tao Z and Xu Y: Down-regulation of Tet2 is associated with Foxp3 TSDR hypermethylation in regulatory T cell of allergic rhinitis. Life Sci. 241:1171012020. View Article : Google Scholar : PubMed/NCBI

16 

Wang L, Lv Q, Song X, Jiang K and Zhang J: ADRB2 suppresses IL-13-induced allergic rhinitis inflammatory cytokine regulated by miR-15a-5p. Hum Cell. 32:306–315. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Xiang R, Xu Y, Zhang W, Kong YG, Tan L, Chen SM, Deng YQ and Tao ZZ: Semaphorin 3A inhibits allergic inflammation by regulating immune responses in a mouse model of allergic rhinitis. Int Forum Allergy Rhinol. 9:528–537. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−ΔΔC(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Wang J, Cui Z, Liu L, Zhang S, Zhang Y, Zhang Y, Su H and Zhao Y: MiR-146a mimic attenuates murine allergic rhinitis by downregulating TLR4/TRAF6/NF-κB pathway. Immunotherapy. 11:1095–1105. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Liu HJ, Zhang AF, Zhao N and Li XZ: Role of miR-146a in enforcing effect of specific immunotherapy on allergic rhinitis. Immunol Invest. 45:1–10. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Singh PB, Pua HH, Happ HC, Schneider C, von Moltke J, Locksley RM, Baumjohann D and Ansel KM: MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation. J Exp Med. 214:3627–3643. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Lu TX and Rothenberg ME: Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases. J Allergy Clin Immunol. 132:3–13, quiz 14. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Stepicheva NA and Song JL: Function and regulation of microRNA-31 in development and disease. Mol Reprod Dev. 83:654–674. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Xu N, Meisgen F, Butler LM, Han G, Wang XJ, Söderberg-Nauclér C, Ståhle M, Pivarcsi A and Sonkoly E: MicroRNA-31 is overexpressed in psoriasis and modulates inflammatory cytokine and chemokine production in keratinocytes via targeting serine/threonine kinase 40. J Immunol. 190:678–688. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Yu S, Han B, Liu S, Wang H, Zhuang W, Huang Y and Zhang R: Derp1-modified dendritic cells attenuate allergic inflammation by regulating the development of T helper type1(Th1)/Th2 cells and regulatory T cells in a murine model of allergic rhinitis. Mol Immunol. 90:172–181. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Cunha S, Amaral MH, Lobo JMS and Silva AC: Lipid nanoparticles for nasal/intranasal drug delivery. Crit Rev Ther Drug Carrier Syst. 34:257–282. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Shimizu S, Kouzaki H, Ogawa T, Takezawa K, Tojima I and Shimizu T: Eosinophil-epithelial cell interactions stimulate the production of MUC5AC mucin and profibrotic cytokines involved in airway tissue remodeling. Am J Rhinol Allergy. 28:103–109. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Wang Y, Bai C, Li K, Adler KB and Wang X: Role of airway epithelial cells in development of asthma and allergic rhinitis. Respir Med. 102:949–955. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Adam E, Coulon L and Jaumotte E: The house dust mite protease allergen Der p1 induced IL-8 production in human airway epithelial cells through activation of ERK1/2 mitogen-activated protein kinase and AP-1 signaling pathways. J Allergy Clin Immunol. 113:S339. 2004. View Article : Google Scholar

30 

Matsukura S, Stellato C, Georas SN, Casolaro V, Plitt JR, Miura K, Kurosawa S, Schindler U and Schleimer RP: Interleukin-13 upregulates eotaxin expression in airway epithelial cells by a STAT6-dependent mechanism. Am J Respir Cell Mol Biol. 24:755–761. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Shi J, Luo Q, Chen F, Chen D, Xu G and Li H: Induction of IL-6 and IL-8 by house dust mite allergen Der p1 in cultured human nasal epithelial cells is associated with PAR/PI3K/NFkappaB signaling. ORL J Otorhinolaryngol Relat Spec. 72:256–265. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Bartel S, La Grutta S, Cilluffo G, Perconti G, Bongiovanni A, Giallongo A, Behrends J, Kruppa J, Hermann S, Chiang D, et al: Human airway epithelial extracellular vesicle miRNA signature is altered upon asthma development. Allergy. 75:346–356. 2020. View Article : Google Scholar : PubMed/NCBI

33 

O'Shea JJ, Gadina M and Schreiber RD: Cytokine signaling in 2002: New surprises in the Jak/Stat pathway. Cell. 109 (Suppl 1):S121–S131. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Kuperman D, Schofield B, Wills-Karp M and Grusby MJ: Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. J Exp Med. 187:939–948. 1998. View Article : Google Scholar : PubMed/NCBI

35 

Urban JF Jr, Noben-Trauth N, Donaldson DD, Madden KB, Morris SC, Collins M and Finkelman FD: IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. Immunity. 8:255–264. 1998. View Article : Google Scholar : PubMed/NCBI

36 

Miyata M, Nakamura Y, Shimokawa N, Ohnuma Y, Katoh R, Matsuoka S, Okumura K, Ogawa H, Masuyama K and Nakao A: Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation. Eur J Immunol. 39:3078–3083. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Wang X, Li Y, Luo D, Wang X, Zhang Y, Liu Z, Zhong N, Wu M and Li G: Lyn regulates mucus secretion and MUC5AC via the STAT6 signaling pathway during allergic airway inflammation. Sci Rep. 7:426752017. View Article : Google Scholar : PubMed/NCBI

38 

Takai T: TSLP expression: Cellular sources, triggers, and regulatory mechanisms. Allergol Int. 61:3–17. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Teng Y, Zhang R, Liu C, Zhou L, Wang H, Zhuang W, Huang Y and Hong Z: miR-143 inhibits interleukin-13-induced inflammatory cytokine and mucus production in nasal epithelial cells from allergic rhinitis patients by targeting IL13Rα1. Biochem Biophys Res Commun. 457:58–64. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Matsuwaki Y, Wada K, White T, Moriyama H and Kita H: Alternaria fungus induces the production of GM-CSF, interleukin-6 and interleukin-8 and calcium signaling in human airway epithelium through protease-activated receptor 2. Int Arch Allergy Immunol. 158 (Suppl 1):19–29. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Daffern PJ, Jagels MA, Saad JJ, Fischer W and Hugli TE: Upper airway epithelial cells support eosinophil survival in vitro through production of GM-CSF and prostaglandin E2: Regulation by glucocorticoids and TNF-alpha. Allergy Asthma Proc. 20:243–253. 1999. View Article : Google Scholar : PubMed/NCBI

42 

Tomazic PV, Darnhofer B and Birner-Gruenberger R: Nasal mucus proteome and its involvement in allergic rhinitis. Expert Rev Proteomics. 17:191–199. 2020. View Article : Google Scholar : PubMed/NCBI

43 

Zhang XH, Zhang YN, Li HB, Hu CY, Wang N, Cao PP, Liao B, Lu X, Cui YH and Liu Z: Overexpression of miR-125b, a novel regulator of innate immunity, in eosinophilic chronic rhinosinusitis with nasal polyps. Am J Respir Crit Care Med. 185:140–151. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhou F, Liu P, Lv H, Gao Z, Chang W and Xu Y: miR-31 attenuates murine allergic rhinitis by suppressing interleukin-13-induced nasal epithelial inflammatory responses. Mol Med Rep 23: 42, 2021.
APA
Zhou, F., Liu, P., Lv, H., Gao, Z., Chang, W., & Xu, Y. (2021). miR-31 attenuates murine allergic rhinitis by suppressing interleukin-13-induced nasal epithelial inflammatory responses. Molecular Medicine Reports, 23, 42. https://doi.org/10.3892/mmr.2020.11680
MLA
Zhou, F., Liu, P., Lv, H., Gao, Z., Chang, W., Xu, Y."miR-31 attenuates murine allergic rhinitis by suppressing interleukin-13-induced nasal epithelial inflammatory responses". Molecular Medicine Reports 23.1 (2021): 42.
Chicago
Zhou, F., Liu, P., Lv, H., Gao, Z., Chang, W., Xu, Y."miR-31 attenuates murine allergic rhinitis by suppressing interleukin-13-induced nasal epithelial inflammatory responses". Molecular Medicine Reports 23, no. 1 (2021): 42. https://doi.org/10.3892/mmr.2020.11680
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou F, Liu P, Lv H, Gao Z, Chang W and Xu Y: miR-31 attenuates murine allergic rhinitis by suppressing interleukin-13-induced nasal epithelial inflammatory responses. Mol Med Rep 23: 42, 2021.
APA
Zhou, F., Liu, P., Lv, H., Gao, Z., Chang, W., & Xu, Y. (2021). miR-31 attenuates murine allergic rhinitis by suppressing interleukin-13-induced nasal epithelial inflammatory responses. Molecular Medicine Reports, 23, 42. https://doi.org/10.3892/mmr.2020.11680
MLA
Zhou, F., Liu, P., Lv, H., Gao, Z., Chang, W., Xu, Y."miR-31 attenuates murine allergic rhinitis by suppressing interleukin-13-induced nasal epithelial inflammatory responses". Molecular Medicine Reports 23.1 (2021): 42.
Chicago
Zhou, F., Liu, P., Lv, H., Gao, Z., Chang, W., Xu, Y."miR-31 attenuates murine allergic rhinitis by suppressing interleukin-13-induced nasal epithelial inflammatory responses". Molecular Medicine Reports 23, no. 1 (2021): 42. https://doi.org/10.3892/mmr.2020.11680
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